JP5373778B2 - バイオチップのための解析ツールとしての原子間力顕微鏡の使用 - Google Patents

バイオチップのための解析ツールとしての原子間力顕微鏡の使用 Download PDF

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Publication number
JP5373778B2
JP5373778B2 JP2010511747A JP2010511747A JP5373778B2 JP 5373778 B2 JP5373778 B2 JP 5373778B2 JP 2010511747 A JP2010511747 A JP 2010511747A JP 2010511747 A JP2010511747 A JP 2010511747A JP 5373778 B2 JP5373778 B2 JP 5373778B2
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Japan
Prior art keywords
probe
dna
target ligand
solid substrate
target
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JP2010511747A
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Japanese (ja)
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JP2010529474A (ja
JP2010529474A5 (enExample
Inventor
ウォン パーク，ジューン
ジン ホン，ボン
ホン クウォン，スン
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POSTECH Academy Industry Foundation
Posco Holdings Inc
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Posco Co Ltd
POSTECH Academy Industry Foundation
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01Q—SCANNING-PROBE TECHNIQUES OR APPARATUS; APPLICATIONS OF SCANNING-PROBE TECHNIQUES, e.g. SCANNING PROBE MICROSCOPY [SPM]
    • G01Q60/00—Particular types of SPM [Scanning Probe Microscopy] or microscopes; Essential components thereof
    • G01Q60/24—AFM [Atomic Force Microscopy] or apparatus therefor, e.g. AFM probes
    • G01Q60/38—Probes, their manufacture, or their related instrumentation, e.g. holders
    • G01Q60/42—Functionalisation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2010511747A 2007-06-14 2008-06-16 バイオチップのための解析ツールとしての原子間力顕微鏡の使用 Expired - Fee Related JP5373778B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94405607P 2007-06-14 2007-06-14
US60/944,056 2007-06-14
PCT/IB2008/003959 WO2009109809A2 (en) 2007-06-14 2008-06-16 Atomic force microscope as an analyzing tool for biochip

Publications (3)

Publication Number Publication Date
JP2010529474A JP2010529474A (ja) 2010-08-26
JP2010529474A5 JP2010529474A5 (enExample) 2012-08-02
JP5373778B2 true JP5373778B2 (ja) 2013-12-18

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JP2010511747A Expired - Fee Related JP5373778B2 (ja) 2007-06-14 2008-06-16 バイオチップのための解析ツールとしての原子間力顕微鏡の使用

Country Status (5)

Country Link
US (1) US20100261615A9 (enExample)
EP (1) EP2164986A4 (enExample)
JP (1) JP5373778B2 (enExample)
CN (1) CN101849021A (enExample)
WO (1) WO2009109809A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150114177A (ko) * 2014-04-01 2015-10-12 연세대학교 원주산학협력단 측면 유전영동기술 기반의 힘 분광기법을 이용하여 생체분자 간 화학결합력을 측정하는 방법

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8021841B1 (en) * 2007-07-11 2011-09-20 Kenneth David Schatz Methods and apparatuses for spatially separating molecules attached to a support and uses in biotechnology
US20100175155A1 (en) * 2009-01-06 2010-07-08 President And Fellows Of Harvard College Measurement and Mapping of Molecular Stretching and Rupture Forces
AU2011218847B2 (en) 2010-02-23 2015-03-12 Christopher Gordon Atwood Methods for the detection of biologically relevant molecules and their interaction characteristics
ES2562008T3 (es) * 2010-12-10 2016-03-02 Universität Basel Método para estadificar la progresión del cáncer con MFA
CN102153774B (zh) * 2011-01-27 2012-05-23 济南大学 一种聚甲基丙烯酸甲酯微流控芯片的表面修饰方法及微流控涂层芯片和应用
KR101337504B1 (ko) * 2011-12-19 2013-12-05 한국기계연구원 바이오 칩 및 그의 제조 방법
TWI614343B (zh) * 2014-04-21 2018-02-11 National Tsing Hua University 膜電化學訊號之檢測系統
CN104991090B (zh) * 2015-07-01 2016-08-17 青岛大学 一种原子力显微镜检测单分子水平分子间相互作用的方法
US10300485B2 (en) * 2015-10-23 2019-05-28 The Royal Institution For The Advancement Of Learning/Mcgill University Nanoarray-in-microarray multiplexed analysis methods and systems
US10067160B2 (en) 2016-11-16 2018-09-04 CBN Nano Technologies, Inc. Sequential tip systems and methods for positionally controlled chemistry
US11708384B2 (en) 2016-05-12 2023-07-25 Cbn Nano Technologies Inc. Systems and methods for mechanosynthesis
US10822229B2 (en) 2016-11-16 2020-11-03 Cbn Nano Technologies Inc. Systems and methods for mechanosynthesis
CN109142795B (zh) * 2018-10-31 2021-05-28 国网山东省电力公司电力科学研究院 一种基于原子力显微镜的粘滞力比较方法
JP7292741B2 (ja) * 2018-11-01 2023-06-19 エヌビー ポステク 非共有結合的に付着された有機ナノ構造分子を含むニトロセルロース膜
CN114072499B (zh) * 2019-04-30 2024-08-06 Encodia公司 用于制备分析物的方法和相关试剂盒
WO2022224021A1 (en) * 2021-04-23 2022-10-27 Postech Research And Business Development Foundation (Postech) Apparatus and methods for detecting gene mutation
CN114264654B (zh) * 2021-12-20 2023-06-02 中国农业科学院油料作物研究所 一种真菌毒素、辣椒素、苯并[α]芘混合污染物智能微阵列检测设备及方法
CN119559634B (zh) * 2024-11-22 2025-11-04 南京邮电大学 一种afm场景下面向dna纳米结构的目标检测方法及系统

