CA2676244C - Use of anti-egfr antibodies in treatment of egfr mutant mediated disease - Google Patents
Use of anti-egfr antibodies in treatment of egfr mutant mediated disease Download PDFInfo
- Publication number
- CA2676244C CA2676244C CA2676244A CA2676244A CA2676244C CA 2676244 C CA2676244 C CA 2676244C CA 2676244 A CA2676244 A CA 2676244A CA 2676244 A CA2676244 A CA 2676244A CA 2676244 C CA2676244 C CA 2676244C
- Authority
- CA
- Canada
- Prior art keywords
- egfr
- cancer
- antibody
- mab806
- lung
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89738307P | 2007-01-25 | 2007-01-25 | |
| US60/897,383 | 2007-01-25 | ||
| PCT/US2008/001024 WO2008091701A2 (en) | 2007-01-25 | 2008-01-24 | Use of anti-egfr antibodies in treatment of egfr mutant mediated disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2676244A1 CA2676244A1 (en) | 2008-07-31 |
| CA2676244C true CA2676244C (en) | 2017-01-17 |
Family
ID=39645091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2676244A Active CA2676244C (en) | 2007-01-25 | 2008-01-24 | Use of anti-egfr antibodies in treatment of egfr mutant mediated disease |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9090693B2 (https=) |
| EP (1) | EP2126127B1 (https=) |
| JP (1) | JP5276017B2 (https=) |
| CN (4) | CN104043123B (https=) |
| CA (1) | CA2676244C (https=) |
| ES (1) | ES2609094T3 (https=) |
| MX (2) | MX2009007987A (https=) |
| WO (1) | WO2008091701A2 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| AU2002311919B8 (en) | 2001-05-11 | 2007-03-22 | Ludwig Institute For Cancer Research Ltd | Specific binding proteins and uses thereof |
| US7767792B2 (en) * | 2004-02-20 | 2010-08-03 | Ludwig Institute For Cancer Research Ltd. | Antibodies to EGF receptor epitope peptides |
| KR101313702B1 (ko) | 2005-02-03 | 2013-10-04 | 와이어쓰 | 제피티니브 및/또는 에를로티니브 내성암 치료용 약제학적 조성물 |
| EP1942937A1 (en) | 2005-11-04 | 2008-07-16 | Wyeth | Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272 |
| JP5688877B2 (ja) | 2005-11-11 | 2015-03-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌疾患の治療用キナゾリン誘導体 |
| US9090693B2 (en) | 2007-01-25 | 2015-07-28 | Dana-Farber Cancer Institute | Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease |
| CA2680854C (en) | 2007-03-15 | 2017-02-14 | Ludwig Institute For Cancer Research | Treatment method using egfr antibodies and src inhibitors and related formulations |
| CN108424454B (zh) | 2007-08-14 | 2022-05-31 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| BRPI0914790A2 (pt) | 2008-06-17 | 2015-10-20 | Wyeth Llc | uso de um composto de vinorelbina e um composto de hki-272, composição farmacêutica e produto e kit para o tratamento de neoplasma |
| US8669273B2 (en) | 2008-08-04 | 2014-03-11 | Wyeth Llc | Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine |
| DK3000467T3 (da) | 2009-04-06 | 2023-03-27 | Wyeth Llc | Behandling med neratinib mod brystkræft |
| PT2451445T (pt) | 2009-07-06 | 2019-07-10 | Boehringer Ingelheim Int | Processo para secagem de bibw2992, dos seus sais e de formulações farmacêuticas sólidas compreendendo este ingrediente ativo |
| JP5680087B2 (ja) * | 2009-09-22 | 2015-03-04 | シャンハイ・イージェー・バイオテクノロジー・カンパニー、リミテッドShanghai Yijie Biotechnology Co.,Ltd | 特異的結合タンパク質およびその使用 |
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| EA201390472A1 (ru) | 2010-10-29 | 2014-02-28 | Иммьюноджен, Инк. | Новые молекулы, связывающиеся с egfr, и их иммуноконъюгаты |
| EA201390575A1 (ru) | 2010-10-29 | 2014-01-30 | Иммьюноджен, Инк. | Неантагонистические egfr-связывающие молекулы и их иммуноконъюгаты |
| CN102735844B (zh) * | 2011-04-11 | 2016-01-06 | 中国医学科学院肿瘤医院 | 蛋白组合物及其在制备肺癌诊断试剂盒中的应用 |
| US8828391B2 (en) * | 2011-05-17 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Method for EGFR directed combination treatment of non-small cell lung cancer |
| EP2554551A1 (en) * | 2011-08-03 | 2013-02-06 | Fundacio Institut mar d'Investigacions Médiques (IMIM) | Mutations in the epidermal growth factor receptor gene |
| JP2014528333A (ja) * | 2011-10-10 | 2014-10-27 | モナシュ ユニバーシティ | 心臓のイメージング方法 |
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| PL2838998T3 (pl) * | 2012-04-18 | 2018-04-30 | Cell Signaling Technology, Inc. | EGFR i ROS1 w nowotworze |
