KR20130024963A - 개선된 ｎ4 킬레이트제 결합체 - Google Patents
개선된 ｎ4 킬레이트제 결합체 Download PDFInfo
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- KR20130024963A KR20130024963A KR1020137002190A KR20137002190A KR20130024963A KR 20130024963 A KR20130024963 A KR 20130024963A KR 1020137002190 A KR1020137002190 A KR 1020137002190A KR 20137002190 A KR20137002190 A KR 20137002190A KR 20130024963 A KR20130024963 A KR 20130024963A
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- 238000003608 radiolysis reaction Methods 0.000 description 1
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- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 description 1
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- BIXNGBXQRRXPLM-UHFFFAOYSA-K ruthenium(3+);trichloride;hydrate Chemical compound O.Cl[Ru](Cl)Cl BIXNGBXQRRXPLM-UHFFFAOYSA-K 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
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- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 230000003335 steric effect Effects 0.000 description 1
- 238000012027 sterile manufacturing Methods 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- BUUPQKDIAURBJP-UHFFFAOYSA-N sulfinic acid Chemical compound OS=O BUUPQKDIAURBJP-UHFFFAOYSA-N 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- CVKJXWOUXWRRJT-UHFFFAOYSA-N technetium dioxide Chemical compound O=[Tc]=O CVKJXWOUXWRRJT-UHFFFAOYSA-N 0.000 description 1
- DVBDHOBEQUATIG-UHFFFAOYSA-N tert-butyl N-[3,5-bis[(2-methylpropan-2-yl)oxycarbonylamino]-2-(2-phenylmethoxyethyl)pentyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCC(NC(=O)OC(C)(C)C)C(CNC(=O)OC(C)(C)C)CCOCC1=CC=CC=C1 DVBDHOBEQUATIG-UHFFFAOYSA-N 0.000 description 1
- MFPWEWYKQYMWRO-UHFFFAOYSA-N tert-butyl carboxy carbonate Chemical compound CC(C)(C)OC(=O)OC(O)=O MFPWEWYKQYMWRO-UHFFFAOYSA-N 0.000 description 1
- XDJDIXXMKQBMRF-UHFFFAOYSA-N tert-butyl n-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]-n-[2-[[(2-methylpropan-2-yl)oxycarbonyl-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]amino]methyl]-4-phenylmethoxybutyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCN(C(=O)OC(C)(C)C)CC(CN(CCNC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)CCOCC1=CC=CC=C1 XDJDIXXMKQBMRF-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- 150000003556 thioamides Chemical class 0.000 description 1
- 150000003567 thiocyanates Chemical class 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 229960004906 thiomersal Drugs 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000006478 transmetalation reaction Methods 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
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- 229930004006 tropane Natural products 0.000 description 1
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- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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| GB0416062.8 | 2004-07-19 | ||
| GBGB0416062.8A GB0416062D0 (en) | 2004-07-19 | 2004-07-19 | Improved N4 chelator conjugates |
| PCT/GB2005/002807 WO2006008496A2 (en) | 2004-07-19 | 2005-07-19 | Improved n4 chelator conjugates |
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| KR1020077001298A Division KR20070034064A (ko) | 2004-07-19 | 2005-07-19 | 개선된 ｎ4 킬레이트제 결합체 |
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| KR20130024963A true KR20130024963A (ko) | 2013-03-08 |
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| KR1020137002190A Ceased KR20130024963A (ko) | 2004-07-19 | 2005-07-19 | 개선된 ｎ4 킬레이트제 결합체 |
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| AU (1) | AU2005263942B2 (enExample) |
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| CA (1) | CA2573384C (enExample) |
| ES (1) | ES2628935T3 (enExample) |
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| MX (1) | MX2007000744A (enExample) |
| NO (1) | NO20070348L (enExample) |
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| TWI448284B (zh) * | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
| CN101732736B (zh) * | 2009-12-02 | 2012-04-04 | 北京师范大学 | 制备锝-99m标记的DTPA-LSA的药盒及制备方法和应用 |
| GB0922014D0 (en) | 2009-12-17 | 2010-02-03 | Ge Healthcare Ltd | Novel integrin binders |
| GB201016206D0 (en) * | 2010-09-27 | 2010-11-10 | Ge Healthcare Ltd | Apoptosis imaging agents |
| RU2465011C1 (ru) * | 2011-04-27 | 2012-10-27 | Общество с ограниченной ответственностью "ИНТЕРА-МЕД" | Радиофармацевтический препарат для диагностики меланомы и ее метастазов |
| GB201110767D0 (en) | 2011-06-24 | 2011-08-10 | Ge Healthcare Ltd | Infection imaging |
| GB201600161D0 (en) * | 2016-01-05 | 2016-02-17 | Bayer As | Isotope purification method |
