JP5499321B2 - 医療コーティングのためのコーティング調合物 - Google Patents
医療コーティングのためのコーティング調合物 Download PDFInfo
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- JP5499321B2 JP5499321B2 JP2009527743A JP2009527743A JP5499321B2 JP 5499321 B2 JP5499321 B2 JP 5499321B2 JP 2009527743 A JP2009527743 A JP 2009527743A JP 2009527743 A JP2009527743 A JP 2009527743A JP 5499321 B2 JP5499321 B2 JP 5499321B2
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- 238000002360 preparation method Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical group CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 238000003847 radiation curing Methods 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000009131 signaling function Effects 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000010583 slow cooling Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 description 1
- ADWNFGORSPBALY-UHFFFAOYSA-M sodium;2-[dodecyl(methyl)amino]acetate Chemical class [Na+].CCCCCCCCCCCCN(C)CC([O-])=O ADWNFGORSPBALY-UHFFFAOYSA-M 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000004528 spin coating Methods 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 125000000626 sulfinic acid group Chemical group 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium group Chemical group [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical group S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000001029 thermal curing Methods 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- YRHRIQCWCFGUEQ-UHFFFAOYSA-N thioxanthen-9-one Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3SC2=C1 YRHRIQCWCFGUEQ-UHFFFAOYSA-N 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical class Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Substances OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical compound OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 description 1
- 150000007964 xanthones Chemical class 0.000 description 1
Classifications
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
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- C09D4/00—Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; Coating compositions, based on monomers of macromolecular compounds of groups C09D183/00 - C09D183/16
- C09D4/06—Organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups C09D159/00 - C09D187/00
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- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
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- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
