CN101849021A - 作为用于生物芯片的分析工具的原子力显微镜 - Google Patents

作为用于生物芯片的分析工具的原子力显微镜 Download PDF

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Publication number
CN101849021A
CN101849021A CN200880103613A CN200880103613A CN101849021A CN 101849021 A CN101849021 A CN 101849021A CN 200880103613 A CN200880103613 A CN 200880103613A CN 200880103613 A CN200880103613 A CN 200880103613A CN 101849021 A CN101849021 A CN 101849021A
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CN
China
Prior art keywords
probe
dna
detection
target
molecule
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Pending
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CN200880103613A
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English (en)
Chinese (zh)
Inventor
朴准远
洪凤振
权圣弘
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
POSTECH Academy Industry Foundation
Posco Holdings Inc
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Posco Co Ltd
POSTECH Academy Industry Foundation
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Application filed by Posco Co Ltd, POSTECH Academy Industry Foundation filed Critical Posco Co Ltd
Publication of CN101849021A publication Critical patent/CN101849021A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01Q—SCANNING-PROBE TECHNIQUES OR APPARATUS; APPLICATIONS OF SCANNING-PROBE TECHNIQUES, e.g. SCANNING PROBE MICROSCOPY [SPM]
    • G01Q60/00—Particular types of SPM [Scanning Probe Microscopy] or microscopes; Essential components thereof
    • G01Q60/24—AFM [Atomic Force Microscopy] or apparatus therefor, e.g. AFM probes
    • G01Q60/38—Probes, their manufacture, or their related instrumentation, e.g. holders
    • G01Q60/42—Functionalisation

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN200880103613A 2007-06-14 2008-06-16 作为用于生物芯片的分析工具的原子力显微镜 Pending CN101849021A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94405607P 2007-06-14 2007-06-14
US60/944,056 2007-06-14
PCT/IB2008/003959 WO2009109809A2 (en) 2007-06-14 2008-06-16 Atomic force microscope as an analyzing tool for biochip

Publications (1)

Publication Number Publication Date
CN101849021A true CN101849021A (zh) 2010-09-29

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880103613A Pending CN101849021A (zh) 2007-06-14 2008-06-16 作为用于生物芯片的分析工具的原子力显微镜

Country Status (5)

Country Link
US (1) US20100261615A9 (enExample)
EP (1) EP2164986A4 (enExample)
JP (1) JP5373778B2 (enExample)
CN (1) CN101849021A (enExample)
WO (1) WO2009109809A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102153774A (zh) * 2011-01-27 2011-08-17 济南大学 一种聚甲基丙烯酸甲酯微流控芯片的表面修饰方法及微流控涂层芯片和应用
CN103460039A (zh) * 2010-12-10 2013-12-18 巴塞尔大学 通过afm将癌进展分期的方法
CN104991090A (zh) * 2015-07-01 2015-10-21 青岛大学 一种原子力显微镜检测单分子水平分子间相互作用的方法
CN109142795A (zh) * 2018-10-31 2019-01-04 国网山东省电力公司电力科学研究院 一种基于原子力显微镜的粘滞力比较方法
CN114264654A (zh) * 2021-12-20 2022-04-01 中国农业科学院油料作物研究所 一种真菌毒素、辣椒素、苯并[α]芘混合污染物智能微阵列检测设备及方法
CN119559634A (zh) * 2024-11-22 2025-03-04 南京邮电大学 一种afm场景下面向dna纳米结构的目标检测方法及系统

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* Cited by examiner, † Cited by third party
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US8021841B1 (en) * 2007-07-11 2011-09-20 Kenneth David Schatz Methods and apparatuses for spatially separating molecules attached to a support and uses in biotechnology
US20100175155A1 (en) * 2009-01-06 2010-07-08 President And Fellows Of Harvard College Measurement and Mapping of Molecular Stretching and Rupture Forces
CA2788813C (en) 2010-02-23 2021-02-23 Christopher Gordon Atwood Methods for the detection of biologically relevant molecules and their interaction characteristics
KR101337504B1 (ko) * 2011-12-19 2013-12-05 한국기계연구원 바이오 칩 및 그의 제조 방법
KR101599606B1 (ko) * 2014-04-01 2016-03-03 연세대학교 원주산학협력단 측면 유전영동기술 기반의 힘 분광기법을 이용하여 생체분자 간 화학결합력을 측정하는 방법
TWI614343B (zh) * 2014-04-21 2018-02-11 National Tsing Hua University 膜電化學訊號之檢測系統
US10300485B2 (en) * 2015-10-23 2019-05-28 The Royal Institution For The Advancement Of Learning/Mcgill University Nanoarray-in-microarray multiplexed analysis methods and systems
US10067160B2 (en) * 2016-11-16 2018-09-04 CBN Nano Technologies, Inc. Sequential tip systems and methods for positionally controlled chemistry
US11708384B2 (en) 2016-05-12 2023-07-25 Cbn Nano Technologies Inc. Systems and methods for mechanosynthesis
US10822229B2 (en) 2016-11-16 2020-11-03 Cbn Nano Technologies Inc. Systems and methods for mechanosynthesis
KR20210125976A (ko) * 2018-11-01 2021-10-19 주식회사 엔비포스텍 비-공유적으로 부착된 유기 나노구조화된 분자를 포함하는 니트로셀룰로스 막
CN114072499B (zh) * 2019-04-30 2024-08-06 Encodia公司 用于制备分析物的方法和相关试剂盒
KR20240012357A (ko) * 2021-04-23 2024-01-29 포항공과대학교 산학협력단 유전자 돌연변이 검출 장치 및 방법