| US20130343996A1 (en) * | 2012-04-25 | 2013-12-26 | Rutgers, The State University Of New Jersey | Graphite-coated magnetic nanoparticles |
| WO2014024965A1 (ja) * | 2012-08-10 | 2014-02-13 | 学校法人 久留米大学 | 上皮成長因子受容体のt790m点突然変異配列に由来する抗原ペプチド |
| US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| CN104781421B (zh) | 2012-09-04 | 2020-06-05 | 夸登特健康公司 | 检测稀有突变和拷贝数变异的系统和方法 |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| CN103626871A (zh) * | 2013-04-19 | 2014-03-12 | 武汉纽斯特生物技术有限公司 | 特异性识别egfr突变蛋白的单克隆抗体、制备方法及其应用 |
| ES2660989T3 (es) * | 2013-12-28 | 2018-03-27 | Guardant Health, Inc. | Métodos y sistemas para detectar variantes genéticas |
| US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
| KR20240144452A (ko) * | 2014-03-05 | 2024-10-02 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체 및 또 다른 항암제의 조합물을 이용한 신장암의 치료 |
| AR099812A1 (es) * | 2014-03-21 | 2016-08-17 | Abbvie Inc | Anticuerpos y conjugados de anticuerpo y fármaco anti-egfr |
| ES2844229T3 (es) * | 2014-05-13 | 2021-07-21 | Univ Texas | Mutaciones génicas y alteraciones en el número de copias de EGFR, KRAS y MET |
| CN104623660B (zh) * | 2015-01-21 | 2017-05-17 | 广州珂纳偲生物技术有限公司 | 掺杂铜的金纳米棒在制备抗肿瘤药物中的应用 |
| CA2983890A1 (en) * | 2015-04-24 | 2016-10-27 | Merrimack Pharmaceuticals, Inc. | Methods of treating patients having mutations in the extracellular domain of epidermal growth factor receptor (egfr) with a combination of three fully human monoclonal anti-egfr antibodies |
| SG11201805119QA (en) | 2015-12-17 | 2018-07-30 | Guardant Health Inc | Methods to determine tumor gene copy number by analysis of cell-free dna |
| WO2017189906A1 (en) * | 2016-04-27 | 2017-11-02 | Mira Dx, Inc. | Immune-based treatment of kras-variant cancer patients |
| CN107188957A (zh) * | 2017-07-06 | 2017-09-22 | 江苏迈健生物科技发展股份有限公司 | 抗原肽t790m‑1及其在制备治疗非小细胞肺癌的药物中的应用 |
| TW202206460A (zh) * | 2020-04-24 | 2022-02-16 | 荷蘭商美勒斯公司 | 使用結合lgr5及egfr之抗體的癌症治療 |
| AR124681A1 (es) | 2021-01-20 | 2023-04-26 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
| CN112941177A (zh) * | 2021-02-03 | 2021-06-11 | 复旦大学附属金山医院(上海市金山区核化伤害应急救治中心、上海市金山区眼病防治所) | Cflar作为诊断标志物在构建肺鳞癌预后预测模型中的应用 |
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| CN108424454B (zh) | 2007-08-14 | 2022-05-31 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
| US20090269343A1 (en) | 2008-04-11 | 2009-10-29 | Duke University | Dual Specific Immunotoxin for Brain Tumor Therapy |
| NZ610239A (en) | 2008-04-30 | 2014-11-28 | Immunogen Inc | Cross-linkers and their uses |
| TW201006485A (en) | 2008-06-03 | 2010-02-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| RU2683325C2 (ru) | 2009-02-05 | 2019-03-28 | Иммьюноджен, Инк. | Новые производные бензодиазепина |
| US20110008766A1 (en) * | 2009-05-01 | 2011-01-13 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
| JP5680087B2 (ja) | 2009-09-22 | 2015-03-04 | シャンハイ・イージェー・バイオテクノロジー・カンパニー、リミテッドShanghai Yijie Biotechnology Co.,Ltd | 特異的結合タンパク質およびその使用 |
| US20110076232A1 (en) * | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
-
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- 2008-01-24 US US12/449,129 patent/US9090693B2/en active Active
- 2008-01-24 ES ES08724838.1T patent/ES2609094T3/es active Active
- 2008-01-24 CN CN201310593730.2A patent/CN104043123B/zh active Active
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- 2008-01-24 JP JP2009547312A patent/JP5276017B2/ja active Active
- 2008-01-24 CA CA2676244A patent/CA2676244C/en active Active
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| MX2009007987A (es) | 2010-03-01 |
| WO2008091701A9 (en) | 2008-12-04 |
| ES2609094T3 (es) | 2017-04-18 |
| EP2126127A2 (en) | 2009-12-02 |
| CN104013956A (zh) | 2014-09-03 |
| MX338185B (es) | 2016-04-05 |
| US9090693B2 (en) | 2015-07-28 |
| WO2008091701A3 (en) | 2008-10-09 |
| JP5276017B2 (ja) | 2013-08-28 |
| CA2676244A1 (en) | 2008-07-31 |
| EP2126127B1 (en) | 2016-09-28 |
| WO2008091701A2 (en) | 2008-07-31 |
| CN101711284A (zh) | 2010-05-19 |
| CN104043123A (zh) | 2014-09-17 |
| CN104013956B (zh) | 2018-12-18 |
| CN110613845A (zh) | 2019-12-27 |
| CN104043123B (zh) | 2019-08-13 |
| CN110613845B (zh) | 2025-08-26 |
| JP2010516770A (ja) | 2010-05-20 |
| EP2126127A4 (en) | 2011-11-09 |
| US20100166744A1 (en) | 2010-07-01 |
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