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- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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- C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
- C08G2650/50—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing nitrogen, e.g. polyetheramines or Jeffamines(r)
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- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
- C23C14/06—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
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- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
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- Y10T428/31855—Of addition polymer from unsaturated monomers
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- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Materials For Medical Uses (AREA)
- Paints Or Removers (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Medicinal Preparation (AREA)
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Description
式(1)
(式中、
Gは少なくともn個の官能基を有する多官能性化合物の残基であり、各R1および各R2は独立して水素を表し、または場合により1つ以上のヘテロ原子を含有する置換および非置換炭化水素から選択される基を表し、好ましくは水素またはC1〜C20炭化水素、より好ましくは水素またはC1〜C20アルキルであり;nは少なくとも2、好ましくは2〜100、より好ましくは2〜8、特に2または3の値を有する整数である)
に記載の多官能重合性化合物を使用して得られることが、今や意外にも発見された。
(a)式(1)
(式中、
Gは少なくともn個の官能基を有する多官能性化合物の残基であり、各R1および各R2は独立して水素または場合により1つ以上のヘテロ原子を含有する置換および非置換炭化水素から選択される基を表し、好ましくは水素またはC1〜C20炭化水素、より好ましくは水素またはC1〜C20アルキルであり;nは少なくとも2、好ましくは2〜100、より好ましくは2〜8、特に2または3の値を有する整数である)に記載の少なくとも1つの多官能重合性化合物、および
(b)少なくとも1つの重合開始剤
を含んでなる、医療コーティングを調製するためのコーティング調合物に関する。
[1.多官能重合性化合物の合成]
[1.1 PEG−ジアクリレート;PEGDAの合成]
[PEG4000DA]
PEG(150g、75mmol OH、フルカ(Fluka)からのBiochemika Ultra[95904]、#427345/1、OH−値:28.02mg KOH/g、499.5meq/kg、Mn:4004mol/g)を窒素雰囲気下で45℃で350mLの乾燥トルエン(メルク(Merck)プロアナリシス(pro analysis)、分子ふるい(molsieves)上(4Å)で乾燥)に溶解し、ラジカル安定剤としてイルガキュア1035(0.2g、約0.15w%、チバ・スペシャルティ・ケミカルズ(Ciba Specialty Chemicals))を添加した。PEG/トルエン溶液を一晩共沸蒸留し(50℃/70mbar)、凝縮トルエンを4Å分子ふるい上に導いた。OH滴定(分析参照)によりPEGの各バッチについてヒドロキシル値を正確に判定して、添加する塩化アクリロイル(メルク、合成用、5℃で保存してそのまま使用)の量を計算し、反応中の変換を判定することが重要である。
窒素下で、20g(13.3mmol)のPEG−ジアミン(Mn1500g/mol;アルドリッチ)を400mLのトルエン中で共沸蒸留し、約100mLのトルエンを除去した。溶液を窒素下で室温に冷却し、次に氷浴内で冷却した。50mLのジクロロメタン(メルク)を添加した。4.04g(39.7mmol)のトリエチルアミンを滴下して添加し、続いて3.48g(39.7mmol)の塩化アクリロイル(さらなる精製なしに使用した)を滴下して添加した。反応は窒素下で一晩進行した。溶液を氷浴内で冷却しNEt3・HCl塩を沈殿させ、次に濾過した。1%(w/w)イルガノックス(Irganox)1035の添加後、濾液を真空下で濃縮した。濃縮物を75mLのジクロロメタンに溶解し、続いて1.5L氷冷ジエチルエーテル中で沈殿させた。生成物を濾過して収集し、続いてジエチルエーテルで洗浄した。
合成:PEG−ジアクリルアミドの合成と同様。
塩化アクリロイルの代わりに塩化メタクリロイル(アクロス(Acros))を使用した。
