JP5557425B2 - 改良ｎ４キレーターコンジュゲート - Google Patents

改良ｎ４キレーターコンジュゲート Download PDF

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Publication number
JP5557425B2
JP5557425B2 JP2007522011A JP2007522011A JP5557425B2 JP 5557425 B2 JP5557425 B2 JP 5557425B2 JP 2007522011 A JP2007522011 A JP 2007522011A JP 2007522011 A JP2007522011 A JP 2007522011A JP 5557425 B2 JP5557425 B2 JP 5557425B2
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JP
Japan
Prior art keywords
group
acid
formula
tert
compound
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JP2007522011A
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English (en)
Japanese (ja)
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JP2008510683A (ja
JP2008510683A5 (enExample
Inventor
ストーリー，アンソニー・イーモン
ワズワース，ハリー
パウエル，ナイジェル・アンソニー
ダンカンソン，フィリップ
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
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Publication of JP2008510683A5 publication Critical patent/JP2008510683A5/ja
Application granted granted Critical
Publication of JP5557425B2 publication Critical patent/JP5557425B2/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2007522011A 2004-07-19 2005-07-19 改良ｎ４キレーターコンジュゲート Expired - Lifetime JP5557425B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0416062.8A GB0416062D0 (en) 2004-07-19 2004-07-19 Improved N4 chelator conjugates
GB0416062.8 2004-07-19
PCT/GB2005/002807 WO2006008496A2 (en) 2004-07-19 2005-07-19 Improved n4 chelator conjugates

Publications (3)

Publication Number Publication Date
JP2008510683A JP2008510683A (ja) 2008-04-10
JP2008510683A5 JP2008510683A5 (enExample) 2008-09-04
JP5557425B2 true JP5557425B2 (ja) 2014-07-23

Family

ID=32893775

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007522011A Expired - Lifetime JP5557425B2 (ja) 2004-07-19 2005-07-19 改良ｎ４キレーターコンジュゲート

Country Status (14)

Country Link
US (1) US7767796B2 (enExample)
EP (1) EP1768708B1 (enExample)
JP (1) JP5557425B2 (enExample)
KR (2) KR20130024963A (enExample)
CN (1) CN101128219B (enExample)
AU (1) AU2005263942B2 (enExample)
BR (1) BRPI0513456A (enExample)
CA (1) CA2573384C (enExample)
ES (1) ES2628935T3 (enExample)
GB (1) GB0416062D0 (enExample)
MX (1) MX2007000744A (enExample)
NO (1) NO20070348L (enExample)
RU (1) RU2360701C2 (enExample)
WO (1) WO2006008496A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI448284B (zh) * 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
CN101732736B (zh) * 2009-12-02 2012-04-04 北京师范大学 制备锝-99m标记的DTPA-LSA的药盒及制备方法和应用
GB0922014D0 (en) 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel integrin binders
GB201016206D0 (en) * 2010-09-27 2010-11-10 Ge Healthcare Ltd Apoptosis imaging agents
RU2465011C1 (ru) * 2011-04-27 2012-10-27 Общество с ограниченной ответственностью "ИНТЕРА-МЕД" Радиофармацевтический препарат для диагностики меланомы и ее метастазов
GB201110767D0 (en) 2011-06-24 2011-08-10 Ge Healthcare Ltd Infection imaging
GB201600161D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope purification method
RU2655392C1 (ru) * 2017-03-02 2018-05-28 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский политехнический университет" Способ получения комплекса технеция-99м с октреотидом для диагностики нейроэндокринных опухолей
CA3100235A1 (en) 2018-05-16 2019-11-21 Emory University Styrylbenzothiazole derivatives and uses in imaging

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242679A (en) * 1985-01-14 1993-09-07 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US5175343A (en) * 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
EP0188256B1 (en) * 1985-01-14 1991-08-21 NeoRx Metal radionuclide labeled proteins for diagnosis and therapy
EP0354923B1 (en) * 1987-04-02 1994-06-29 Centocor, Inc. Method for labelling antibodies with a metal ion
US4952393A (en) * 1987-04-02 1990-08-28 The General Hospital Corporation Organ infarct imaging with technetium labelled glucarate
US5053493A (en) * 1987-04-02 1991-10-01 Centocor Cardiovascular Imaging Partners, L.P. Method for labeling antibodies with a metal ion
US4994560A (en) * 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
US5489425A (en) * 1987-06-24 1996-02-06 The Dow Chemical Company Functionalized polyamine chelants
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
EP0607103A3 (en) * 1993-01-12 1997-07-09 Sandoz Ltd Somatostatin analogs containing chelating groups and their radiolabeled compositions.
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
WO1997010854A1 (en) * 1995-09-18 1997-03-27 Mallinckrodt Medical, Inc. (radio) labelled biotin derivatives
GR1003661B (el) * 2000-05-25 2001-09-05 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ
GB0116815D0 (en) * 2001-07-10 2001-08-29 Nycomed Amersham Plc Improved chelator conjugates
EP2347771A1 (en) 2001-07-10 2011-07-27 Ge Healthcare As Peptide-based compounds for targeted imaging
GB0130305D0 (en) * 2001-12-19 2002-02-06 Amersham Plc Compounds for imaging alzheimers disease
JP2007510643A (ja) * 2003-11-06 2007-04-26 ジーイー・ヘルスケア・アクスイェ・セルスカプ 医薬化合物
JP2007512321A (ja) * 2003-11-24 2007-05-17 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
ATE447417T1 (de) * 2004-03-04 2009-11-15 Ge Healthcare As Konjugate von angiotensin-peptid analoga und chelatbildner für diagnose und therapie

Also Published As

Publication number Publication date
RU2007101515A (ru) 2008-08-27
MX2007000744A (es) 2007-06-25
CA2573384A1 (en) 2006-01-26
KR20130024963A (ko) 2013-03-08
ES2628935T3 (es) 2017-08-04
AU2005263942B2 (en) 2009-02-26
KR20070034064A (ko) 2007-03-27
US20080131368A1 (en) 2008-06-05
US7767796B2 (en) 2010-08-03
AU2005263942A1 (en) 2006-01-26
WO2006008496A3 (en) 2006-07-27
BRPI0513456A (pt) 2008-05-06
GB0416062D0 (en) 2004-08-18
CN101128219B (zh) 2012-06-20
WO2006008496A2 (en) 2006-01-26
EP1768708A2 (en) 2007-04-04
JP2008510683A (ja) 2008-04-10
CA2573384C (en) 2013-09-10
EP1768708B1 (en) 2017-05-17
CN101128219A (zh) 2008-02-20
RU2360701C2 (ru) 2009-07-10
NO20070348L (no) 2007-02-16

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