JP5578171B2 - 複合体及びその製造方法、ならびに粒状剤及び錠剤 - Google Patents
複合体及びその製造方法、ならびに粒状剤及び錠剤 Download PDFInfo
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- JP5578171B2 JP5578171B2 JP2011508387A JP2011508387A JP5578171B2 JP 5578171 B2 JP5578171 B2 JP 5578171B2 JP 2011508387 A JP2011508387 A JP 2011508387A JP 2011508387 A JP2011508387 A JP 2011508387A JP 5578171 B2 JP5578171 B2 JP 5578171B2
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- ibuprofen
- composite
- tablet
- aluminum hydroxide
- complex
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- 229960000620 ranitidine Drugs 0.000 description 1
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 1
- 229960003147 reserpine Drugs 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
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- 229940085605 saccharin sodium Drugs 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 238000000790 scattering method Methods 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229940033134 talc Drugs 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- NZHGWWWHIYHZNX-CSKARUKUSA-N tranilast Chemical compound C1=C(OC)C(OC)=CC=C1\C=C\C(=O)NC1=CC=CC=C1C(O)=O NZHGWWWHIYHZNX-CSKARUKUSA-N 0.000 description 1
- 229960005342 tranilast Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229960004974 trepibutone Drugs 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 229960003386 triazolam Drugs 0.000 description 1
- JOFWLTCLBGQGBO-UHFFFAOYSA-N triazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl JOFWLTCLBGQGBO-UHFFFAOYSA-N 0.000 description 1
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 description 1
- 229960001661 ursodiol Drugs 0.000 description 1
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 description 1
- 229960000604 valproic acid Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
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- 239000011719 vitamin A Substances 0.000 description 1
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- 239000011720 vitamin B Substances 0.000 description 1
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- 239000011727 vitamin B9 Substances 0.000 description 1