乾燥不活性雰囲気内で、トルエンジイソシアネート(TDIまたはT、アルドリッチ、95%純度、87.1g、0.5mol)、イルガノックス1035(チバ・スペシャルティ・ケミカルズ、0.58g、アクリル酸ヒドロキシエチル(HEAまたはH)に対して1重量%)およびヘキサン酸2−エチルスズ(II)(シグマ(Sigma)、95%純度、0.2g、0.5mol)を1リットルフラスコ内に入れて30分間撹拌した。氷浴を使用して反応混合物を0℃に冷却した。HEA(アルドリッチ、96%純度、58.1g、0.5mol)を30分間滴下して添加し、その後氷浴を除去して混合物が室温に暖まるまで置いた。3時間後に反応が完結した。ポリ(2−メチル−1,4−ブタンジオール)−alt−ポリ(テトラメチレングリコール)(PTGL、保土谷化学工業、Mn=1000g/mol、250g、0.25mol)を30分間滴下して添加した。続いて反応混合物を60℃に加熱し、18時間撹拌した時点で、GPC(HEAの完全な消費を示す)、IR(NCO関連バンドがないことを示す)、およびNCO滴定(0.02重量%未満のNCO含量)により反応が完結したことが示された。
[3.1.NMR測定]
核磁気共鳴(NMR)測定はVarian Inova 300分光計上で実施した。
Spectrumソフトウェアを使用して、パーキン・エルマー(Perkin Elmer)Spectrum One分光光度計を用いて、フーリエ変換赤外線(FTIR)測定を実施した。
#12マイヤー・バー(MeyerBar)を使用して、表1に従ったプライマーコーティング調合物を120μmのPETホイル上に被覆し、およそ550nmの乾燥フィルム厚さを得た。空気中でDランプを使用して、プライマーコーティング調合物を1.10J/cm2に硬化させた。引き続いて表3のコーティング調合物をプライマーに被覆した。コーティングを25℃で1分間放置して乾燥させ、空気中でDランプを使用して、1.10J/cm2のUV単回パスに曝露した。得られた塗り厚は2μmであった。
ハーランドPCX塗布機によって浸漬コーティングを実施した。インターナショナル・ライト(International Light)検出器SED005#989を装着したハーランドUVR335(IL 1400としてもまた知られている)によってランプ強度を測定した。入力光学素子:W#11521、フィルターwbs320#27794。
ハーランドFTS 5000摩擦試験機を使用した。ハーランド・メディカル・システムズ(Harland Medical Systems)からの摩擦試験機パッド、P/N102692、FTS5000摩擦試験機パッド、0.125*0.5*0.125、60デュロメーターを使用した。
実施例1および比較実験Aのコーティング調合物の安定性を試験するために、次の試験を実施した。
実施例1〜2のコーティング調合物の安定性を試験するために、次の試験を実施した。
滑性コーティングを調製するのに使用したコーティング調合物の安定性を試験するために、次の試験を実施した。
[4.1.実施例1および比較実験A:摩擦試験によって判定されたコーティングの安定性]
[4.2 1.コーティングの外観]
PEG(AM)2(実施例3)、PEG(MAM)2(実施例4)、およびPEGDA(比較実験C)を含有する新鮮な調合物を硬化させると、透明なコーティングが得られた。PEGDAを含有するコーティング調合物を閉じられた容器内において50℃でインキュベートすると、得られたコーティングは、ますます不透明になる。PEG(AM)2およびPEG(MAM)2を含有する調合物からできたコーティングは、調合物を50℃でインキュベートした際に透明なままであった。これはコーティング調合物の改善された安定性を示す。
図1(比較実験C)は、滑性コーティングを調製するのに使用されるPEGDAを含んでなるコーティング調合物を50℃で2日間(塗りつぶし三角)インキュベートした後に、摩擦力(摩擦力が高いほど潤滑性は低い)で表わされる潤滑性が顕著に低下することを示す。40〜80gの範囲の摩擦力が測定された。実際に、PEGDA含有コーティング調合物から調製されたコーティングでは、第1回目の試験シリーズの最初のサイクル中に、コーティングの一部が摩擦試験機のクランプパッドによって除去された。その結果、コーティングは破損した。したがって2日間のインキュベーション後の試験シリーズの2回目の試験では、70〜140gの範囲のなおもより高い摩擦力(白抜き三角)という結果になった。これは新鮮なコーティング調合物(0日間インキュベーション)(塗りつぶしおよび白抜き四角)から調製されたコーティングでは観察されなかった。およそ10gの摩擦力が双方の試験シリーズで測定された。
Claims (23)
- (a)式(1)、
Gは少なくともn個の官能基を有するポリエーテルである親水性多官能性化合物の残基であり、各R1および各R2は独立して水素または場合により1つ以上のヘテロ原子を含有する置換および非置換炭化水素から選択される基を表し、nは2〜8の値を有する整数である。)に記載の少なくとも1つの多官能重合性化合物、
(b)少なくとも1つの重合開始剤
を含んでなる、医療コーティングを調製するためのコーティング調合物から調製される医療コーティングを備える、医療用物品。 - Gが少なくとも1つのヘテロ原子を含んでなる、請求項1に記載の医療用物品。
- 式(1)に記載の多官能重合性化合物が500g/mol以上の数平均分子量(Mn)を有する、請求項1または2に記載の医療用物品。
- 式(1)に記載の多官能重合性化合物が2000g/mol以下の数平均分子量(Mn)を有する、請求項1〜3のいずれか一項に記載の医療用物品。
- 式(1)に記載の多官能重合性化合物が極性溶剤に可溶性である、請求項1〜4のいずれか一項に記載の医療用物品。
