JP2009515963A5 - - Google Patents

Info

Publication number

JP2009515963A5

JP2009515963A5 JP2008541229A JP2008541229A JP2009515963A5 JP 2009515963 A5 JP2009515963 A5 JP 2009515963A5 JP 2008541229 A JP2008541229 A JP 2008541229A JP 2008541229 A JP2008541229 A JP 2008541229A JP 2009515963 A5 JP2009515963 A5 JP 2009515963A5

Authority

JP

Japan

Prior art keywords

protein

glcnac

host cell

linked glycosylation

nucleic acid

Prior art date

2006-11-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 18
• 210000004027 cell Anatomy 0.000 claims 17
• 102000004169 proteins and genes Human genes 0.000 claims 17
• 108090000623 proteins and genes Proteins 0.000 claims 17
• 230000004989 O-glycosylation Effects 0.000 claims 13
• 102000039446 nucleic acids Human genes 0.000 claims 10
• 108020004707 nucleic acids Proteins 0.000 claims 10
• 150000007523 nucleic acids Chemical class 0.000 claims 10
• 108010009689 mannosyl-oligosaccharide 1,2-alpha-mannosidase Proteins 0.000 claims 8
• 230000001939 inductive effect Effects 0.000 claims 7
• 239000003112 inhibitor Substances 0.000 claims 5
• 102000003886 Glycoproteins Human genes 0.000 claims 4
• 108090000288 Glycoproteins Proteins 0.000 claims 4
• 229940121672 Glycosylation inhibitor Drugs 0.000 claims 4
• 239000000411 inducer Substances 0.000 claims 4
• 230000001404 mediated effect Effects 0.000 claims 4
• 125000005975 2-phenylethyloxy group Chemical group 0.000 claims 2
• 230000002538 fungal effect Effects 0.000 claims 2
• 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• JGRMXPSUZIYDRR-UHFFFAOYSA-N 2-(4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)acetic acid Chemical compound OC(=O)CN1C(=O)CSC1=S JGRMXPSUZIYDRR-UHFFFAOYSA-N 0.000 claims 1
• OOENNZREZDKUHB-UHFFFAOYSA-N 2-[5-[[3,4-bis(phenylmethoxy)phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid Chemical compound O=C1N(CC(=O)O)C(=S)SC1=CC(C=C1OCC=2C=CC=CC=2)=CC=C1OCC1=CC=CC=C1 OOENNZREZDKUHB-UHFFFAOYSA-N 0.000 claims 1
• SGIZECXZFLAGBW-UHFFFAOYSA-N 5-benzylidene-1,3-thiazolidine-2,4-dione Chemical group S1C(=O)NC(=O)C1=CC1=CC=CC=C1 SGIZECXZFLAGBW-UHFFFAOYSA-N 0.000 claims 1
• 241000228212 Aspergillus Species 0.000 claims 1
• 102100021771 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 241000235058 Komagataella pastoris Species 0.000 claims 1
• SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 claims 1
• 230000004988 N-glycosylation Effects 0.000 claims 1
• 241001452677 Ogataea methanolica Species 0.000 claims 1
• 241000235648 Pichia Species 0.000 claims 1
• 241000235070 Saccharomyces Species 0.000 claims 1
• 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
• 241000499912 Trichoderma reesei Species 0.000 claims 1
• WYUKJASPBYYQRJ-VSJOFRJTSA-N beta-D-GlcpNAc-(1->2)-alpha-D-Manp-(1->3)-[beta-D-GlcpNAc-(1->2)-alpha-D-Manp-(1->6)]-beta-D-Manp-(1->4)-beta-GlcpNAc-(1->4)-beta-D-GlcpNAc Chemical compound O[C@@H]1[C@@H](NC(=O)C)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O[C@@H]3[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)NC(C)=O)[C@H](O)[C@@H](CO[C@@H]3[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)NC(C)=O)O2)O)[C@@H](CO)O1 WYUKJASPBYYQRJ-VSJOFRJTSA-N 0.000 claims 1
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
• 230000006698 induction Effects 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 241000894007 species Species 0.000 claims 1
• 210000005253 yeast cell Anatomy 0.000 claims 1