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- 239000011718 vitamin C Substances 0.000 description 1
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- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
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- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61K2121/00—Preparations for use in therapy
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- Medicinal Preparation (AREA)
Description
[1].イブプロフェン又はその塩と水酸化アルミニウムとを含有し、イブプロフェンが非晶質イブプロフェンであり、イブプロフェン/水酸化アルミニウムで表される質量比が1/1〜3であることを特徴とする複合体。
[2].イブプロフェン又はその塩と溶媒とからなるイブプロフェン溶液に、水酸化アルミニウムを分散させた後、溶媒留去してなることを特徴とする[1]記載の複合体。
[3].水酸化アルミニウムの吸油量が1mL/g以上である[1]又は[2]記載の複合体。
[4].[1]〜[3]のいずれかに記載の複合体又はこの複合体を含む複合体粒子と、ソーマチンとを含む粒状剤。
[5].[1]〜[3]のいずれかに記載の複合体又はこの複合体を含む複合体粒子と、メジアン径が30μm未満のクロスポビドンとを含む粒状剤。
[6].[1]〜[3]のいずれかに記載の複合体又はこの複合体を含む複合体粒子と、ソーマチンとを含む錠剤。
[7].[1]〜[3]のいずれかに記載の複合体又はこの複合体を含む複合体粒子と、メジアン径が30μm未満のクロスポビドンとを含む錠剤。
[8].錠剤が、口腔内崩壊錠、口腔内溶解錠又はチュアブル錠である[6]又は[7]記載の錠剤。
[9].イブプロフェン又はその塩と溶媒とからなるイブプロフェン溶液に、水酸化アルミニウムを分散させた後、溶媒留去することを特徴とする[1]記載の複合体の製造方法。
イブプロフェン又はその塩としては、イブプロフェン(2−(4−isobutylphenyl)propionic acid)及びその塩類、例えば、ナトリウム、カリウム、マグネシウム、カルシウム、アンモニウム、メチルグルカミン、さらにはリジン等のアミノ酸との塩等が挙げられる。イブプロフェン又はその塩は解熱鎮痛薬として有効であるが、溶出性に問題があり、苦味を有する。イブプロフェンの複合体及び製剤(粒状剤及び錠剤)への配合量は、OTC医薬品承認基準量に基づき、1日服用量が450mgとなるように適宜選定される。
水酸化アルミニウムは、非晶質化イブプロフェンの担体となるものである。水酸化アルミニウムとしては、好ましくは吸油量1mL/g以上、より好ましくは1.2mL/g以上の水酸化アルミニウムを用いることができる。吸油量が1mL/g未満では非晶質の安定性が不十分となるおそれがある。吸油量の上限は特に限定されないが、吸油量が大きすぎると複合体の製造性に問題が生じる場合があり、7mL/g以下が好ましい。イブプロフェンの複合体及び製剤(粒状剤及び錠剤)への配合量は、イブプロフェン/水酸化アルミニウムで表される質量比が1/0.5〜7が好ましく、1/1〜4がより好ましい。
複合体は、例えば、イブプロフェン又はその塩と溶媒とからなるイブプロフェン溶液に、水酸化アルミニウムを分散又は溶解させた後、溶媒留去する方法、イブプロフェン又はその塩に水酸化アルミニウムゲルを加え、加熱溶融させた後に冷却し、固化させる方法等により得ることができる。このように、イブプロフェン又はその塩を一度溶解させ、水酸化アルミニウムを担体として、再析出させることで、イブプロフェンが非結晶化され、非晶質イブプロフェンが水酸化アルミニウムに担持された複合体となる。非結晶化は、熱分析(DSC)回折装置にて、イブプロフェン結晶由来の回折ピークが観察されないことから確認できる。
本発明の複合体又は複合体粒子を配合し、これを含有する粒状剤又は錠剤の製剤とすることができる。特に錠剤が、口腔内崩壊錠、口腔内溶解錠又は口中で咀嚼して服用可能なチュアブル錠等にした場合、本発明の効果が顕著に発揮される。複合体の配合量は、上記イブプロフェン又はその塩、水酸化アルミニウムの摂取量に合わせ、適宜選定される。例えば、1回2錠で、イブプロフェンと水酸化アルミニウムの質量比(イブプロフェン/水酸化アルミニウム)が1/1の場合、1錠当たりの複合体配合量としては150mgとなる。
