JP5454943B2 - 抗癌剤として有用なｓｍａｃ模倣二量体及び三量体 - Google Patents
抗癌剤として有用なｓｍａｃ模倣二量体及び三量体 Download PDFInfo
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- JP5454943B2 JP5454943B2 JP2010503257A JP2010503257A JP5454943B2 JP 5454943 B2 JP5454943 B2 JP 5454943B2 JP 2010503257 A JP2010503257 A JP 2010503257A JP 2010503257 A JP2010503257 A JP 2010503257A JP 5454943 B2 JP5454943 B2 JP 5454943B2
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- 0 CC(C(C)(C)C*CC1)N1C(C(N(*)C(*)=O)S(C)=C)=O Chemical compound CC(C(C)(C)C*CC1)N1C(C(N(*)C(*)=O)S(C)=C)=O 0.000 description 21
- XDTMQSROBMDMFD-UHFFFAOYSA-N C1CCCCC1 Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- BGKNSGWKWWJHFQ-OIISXLGYSA-N CC(C)(C)OC(N(C[C@@H](C1)O)[C@@H]1C(N[C@H]1c2ccccc2CCC1)=O)=O Chemical compound CC(C)(C)OC(N(C[C@@H](C1)O)[C@@H]1C(N[C@H]1c2ccccc2CCC1)=O)=O BGKNSGWKWWJHFQ-OIISXLGYSA-N 0.000 description 1
- UMEKDNIDTKWJFM-HIZCFMLWSA-N CC(C)C(N[C@H](C(C)N(CC1)C[C@H]1NC(CC(N[C@H](CCC1CC([C@H](C(C)(C)C)NC([C@H](C)NC)=O)=O)C[C@H]1C(N[C@H](CCC1)c2c1cccc2)=O)=O)O)C(C)(C)C)=O Chemical compound CC(C)C(N[C@H](C(C)N(CC1)C[C@H]1NC(CC(N[C@H](CCC1CC([C@H](C(C)(C)C)NC([C@H](C)NC)=O)=O)C[C@H]1C(N[C@H](CCC1)c2c1cccc2)=O)=O)O)C(C)(C)C)=O UMEKDNIDTKWJFM-HIZCFMLWSA-N 0.000 description 1
- JQEUPNKUYMHYPW-UHFFFAOYSA-N CNC1c2ccccc2CCC1 Chemical compound CNC1c2ccccc2CCC1 JQEUPNKUYMHYPW-UHFFFAOYSA-N 0.000 description 1
- APXDOBUTXOLGAZ-VYAYZGMFSA-N C[C@@H](C(C([C@@H](C(C)(C)C)C(C=C)=C)=C)I)N Chemical compound C[C@@H](C(C([C@@H](C(C)(C)C)C(C=C)=C)=C)I)N APXDOBUTXOLGAZ-VYAYZGMFSA-N 0.000 description 1
- FDBQIKLDFHFWOU-RZPORYGBSA-N C[C@@H](C(N[C@@H](C(C)(C)C)C(N(C[C@@H](C)C1)[C@@H]1C(NC[C@H]1c2ccccc2CCC1)=O)=O)=O)N(C)C(OC(C)(C)C)=O Chemical compound C[C@@H](C(N[C@@H](C(C)(C)C)C(N(C[C@@H](C)C1)[C@@H]1C(NC[C@H]1c2ccccc2CCC1)=O)=O)=O)N(C)C(OC(C)(C)C)=O FDBQIKLDFHFWOU-RZPORYGBSA-N 0.000 description 1
- PPJDVUDPICSPKB-YHUYYLMFSA-N C[C@@H](C(N[C@@H](C(C)(C)C)C(N(C[C@@H](C)C1)[C@@H]1C(OC)=O)=O)=O)N(C)C(OC(C)(C)C)=O Chemical compound C[C@@H](C(N[C@@H](C(C)(C)C)C(N(C[C@@H](C)C1)[C@@H]1C(OC)=O)=O)=O)N(C)C(OC(C)(C)C)=O PPJDVUDPICSPKB-YHUYYLMFSA-N 0.000 description 1
- PDUIHALPJPNLGM-HVKUZNLGSA-N C[C@@H](C(N[C@@H](C(C)(C)C)C(N(C[C@H](C1)NC(C(N[C@@H](C[C@H]2C(N[C@H]3c4ccccc4CCC3)=O)CN2C([C@H](C(C)(C)C)NC([C@H](C)NC)=O)=O)=O)=O)[C@@H]1C(N[C@H](CCC1)C2=C1C=CCC2)=O)=O)=O)NC Chemical compound C[C@@H](C(N[C@@H](C(C)(C)C)C(N(C[C@H](C1)NC(C(N[C@@H](C[C@H]2C(N[C@H]3c4ccccc4CCC3)=O)CN2C([C@H](C(C)(C)C)NC([C@H](C)NC)=O)=O)=O)=O)[C@@H]1C(N[C@H](CCC1)C2=C1C=CCC2)=O)=O)=O)NC PDUIHALPJPNLGM-HVKUZNLGSA-N 0.000 description 1
- JDPPZHJNLCJZMO-KVJIRVJXSA-N C[C@@H](C[C@H]1C(N[C@H]2c3ccccc3CCC2)=O)CN1C([C@H](C(C)(C)C)NC(OC(C)(C)C)=O)=O Chemical compound C[C@@H](C[C@H]1C(N[C@H]2c3ccccc3CCC2)=O)CN1C([C@H](C(C)(C)C)NC(OC(C)(C)C)=O)=O JDPPZHJNLCJZMO-KVJIRVJXSA-N 0.000 description 1