- Gが、ポリエチレングリコールまたはポリプロピレングリコールブロックからなる親水性多官能性化合物の残基である、請求項1〜5のいずれか一項に記載の医療用物品。
- R1=HおよびR2=Hである、請求項1〜6のいずれか一項に記載の医療用物品。
- R1がCH3およびR2=Hである、請求項1〜6のいずれか一項に記載の医療用物品。
- 機能性ポリマー(c)をさらに含んでなる、請求項1〜8のいずれか一項に記載の医療用物品。
- 機能性ポリマー(c)が、ポリビニルピロリドン(PVP)、ポリ(ラクタム)、ポリウレタン、アクリル酸およびメタクリル酸のホモポリマーおよび共重合体、ポリビニルアルコール、ポリビニルエーテル、無水マレイン酸ベースの共重合体、ポリエステル、ビニルアミン、ポリエチレンイミン、ポリエチレンオキシド、ポリ(カルボン酸)、ポリアミド、ポリ酸無水物、ポリホスファゼン、セルロース系材料、ヘパリン、デキストラン、ポリペプチド、多糖類、ポリペプチド、及びそれらの混合物よりなる群から選択される親水性ポリマーである、請求項9に記載の医療用物品。
- 親水性ポリマーが、ポリアクリルアミド−コ−アクリル酸ナトリウム塩、ポリアクリル酸ナトリウム塩、ポリメタクリル酸ナトリウム塩、ポリアクリルアミド−2−メチル−1−プロパンスルホン酸ナトリウム塩、ポリ(4−スチレンスルホン酸)ナトリウム塩、ポリ(塩化アクリルアミド−コ−ジアルキルアンモニウム)、四級化ポリ[ビス−(2−クロロエチル)エーテル−alt−1,3−ビス[3−(ジメチルアミノ)プロピル]尿素]およびポリ(塩化ジアリルジメチルアンモニウム)、ポリアリルアンモニウムホスフェート、ポリ(塩化ジアリルジメチルアンモニウム)、ポリ(ナトリウムトリメチレンオキシエチレンスルホネート)、ポリ(臭化ジメチルドデシル(2−アクリルアミドエチル)アンモニウム)、ポリ(2−Nメチルピリジニウムエチレンヨウ素)、ポリビニルスルホン酸、およびポリ(ビニル)ピリジン、ポリエチレンイミン、およびポリリジンの塩、およびそれらの混合物よりなる群から選択されるポリ電解質である、請求項9に記載の医療用物品。
- ポリ電解質または低分子塩をさらに含んでなる、請求項1〜11のいずれか一項に記載の医療用物品。
- 少なくとも1つの界面活性剤をさらに含んでなる、請求項1〜12のいずれか一項に記載の医療用物品。
- 極性溶剤をさらに含んでなる、請求項1〜13のいずれか一項に記載の医療用物品。
- ポリ電解質または低分子量塩を含んでなる湿潤性流体をさらに含んでなる、請求項10〜14のいずれか一項に記載の医療用物品。
- 前記医療コーティング調合物を硬化させて得られる医療コーティングを含む、請求項1〜14のいずれか一項に記載の医療用物品。
- 前記医療コーティングが親水性医療コーティングである、請求項16に記載の医療用物品。
- 湿潤性流体を塗布することで前記親水性医療コーティングを濡らして得られる滑性医療コーティングを含む、請求項17に記載の医療用物品。
- 前記湿潤性流体がイオン性化合物を含んでなる、請求項18に記載の医療用物品。
- 前記コーティング調合物を硬化させ、得られたコーティングを濡らして得られる、滑性医療コーティングを含む、請求項15に記載の医療用物品。
- 医療用物品が医療装置または医療構成要素である請求項1〜20のいずれか一項に記載の医療用物品。
- 前記医療装置または医療構成要素が、カテーテル、医療チューブ、ガイドワイヤ、ステント、フィルター、浸透および逆浸透膜、並びに透析膜を含んでなる、請求項21に記載の医療用物品。
- −(a)式(1)、
Gは少なくともn個の官能基を有するポリエーテルである親水性多官能性化合物の残基であり、各R1および各R2は独立して水素または場合により1つ以上のヘテロ原子を含有する置換および非置換炭化水素から選択される基を表し、nは2〜8の値を有する整数である。)に記載の少なくとも1つの多官能重合性化合物、
(b)少なくとも1つの重合開始剤
を含んでなるコーティング調合物を医療用物品の少なくとも1つの表面に塗布するステップと、
−調合物を電磁放射に曝露してそれによって重合開始剤を活性化させ、コーティング調合物を硬化させるステップと、
−滑性コーティングの場合は続いてコーティングを湿潤性流体中で濡らすステップと
を含んでなる、医療、親水性または滑性コーティングを医療用物品上に形成する方法。
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-
2007
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US20140180221A1 (en) | 2014-06-26 |
JP2010506828A (ja) | 2010-03-04 |
EP2059272A1 (en) | 2009-05-20 |
JP2010503436A (ja) | 2010-02-04 |
WO2008031595A3 (en) | 2008-06-05 |
WO2008031596A1 (en) | 2008-03-20 |
EP2061526B1 (en) | 2015-07-29 |
US8828546B2 (en) | 2014-09-09 |
WO2008031595A2 (en) | 2008-03-20 |
EP2059272B1 (en) | 2018-02-28 |
US20100076546A1 (en) | 2010-03-25 |
US20160310643A1 (en) | 2016-10-27 |
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EP2061526A2 (en) | 2009-05-27 |
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