JP5344558B2 - カチオン性ナノゲルを用いる粘膜ワクチン - Google Patents

カチオン性ナノゲルを用いる粘膜ワクチン Download PDF

Info

Publication number
JP5344558B2
JP5344558B2 JP2008281065A JP2008281065A JP5344558B2 JP 5344558 B2 JP5344558 B2 JP 5344558B2 JP 2008281065 A JP2008281065 A JP 2008281065A JP 2008281065 A JP2008281065 A JP 2008281065A JP 5344558 B2 JP5344558 B2 JP 5344558B2
Authority
JP
Japan
Prior art keywords
vaccine
mucosal
antigen
nanogel
vaccine preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2008281065A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010105968A (ja
JP2010105968A5 (enExample
Inventor
一成 秋吉
宏 清野
義和 幸
智法 野地
Original Assignee
国立大学法人 東京医科歯科大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2008281065A priority Critical patent/JP5344558B2/ja
Application filed by 国立大学法人 東京医科歯科大学 filed Critical 国立大学法人 東京医科歯科大学
Priority to EP09823688.8A priority patent/EP2345419B8/en
Priority to PCT/JP2009/068647 priority patent/WO2010050578A1/ja
Priority to US13/126,357 priority patent/US20110206729A1/en
Priority to ES09823688.8T priority patent/ES2624722T3/es
Publication of JP2010105968A publication Critical patent/JP2010105968A/ja
Publication of JP2010105968A5 publication Critical patent/JP2010105968A5/ja
Application granted granted Critical
Publication of JP5344558B2 publication Critical patent/JP5344558B2/ja
Priority to US14/478,127 priority patent/US8961983B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Botany (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Inorganic Chemistry (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2008281065A 2008-10-31 2008-10-31 カチオン性ナノゲルを用いる粘膜ワクチン Active JP5344558B2 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2008281065A JP5344558B2 (ja) 2008-10-31 2008-10-31 カチオン性ナノゲルを用いる粘膜ワクチン
PCT/JP2009/068647 WO2010050578A1 (ja) 2008-10-31 2009-10-30 カチオン性ナノゲルを用いる粘膜ワクチン
US13/126,357 US20110206729A1 (en) 2008-10-31 2009-10-30 Mucosal vaccine using cationic nanogel
ES09823688.8T ES2624722T3 (es) 2008-10-31 2009-10-30 Vacuna mucosa que emplea nanogel catiónico
EP09823688.8A EP2345419B8 (en) 2008-10-31 2009-10-30 Mucosal vaccine using cationic nanogel
US14/478,127 US8961983B2 (en) 2008-10-31 2014-09-05 Mucosal vaccine using cationic nanogel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2008281065A JP5344558B2 (ja) 2008-10-31 2008-10-31 カチオン性ナノゲルを用いる粘膜ワクチン

Publications (3)

Publication Number Publication Date
JP2010105968A JP2010105968A (ja) 2010-05-13
JP2010105968A5 JP2010105968A5 (enExample) 2011-11-24
JP5344558B2 true JP5344558B2 (ja) 2013-11-20

Family

ID=42128937

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008281065A Active JP5344558B2 (ja) 2008-10-31 2008-10-31 カチオン性ナノゲルを用いる粘膜ワクチン

Country Status (5)

Country Link
US (2) US20110206729A1 (enExample)
EP (1) EP2345419B8 (enExample)
JP (1) JP5344558B2 (enExample)
ES (1) ES2624722T3 (enExample)
WO (1) WO2010050578A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015122518A1 (ja) * 2014-02-17 2015-08-20 Ｌｓｉｐファンド運営合同会社 肺炎球菌経鼻ワクチン
US11564993B2 (en) 2018-08-03 2023-01-31 The University Of Tokyo Intranasal vaccine that induces cellular immunity

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2153820A4 (en) 2007-05-14 2013-12-25 Konica Minolta Holdings Inc LIPOSOME AND METHOD FOR PREPARING THE SAME
JP5344558B2 (ja) 2008-10-31 2013-11-20 国立大学法人 東京医科歯科大学 カチオン性ナノゲルを用いる粘膜ワクチン
JP5951490B2 (ja) * 2009-10-21 2016-07-13 ルバンス セラピュティックス インク．Ｒｅｖａｎｃｅ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 非複合ボツリヌス神経毒素を精製するための方法およびシステム
EP2663294B1 (en) 2011-01-11 2015-09-30 Capsugel Belgium NV New hard capsules comprising pullulan
TR201808733T4 (tr) * 2011-10-03 2018-07-23 Mx Adjuvac Ab Kanser tedavisini ve gıda ile ilgili bileşikleri içeren tıp alanlarında amfipatik veya hidrofobik moleküller için taşıyıcı olarak nano-parçacıklar, preparasyon için proses ve bunların kullanımı.
JPWO2013085021A1 (ja) * 2011-12-09 2015-04-27 株式会社林原 抗体産生増強用の組成物
JP6541158B2 (ja) * 2014-06-04 2019-07-10 国立大学法人大阪大学 粘膜ワクチン用アジュバント
US20170319706A1 (en) * 2014-11-18 2017-11-09 Dow Global Technologies Llc Delivering a drug to a mucosal surface
AU2017366726B2 (en) 2016-12-03 2021-12-09 The Uab Research Foundation Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein A
CN110678555B (zh) 2017-04-14 2023-10-13 比利时胶囊公司 制作普鲁兰的方法
JP2020516653A (ja) 2017-04-14 2020-06-11 カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップＣａｐｓｕｇｅｌ Ｂｅｌｇｉｕｍ ＮＶ プルランカプセル
CN107583059B (zh) * 2017-10-31 2021-03-30 宁夏医科大学 一种可包载量子点的阳离子脂质体流感疫苗及其制备方法
JP2020019754A (ja) * 2018-08-03 2020-02-06 国立研究開発法人農業・食品産業技術総合研究機構 ウシ乳房炎に対する粘膜ワクチン組成物
CA3212267A1 (en) 2021-03-30 2022-10-06 Hiroshi Kiyono Nanogel-coated vaccine
EP4444346A1 (en) 2021-12-08 2024-10-16 ImmunityBio, Inc. Neoepitope vaccine delivery vehicle and methods of making the same

