AU2006316838B2 - Production of glycoproteins with reduced O-glycosylation - Google Patents

Production of glycoproteins with reduced O-glycosylation Download PDF

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Publication number
AU2006316838B2
AU2006316838B2 AU2006316838A AU2006316838A AU2006316838B2 AU 2006316838 B2 AU2006316838 B2 AU 2006316838B2 AU 2006316838 A AU2006316838 A AU 2006316838A AU 2006316838 A AU2006316838 A AU 2006316838A AU 2006316838 B2 AU2006316838 B2 AU 2006316838B2
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AU
Australia
Prior art keywords
protein
linked glycosylation
glycosylation
glycoprotein
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006316838A
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English (en)
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AU2006316838A1 (en
Inventor
Piotr Bobrowicz
James W. Cook
Warren Kett
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Glycofi Inc
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Glycofi Inc
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Publication of AU2006316838A1 publication Critical patent/AU2006316838A1/en
Application granted granted Critical
Publication of AU2006316838B2 publication Critical patent/AU2006316838B2/en
Priority to AU2012203729A priority Critical patent/AU2012203729B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AU2006316838A 2005-11-15 2006-11-10 Production of glycoproteins with reduced O-glycosylation Ceased AU2006316838B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012203729A AU2012203729B2 (en) 2005-11-22 2012-06-22 Production of glycoproteins with reduced O-glycosylation

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73710805P 2005-11-15 2005-11-15
US60/737,108 2005-11-15
PCT/US2006/043535 WO2007061631A2 (en) 2005-11-15 2006-11-10 Production of glycoproteins with reduced o-glycosylation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012203729A Division AU2012203729B2 (en) 2005-11-22 2012-06-22 Production of glycoproteins with reduced O-glycosylation

Publications (2)

Publication Number Publication Date
AU2006316838A1 AU2006316838A1 (en) 2007-05-31
AU2006316838B2 true AU2006316838B2 (en) 2012-04-12

Family

ID=38067716

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006316838A Ceased AU2006316838B2 (en) 2005-11-15 2006-11-10 Production of glycoproteins with reduced O-glycosylation

Country Status (8)

Country Link
US (3) US8206949B2 (enExample)
EP (1) EP1954815B1 (enExample)
JP (1) JP5284789B2 (enExample)
CN (1) CN101365783B (enExample)
AU (1) AU2006316838B2 (enExample)
CA (1) CA2628725A1 (enExample)
ES (1) ES2534465T3 (enExample)
WO (1) WO2007061631A2 (enExample)

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CN103003438B (zh) * 2010-02-10 2016-01-20 拜康有限公司 减少蛋白质糖基化的方法和过程及其蛋白质
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RU2604811C2 (ru) 2010-05-27 2016-12-10 Мерк Шарп Энд Домэ Корп. Способ получения антител с улучшенными свойствами
TWI537385B (zh) 2010-11-04 2016-06-11 中央研究院 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法
WO2012074948A2 (en) 2010-12-01 2012-06-07 Merck Sharp & Dohme Corp. Surface, anchored fc-bait antibody display system
CN103764837A (zh) 2011-02-25 2014-04-30 默沙东公司 用于生产具有修饰的o-糖基化的蛋白的酵母菌株
US20130330340A1 (en) * 2011-02-25 2013-12-12 Stephen R. Hamilton Production of n- and o-sialylated tnfrii-fc fusion protein in yeast
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US20140302556A1 (en) * 2011-10-27 2014-10-09 Merck Sharp & Doheme Corp. Controlling o-glycosylation in lower eukaryotes
CN104271816A (zh) 2012-05-11 2015-01-07 默沙东公司 表面锚定的轻链诱饵抗体展示系统
US10683521B2 (en) * 2012-06-19 2020-06-16 Nanyang Technological University Expression construct for sensing cell density and substrate availability and its use in conversion of hydroxycinnamic acids
US9707276B2 (en) 2012-12-03 2017-07-18 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
WO2014152145A1 (en) * 2013-03-15 2014-09-25 Bristol-Myers Squibb Company Methods for producing antibodies
HRP20191069T1 (hr) * 2013-07-04 2019-11-01 Glykos Finland Oy Stanice filamentoznih gljiva s deficijencijom o-manozil transferaze i postupci njihove uporabe
WO2015013116A1 (en) * 2013-07-25 2015-01-29 Merck Sharp & Dohme Corp. Method for reducing the extent of o-mannosylation of glycoproteins
EP2871235A1 (en) * 2013-11-07 2015-05-13 Centre National de la Recherche Scientifique (CNRS) New methods to produce active hTERT
WO2015195703A1 (en) * 2014-06-16 2015-12-23 Invista Technologies S.A R.L. Methods, reagents and cells for biosynthesizing compounds
CN108064266A (zh) * 2014-07-21 2018-05-22 格利科斯芬兰公司 在丝状真菌中具有哺乳动物样n-聚糖的糖蛋白的制备
CN104198613B (zh) * 2014-09-17 2016-04-06 山东大学 一种分析蛋白o-糖基化位点的方法
WO2020010284A1 (en) * 2018-07-04 2020-01-09 Cytoimmune Therapeutics, LLC Compositions and methods for immunotherapy targeting flt3, pd-1, and/or pd-l1
CN112888315A (zh) * 2018-08-21 2021-06-01 克莱拉食品公司 微生物中的蛋白质糖基化的修饰
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WO2024147113A1 (en) 2023-01-05 2024-07-11 Glycoera Ag Glycoengineered polypeptides targeting anti-podocyte autoantibodies and uses thereof
WO2024147112A1 (en) 2023-01-05 2024-07-11 Glycoera Ag Glycoengineered polypeptides targeting immunoglobulin a and complexes comprising the same
WO2024218743A1 (en) 2023-04-21 2024-10-24 Glycoera Ag Multi-functional molecules comprising glycans and uses thereof
WO2025215516A1 (en) 2024-04-08 2025-10-16 Glycoera Ag Glycoengineered polypeptides targeting igg4 autoantibodies and uses thereof

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Also Published As

Publication number Publication date
WO2007061631A3 (en) 2008-10-23
US20090170159A1 (en) 2009-07-02
JP2009515963A (ja) 2009-04-16
CA2628725A1 (en) 2007-05-31
US8206949B2 (en) 2012-06-26
AU2006316838A1 (en) 2007-05-31
EP1954815B1 (en) 2015-02-25
US8501438B2 (en) 2013-08-06
WO2007061631A2 (en) 2007-05-31
CN101365783A (zh) 2009-02-11
ES2534465T3 (es) 2015-04-23
US20120237973A1 (en) 2012-09-20
WO2007061631A8 (en) 2008-05-02
CN101365783B (zh) 2013-07-17
JP5284789B2 (ja) 2013-09-11
EP1954815A2 (en) 2008-08-13
US20120322101A1 (en) 2012-12-20
US8795984B2 (en) 2014-08-05
EP1954815A4 (en) 2010-07-07

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired