CN101128219B - 改进的n4螯合剂缀合物 - Google Patents

改进的n4螯合剂缀合物 Download PDF

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Publication number
CN101128219B
CN101128219B CN2005800297360A CN200580029736A CN101128219B CN 101128219 B CN101128219 B CN 101128219B CN 2005800297360 A CN2005800297360 A CN 2005800297360A CN 200580029736 A CN200580029736 A CN 200580029736A CN 101128219 B CN101128219 B CN 101128219B
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CN
China
Prior art keywords
technetium
compound
group
chelator
technetium complex
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Expired - Lifetime
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CN2005800297360A
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English (en)
Chinese (zh)
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CN101128219A (zh
Inventor
A·E·斯托里
H·沃兹沃思
N·A·鲍威尔
P·邓坎森
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication of CN101128219A publication Critical patent/CN101128219A/zh
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Publication of CN101128219B publication Critical patent/CN101128219B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN2005800297360A 2004-07-19 2005-07-19 改进的n4螯合剂缀合物 Expired - Lifetime CN101128219B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0416062.8A GB0416062D0 (en) 2004-07-19 2004-07-19 Improved N4 chelator conjugates
GB0416062.8 2004-07-19
PCT/GB2005/002807 WO2006008496A2 (en) 2004-07-19 2005-07-19 Improved n4 chelator conjugates

Publications (2)

Publication Number Publication Date
CN101128219A CN101128219A (zh) 2008-02-20
CN101128219B true CN101128219B (zh) 2012-06-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800297360A Expired - Lifetime CN101128219B (zh) 2004-07-19 2005-07-19 改进的n4螯合剂缀合物

Country Status (14)

Country Link
US (1) US7767796B2 (enExample)
EP (1) EP1768708B1 (enExample)
JP (1) JP5557425B2 (enExample)
KR (2) KR20070034064A (enExample)
CN (1) CN101128219B (enExample)
AU (1) AU2005263942B2 (enExample)
BR (1) BRPI0513456A (enExample)
CA (1) CA2573384C (enExample)
ES (1) ES2628935T3 (enExample)
GB (1) GB0416062D0 (enExample)
MX (1) MX2007000744A (enExample)
NO (1) NO20070348L (enExample)
RU (1) RU2360701C2 (enExample)
WO (1) WO2006008496A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI448284B (zh) * 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
CN101732736B (zh) * 2009-12-02 2012-04-04 北京师范大学 制备锝-99m标记的DTPA-LSA的药盒及制备方法和应用
GB0922014D0 (en) 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel integrin binders
GB201016206D0 (en) * 2010-09-27 2010-11-10 Ge Healthcare Ltd Apoptosis imaging agents
RU2465011C1 (ru) * 2011-04-27 2012-10-27 Общество с ограниченной ответственностью "ИНТЕРА-МЕД" Радиофармацевтический препарат для диагностики меланомы и ее метастазов
GB201110767D0 (en) 2011-06-24 2011-08-10 Ge Healthcare Ltd Infection imaging
GB201600161D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope purification method
RU2655392C1 (ru) * 2017-03-02 2018-05-28 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский политехнический университет" Способ получения комплекса технеция-99м с октреотидом для диагностики нейроэндокринных опухолей
CN112105393A (zh) 2018-05-16 2020-12-18 爱默蕾大学 苯乙烯基苯并噻唑衍生物及在成像中的用途
US20250215027A1 (en) * 2021-08-11 2025-07-03 Cancer Research Technology Limited Diphosphine compounds and complexes

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489425A (en) * 1987-06-24 1996-02-06 The Dow Chemical Company Functionalized polyamine chelants
EP0296522B1 (en) * 1987-06-24 1996-09-25 The Dow Chemical Company Functionalized polyamine chelants and rhodium complexes thereof and process for their preparation
CN1527727A (zh) * 2001-07-10 2004-09-08 ��Ĭɳķ�������޹�˾ 改进的螯合剂共轭物
CN1622830A (zh) * 2001-07-10 2005-06-01 安盛药业有限公司 肽基化合物