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63270555A (ja) 1987-04-28 1988-11-08 日鉄鉱業株式会社 ロ−ルクラツシヤ
JPH05339169A (ja) 1992-03-03 1993-12-21 Dai Ichi Seiyaku Co Ltd 経口ワクチン
US5866135A (en) * 1994-04-21 1999-02-02 North American Vaccine, Inc. Group A streptococcal polysaccharide immunogenic compositions and methods
US6967088B1 (en) * 1995-03-16 2005-11-22 Allergan, Inc. Soluble recombinant botulinum toxin proteins
US6656481B1 (en) * 1996-09-06 2003-12-02 Mitsubishi Chemical Corporation Vaccinal preparations
EP1026174B1 (en) 1998-08-31 2005-05-18 Nof Corporation High-purity polysaccharide containing hydrophobic groups and process for producing the same
JP4599550B2 (ja) 2004-04-09 2010-12-15 国立大学法人 東京医科歯科大学 ナノゲル工学によるハイブリッドゲルの調製とバイオマテリアル応用
WO2006049032A1 (ja) 2004-11-01 2006-05-11 Tokyo Medical And Dental University ナノゲル－アパタイト複合体の調製
JP4550555B2 (ja) 2004-11-17 2010-09-22 国立大学法人 東京医科歯科大学 量子ドット（Ｑｄｏｔ）−ナノゲル複合体の調製
EP1974754A4 (en) 2006-01-18 2012-09-05 Nat Univ Corp Tokyo Med & Dent BIOMATERIAL FOR OSTEOGENESIS CONTAINING A PROMOTER OF OSTEOGENESIS AND A NANOGEL
JP2007252304A (ja) * 2006-03-24 2007-10-04 Tokyo Medical & Dental Univ ナノゲルを用いたタンパク質の細胞内導入法
JP5428017B2 (ja) * 2007-03-23 2014-02-26 国立大学法人 熊本大学 ワクチン剤
JP2008281065A (ja) 2007-05-09 2008-11-20 Nsk Ltd 玉軸受
GB0717864D0 (en) * 2007-09-13 2007-10-24 Peptcell Ltd Peptide sequences and compositions
JP5344558B2 (ja) 2008-10-31 2013-11-20 国立大学法人 東京医科歯科大学 カチオン性ナノゲルを用いる粘膜ワクチン

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015122518A1 (ja) * 2014-02-17 2015-08-20 Ｌｓｉｐファンド運営合同会社 肺炎球菌経鼻ワクチン
JP2015151375A (ja) * 2014-02-17 2015-08-24 Ｌｓｉｐファンド運営合同会社 肺炎球菌経鼻ワクチン
US9833407B2 (en) 2014-02-17 2017-12-05 Intellectual Property Strategy Network, Inc. Nasal vaccine for Streptococcus pneumoniae
US11564993B2 (en) 2018-08-03 2023-01-31 The University Of Tokyo Intranasal vaccine that induces cellular immunity

Also Published As

Publication number Publication date
US8961983B2 (en) 2015-02-24
US20140370056A1 (en) 2014-12-18
EP2345419B8 (en) 2017-04-26
EP2345419A1 (en) 2011-07-20
WO2010050578A1 (ja) 2010-05-06
US20110206729A1 (en) 2011-08-25
EP2345419B1 (en) 2017-02-22
EP2345419A4 (en) 2013-07-10
ES2624722T3 (es) 2017-07-17
JP2010105968A (ja) 2010-05-13

Similar Documents

Publication Publication Date Title
JP5344558B2 (ja) カチオン性ナノゲルを用いる粘膜ワクチン
JP6407208B2 (ja) 合成ナノキャリア混合ワクチン
JP5745221B2 (ja) タンパク質マトリックスワクチンおよびそのようなワクチンの製造方法および投与方法
US7285289B2 (en) Nanoparticle vaccines
JP6382936B2 (ja) ナノ粒子ベースの組成物
US20080233181A1 (en) Nanoparticle adjuvants for sub-unit vaccines
KR20180043352A (ko) 다가 vlp 접합체
Mat Rani et al. Outer membrane vesicles as biomimetic vaccine carriers against infections and cancers
US9540420B2 (en) Mucosal vaccines
JP5841044B2 (ja) 複合糖質ワクチン
CN112789056B (zh) 粘膜佐剂
WO2013085021A1 (ja) 抗体産生増強用の組成物
Yılmaz Çolak Bacterial Membrane Vesicles as a Novel Vaccine Platform against SARS-CoV-2
Rosales-Mendoza et al. Silica-based mucosal nanovaccines
US20250144203A1 (en) Nanostructure-based vector system for bacterial and viral antigens
Compostella et al. Antibacterial Carbohydrate Vaccines
WO2020257315A1 (en) Multiple antigen protein displayed adjuvant systems
BRPI0700860B1 (pt) Forma farmacêutica na forma de uma microesfera de pss recoberta com dodab e biomolécula com carga oposta à camada de dodab, composição farmacêutica, medicamento, e uso da forma farmacêutica

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111007

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20111007

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130507

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130704

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130723

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130808

R150 Certificate of patent or registration of utility model

Ref document number: 5344558

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250