- KSLUMBXFHCQVTA-LZWOXQAQSA-N C[C@H](c1ccccc1)NC([C@H](C[C@H](C)C1)N1C(OC(C)(C)C)=O)=O Chemical compound C[C@H](c1ccccc1)NC([C@H](C[C@H](C)C1)N1C(OC(C)(C)C)=O)=O KSLUMBXFHCQVTA-LZWOXQAQSA-N 0.000 description 1
- APBBTKKLSNPFDP-SECBINFHSA-N C[C@H]1c2ccccc2CCC1 Chemical compound C[C@H]1c2ccccc2CCC1 APBBTKKLSNPFDP-SECBINFHSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91147207P | 2007-04-12 | 2007-04-12 | |
| US60/911,472 | 2007-04-12 | ||
| US95249307P | 2007-07-27 | 2007-07-27 | |
| US60/952,493 | 2007-07-27 | ||
| PCT/US2008/060140 WO2008128121A1 (en) | 2007-04-12 | 2008-04-11 | Smac mimetic dimers and trimers useful as anti-cancer agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523717A JP2010523717A (ja) | 2010-07-15 |
| JP2010523717A5 JP2010523717A5 (US07794700-20100914-C00152.png) | 2012-02-09 |
| JP5454943B2 true JP5454943B2 (ja) | 2014-03-26 |
Family
ID=39864357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503257A Expired - Fee Related JP5454943B2 (ja) | 2007-04-12 | 2008-04-11 | 抗癌剤として有用なｓｍａｃ模倣二量体及び三量体 |
Country Status (10)
Families Citing this family (61)
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| WO2006020060A2 (en) | 2004-07-15 | 2006-02-23 | Tetralogic Pharmaceuticals Corporation | Iap binding compounds |
| US7517906B2 (en) | 2005-02-25 | 2009-04-14 | Tetralogic Pharmaceuticals Corporation | Dimeric IAP inhibitors |
| JP4954983B2 (ja) | 2005-05-18 | 2012-06-20 | ファーマサイエンス・インコーポレイテッド | Ｂｉｒドメイン結合化合物 |
| US20100256046A1 (en) * | 2009-04-03 | 2010-10-07 | Tetralogic Pharmaceuticals Corporation | Treatment of proliferative disorders |
| KR20080067357A (ko) | 2005-10-25 | 2008-07-18 | 에게라 쎄라퓨틱스 인코포레이티드 | Ｉａｐ ｂｉｒ 도메인 결합 화합물 |
| TWI543988B (zh) | 2006-03-16 | 2016-08-01 | 科學製藥股份有限公司 | 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物 |
| RU2008152171A (ru) | 2006-07-05 | 2010-08-10 | Интермьюн, Инк. (Us) | Новые ингибиторы вирусной репликации гепатита с |
| US20100144650A1 (en) * | 2006-07-24 | 2010-06-10 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| WO2008014238A2 (en) * | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| US20100113326A1 (en) * | 2006-07-24 | 2010-05-06 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| CN101516904A (zh) * | 2006-07-24 | 2009-08-26 | 泰特拉洛吉克药业公司 | 二聚的iap拮抗剂 |
| CL2007002166A1 (es) * | 2006-07-24 | 2008-01-25 | Tetralogic Pharm Corp | Compuestos derivados de heterociclos de nitrogeno, antagonistas de los inhibidores de las proteinas de la apoptosis; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento del cancer. |
