JP5276017B2 - Egfr変異体仲介性疾患の治療における抗egfr抗体の使用 - Google Patents
Egfr変異体仲介性疾患の治療における抗egfr抗体の使用 Download PDFInfo
- Publication number
- JP5276017B2 JP5276017B2 JP2009547312A JP2009547312A JP5276017B2 JP 5276017 B2 JP5276017 B2 JP 5276017B2 JP 2009547312 A JP2009547312 A JP 2009547312A JP 2009547312 A JP2009547312 A JP 2009547312A JP 5276017 B2 JP5276017 B2 JP 5276017B2
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- Prior art keywords
- egfr
- antibody
- cancer
- lung
- treatment
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89738307P | 2007-01-25 | 2007-01-25 | |
| US60/897,383 | 2007-01-25 | ||
| PCT/US2008/001024 WO2008091701A2 (en) | 2007-01-25 | 2008-01-24 | Use of anti-egfr antibodies in treatment of egfr mutant mediated disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010516770A JP2010516770A (ja) | 2010-05-20 |
| JP2010516770A5 JP2010516770A5 (https=) | 2012-03-08 |
| JP5276017B2 true JP5276017B2 (ja) | 2013-08-28 |
Family
ID=39645091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009547312A Active JP5276017B2 (ja) | 2007-01-25 | 2008-01-24 | Egfr変異体仲介性疾患の治療における抗egfr抗体の使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9090693B2 (https=) |
| EP (1) | EP2126127B1 (https=) |
| JP (1) | JP5276017B2 (https=) |
| CN (4) | CN110613845B (https=) |
| CA (1) | CA2676244C (https=) |
| ES (1) | ES2609094T3 (https=) |
| MX (2) | MX2009007987A (https=) |
| WO (1) | WO2008091701A2 (https=) |
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| EP1392359B2 (en) | 2001-05-11 | 2013-03-13 | Ludwig Institute for Cancer Research Ltd. | Specific binding proteins and uses thereof |
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| CA2833706C (en) | 2005-11-11 | 2014-10-21 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
| US9090693B2 (en) | 2007-01-25 | 2015-07-28 | Dana-Farber Cancer Institute | Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease |
| ES2542152T3 (es) | 2007-03-15 | 2015-07-31 | Ludwig Institute For Cancer Research Ltd. | Método de tratamiento que emplea anticuerpos de EGFR e inhibidores de Src y formulaciones relacionadas |
| CN108424454B (zh) | 2007-08-14 | 2022-05-31 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| ES2692769T3 (es) | 2008-06-17 | 2018-12-05 | Wyeth Llc | Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina |
| CN105147713A (zh) | 2008-08-04 | 2015-12-16 | 惠氏有限责任公司 | 4-苯胺基-3-氰基喹啉和卡培他滨的抗肿瘤组合 |
| SG174382A1 (en) | 2009-04-06 | 2011-11-28 | Wyeth Llc | Treatment regimen utilizing neratinib for breast cancer |
| PL2451445T3 (pl) | 2009-07-06 | 2019-09-30 | Boehringer Ingelheim International Gmbh | Sposób suszenia BIBW2992, jego soli i stałych preparatów farmaceutycznych zawierających tę substancję czynną |
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| CN103298489A (zh) | 2010-10-29 | 2013-09-11 | 伊缪诺金公司 | 新型egfr结合分子及其免疫偶联物 |
| CN105399831A (zh) | 2010-10-29 | 2016-03-16 | 伊缪诺金公司 | 非拮抗性egfr结合分子及其免疫偶联物 |
| CN102735844B (zh) * | 2011-04-11 | 2016-01-06 | 中国医学科学院肿瘤医院 | 蛋白组合物及其在制备肺癌诊断试剂盒中的应用 |
| US8828391B2 (en) * | 2011-05-17 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Method for EGFR directed combination treatment of non-small cell lung cancer |
| EP2554551A1 (en) * | 2011-08-03 | 2013-02-06 | Fundacio Institut mar d'Investigacions Médiques (IMIM) | Mutations in the epidermal growth factor receptor gene |
| AU2012323829A1 (en) * | 2011-10-10 | 2014-04-17 | 4Dx Ltd | Heart imaging method |
| US9233171B2 (en) * | 2011-11-21 | 2016-01-12 | Immunogen, Inc. | Method of treatment of tumors that are resistant to EGFR antibody therapies by EGFR antibody cytotoxic agent conjugate |
| DK2838998T3 (en) * | 2012-04-18 | 2018-01-15 | Cell Signaling Technology Inc | EGFR AND ROS1 IN CANCER |
| US20130343996A1 (en) * | 2012-04-25 | 2013-12-26 | Rutgers, The State University Of New Jersey | Graphite-coated magnetic nanoparticles |
