JP5298020B2 - ヘキソースおよびｎ−アセチルヘキソサミンの糖模倣体置換 - Google Patents

ヘキソースおよびｎ−アセチルヘキソサミンの糖模倣体置換 Download PDF

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JP5298020B2
JP5298020B2 JP2009532370A JP2009532370A JP5298020B2 JP 5298020 B2 JP5298020 B2 JP 5298020B2 JP 2009532370 A JP2009532370 A JP 2009532370A JP 2009532370 A JP2009532370 A JP 2009532370A JP 5298020 B2 JP5298020 B2 JP 5298020B2
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alkanyl
aryl
alkynyl
alkenyl
heteroaryl
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JP2010506832A (ja
JP2010506832A5 (https=
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ビート アーンスト，
ダニエル シュウィッツァー，
アラン ケー． サルカール，
ジョン エル． マグナニ，
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グリコミメティクス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP2009532370A 2006-10-12 2007-10-09 ヘキソースおよびｎ−アセチルヘキソサミンの糖模倣体置換 Expired - Fee Related JP5298020B2 (ja)

Applications Claiming Priority (3)

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US85146706P 2006-10-12 2006-10-12
US60/851,467 2006-10-12
PCT/US2007/021541 WO2008060378A2 (en) 2006-10-12 2007-10-09 Glycomimetic replacements for hexoses and n-acetyl hexosamines

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JP2013126449A Division JP2013189471A (ja) 2006-10-12 2013-06-17 ヘキソースおよびｎ−アセチルヘキソサミンの糖模倣体置換

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JP2010506832A JP2010506832A (ja) 2010-03-04
JP2010506832A5 JP2010506832A5 (https=) 2010-04-22
JP5298020B2 true JP5298020B2 (ja) 2013-09-25

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JP2013126449A Withdrawn JP2013189471A (ja) 2006-10-12 2013-06-17 ヘキソースおよびｎ−アセチルヘキソサミンの糖模倣体置換

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US (2) US7964569B2 (https=)
EP (1) EP2074132B1 (https=)
JP (2) JP5298020B2 (https=)
CA (1) CA2666103C (https=)
WO (1) WO2008060378A2 (https=)

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JP2019502727A (ja) 2016-01-22 2019-01-31 グリコミメティクス， インコーポレイテッド Ｐａ−ｉｌおよび／またはｐａ−ｉｉｌレクチンの糖模倣体阻害剤
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
EP3497131B1 (en) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
US11072625B2 (en) * 2016-10-07 2021-07-27 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
CA3054605A1 (en) * 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
WO2019108750A1 (en) 2017-11-30 2019-06-06 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
CN111566117A (zh) 2017-12-29 2020-08-21 糖模拟物有限公司 E-选择蛋白和半乳凝素-3的异双功能抑制剂
WO2019173229A1 (en) 2018-03-05 2019-09-12 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
CN114340736A (zh) 2019-04-24 2022-04-12 糖模拟物有限公司 E-选择蛋白、半乳凝素-3和/或cxcr4趋化因子受体的半乳糖-连接的多聚体糖模拟物抑制剂

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Publication number Publication date
WO2008060378A3 (en) 2008-10-02
CA2666103C (en) 2014-02-18
US20110257380A1 (en) 2011-10-20
JP2010506832A (ja) 2010-03-04
EP2074132A2 (en) 2009-07-01
JP2013189471A (ja) 2013-09-26
US20080161546A1 (en) 2008-07-03
CA2666103A1 (en) 2008-05-22
EP2074132B1 (en) 2013-05-15
WO2008060378A2 (en) 2008-05-22
US7964569B2 (en) 2011-06-21

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