結晶性イブプロフェン100gをエタノール200gに溶解した。これに乾燥水酸化アルミニウムゲル50gを加えて均一なスラリーとした後、ロータリーエバポレーターにて溶媒を留去した。残留物の結晶性を理学電気(株)製熱分析装置にて評価したところ、イブプロフェン結晶由来の融解ピークは観察されず、イブプロフェンは非晶質化していた。残留物を150〜355μmの篩いで篩過し、体積平均粒径200μmの粒子を得た。
なお、参考例1の粒子の熱分析(DSC)結果を示すチャートを図1に示す。
乾燥水酸化アルミニウムゲルを表1,2の成分及び量に変更する以外は、参考例1と同様の方法で、粒子を得た。粒子の結晶性を理学電気(株)製熱分析装置にて評価した。イブプロフェンの結晶又は非晶質化は表に示す通りである。
していた。さらに、表中にソーマチン(三栄源エフ・エフ・アイ社 サンスイートT−147)又はスクラロース(三栄源エフ・エフ・アイ社 スクラロース)量の記載がある場合は、これらを添加・混合し、粒状剤を得た。
結晶性イブプロフェン100gに乾燥水酸化アルミニウムゲル50gを加えた後、90℃の水浴上でイブプロフェンを撹拌しながら溶融した。溶融分散物をステンレス製のバットにあけて室温まで冷却し、固化物を乳鉢で粉砕した。固化物の結晶性を理学電気(株)製熱分析装置にて評価したところ、イブプロフェン結晶由来の融解ピークは観察されず、イブプロフェンは非晶質化していた。
結晶性イブプロフェン100gと乾燥水酸化アルミニウムゲル100g、ソーマチン0.05gとをビニール袋に入れ、手で30回振って混合した。混合物の結晶性を理学電気(株)製熱分析装置にて評価したところ、イブプロフェン結晶由来の融解ピークが観察され、イブプロフェンは結晶性であった。
比較例5で得られた粒子を核粒子とし、エチルセルロース20%、トリアセチン3%の水分散液をコーティング液とし、MP−01ワースター型微粒子コーティング装置(パウレック社製)にて、給気温度は70℃、排気温度30℃で造粒し、その後、80℃・1時間クエンチングして、コーティング粒子を得た。コーティング率は、イブプロフェンと乾燥水酸化アルミニウムゲルの合計量100部に対して15部であった。コーティング剤については、表に記載していない。
表3,4に示す組成物を混合し、タブレッティングテスターにて打錠圧400kgで打錠し、直径10mmの口腔内崩壊錠を得た。
実施例1で得られた複合粒子を、比較例6で得られたコーティング粒子にする以外は、実施例5と同様の方法で、口腔内崩壊錠を得た。
<苦味抑制>
イブプロフェン量として75mgとなる量の粒状剤、及び口腔内崩壊錠を専門パネル8名が口中で20秒間溶解させた。溶解物を吐き出した後、下記評価基準に従って官能評価を行った。結果を平均値で示す。
1点:非常に苦い
2点:かなり苦い
3点:苦い
4点:やや苦い
5点:苦くない
日局一般試験法に準じ、溶出液にpH4.5のクエン酸緩衝液を用い、イブプロフェン量として75mgとなる量の粒状剤、及び口腔内崩壊錠を溶解させ、10分における溶出率を算出した。結果を溶出率と評価下記基準で示す。
◎:溶出率70%以上
○:溶出率55%以上70%未満
△:溶出率40%以上55%未満
×:溶出率40%未満
参考例1、実施例1、4、参考例2及び3の複合粒子を核粒子とし、エチルセルロース20%、トリアセチン3%の水分散液をコーティング液とし、MP−01ワースター型微粒子コーティング装置(パウレック社製)にて、給気温度は70℃、排気温度30℃で造粒し、その後80℃・1時間クエンチングし、コーティング粒子を得た。コーティング率は、イブプロフェンと乾燥水酸化アルミニウムゲルの合計量100部に対して15部であった。これらコーティング粒子のイブプロフェンはいずれも非晶質となっており、苦味、溶出性とも実施例1〜12、参考例1〜4と同様に優れていた。
結晶性イブプロフェン100gをエタノール200gに溶解した。これに乾燥水酸化アルミニウムゲル100g及びメタケイ酸アルミン酸マグネシウム50gを加えて均一なスラリーとした後、ロータリーエバポレーターにて溶媒を留去した。残留物の結晶性を理学電気(株)製熱分析装置にて評価したところ、イブプロフェン結晶由来の融解ピークは観察されず、イブプロフェンは非晶質化していた。残留物を150〜355μmの篩いで篩過し、平均粒径200μmの複合粒子を得た。
実施例15で得られた複合粒子を用いて下記組成の混合物を調製し、この混合物422.55mgをタブレッティングテスターにて打錠圧400kgで打錠し、直径10mmの口腔内崩壊錠を得た。
混合物組成
複合粒子(実施例15) 187.5g
結晶セルロース(セオラスKG801) 150g
クロスポビドン(ポリプラスドンINF−10) 80g
ソーマチン 0.05g
ステアリン酸マグネシウム 5g
合計 422.55g
イブプロフェン100g、乾燥水酸化アルミニウムゲル200g、メタケイ酸アルミン酸マグネシウム100gとする以外は実施例15と同様の方法で、複合粒子を得た。得られた複合粒子を参考例5と同様の方法で造粒し、コーティング粒子を得た。