Family Cites Families (13)

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US5721097A (en) * 1990-02-02 1998-02-24 N. V. Innogenetics S.A. Hybridization probes for the detection of branhamella catarrhalis strains
US5853993A (en) * 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
US5763768A (en) * 1997-03-17 1998-06-09 Iowa State University Research Foundation, Inc. Analytical method using modified scanning probes
CA2340361A1 (en) * 1998-08-21 2000-03-16 Peter C. Cheng Assays using crosslinkable immobilized nucleic acids
CA2392004C (en) * 2000-09-20 2005-11-29 Matsushita Electric Industrial Co., Ltd. Probe for scanning probe microscope and method for producing the same, and scanning probe microscope including the probe and molecular processing method using the scanning probe microscope
US20030033863A1 (en) * 2001-08-08 2003-02-20 Paul Ashby Atomic force microscopy for high throughput analysis
US9201067B2 (en) * 2003-03-05 2015-12-01 Posco Size-controlled macromolecule
US7247384B2 (en) * 2002-12-20 2007-07-24 The University Of Houston Modification of silicon-containing scanning probe microscopy tips and growth of oligo-or poly (ethylene glycol) films on silicon surfaces through formation of Si-C bonds
US7198900B2 (en) * 2003-08-29 2007-04-03 Applera Corporation Multiplex detection compositions, methods, and kits
JP4213577B2 (ja) * 2003-12-05 2009-01-21 独立行政法人科学技術振興機構 グラフト重合鎖固定基材、グラフト重合鎖固定基材の製造方法及び測定方法
JP2005283405A (ja) * 2004-03-30 2005-10-13 Canon Inc 走査型プローブ顕微鏡、走査型プローブ顕微鏡用探針とそれらを用いた生体関連物質の検出方法
WO2006016787A1 (en) * 2004-08-12 2006-02-16 Postech Foundation Cantilever for atomic force microscope, and method of measuring biomolecule interaction using the same
EP1920249A4 (en) * 2005-08-12 2012-01-04 Univ Pohang BIOMOLECULAR INTERACTION WITH THE HELP OF AN ATOMIC MICROSCOPE

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103460039A (zh) * 2010-12-10 2013-12-18 巴塞尔大学 通过afm将癌进展分期的方法
CN102153774A (zh) * 2011-01-27 2011-08-17 济南大学 一种聚甲基丙烯酸甲酯微流控芯片的表面修饰方法及微流控涂层芯片和应用
CN104991090A (zh) * 2015-07-01 2015-10-21 青岛大学 一种原子力显微镜检测单分子水平分子间相互作用的方法
CN109142795A (zh) * 2018-10-31 2019-01-04 国网山东省电力公司电力科学研究院 一种基于原子力显微镜的粘滞力比较方法
CN109142795B (zh) * 2018-10-31 2021-05-28 国网山东省电力公司电力科学研究院 一种基于原子力显微镜的粘滞力比较方法
CN114264654A (zh) * 2021-12-20 2022-04-01 中国农业科学院油料作物研究所 一种真菌毒素、辣椒素、苯并[α]芘混合污染物智能微阵列检测设备及方法
CN119559634A (zh) * 2024-11-22 2025-03-04 南京邮电大学 一种afm场景下面向dna纳米结构的目标检测方法及系统
CN119559634B (zh) * 2024-11-22 2025-11-04 南京邮电大学 一种afm场景下面向dna纳米结构的目标检测方法及系统

Also Published As

Publication number Publication date
US20090048120A1 (en) 2009-02-19
JP2010529474A (ja) 2010-08-26
EP2164986A4 (en) 2010-06-30
JP5373778B2 (ja) 2013-12-18
WO2009109809A3 (en) 2009-11-05
WO2009109809A2 (en) 2009-09-11
EP2164986A2 (en) 2010-03-24
US20100261615A9 (en) 2010-10-14

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Application publication date: 20100929