DK2004847T3 - Oligonucleotides comprising signaling pairs and hydrophobic nucleotides, "stemless beacons", for detection of nucleic acids, methylation status and mutants of nucleic acids - Google Patents
Oligonucleotides comprising signaling pairs and hydrophobic nucleotides, "stemless beacons", for detection of nucleic acids, methylation status and mutants of nucleic acids Download PDFInfo
- Publication number
- DK2004847T3 DK2004847T3 DK07711277.9T DK07711277T DK2004847T3 DK 2004847 T3 DK2004847 T3 DK 2004847T3 DK 07711277 T DK07711277 T DK 07711277T DK 2004847 T3 DK2004847 T3 DK 2004847T3
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- DK
- Denmark
- Prior art keywords
- hydrophobic
- nucleotide
- oligonucleotide
- nucleotides
- nucleic acid
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200600379 | 2006-03-16 | ||
| PCT/DK2007/000134 WO2007104318A2 (en) | 2006-03-16 | 2007-03-16 | Oligonucleotides comprising signalling pairs and hydrophobic nucleotides, stemless beacons, for detection of nucleic acids, methylation status and mutants of nucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2004847T3 true DK2004847T3 (en) | 2017-08-21 |
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| EP2229457A4 (en) | 2007-12-14 | 2011-01-26 | Minitube America Inc | SEX-SPECIFIC SEPARATION OF SPERM AND EMBRYOES |
| US20110053226A1 (en) * | 2008-06-13 | 2011-03-03 | Riboxx Gmbh | Method for enzymatic synthesis of chemically modified rna |
| DE102010012421B4 (de) | 2009-03-23 | 2023-04-20 | Vermicon Ag | Verfahren zum spezifischen Nachweis von Mikroorganismen |
| WO2011032034A2 (en) | 2009-09-10 | 2011-03-17 | University Of Idaho | Nucleobase-functionalized conformationally restricted nucleotides and oligonucleotides for targeting nucleic acids |
| JP5717169B2 (ja) * | 2010-09-14 | 2015-05-13 | 国立大学法人名古屋大学 | オリゴヌクレオチド及びその利用 |
| AU2012283994A1 (en) | 2011-07-19 | 2014-03-06 | University Of Idaho | Embodiments of a probe and method for targeting nucleic acids |
| EP2820157B1 (en) | 2012-03-02 | 2019-05-01 | Winthrop-University Hospital | Method for using probe based pcr detection to measure the levels of circulating demethylated beta cell derived dna as a measure of beta cell loss in diabetes |
| CN102911111B (zh) * | 2012-11-08 | 2014-06-11 | 齐鲁工业大学 | 一种咔唑苯甲醛缩对苯二胺双席夫碱及其制备方法 |
| US10988810B2 (en) | 2015-09-14 | 2021-04-27 | Pentabase Aps | Methods and materials for detection of mutations |
| WO2017218858A1 (en) | 2016-06-15 | 2017-12-21 | Genecapture, Inc. | Compositions, methods and devices comprising stem-loop captor molecules |
| CN108827935B (zh) * | 2018-06-08 | 2021-09-07 | 南京师范大学 | 一种基于金纳米孔阵列的dna甲基化表面增强拉曼散射光谱检测方法及其应用 |
| IL280880B2 (en) | 2018-08-27 | 2025-04-01 | Regeneron Pharma | Using Raman Spectroscopy in Downstream Purification |
| CN114286865A (zh) * | 2019-05-13 | 2022-04-05 | 潘塔贝斯公司 | 检测变体核酸的解链温度方法、试剂盒和报告寡核苷酸 |
| CN110261964B (zh) * | 2019-07-01 | 2021-06-04 | 国检中心深圳珠宝检验实验室有限公司 | 一种用于光纤光谱仪的光纤头 |
| AU2021302551A1 (en) * | 2020-06-29 | 2023-01-05 | Pentabase Aps | Detection of methylation status |
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| US5466578A (en) * | 1992-04-09 | 1995-11-14 | The United States Of America As Represented By The Secretary Of The Navy | Surfactant-enhanced light emission- or absorbance-based binding assays for polynucleic acids |