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721097A (en) * 1990-02-02 1998-02-24 N. V. Innogenetics S.A. Hybridization probes for the detection of branhamella catarrhalis strains
US5853993A (en) * 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
US5763768A (en) * 1997-03-17 1998-06-09 Iowa State University Research Foundation, Inc. Analytical method using modified scanning probes
MXPA01001894A (es) * 1998-08-21 2002-04-24 Naxcor Ensayos utilizando acidos nucleicos inmovilizados reticulables.
US6730905B2 (en) * 2000-09-21 2004-05-04 Matsushita Electric Industrial Co., Ltd. Scanning probe microscopy, method of producing the probe, and molecular processing method using the scanning probe microscope
US20030033863A1 (en) * 2001-08-08 2003-02-20 Paul Ashby Atomic force microscopy for high throughput analysis
US9201067B2 (en) * 2003-03-05 2015-12-01 Posco Size-controlled macromolecule
US7247384B2 (en) * 2002-12-20 2007-07-24 The University Of Houston Modification of silicon-containing scanning probe microscopy tips and growth of oligo-or poly (ethylene glycol) films on silicon surfaces through formation of Si-C bonds
US7198900B2 (en) * 2003-08-29 2007-04-03 Applera Corporation Multiplex detection compositions, methods, and kits
JP4213577B2 (ja) * 2003-12-05 2009-01-21 独立行政法人科学技術振興機構 グラフト重合鎖固定基材、グラフト重合鎖固定基材の製造方法及び測定方法
JP2005283405A (ja) * 2004-03-30 2005-10-13 Canon Inc 走査型プローブ顕微鏡、走査型プローブ顕微鏡用探針とそれらを用いた生体関連物質の検出方法
WO2006016787A1 (en) * 2004-08-12 2006-02-16 Postech Foundation Cantilever for atomic force microscope, and method of measuring biomolecule interaction using the same
JP4753392B2 (ja) * 2005-08-12 2011-08-24 ポーハン ユニバーシティ オブ サイエンス アンド テクノロジー 原子間力顕微鏡を用いた生体分子相互作用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150114177A (ko) * 2014-04-01 2015-10-12 연세대학교 원주산학협력단 측면 유전영동기술 기반의 힘 분광기법을 이용하여 생체분자 간 화학결합력을 측정하는 방법
KR101599606B1 (ko) 2014-04-01 2016-03-03 연세대학교 원주산학협력단 측면 유전영동기술 기반의 힘 분광기법을 이용하여 생체분자 간 화학결합력을 측정하는 방법

Also Published As

Publication number Publication date
CN101849021A (zh) 2010-09-29
JP2010529474A (ja) 2010-08-26
US20100261615A9 (en) 2010-10-14
US20090048120A1 (en) 2009-02-19
EP2164986A4 (en) 2010-06-30
EP2164986A2 (en) 2010-03-24
WO2009109809A2 (en) 2009-09-11
WO2009109809A3 (en) 2009-11-05

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