CA2631082C - Oncogenic ras-specific cytotoxic compound and methods of use thereof - Google Patents
Oncogenic ras-specific cytotoxic compound and methods of use thereof Download PDFInfo
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- CA2631082C CA2631082C CA2631082A CA2631082A CA2631082C CA 2631082 C CA2631082 C CA 2631082C CA 2631082 A CA2631082 A CA 2631082A CA 2631082 A CA2631082 A CA 2631082A CA 2631082 C CA2631082 C CA 2631082C
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- butyl
- oncrasin
- methyl
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- indole
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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| US73986505P | 2005-11-23 | 2005-11-23 | |
| US60/739,865 | 2005-11-23 | ||
| PCT/US2006/061219 WO2007062399A2 (en) | 2005-11-23 | 2006-11-22 | Oncogenic ras-specific cytotoxic compound and methods of use thereof |
Publications (2)
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| CA2631082A1 CA2631082A1 (en) | 2007-05-31 |
| CA2631082C true CA2631082C (en) | 2015-02-03 |
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| CA2631082A Expired - Fee Related CA2631082C (en) | 2005-11-23 | 2006-11-22 | Oncogenic ras-specific cytotoxic compound and methods of use thereof |
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| US (1) | US8883841B2 (enExample) |
| EP (1) | EP1956910B1 (enExample) |
| JP (1) | JP5460054B2 (enExample) |
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| AU (1) | AU2006318212C1 (enExample) |
| CA (1) | CA2631082C (enExample) |
| RU (1) | RU2448703C2 (enExample) |
| WO (1) | WO2007062399A2 (enExample) |
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| PL212489B1 (pl) * | 2008-01-22 | 2012-10-31 | Univ Jagiellonski | Pochodne fenoksyalkiloaminoalkanoli i ich zastosowania |
| CN101983188A (zh) * | 2008-04-01 | 2011-03-02 | 安斯泰来制药有限公司 | 吲哚啉酮化合物 |
| WO2010001325A2 (en) * | 2008-06-30 | 2010-01-07 | Silenseed Ltd | Methods, compositions and systems for local delivery of drugs |
| US8304421B2 (en) | 2008-09-30 | 2012-11-06 | Vanderbilt University | Indole compounds and their use as radiation sensitizing agents and chemotherapeutic agents |
| US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US8362277B2 (en) | 2009-01-09 | 2013-01-29 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
| CN102405043B (zh) | 2009-01-09 | 2017-08-22 | 得克萨斯州大学系统董事会 | 前神经原性化合物 |
| WO2011060976A1 (en) * | 2009-11-20 | 2011-05-26 | Universite De Liege | Tryptamine-derived compounds as antibacterial agents |
| EP2513174B1 (en) * | 2009-12-16 | 2014-06-25 | University Of New Hampshire | Emulsion polymerization of esters of itaconic acid |
| CA2804161A1 (en) | 2010-07-07 | 2012-01-12 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| WO2012138739A2 (en) | 2011-04-06 | 2012-10-11 | Chemo-Enhanced Llc | Compositions and methods for treating cancer |
| US9474730B2 (en) * | 2012-04-30 | 2016-10-25 | Board Of Regents Of The University Of Texas System | Methods and compositions for use with K-ras mediated disorders |
| US9701676B2 (en) | 2012-08-24 | 2017-07-11 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| CA2895237C (en) | 2013-01-10 | 2021-10-05 | Merck Patent Gmbh | Piperidinylcarbazole as antimalarial |
| WO2014110555A1 (en) * | 2013-01-14 | 2014-07-17 | Chemo-Enchanced Llc | Compositions and methods for treating cancer |