| US5925517A (en) * | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US6312894B1 (en) * | 1995-04-03 | 2001-11-06 | Epoch Pharmaceuticals, Inc. | Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders |
| DE69610304T2 (de) * | 1995-05-05 | 2001-04-05 | Perkin-Elmer Corp., Foster City | Methoden and reagentien fuer die kombination einer pcr-amplifizierung mit einem hybridisierungs-assay |
| DE69738687D1 (de) * | 1996-04-12 | 2008-06-26 | Phri Properties Inc | Sonden, kits und assays |
| JPH11332595A (ja) | 1997-07-09 | 1999-12-07 | Masao Karube | プローブｐｎａによるｄｎａの検出方法 |
| KR100414936B1 (ko) | 1997-09-12 | 2004-01-13 | 엑시콘 에이/에스 | 이환 및 삼환 뉴클레오시드, 뉴클레오타이드 및올리고뉴클레오타이드 동족체 |
| EP1025120B1 (en) * | 1997-10-27 | 2010-08-18 | Boston Probes, Inc. | Methods, kits and compositions pertaining to pna molecular beacons |
| US6485901B1 (en) | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
| US6037130A (en) * | 1998-07-28 | 2000-03-14 | The Public Health Institute Of The City Of New York, Inc. | Wavelength-shifting probes and primers and their use in assays and kits |
| US20070059752A1 (en) * | 1999-06-09 | 2007-03-15 | Biosearch Technologies, Inc. | Fluorescence energy transfer probes with stabilized conformations |
| DK1715063T3 (da) | 2000-03-29 | 2011-05-16 | Lgc Ltd | Hydridiseringsbeacon og fremgangsmåde til hurtig sekvensdetektion og distinktion |
| WO2003043402A2 (en) * | 2001-10-19 | 2003-05-30 | Proligo Llc | Nucleic acid probes and methods to detect and/or quantify nucleic acid analytes |
| AU2002358462A1 (en) | 2001-12-18 | 2003-06-30 | Human Genetic Signatures Pty Ltd | Linear and hairpin oligonucleotide analogues comprising intercalator pseudonucleotides |
| US20040086879A1 (en) * | 2001-12-20 | 2004-05-06 | Yingufu Li | Tripartite molecular beacons |
| AU2003213557A1 (en) * | 2002-02-27 | 2003-09-09 | Biosource International Inc. | Methods of using FET labeled oligonucleotides that include a 3' - 5' exonuclease resistant quencher domain and compositions for practicing the same |
| GB0223563D0 (en) | 2002-10-10 | 2002-11-20 | Secr Defence | Detection system |
| GB0319949D0 (en) | 2003-08-26 | 2003-09-24 | Univ Strathclyde | Nucleic acid sequence identification |
| JP5162133B2 (ja) * | 2003-12-03 | 2013-03-13 | アボット・ラボラトリーズ | 二本鎖直鎖核酸プローブ及びその使用 |
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- 2007-03-16 CA CA2645136A patent/CA2645136C/en active Active
- 2007-03-16 US US12/293,201 patent/US8133984B2/en active Active
- 2007-03-16 AU AU2007224843A patent/AU2007224843A1/en not_active Abandoned
- 2007-03-16 CN CNA200780017820XA patent/CN101448957A/zh active Pending
- 2007-03-16 WO PCT/DK2007/000134 patent/WO2007104318A2/en not_active Ceased
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- 2007-03-16 EP EP07711277.9A patent/EP2004847B1/en active Active
- 2007-03-16 NZ NZ571966A patent/NZ571966A/en unknown
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| EP2004847B1 (en) | 2017-05-03 |
| US20100068704A1 (en) | 2010-03-18 |
| WO2007104318A2 (en) | 2007-09-20 |
| NZ571966A (en) | 2011-09-30 |
| EP2004847A2 (en) | 2008-12-24 |
| WO2007104318A3 (en) | 2008-03-20 |
| JP5284112B2 (ja) | 2013-09-11 |
| CN101448957A (zh) | 2009-06-03 |
| JP2009529337A (ja) | 2009-08-20 |
| CA2645136C (en) | 2017-09-19 |
| US8133984B2 (en) | 2012-03-13 |
| CA2645136A1 (en) | 2007-09-20 |
| AU2007224843A1 (en) | 2007-09-20 |
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