JP5284789B2 - Ｏ−グリコシル化を減少している糖タンパク質の生成 - Google Patents

Ｏ−グリコシル化を減少している糖タンパク質の生成 Download PDF

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Publication number
JP5284789B2
JP5284789B2 JP2008541229A JP2008541229A JP5284789B2 JP 5284789 B2 JP5284789 B2 JP 5284789B2 JP 2008541229 A JP2008541229 A JP 2008541229A JP 2008541229 A JP2008541229 A JP 2008541229A JP 5284789 B2 JP5284789 B2 JP 5284789B2
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protein
glcnac
host cell
mannosidase
glycosylation
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JP2009515963A5 (enExample
JP2009515963A (ja
Inventor
ボブロビッシュ，ピョートル
クック，ジェームズ，ダブリュ．
ケッテ，ウォリン
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グライコフィ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2008541229A 2005-11-15 2006-11-10 Ｏ−グリコシル化を減少している糖タンパク質の生成 Expired - Fee Related JP5284789B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73710805P 2005-11-15 2005-11-15
US60/737,108 2005-11-15
PCT/US2006/043535 WO2007061631A2 (en) 2005-11-15 2006-11-10 Production of glycoproteins with reduced o-glycosylation

Publications (3)

Publication Number Publication Date
JP2009515963A JP2009515963A (ja) 2009-04-16
JP2009515963A5 JP2009515963A5 (enExample) 2009-10-22
JP5284789B2 true JP5284789B2 (ja) 2013-09-11

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JP2008541229A Expired - Fee Related JP5284789B2 (ja) 2005-11-15 2006-11-10 Ｏ−グリコシル化を減少している糖タンパク質の生成

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Country Link
US (3) US8206949B2 (enExample)
EP (1) EP1954815B1 (enExample)
JP (1) JP5284789B2 (enExample)
CN (1) CN101365783B (enExample)
AU (1) AU2006316838B2 (enExample)
CA (1) CA2628725A1 (enExample)
ES (1) ES2534465T3 (enExample)
WO (1) WO2007061631A2 (enExample)

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US20160024203A1 (en) * 2013-03-15 2016-01-28 Bristol-Myers Squibb Company Methods of producing antibodies in yeast
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WO2015013116A1 (en) * 2013-07-25 2015-01-29 Merck Sharp & Dohme Corp. Method for reducing the extent of o-mannosylation of glycoproteins
EP2871235A1 (en) * 2013-11-07 2015-05-13 Centre National de la Recherche Scientifique (CNRS) New methods to produce active hTERT
WO2015195703A1 (en) * 2014-06-16 2015-12-23 Invista Technologies S.A R.L. Methods, reagents and cells for biosynthesizing compounds
CN108064266A (zh) * 2014-07-21 2018-05-22 格利科斯芬兰公司 在丝状真菌中具有哺乳动物样n-聚糖的糖蛋白的制备
CN104198613B (zh) * 2014-09-17 2016-04-06 山东大学 一种分析蛋白o-糖基化位点的方法
KR20210044774A (ko) * 2018-07-04 2021-04-23 사이토이뮨 테라퓨틱스 인코퍼레이티드 Flt3, pd-1 및/또는 pd-l1을 표적으로 하는 면역요법을 위한 조성물 및 방법
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WO2024147112A1 (en) 2023-01-05 2024-07-11 Glycoera Ag Glycoengineered polypeptides targeting immunoglobulin a and complexes comprising the same
WO2024218743A1 (en) 2023-04-21 2024-10-24 Glycoera Ag Multi-functional molecules comprising glycans and uses thereof
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Also Published As

Publication number Publication date
EP1954815A4 (en) 2010-07-07
WO2007061631A8 (en) 2008-05-02
CA2628725A1 (en) 2007-05-31
US8501438B2 (en) 2013-08-06
WO2007061631A2 (en) 2007-05-31
AU2006316838B2 (en) 2012-04-12
ES2534465T3 (es) 2015-04-23
JP2009515963A (ja) 2009-04-16
US20120237973A1 (en) 2012-09-20
US20120322101A1 (en) 2012-12-20
US8206949B2 (en) 2012-06-26
EP1954815B1 (en) 2015-02-25
AU2006316838A1 (en) 2007-05-31
US8795984B2 (en) 2014-08-05
EP1954815A2 (en) 2008-08-13
US20090170159A1 (en) 2009-07-02
CN101365783A (zh) 2009-02-11
CN101365783B (zh) 2013-07-17
WO2007061631A3 (en) 2008-10-23

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