| JP6158184B2 (ja) * | 2012-08-10 | 2017-07-05 | 株式会社グリーンペプタイド | 上皮成長因子受容体のt790m点突然変異配列に由来する抗原ペプチド |
| US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| GB2533006B (en) | 2012-09-04 | 2017-06-07 | Guardant Health Inc | Systems and methods to detect copy number variation |
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| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| CN103626871A (zh) * | 2013-04-19 | 2014-03-12 | 武汉纽斯特生物技术有限公司 | 特异性识别egfr突变蛋白的单克隆抗体、制备方法及其应用 |
| ES2660989T3 (es) | 2013-12-28 | 2018-03-27 | Guardant Health, Inc. | Métodos y sistemas para detectar variantes genéticas |
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| EP3114144A1 (en) * | 2014-03-05 | 2017-01-11 | Bristol-Myers Squibb Company | Treatment of renal cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent |
| TWI731535B (zh) * | 2014-03-21 | 2021-06-21 | 美商艾伯維有限公司 | 抗-egfr抗體及抗體藥物結合物 |
| EP3805404A1 (en) | 2014-05-13 | 2021-04-14 | Board of Regents, The University of Texas System | Gene mutations and copy number alterations of egfr, kras and met |
| CN104623660B (zh) * | 2015-01-21 | 2017-05-17 | 广州珂纳偲生物技术有限公司 | 掺杂铜的金纳米棒在制备抗肿瘤药物中的应用 |
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| CN107188957A (zh) * | 2017-07-06 | 2017-09-22 | 江苏迈健生物科技发展股份有限公司 | 抗原肽t790m‑1及其在制备治疗非小细胞肺癌的药物中的应用 |
| MX2022013182A (es) * | 2020-04-24 | 2023-01-16 | Merus Nv | Tratamiento de cánceres con un anticuerpo que se une a lgr5 y egfr. |
| UY39610A (es) | 2021-01-20 | 2022-08-31 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
| CN112941177A (zh) * | 2021-02-03 | 2021-06-11 | 复旦大学附属金山医院(上海市金山区核化伤害应急救治中心、上海市金山区眼病防治所) | Cflar作为诊断标志物在构建肺鳞癌预后预测模型中的应用 |
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| ES2542152T3 (es) | 2007-03-15 | 2015-07-31 | Ludwig Institute For Cancer Research Ltd. | Método de tratamiento que emplea anticuerpos de EGFR e inhibidores de Src y formulaciones relacionadas |
| WO2008154927A1 (en) | 2007-06-21 | 2008-12-24 | Genmab A/S | Novel methods for treating egfr-associated tumors |
| CA2695297C (en) | 2007-08-01 | 2017-03-21 | Syntarga B.V. | Substituted cc-1065 analogs and their conjugates |
| CN108424454B (zh) | 2007-08-14 | 2022-05-31 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
| US20090269343A1 (en) | 2008-04-11 | 2009-10-29 | Duke University | Dual Specific Immunotoxin for Brain Tumor Therapy |
| KR20200058590A (ko) | 2008-04-30 | 2020-05-27 | 이뮤노젠 아이엔씨 | 가교제 및 그 용도 |
| BRPI0913366A8 (pt) | 2008-06-03 | 2017-07-11 | Abbott Lab | Imunoglobulinas de domínio variável duplo e seus usos |
| CN102365021B (zh) | 2009-02-05 | 2015-07-15 | 伊缪诺金公司 | 新型苯并二氮杂*衍生物 |
| EP2424566A4 (en) | 2009-05-01 | 2013-07-31 | Abbvie Inc | IMMUNOGLOBULINE WITH DOUBLE VARIABLE DOMAIN AND ITS USE |
| WO2011035465A1 (zh) | 2009-09-22 | 2011-03-31 | 上海市肿瘤研究所 | 特异性结合蛋白及其使用 |
| US20110076232A1 (en) | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
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| CN104013956A (zh) | 2014-09-03 |
| CN110613845B (zh) | 2025-08-26 |
| CA2676244C (en) | 2017-01-17 |
| ES2609094T3 (es) | 2017-04-18 |
| US9090693B2 (en) | 2015-07-28 |
| CN104013956B (zh) | 2018-12-18 |
| WO2008091701A3 (en) | 2008-10-09 |
| MX338185B (es) | 2016-04-05 |
| EP2126127A2 (en) | 2009-12-02 |
| WO2008091701A9 (en) | 2008-12-04 |
| MX2009007987A (es) | 2010-03-01 |
| CA2676244A1 (en) | 2008-07-31 |
| JP2010516770A (ja) | 2010-05-20 |
| WO2008091701A2 (en) | 2008-07-31 |
| CN104043123A (zh) | 2014-09-17 |
| CN110613845A (zh) | 2019-12-27 |
| EP2126127B1 (en) | 2016-09-28 |
| EP2126127A4 (en) | 2011-11-09 |
| CN101711284A (zh) | 2010-05-19 |
| CN104043123B (zh) | 2019-08-13 |
| US20100166744A1 (en) | 2010-07-01 |
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