JP5339566B2 - 真核生物細胞を改変する方法 - Google Patents

真核生物細胞を改変する方法 Download PDF

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JP5339566B2
JP5339566B2 JP2002539535A JP2002539535A JP5339566B2 JP 5339566 B2 JP5339566 B2 JP 5339566B2 JP 2002539535 A JP2002539535 A JP 2002539535A JP 2002539535 A JP2002539535 A JP 2002539535A JP 5339566 B2 JP5339566 B2 JP 5339566B2
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gene
chromosomal locus
ltvec
cells
endogenous gene
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JP2004536556A5 (enExample
JP2004536556A (ja
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アリス エヌ． エコノマイズ，
アンドリュー ジェイ． マーフィー，
デイビッド エム． ヴァレンズエラ，
デイビッド フレンデウェイ，
ジョージ ディー． ヤンコポーロス，
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Regeneron Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine

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  • Genetics & Genomics (AREA)
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  • Chemical & Material Sciences (AREA)
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  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2002539535A 2000-10-31 2001-10-31 真核生物細胞を改変する方法 Expired - Lifetime JP5339566B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24466500P 2000-10-31 2000-10-31
US60/244,665 2000-10-31
US09/732,234 2000-12-07
US09/732,234 US6586251B2 (en) 2000-10-31 2000-12-07 Methods of modifying eukaryotic cells
PCT/US2001/045375 WO2002036789A2 (en) 2000-10-31 2001-10-31 Methods of modifying eukaryotic cells

Related Child Applications (2)

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JP2010136321A Division JP2010220628A (ja) 2000-10-31 2010-06-15 真核生物細胞を改変する方法
JP2013108631A Division JP5892975B2 (ja) 2000-10-31 2013-05-23 真核生物細胞を改変する方法

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JP2004536556A JP2004536556A (ja) 2004-12-09
JP2004536556A5 JP2004536556A5 (enExample) 2005-04-07
JP5339566B2 true JP5339566B2 (ja) 2013-11-13

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JP2002539535A Expired - Lifetime JP5339566B2 (ja) 2000-10-31 2001-10-31 真核生物細胞を改変する方法
JP2010136321A Pending JP2010220628A (ja) 2000-10-31 2010-06-15 真核生物細胞を改変する方法
JP2013108631A Expired - Lifetime JP5892975B2 (ja) 2000-10-31 2013-05-23 真核生物細胞を改変する方法
JP2013247817A Expired - Lifetime JP5945263B2 (ja) 2000-10-31 2013-11-29 真核生物細胞を改変する方法
JP2014265082A Withdrawn JP2015062432A (ja) 2000-10-31 2014-12-26 真核生物細胞を改変する方法
JP2017024802A Withdrawn JP2017123855A (ja) 2000-10-31 2017-02-14 真核生物細胞を改変する方法
JP2017024803A Expired - Lifetime JP6486979B2 (ja) 2000-10-31 2017-02-14 真核生物細胞を改変する方法

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JP2010136321A Pending JP2010220628A (ja) 2000-10-31 2010-06-15 真核生物細胞を改変する方法
JP2013108631A Expired - Lifetime JP5892975B2 (ja) 2000-10-31 2013-05-23 真核生物細胞を改変する方法
JP2013247817A Expired - Lifetime JP5945263B2 (ja) 2000-10-31 2013-11-29 真核生物細胞を改変する方法
JP2014265082A Withdrawn JP2015062432A (ja) 2000-10-31 2014-12-26 真核生物細胞を改変する方法
JP2017024802A Withdrawn JP2017123855A (ja) 2000-10-31 2017-02-14 真核生物細胞を改変する方法
JP2017024803A Expired - Lifetime JP6486979B2 (ja) 2000-10-31 2017-02-14 真核生物細胞を改変する方法

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US (1) US6586251B2 (enExample)
EP (1) EP1399575B1 (enExample)
JP (7) JP5339566B2 (enExample)
KR (1) KR100833136B1 (enExample)
CN (1) CN100497642C (enExample)
AT (1) ATE332388T1 (enExample)
AU (2) AU2004802A (enExample)
BR (1) BRPI0115096B1 (enExample)
CA (1) CA2426398C (enExample)
CZ (1) CZ304856B6 (enExample)
DE (1) DE60121372T2 (enExample)
HU (1) HU227639B1 (enExample)
MX (1) MXPA03003797A (enExample)
NO (1) NO332300B1 (enExample)
NZ (1) NZ525511A (enExample)
PL (1) PL204759B1 (enExample)
RU (1) RU2290441C2 (enExample)
WO (1) WO2002036789A2 (enExample)

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