CN101365783B - 具有降低的o-糖基化的糖蛋白的产生 - Google Patents

具有降低的o-糖基化的糖蛋白的产生 Download PDF

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Publication number
CN101365783B
CN101365783B CN2006800425908A CN200680042590A CN101365783B CN 101365783 B CN101365783 B CN 101365783B CN 2006800425908 A CN2006800425908 A CN 2006800425908A CN 200680042590 A CN200680042590 A CN 200680042590A CN 101365783 B CN101365783 B CN 101365783B
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glcnac
protein
host cell
nucleic acid
mannosidase
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CN101365783A (zh
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P·博布罗维奇
J·W·库克
W·克特
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Glycofi Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CN2006800425908A 2005-11-15 2006-11-10 具有降低的o-糖基化的糖蛋白的产生 Expired - Fee Related CN101365783B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73710805P 2005-11-15 2005-11-15
US60/737,108 2005-11-15
PCT/US2006/043535 WO2007061631A2 (en) 2005-11-15 2006-11-10 Production of glycoproteins with reduced o-glycosylation

Publications (2)

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CN101365783A CN101365783A (zh) 2009-02-11
CN101365783B true CN101365783B (zh) 2013-07-17

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CN2006800425908A Expired - Fee Related CN101365783B (zh) 2005-11-15 2006-11-10 具有降低的o-糖基化的糖蛋白的产生

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US (3) US8206949B2 (enExample)
EP (1) EP1954815B1 (enExample)
JP (1) JP5284789B2 (enExample)
CN (1) CN101365783B (enExample)
AU (1) AU2006316838B2 (enExample)
CA (1) CA2628725A1 (enExample)
ES (1) ES2534465T3 (enExample)
WO (1) WO2007061631A2 (enExample)

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CN103003438B (zh) * 2010-02-10 2016-01-20 拜康有限公司 减少蛋白质糖基化的方法和过程及其蛋白质
AU2011220878A1 (en) 2010-02-24 2012-08-23 Merck Sharp & Dohme Corp. Method for increasing N-glycosylation site occupancy on therapeutic glycoproteins produced in Pichia pastoris
RU2604811C2 (ru) 2010-05-27 2016-12-10 Мерк Шарп Энд Домэ Корп. Способ получения антител с улучшенными свойствами
TWI537385B (zh) 2010-11-04 2016-06-11 中央研究院 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法
WO2012074948A2 (en) 2010-12-01 2012-06-07 Merck Sharp & Dohme Corp. Surface, anchored fc-bait antibody display system
CN103764837A (zh) 2011-02-25 2014-04-30 默沙东公司 用于生产具有修饰的o-糖基化的蛋白的酵母菌株
US20130330340A1 (en) * 2011-02-25 2013-12-12 Stephen R. Hamilton Production of n- and o-sialylated tnfrii-fc fusion protein in yeast
WO2012162277A1 (en) 2011-05-25 2012-11-29 Merck Sharp & Dohme Corp. METHOD FOR PREPARING Fc-CONTAINING POLYPEPTIDES HAVING IMPROVED PROPERTIES
US20140302556A1 (en) * 2011-10-27 2014-10-09 Merck Sharp & Doheme Corp. Controlling o-glycosylation in lower eukaryotes
CN104271816A (zh) 2012-05-11 2015-01-07 默沙东公司 表面锚定的轻链诱饵抗体展示系统
US10683521B2 (en) * 2012-06-19 2020-06-16 Nanyang Technological University Expression construct for sensing cell density and substrate availability and its use in conversion of hydroxycinnamic acids
US9707276B2 (en) 2012-12-03 2017-07-18 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
WO2014152145A1 (en) * 2013-03-15 2014-09-25 Bristol-Myers Squibb Company Methods for producing antibodies
HRP20191069T1 (hr) * 2013-07-04 2019-11-01 Glykos Finland Oy Stanice filamentoznih gljiva s deficijencijom o-manozil transferaze i postupci njihove uporabe
WO2015013116A1 (en) * 2013-07-25 2015-01-29 Merck Sharp & Dohme Corp. Method for reducing the extent of o-mannosylation of glycoproteins
EP2871235A1 (en) * 2013-11-07 2015-05-13 Centre National de la Recherche Scientifique (CNRS) New methods to produce active hTERT
WO2015195703A1 (en) * 2014-06-16 2015-12-23 Invista Technologies S.A R.L. Methods, reagents and cells for biosynthesizing compounds
CN108064266A (zh) * 2014-07-21 2018-05-22 格利科斯芬兰公司 在丝状真菌中具有哺乳动物样n-聚糖的糖蛋白的制备
CN104198613B (zh) * 2014-09-17 2016-04-06 山东大学 一种分析蛋白o-糖基化位点的方法
WO2020010284A1 (en) * 2018-07-04 2020-01-09 Cytoimmune Therapeutics, LLC Compositions and methods for immunotherapy targeting flt3, pd-1, and/or pd-l1
CN112888315A (zh) * 2018-08-21 2021-06-01 克莱拉食品公司 微生物中的蛋白质糖基化的修饰
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WO2024147112A1 (en) 2023-01-05 2024-07-11 Glycoera Ag Glycoengineered polypeptides targeting immunoglobulin a and complexes comprising the same
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WO2025215516A1 (en) 2024-04-08 2025-10-16 Glycoera Ag Glycoengineered polypeptides targeting igg4 autoantibodies and uses thereof

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WO2007061631A3 (en) 2008-10-23
US20090170159A1 (en) 2009-07-02
JP2009515963A (ja) 2009-04-16
CA2628725A1 (en) 2007-05-31
US8206949B2 (en) 2012-06-26
AU2006316838A1 (en) 2007-05-31
EP1954815B1 (en) 2015-02-25
US8501438B2 (en) 2013-08-06
WO2007061631A2 (en) 2007-05-31
CN101365783A (zh) 2009-02-11
ES2534465T3 (es) 2015-04-23
US20120237973A1 (en) 2012-09-20
AU2006316838B2 (en) 2012-04-12
WO2007061631A8 (en) 2008-05-02
JP5284789B2 (ja) 2013-09-11
EP1954815A2 (en) 2008-08-13
US20120322101A1 (en) 2012-12-20
US8795984B2 (en) 2014-08-05
EP1954815A4 (en) 2010-07-07

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