| US20100056495A1 (en) * | 2006-07-24 | 2010-03-04 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| JP2010528587A (ja) * | 2007-05-07 | 2010-08-26 | テトラロジック ファーマシューティカルズ コーポレーション | アポトーシス阻害タンパク質のアンタゴニストに対する感受性のバイオマーカーとしてＴＮＦα遺伝子の発現を用いる方法 |
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| US8283372B2 (en) | 2009-07-02 | 2012-10-09 | Tetralogic Pharmaceuticals Corp. | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic |
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| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
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| CN104710510A (zh) * | 2013-12-12 | 2015-06-17 | 深圳先进技术研究院 | Smac蛋白二聚拟合物及其鉴定方法 |
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| US20170327469A1 (en) | 2015-01-20 | 2017-11-16 | Arvinas, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| KR20220029783A (ko) | 2015-01-20 | 2022-03-08 | 아비나스 오퍼레이션스, 인코포레이티드 | 안드로겐 수용체의 표적화된 분해를 위한 화합물 및 방법 |
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| JP6953435B2 (ja) * | 2016-05-09 | 2021-10-27 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 二量体化合物 |
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| KR102564201B1 (ko) | 2016-12-23 | 2023-08-07 | 아비나스 오퍼레이션스, 인코포레이티드 | 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법 |
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| CN112912376A (zh) | 2018-08-20 | 2021-06-04 | 阿尔维纳斯运营股份有限公司 | 用于治疗神经变性疾病的具有E3泛素连接酶结合活性并靶向α-突触核蛋白的蛋白水解靶向嵌合(PROTAC)化合物 |
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-
2008
- 2008-04-11 AU AU2008240153A patent/AU2008240153B2/en not_active Ceased
- 2008-04-11 CN CN200880011260.1A patent/CN101668426B/zh not_active Expired - Fee Related
- 2008-04-11 WO PCT/US2008/060140 patent/WO2008128121A1/en active Application Filing
- 2008-04-11 EP EP08745697.6A patent/EP2079309B1/en not_active Withdrawn - After Issue
- 2008-04-11 JP JP2010503257A patent/JP5454943B2/ja not_active Expired - Fee Related
- 2008-04-11 NZ NZ580313A patent/NZ580313A/en not_active IP Right Cessation
- 2008-04-11 US US12/101,733 patent/US8642554B2/en not_active Expired - Fee Related
- 2008-04-11 BR BRPI0810178-7A patent/BRPI0810178A2/pt not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2010523717A (ja) | 2010-07-15 |
| CA2684169A1 (en) | 2008-10-23 |
| EP2079309B1 (en) | 2015-11-11 |
| AU2008240153B2 (en) | 2013-01-31 |
| BRPI0810178A2 (pt) | 2014-09-23 |
| US20140127155A1 (en) | 2014-05-08 |
| EP2079309A4 (en) | 2011-07-06 |
| CN101668426B (zh) | 2014-01-15 |
| CN101668426A (zh) | 2010-03-10 |
| MX2009010667A (es) | 2010-02-24 |
| EP2079309A1 (en) | 2009-07-22 |
| AU2008240153A1 (en) | 2008-10-23 |
| CA2684169C (en) | 2012-06-19 |
| US8642554B2 (en) | 2014-02-04 |
| WO2008128121A1 (en) | 2008-10-23 |
| US20090104151A1 (en) | 2009-04-23 |
| NZ580313A (en) | 2011-11-25 |
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