| RU2655392C1 (ru) * | 2017-03-02 | 2018-05-28 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский политехнический университет" | Способ получения комплекса технеция-99м с октреотидом для диагностики нейроэндокринных опухолей |
| WO2019222454A1 (en) | 2018-05-16 | 2019-11-21 | Emory University | Styrylbenzothiazole derivatives and uses in imaging |
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| US5175343A (en) * | 1985-01-14 | 1992-12-29 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| EP0188256B1 (en) * | 1985-01-14 | 1991-08-21 | NeoRx | Metal radionuclide labeled proteins for diagnosis and therapy |
| US5242679A (en) * | 1985-01-14 | 1993-09-07 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| US5053493A (en) * | 1987-04-02 | 1991-10-01 | Centocor Cardiovascular Imaging Partners, L.P. | Method for labeling antibodies with a metal ion |
| DE3850497T2 (de) * | 1987-04-02 | 1995-02-23 | Centocor Inc | Methode zur markierung von antikörpern mit einem metallion. |
| US4952393A (en) * | 1987-04-02 | 1990-08-28 | The General Hospital Corporation | Organ infarct imaging with technetium labelled glucarate |
| US4994560A (en) * | 1987-06-24 | 1991-02-19 | The Dow Chemical Company | Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies |
| US5489425A (en) * | 1987-06-24 | 1996-02-06 | The Dow Chemical Company | Functionalized polyamine chelants |
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| US5650134A (en) * | 1993-01-12 | 1997-07-22 | Novartis Ag (Formerly Sandoz Ltd.) | Peptides |
| NZ250653A (en) * | 1993-01-12 | 1995-12-21 | Sandoz Ltd | Somatostatin derivatives and pharmaceutical or diagnostic imaging compositions |
| JPH11513374A (ja) * | 1995-09-18 | 1999-11-16 | マリンクロッド・メディカル・インコーポレイテッド | （放射性）標識化ビオチン誘導体類 |
| GR1003661B (el) * | 2000-05-25 | 2001-09-05 | Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... | ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ |
| GB0116815D0 (en) * | 2001-07-10 | 2001-08-29 | Nycomed Amersham Plc | Improved chelator conjugates |
| JP4510444B2 (ja) | 2001-07-10 | 2010-07-21 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | ペプチドベースの化合物 |
| GB0130305D0 (en) * | 2001-12-19 | 2002-02-06 | Amersham Plc | Compounds for imaging alzheimers disease |
| US7785566B2 (en) * | 2003-11-06 | 2010-08-31 | Ge Healthcare, Inc. | Pharmaceutical compounds |
| US7431914B2 (en) * | 2003-11-24 | 2008-10-07 | Ge Healthcare As | Contrast agent |
| JP2007526300A (ja) * | 2004-03-04 | 2007-09-13 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 医薬化合物 |
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2004
- 2004-07-19 GB GBGB0416062.8A patent/GB0416062D0/en not_active Ceased
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2005
- 2005-07-19 CN CN2005800297360A patent/CN101128219B/zh not_active Expired - Lifetime
- 2005-07-19 JP JP2007522011A patent/JP5557425B2/ja not_active Expired - Lifetime
- 2005-07-19 BR BRPI0513456-0A patent/BRPI0513456A/pt not_active IP Right Cessation
- 2005-07-19 EP EP05763654.0A patent/EP1768708B1/en not_active Expired - Lifetime
- 2005-07-19 RU RU2007101515/04A patent/RU2360701C2/ru not_active IP Right Cessation
- 2005-07-19 AU AU2005263942A patent/AU2005263942B2/en not_active Ceased
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- 2005-07-19 KR KR1020077001298A patent/KR20070034064A/ko not_active Ceased
- 2005-07-19 KR KR1020137002190A patent/KR20130024963A/ko not_active Ceased
- 2005-07-19 WO PCT/GB2005/002807 patent/WO2006008496A2/en not_active Ceased
- 2005-07-19 CA CA2573384A patent/CA2573384C/en not_active Expired - Fee Related
- 2005-07-19 ES ES05763654.0T patent/ES2628935T3/es not_active Expired - Lifetime
- 2005-07-19 MX MX2007000744A patent/MX2007000744A/es active IP Right Grant
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2007
- 2007-01-18 NO NO20070348A patent/NO20070348L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101128219B (zh) | 2012-06-20 |
| AU2005263942A1 (en) | 2006-01-26 |
| BRPI0513456A (pt) | 2008-05-06 |
| NO20070348L (no) | 2007-02-16 |
| GB0416062D0 (en) | 2004-08-18 |
| MX2007000744A (es) | 2007-06-25 |
| ES2628935T3 (es) | 2017-08-04 |
| EP1768708B1 (en) | 2017-05-17 |
| US20080131368A1 (en) | 2008-06-05 |
| RU2360701C2 (ru) | 2009-07-10 |
| EP1768708A2 (en) | 2007-04-04 |
| CA2573384C (en) | 2013-09-10 |
| JP5557425B2 (ja) | 2014-07-23 |
| RU2007101515A (ru) | 2008-08-27 |
| CN101128219A (zh) | 2008-02-20 |
| WO2006008496A2 (en) | 2006-01-26 |
| US7767796B2 (en) | 2010-08-03 |
| WO2006008496A3 (en) | 2006-07-27 |
| AU2005263942B2 (en) | 2009-02-26 |
| JP2008510683A (ja) | 2008-04-10 |
| CA2573384A1 (en) | 2006-01-26 |
| KR20070034064A (ko) | 2007-03-27 |
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