JP5459644B2 - 肝機能改善剤組成物 - Google Patents
肝機能改善剤組成物 Download PDFInfo
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- JP5459644B2 JP5459644B2 JP2012538743A JP2012538743A JP5459644B2 JP 5459644 B2 JP5459644 B2 JP 5459644B2 JP 2012538743 A JP2012538743 A JP 2012538743A JP 2012538743 A JP2012538743 A JP 2012538743A JP 5459644 B2 JP5459644 B2 JP 5459644B2
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- liver function
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Botany (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
<実施例1>ネムノキ抽出物の製造例1
ネムノキの葉、茎、花、根、皮、実の混合粉砕物を80%エタノールに浸漬させ、12時間80℃の温度で抽出した後、抽出残渣を除去し、減圧濃縮して粉末状のネムノキ抽出物を得た。
前記実施例1と同様にネムノキ抽出物を製造するが、80%メタノールを使用した。
前記実施例1と同様にしてネムノキ抽出物を製造するが、酢酸エチルを使用した。
<実験例1>肝機能改善動物実験
前記実施例で得られたネムノキ抽出物の肝機能改善効果を確認するために、実験動物に高脂肪食餌を給与して肝毒性を誘発した。
前記実施例1の抽出物80重量%及び蜂蜜20%の混合物100gに水1200ミリリットルを混合して飲料を製造し、この飲料を、肝機能障害を有する15名に1日1回、合計8週間飲ませ、実験開始時、実験開始から4週後及び実験開始から8週後にそれぞれ採血して、血清のGPT、GOT及びγ−GPTの活性を測定した。ここでは代表的に実施例1の抽出物のみを使用した。
Claims (4)
- ネムノキ抽出物を有効成分として含み、
黄耆の粉末又は抽出物、党参の粉末又は抽出物、黄精の粉末又は抽出物、五味子の粉末又は抽出物、ハスカップの実の粉末又は抽出物、ケンポナシ(葉、茎、花、根、皮、実)の粉末又は抽出物、茵陳蒿の粉末又は抽出物、ソウジュツの粉末又は抽出物、ハンノキ(葉、茎、花、根、皮、実)の粉末又は抽出物、ナナカマド(葉、茎、花、根、皮、実)の粉末又は抽出物、冬虫夏草の粉末又は抽出物、及び桑枝の粉末又は抽出物よりなる群から選ばれたものを一つ以上含むことを特徴とする肝機能改善剤組成物。 - 前記組成物が食品組成物であることを特徴とする請求項1に記載の肝機能改善剤組成物。
- 前記食品組成物が飲料であることを特徴とする請求項2に記載の肝機能改善剤組成物。
- 前記組成物が薬学的組成物であることを特徴とする請求項1〜3のいずれか1項に記載の肝機能改善剤組成物。
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KR10-2009-0110299 | 2009-11-16 | ||
KR1020090110299A KR101054594B1 (ko) | 2009-11-16 | 2009-11-16 | 간 기능 개선제 조성물 |
PCT/KR2010/002462 WO2011059150A1 (ko) | 2009-11-16 | 2010-04-20 | 간 기능 개선제 조성물 |
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JP2013510846A JP2013510846A (ja) | 2013-03-28 |
JP5459644B2 true JP5459644B2 (ja) | 2014-04-02 |
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JP2012538743A Active JP5459644B2 (ja) | 2009-11-16 | 2010-04-20 | 肝機能改善剤組成物 |
Country Status (6)
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US (1) | US20120251567A1 (ja) |
EP (1) | EP2502629A4 (ja) |
JP (1) | JP5459644B2 (ja) |
KR (1) | KR101054594B1 (ja) |
CN (1) | CN102686231A (ja) |
WO (1) | WO2011059150A1 (ja) |
Families Citing this family (8)
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JP2018524364A (ja) * | 2015-07-15 | 2018-08-30 | ユニゲン・インコーポレーテッド | 肝臓の治療および肝臓の健康維持のための組成物、方法および医薬組成物 |
CN108348566A (zh) * | 2015-07-15 | 2018-07-31 | 尤尼根公司 | 用于治疗肝脏和维持肝脏健康的组合物、方法和药物组合物 |
CN105477465A (zh) * | 2016-01-05 | 2016-04-13 | 吉林省中医药科学院 | 一种具有保护肝功能的中药制剂及其制备工艺 |
CN107625831A (zh) * | 2017-09-26 | 2018-01-26 | 黄经卫 | 一种改善肝功能的中药组合物 |
CN107625902A (zh) * | 2017-09-26 | 2018-01-26 | 覃益祥 | 一种调节肝功能的中药组合物 |
