JP5284112B2 - 核酸、メチル化状態及び核酸の突然変異体を検出するための、シグナリングペア及び疎水性ヌクレオチドを含んだオリゴヌクレオチド、ステムレスビーコン - Google Patents

核酸、メチル化状態及び核酸の突然変異体を検出するための、シグナリングペア及び疎水性ヌクレオチドを含んだオリゴヌクレオチド、ステムレスビーコン Download PDF

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JP5284112B2
JP5284112B2 JP2008558640A JP2008558640A JP5284112B2 JP 5284112 B2 JP5284112 B2 JP 5284112B2 JP 2008558640 A JP2008558640 A JP 2008558640A JP 2008558640 A JP2008558640 A JP 2008558640A JP 5284112 B2 JP5284112 B2 JP 5284112B2
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oligonucleotide
hydrophobic
nucleotide
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クリステンセン，ウルフベック
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ペンタベイス エイピーエス
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays

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JP2008558640A 2006-03-16 2007-03-16 核酸、メチル化状態及び核酸の突然変異体を検出するための、シグナリングペア及び疎水性ヌクレオチドを含んだオリゴヌクレオチド、ステムレスビーコン Active JP5284112B2 (ja)

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DKPA200600379 2006-03-16
DKPA200600379 2006-03-16
PCT/DK2007/000134 WO2007104318A2 (en) 2006-03-16 2007-03-16 Oligonucleotides comprising signalling pairs and hydrophobic nucleotides, stemless beacons, for detection of nucleic acids, methylation status and mutants of nucleic acids

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JP2009529337A JP2009529337A (ja) 2009-08-20
JP2009529337A5 JP2009529337A5 (enExample) 2010-07-08
JP5284112B2 true JP5284112B2 (ja) 2013-09-11

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CN (1) CN101448957A (enExample)
AU (1) AU2007224843A1 (enExample)
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DK (1) DK2004847T3 (enExample)
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CA2708751A1 (en) 2007-12-14 2009-06-25 Minitube Of America, Inc. Gender-specific separation of sperm cells and embryos
WO2009150156A1 (en) * 2008-06-13 2009-12-17 Riboxx Gmbh Method for enzymatic synthesis of chemically modified rna
DE102010012421B4 (de) 2009-03-23 2023-04-20 Vermicon Ag Verfahren zum spezifischen Nachweis von Mikroorganismen
WO2011032034A2 (en) 2009-09-10 2011-03-17 University Of Idaho Nucleobase-functionalized conformationally restricted nucleotides and oligonucleotides for targeting nucleic acids
JP5717169B2 (ja) * 2010-09-14 2015-05-13 国立大学法人名古屋大学 オリゴヌクレオチド及びその利用
RU2014106024A (ru) 2011-07-19 2015-08-27 Юниверсити Оф Айдахо Варианты осуществления зонда и способы направленного действия на нуклеиновые кислоты
WO2013131083A1 (en) 2012-03-02 2013-09-06 Winthrop-University Hospital METHOD FOR USING PROBE BASED PCR DETECTION TO MEASURE THE LEVELS OF CIRCULATING DEMETHYLATED β CELL DERIVED DNA AS A MEASURE OF β CELL LOSS IN DIABETES
CN102911111B (zh) * 2012-11-08 2014-06-11 齐鲁工业大学 一种咔唑苯甲醛缩对苯二胺双席夫碱及其制备方法
EP3350347B1 (en) 2015-09-14 2021-01-20 Pentabase APS Methods and materials for detection of mutations
WO2017218858A1 (en) 2016-06-15 2017-12-21 Genecapture, Inc. Compositions, methods and devices comprising stem-loop captor molecules
CN108827935B (zh) * 2018-06-08 2021-09-07 南京师范大学 一种基于金纳米孔阵列的dna甲基化表面增强拉曼散射光谱检测方法及其应用
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
WO2020229510A1 (en) * 2019-05-13 2020-11-19 Pentabase Aps Melting temperature methods, kits and reporter oligo for detecting variant nucleic acids
CN110261964B (zh) * 2019-07-01 2021-06-04 国检中心深圳珠宝检验实验室有限公司 一种用于光纤光谱仪的光纤头
AU2021302551A1 (en) * 2020-06-29 2023-01-05 Pentabase Aps Detection of methylation status

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AU1366299A (en) 1997-10-27 1999-05-17 Boston Probes, Inc. Methods, kits and compositions pertaining to pna molecular beacons
US6037130A (en) 1998-07-28 2000-03-14 The Public Health Institute Of The City Of New York, Inc. Wavelength-shifting probes and primers and their use in assays and kits
US20070059752A1 (en) * 1999-06-09 2007-03-15 Biosearch Technologies, Inc. Fluorescence energy transfer probes with stabilized conformations
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AU2002358464B2 (en) * 2001-12-18 2006-04-27 Human Genetic Signatures Pty Ltd Pseudonucleotide comprising an intercalator
US20040086879A1 (en) 2001-12-20 2004-05-06 Yingufu Li Tripartite molecular beacons
JP4481656B2 (ja) * 2002-02-27 2010-06-16 ライフ テクノロジーズ コーポレーション ３’→５’エキソヌクレアーゼ耐性クエンチャードメインを含むｆｅｔ標識オリゴヌクレオチドを使用する方法およびそれを実施するための組成物
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EP1709200B1 (en) 2003-12-03 2012-05-09 Abbott Laboratories Double stranded linear nucleic acid probe and uses thereof

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JP2009529337A (ja) 2009-08-20
AU2007224843A1 (en) 2007-09-20
CA2645136C (en) 2017-09-19
US20100068704A1 (en) 2010-03-18
WO2007104318A2 (en) 2007-09-20
US8133984B2 (en) 2012-03-13
NZ571966A (en) 2011-09-30
EP2004847A2 (en) 2008-12-24
EP2004847B1 (en) 2017-05-03
WO2007104318A3 (en) 2008-03-20
CA2645136A1 (en) 2007-09-20
CN101448957A (zh) 2009-06-03
DK2004847T3 (en) 2017-08-21

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