JP5460054B2 - 腫瘍形成性ｒａｓ特異的細胞障害性化合物およびその使用法 - Google Patents

腫瘍形成性ｒａｓ特異的細胞障害性化合物およびその使用法 Download PDF

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JP5460054B2
JP5460054B2 JP2008542528A JP2008542528A JP5460054B2 JP 5460054 B2 JP5460054 B2 JP 5460054B2 JP 2008542528 A JP2008542528 A JP 2008542528A JP 2008542528 A JP2008542528 A JP 2008542528A JP 5460054 B2 JP5460054 B2 JP 5460054B2
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butyl
oncrasin
methyl
chloro
hydrogen
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JP2009517401A5 (enExample
JP2009517401A (ja
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ビンリン ファング
ジンソン リュー
ウェイ クオ
シューホン ウー
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University of Texas System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2008542528A 2005-11-23 2006-11-22 腫瘍形成性ｒａｓ特異的細胞障害性化合物およびその使用法 Expired - Fee Related JP5460054B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73986505P 2005-11-23 2005-11-23
US60/739,865 2005-11-23
PCT/US2006/061219 WO2007062399A2 (en) 2005-11-23 2006-11-22 Oncogenic ras-specific cytotoxic compound and methods of use thereof

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JP2009517401A JP2009517401A (ja) 2009-04-30
JP2009517401A5 JP2009517401A5 (enExample) 2010-07-29
JP5460054B2 true JP5460054B2 (ja) 2014-04-02

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US (1) US8883841B2 (enExample)
EP (1) EP1956910B1 (enExample)
JP (1) JP5460054B2 (enExample)
CN (1) CN101360422B (enExample)
AU (1) AU2006318212C1 (enExample)
CA (1) CA2631082C (enExample)
RU (1) RU2448703C2 (enExample)
WO (1) WO2007062399A2 (enExample)

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US9474730B2 (en) * 2012-04-30 2016-10-25 Board Of Regents Of The University Of Texas System Methods and compositions for use with K-ras mediated disorders
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Also Published As

Publication number Publication date
AU2006318212C1 (en) 2012-08-30
US20090286847A1 (en) 2009-11-19
EP1956910A4 (en) 2010-03-24
CN101360422A (zh) 2009-02-04
CA2631082A1 (en) 2007-05-31
AU2006318212A1 (en) 2007-05-31
US8883841B2 (en) 2014-11-11
CN101360422B (zh) 2013-10-23
AU2006318212B2 (en) 2012-01-12
EP1956910B1 (en) 2014-09-17
EP1956910A2 (en) 2008-08-20
WO2007062399A2 (en) 2007-05-31
JP2009517401A (ja) 2009-04-30
CA2631082C (en) 2015-02-03
RU2008125065A (ru) 2009-12-27
RU2448703C2 (ru) 2012-04-27
WO2007062399A3 (en) 2007-12-21

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