KR102001557B1 (ko) * | 2018-11-30 | 2019-07-17 | 메디케어제약 주식회사 | 인진호 및 진피 복합추출물을 유효성분으로 함유하는 대사성 질환 예방 또는 치료용 조성물 |
KR102642547B1 (ko) * | 2022-11-11 | 2024-03-05 | 한국식품연구원 | 레비락토바실러스 브레비스 WiKim0168을 포함하는 숙취 해소 및 간 기능 개선용 조성물 |
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JP2000128798A (ja) * | 1998-10-23 | 2000-05-09 | Seiwa Yakuhin Kk | 活性酸素消去作用剤およびアルドースリダクターゼ阻害作用剤 |
KR100380867B1 (ko) * | 2000-12-06 | 2003-04-18 | 한국 한의학 연구원 | 골다공증 예방 및 치료에 효과를 갖는 합환피 추출물 |
KR100443588B1 (ko) * | 2002-01-25 | 2004-08-09 | 나드리화장품주식회사 | 목단피추출물과 자귀나무추출물을 함유하는 노화방지화장료 조성물 |
KR100495825B1 (ko) | 2003-03-28 | 2005-06-16 | 라이브켐 주식회사 | 간 기능 개선 및 간 질환 치료를 위한 기능성 식품 조성물및 이의 제조방법 |
CN1528333A (zh) * | 2003-10-04 | 2004-09-15 | 李学坚 | 具有保肝降酶作用的中药制剂及其生产方法 |
CN1305523C (zh) * | 2004-02-20 | 2007-03-21 | 朴东春 | 解酒饮料及其制备方法 |
KR100605115B1 (ko) * | 2004-03-16 | 2006-07-28 | 주식회사 오스코텍 | 합환피 추출물을 유효성분으로 함유하는 면역억제제 |
US20060165812A1 (en) * | 2005-01-21 | 2006-07-27 | Amershire Investment Corporation | Method and topical formulation for treating headaches |
KR100699782B1 (ko) | 2005-07-13 | 2007-03-27 | 주식회사 에이치앤케이바이오사이언스 | 댕댕이나무 추출물을 포함하는 간 기능 회복용 식품 조성물 |
KR100795822B1 (ko) * | 2006-03-24 | 2008-01-17 | 남종현 | 고지혈증 및 뇌졸중 회복 및 예방에 효과가 있는 천연 식물추출물 조성물, 이를 유효성분으로 하는 천연차 및 이의제조방법 |
KR100771524B1 (ko) | 2006-04-10 | 2007-10-30 | 주식회사 당바이오텍 | 혼합 생약 추출물을 유효성분으로 함유하는 간 기능 개선용조성물 |
KR100733764B1 (ko) * | 2006-04-20 | 2007-07-02 | 주식회사 베터앤베터 | 합환피 추출물 또는 그로부터 분리한 쿠라리디놀을함유하는 고지혈증의 예방 및 치료용 조성물 |
CN1935249A (zh) * | 2006-08-05 | 2007-03-28 | 李华林 | 舒肝利胆饮 |
CN101062228A (zh) * | 2007-05-30 | 2007-10-31 | 方阳 | 消斑加减汤 |
CN101062302A (zh) * | 2007-06-07 | 2007-10-31 | 李春青 | 治疗乙型肝炎的中药方剂 |
CN101828620A (zh) * | 2010-05-11 | 2010-09-15 | 高玲 | 一种治疗肝郁不畅的保健茶 |
CN102217881B (zh) * | 2011-03-17 | 2014-10-29 | 上海韬鸿化工科技有限公司 | 护肝益肝保健枕 |
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- 2009-11-16 KR KR1020090110299A patent/KR101054594B1/ko active IP Right Grant
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- 2010-04-20 CN CN2010800507497A patent/CN102686231A/zh active Pending
- 2010-04-20 WO PCT/KR2010/002462 patent/WO2011059150A1/ko active Application Filing
- 2010-04-20 EP EP10830083.1A patent/EP2502629A4/en not_active Withdrawn
- 2010-04-20 JP JP2012538743A patent/JP5459644B2/ja active Active
- 2010-04-20 US US13/509,990 patent/US20120251567A1/en not_active Abandoned
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KR20110053670A (ko) | 2011-05-24 |
WO2011059150A1 (ko) | 2011-05-19 |
EP2502629A1 (en) | 2012-09-26 |
KR101054594B1 (ko) | 2011-08-04 |
CN102686231A (zh) | 2012-09-19 |
EP2502629A4 (en) | 2014-12-17 |
JP2013510846A (ja) | 2013-03-28 |
US20120251567A1 (en) | 2012-10-04 |
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