ES2534465T3 - Producción de glucoproteínas con O-glucosilación reducida - Google Patents

Producción de glucoproteínas con O-glucosilación reducida Download PDF

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Publication number
ES2534465T3
ES2534465T3 ES06837184.8T ES06837184T ES2534465T3 ES 2534465 T3 ES2534465 T3 ES 2534465T3 ES 06837184 T ES06837184 T ES 06837184T ES 2534465 T3 ES2534465 T3 ES 2534465T3
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ES
Spain
Prior art keywords
host cell
reduced
linked glycosylation
protein
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06837184.8T
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English (en)
Spanish (es)
Inventor
Piotr Bobrowicz
James W. Cook
Warren Kett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glycofi Inc
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Glycofi Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of ES2534465T3 publication Critical patent/ES2534465T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
ES06837184.8T 2005-11-15 2006-11-10 Producción de glucoproteínas con O-glucosilación reducida Active ES2534465T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73710805P 2005-11-15 2005-11-15
US737108P 2005-11-22
PCT/US2006/043535 WO2007061631A2 (en) 2005-11-15 2006-11-10 Production of glycoproteins with reduced o-glycosylation

Publications (1)

Publication Number Publication Date
ES2534465T3 true ES2534465T3 (es) 2015-04-23

Family

ID=38067716

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06837184.8T Active ES2534465T3 (es) 2005-11-15 2006-11-10 Producción de glucoproteínas con O-glucosilación reducida

Country Status (8)

Country Link
US (3) US8206949B2 (enExample)
EP (1) EP1954815B1 (enExample)
JP (1) JP5284789B2 (enExample)
CN (1) CN101365783B (enExample)
AU (1) AU2006316838B2 (enExample)
CA (1) CA2628725A1 (enExample)
ES (1) ES2534465T3 (enExample)
WO (1) WO2007061631A2 (enExample)

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JP2012518999A (ja) * 2009-02-26 2012-08-23 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 宿主細胞およびその使用方法
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AU2010313492B2 (en) 2009-10-30 2014-05-29 Merck Sharp & Dohme Corp. Method for producing therapeutic proteins in Pichia pastoris lacking dipeptidyl aminopeptidase activity
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WO2011099028A1 (en) * 2010-02-10 2011-08-18 Biocon Limited Method of reducing glycosylation of proteins, processes and proteins thereof
CN102858949B (zh) 2010-02-24 2016-07-06 默沙东公司 用于增加在巴氏毕赤酵母中生产的治疗性糖蛋白上的n-糖基化位点占据的方法
US9187552B2 (en) 2010-05-27 2015-11-17 Merck Sharp & Dohme Corp. Method for preparing antibodies having improved properties
TWI537385B (zh) 2010-11-04 2016-06-11 中央研究院 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法
CN107459577A (zh) 2010-12-01 2017-12-12 默沙东公司 表面锚定的fc‑诱饵抗体展示系统
CA2827732A1 (en) 2011-02-25 2012-08-30 Merck Sharp & Dohme Corp. Yeast strain for the production of proteins with modified o-glycosylation
US20130330340A1 (en) * 2011-02-25 2013-12-12 Stephen R. Hamilton Production of n- and o-sialylated tnfrii-fc fusion protein in yeast
WO2012162277A1 (en) 2011-05-25 2012-11-29 Merck Sharp & Dohme Corp. METHOD FOR PREPARING Fc-CONTAINING POLYPEPTIDES HAVING IMPROVED PROPERTIES
EP2771477A4 (en) * 2011-10-27 2015-04-22 Merck Sharp & Dohme O-GLYCOSYLATION IN LOW EUKARYOTES
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US20160024203A1 (en) * 2013-03-15 2016-01-28 Bristol-Myers Squibb Company Methods of producing antibodies in yeast
US20160376570A1 (en) * 2013-07-04 2016-12-29 Novartis Ag O-Mannosyltransferase Deficient Filamentous Fungal Cells and Methods of Use Thereof
WO2015013116A1 (en) * 2013-07-25 2015-01-29 Merck Sharp & Dohme Corp. Method for reducing the extent of o-mannosylation of glycoproteins
EP2871235A1 (en) * 2013-11-07 2015-05-13 Centre National de la Recherche Scientifique (CNRS) New methods to produce active hTERT
WO2015195703A1 (en) * 2014-06-16 2015-12-23 Invista Technologies S.A R.L. Methods, reagents and cells for biosynthesizing compounds
CN108064266A (zh) * 2014-07-21 2018-05-22 格利科斯芬兰公司 在丝状真菌中具有哺乳动物样n-聚糖的糖蛋白的制备
CN104198613B (zh) * 2014-09-17 2016-04-06 山东大学 一种分析蛋白o-糖基化位点的方法
KR20210044774A (ko) * 2018-07-04 2021-04-23 사이토이뮨 테라퓨틱스 인코퍼레이티드 Flt3, pd-1 및/또는 pd-l1을 표적으로 하는 면역요법을 위한 조성물 및 방법
AU2019325329A1 (en) * 2018-08-21 2021-04-08 Clara Foods Co. Modification of protein glycosylation in microorganisms
EP4646221A1 (en) 2023-01-05 2025-11-12 GlycoEra AG Glycoengineered polypeptides targeting anti-neutrophil autoantibodies and uses thereof
WO2024147113A1 (en) 2023-01-05 2024-07-11 Glycoera Ag Glycoengineered polypeptides targeting anti-podocyte autoantibodies and uses thereof
WO2024147112A1 (en) 2023-01-05 2024-07-11 Glycoera Ag Glycoengineered polypeptides targeting immunoglobulin a and complexes comprising the same
WO2024218743A1 (en) 2023-04-21 2024-10-24 Glycoera Ag Multi-functional molecules comprising glycans and uses thereof
WO2025215516A1 (en) 2024-04-08 2025-10-16 Glycoera Ag Glycoengineered polypeptides targeting igg4 autoantibodies and uses thereof

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WO2009143041A1 (en) * 2008-05-20 2009-11-26 Merck & Co., Inc. Efficient production of heterologous proteins using mannosyl transferase inhibitors

Also Published As

Publication number Publication date
EP1954815A4 (en) 2010-07-07
WO2007061631A8 (en) 2008-05-02
CA2628725A1 (en) 2007-05-31
US8501438B2 (en) 2013-08-06
WO2007061631A2 (en) 2007-05-31
AU2006316838B2 (en) 2012-04-12
JP2009515963A (ja) 2009-04-16
US20120237973A1 (en) 2012-09-20
US20120322101A1 (en) 2012-12-20
US8206949B2 (en) 2012-06-26
EP1954815B1 (en) 2015-02-25
AU2006316838A1 (en) 2007-05-31
US8795984B2 (en) 2014-08-05
EP1954815A2 (en) 2008-08-13
US20090170159A1 (en) 2009-07-02
JP5284789B2 (ja) 2013-09-11
CN101365783A (zh) 2009-02-11
CN101365783B (zh) 2013-07-17
WO2007061631A3 (en) 2008-10-23

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