| WO2014145576A2 (en) | 2013-03-15 | 2014-09-18 | Northwestern University | Substituted pyrrolo(2,3-d)pyrimidines for the treatment of cancer |
| EP3068388A4 (en) | 2013-11-11 | 2017-04-12 | Board of Regents of the University of Texas System | Neuroprotective compounds and use thereof |
| WO2015070237A1 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective chemicals and methods for identifying and using same |
| CA2950581A1 (en) * | 2014-05-30 | 2015-12-03 | The Trustees Of Columbia University In The City Of New York | Multivalent ras binding compounds |
| WO2015192343A1 (en) * | 2014-06-18 | 2015-12-23 | Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences | P53 activator small molecules |
| CN106573918B (zh) | 2014-07-04 | 2020-06-16 | 默克专利股份有限公司 | 具有抗寄生虫活性的氮杂环庚烷基衍生物和包含它们的药物组合物 |
| AU2016381509A1 (en) * | 2015-12-31 | 2018-07-19 | Syracuse University | Tryptamine-based SHIP inhibitors for the treatment of cancer |
| CA3010615C (en) | 2016-01-14 | 2024-02-20 | Beth Israel Deaconess Medical Center, Inc. | Mast-cell modulators and uses thereof |
| US10918650B2 (en) * | 2016-06-02 | 2021-02-16 | University Of South Florida | Method of treating melanoma using an inhibitor of an atypical protein kinase C |
| EP3515449B1 (en) | 2016-09-26 | 2023-07-12 | Dana-Farber Cancer Institute, Inc. | Quinoline derivatives as chromobox (cbx) protein inhibitors for treating cancer |
| JOP20190086A1 (ar) | 2016-10-21 | 2019-04-18 | Novartis Ag | مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب |
| CN110291084A (zh) | 2016-12-15 | 2019-09-27 | 加利福尼亚大学董事会 | 用于治疗癌症的组合物和方法 |
| CN108251377B (zh) * | 2018-01-16 | 2021-08-27 | 内蒙古大学 | 利用携带Xist Tale抑制性转录因子R6的R6-MEF制备饲养层细胞的方法 |
| US10738139B2 (en) | 2018-12-18 | 2020-08-11 | Itaconix Corporation | Decarboxylation and amidation of polyitaconic acid polymers |
| KR102620902B1 (ko) * | 2020-04-24 | 2024-01-04 | 가천대학교 산학협력단 | 신규 알파-시누클레인 방사성 리간드 및 이를 포함하는 신경퇴행성 질환 진단용 조성물 |
| KR102428024B1 (ko) * | 2020-06-11 | 2022-08-03 | 충북대학교 산학협력단 | 프로카스파제-3의 활성화제로서 신규한 (e)-n-아릴리덴-1-(4-클로로벤질)-1h-인돌-3-카보하이드라지드 및 이를 유효성분으로 포함하는 항암제 조성물 |
| KR102617885B1 (ko) * | 2021-05-07 | 2023-12-27 | 충북대학교 산학협력단 | 신규한 (e)-n'-((1-(4-클로로벤질)-1h-인돌-3-일)메틸렌)-2-(4-옥소퀴나졸린-3(4h)-일)아세토히드라지드 화합물 및 이를 유효성분으로 포함하는 항암제 조성물 |
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- 2006-11-22 US US12/094,739 patent/US8883841B2/en active Active
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- 2006-11-22 RU RU2008125065/15A patent/RU2448703C2/ru not_active IP Right Cessation
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- 2006-11-22 CN CN2006800516184A patent/CN101360422B/zh not_active Expired - Fee Related
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| JP2009517401A (ja) | 2009-04-30 |
| EP1956910B1 (en) | 2014-09-17 |
| US20090286847A1 (en) | 2009-11-19 |
| AU2006318212A1 (en) | 2007-05-31 |
| EP1956910A4 (en) | 2010-03-24 |
| WO2007062399A2 (en) | 2007-05-31 |
| CA2631082A1 (en) | 2007-05-31 |
| WO2007062399A3 (en) | 2007-12-21 |
| RU2008125065A (ru) | 2009-12-27 |
| AU2006318212B2 (en) | 2012-01-12 |
| CN101360422B (zh) | 2013-10-23 |
| EP1956910A2 (en) | 2008-08-20 |
| JP5460054B2 (ja) | 2014-04-02 |
| AU2006318212C1 (en) | 2012-08-30 |
| US8883841B2 (en) | 2014-11-11 |
| RU2448703C2 (ru) | 2012-04-27 |
| CN101360422A (zh) | 2009-02-04 |
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