実施例17で得られたコーティング粒子を用いて下記組成の混合物を調製し、この混合物457.6mgをタブレッティングテスターにて打錠圧400kgで打錠し、直径10mmの口腔内崩壊錠を得た。
混合物組成
コーティング粒子(実施例17) 172.5g
アセトアミノフェンのコーティング物* 85g
D−マンニトール 140g
クロスポピドン(コリドンCL) 50g
ソーマチン 0.05g
ステアリン酸マグネシウム 10g
合計 457.55g
*アセトアミノフェンのコーティング物;アセトアミノフェンを参考例5と同様の方法で造粒し、コーティングした。コーティング率はアセトアミノフェン100質量部に対して15質量部であった。
イブプロフェン100g、乾燥水酸化アルミニウムゲル100g、メタケイ酸アルミン酸マグネシウム200gとする以外は実施例13と同様の方法で、複合粒子を得た。得られた複合粒子を参考例5と同様の方法で造粒し、コーティング粒子を得た。
実施例19で得られたコーティング粒子を用いて下記組成の混合物を調製し、この混合物470mgをタブレッティングテスターにて打錠圧400kgで打錠し、直径10mmの口腔内崩壊錠とした。
混合物組成
コーティング粒子(実施例19) 345g
果糖 100g
クロスポピドン(コリドンCL−SF) 20g
ソーマチン 0.05g
スクラロース 0.3g
ステアリン酸マグネシウム 5g
香料 0.5g
合計 470.85g
実施例15〜20で得られた複合粒子中のイブプロフェンは非晶質であり、苦味、溶出性は実施例実施例1〜12、参考例1〜4と同様に優れていた。
Claims (9)
- イブプロフェン又はその塩と水酸化アルミニウムとを含有し、イブプロフェンが非晶質イブプロフェンであり、イブプロフェン/水酸化アルミニウムで表される質量比が1/1〜3であることを特徴とする複合体。
- イブプロフェン又はその塩と溶媒とからなるイブプロフェン溶液に、水酸化アルミニウムを分散させた後、溶媒留去してなることを特徴とする請求項1記載の複合体。
- 水酸化アルミニウムの吸油量が1mL/g以上である請求項1又は2記載の複合体。
- 請求項1〜3のいずれか1項記載の複合体又はこの複合体を含む複合体粒子と、ソーマチンとを含む粒状剤。
- 請求項1〜3のいずれか1項記載の複合体又はこの複合体を含む複合体粒子と、メジアン径が30μm未満のクロスポビドンとを含む粒状剤。
- 請求項1〜3のいずれか1項記載の複合体又はこの複合体を含む複合体粒子と、ソーマチンとを含む錠剤。
- 請求項1〜3のいずれか1項記載の複合体又はこの複合体を含む複合体粒子と、メジアン径が30μm未満のクロスポビドンとを含む錠剤。
- 錠剤が、口腔内崩壊錠、口腔内溶解錠又はチュアブル錠である請求項6又は7記載の錠剤。
- イブプロフェン又はその塩と溶媒とからなるイブプロフェン溶液に、水酸化アルミニウムを分散させた後、溶媒留去することを特徴とする請求項1記載の複合体の製造方法。
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JPH0249720A (ja) * | 1988-05-18 | 1990-02-20 | Mitsubishi Kasei Corp | 難溶性薬剤組成物 |
JPH05271066A (ja) * | 1991-03-22 | 1993-10-19 | Takeda Chem Ind Ltd | 非晶質組成物およびその製造方法 |
JPH11246404A (ja) * | 1998-03-04 | 1999-09-14 | Taiho Yakuhin Kogyo Kk | 吸収を改善した医薬組成物 |
JP2000290199A (ja) * | 1999-03-31 | 2000-10-17 | Taisho Pharmaceut Co Ltd | 経口用医薬組成物 |
JP2001278810A (ja) * | 2000-03-28 | 2001-10-10 | Lion Corp | 薬剤組成物の製造方法 |
WO2005037254A1 (ja) * | 2003-10-15 | 2005-04-28 | Fuji Chemical Industry Co., Ltd. | 口腔内速崩壊性錠剤 |
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JPH05271066A (ja) * | 1991-03-22 | 1993-10-19 | Takeda Chem Ind Ltd | 非晶質組成物およびその製造方法 |
JPH11246404A (ja) * | 1998-03-04 | 1999-09-14 | Taiho Yakuhin Kogyo Kk | 吸収を改善した医薬組成物 |
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