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US5175343A (en) * 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
ATE66469T1 (de) * 1985-01-14 1991-09-15 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
US5242679A (en) * 1985-01-14 1993-09-07 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US5053493A (en) * 1987-04-02 1991-10-01 Centocor Cardiovascular Imaging Partners, L.P. Method for labeling antibodies with a metal ion
JPH02504387A (ja) * 1987-04-02 1990-12-13 セントカー・カーデイオバスキユラー・イメージング・パートナーズ・エルピー 金属イオンで抗体を標識付けする方法
US4952393A (en) * 1987-04-02 1990-08-28 The General Hospital Corporation Organ infarct imaging with technetium labelled glucarate
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
NO940080L (no) * 1993-01-12 1994-07-13 Sandoz Ag Polypeptider , fremgangsmåte for deres fremstilling og farmasöytiske preparater derav
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
CA2232411A1 (en) * 1995-09-18 1997-03-27 Mallinckrodt Medical, Inc. (radio) labelled biotin derivatives
GR1003661B (el) * 2000-05-25 2001-09-05 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ
GB0130305D0 (en) 2001-12-19 2002-02-06 Amersham Plc Compounds for imaging alzheimers disease
US7785566B2 (en) * 2003-11-06 2010-08-31 Ge Healthcare, Inc. Pharmaceutical compounds
US7431914B2 (en) * 2003-11-24 2008-10-07 Ge Healthcare As Contrast agent
CN1925876A (zh) * 2004-03-04 2007-03-07 通用电气医疗集团股份有限公司 用于诊断和治疗的血管紧张素肽类似物和螯合剂的缀合物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489425A (en) * 1987-06-24 1996-02-06 The Dow Chemical Company Functionalized polyamine chelants
EP0296522B1 (en) * 1987-06-24 1996-09-25 The Dow Chemical Company Functionalized polyamine chelants and rhodium complexes thereof and process for their preparation
CN1527727A (zh) * 2001-07-10 2004-09-08 ��Ĭɳķ�������޹�˾ 改进的螯合剂共轭物
CN1622830A (zh) * 2001-07-10 2005-06-01 安盛药业有限公司 肽基化合物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HEPPELER A ET AL.RECEPTOR TARGETING FOR TUMOR LOCALISATIONAND THERAPY WITH RADIOPETIDES.CURRENT MEDICINAL CHEMISTRY7 9.2000,7(9),971-978.
HEPPELER A ET AL.RECEPTOR TARGETING FOR TUMOR LOCALISATIONAND THERAPY WITH RADIOPETIDES.CURRENT MEDICINAL CHEMISTRY7 9.2000,7(9),971-978. *
MAINA THEODOSIA ET AL.[99mTc]Demotate, a new 99mTc-based[Tyr3]octreotateanalogue for the detection of somatostatin receptor-positivetumours: synthesis and preclinical results.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING29 6.2002,29(6),742-753. *
MAINATHEODOSIAETAL.[99mTc]Demotate a new 99mTc-based[Tyr3]octreotateanalogue for the detection of somatostatin receptor-positivetumours: synthesis and preclinical results.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING29 6.2002

Also Published As

Publication number Publication date
AU2005263942B2 (en) 2009-02-26
EP1768708A2 (en) 2007-04-04
MX2007000744A (es) 2007-06-25
CN101128219A (zh) 2008-02-20
CA2573384C (en) 2013-09-10
US7767796B2 (en) 2010-08-03
US20080131368A1 (en) 2008-06-05
KR20070034064A (ko) 2007-03-27
EP1768708B1 (en) 2017-05-17
CA2573384A1 (en) 2006-01-26
NO20070348L (no) 2007-02-16
GB0416062D0 (en) 2004-08-18
KR20130024963A (ko) 2013-03-08
AU2005263942A1 (en) 2006-01-26
WO2006008496A3 (en) 2006-07-27
BRPI0513456A (pt) 2008-05-06
ES2628935T3 (es) 2017-08-04
JP2008510683A (ja) 2008-04-10
JP5557425B2 (ja) 2014-07-23
RU2360701C2 (ru) 2009-07-10
WO2006008496A2 (en) 2006-01-26
RU2007101515A (ru) 2008-08-27

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Granted publication date: 20120620