JP5270684B2 - 脂肪肝疾患用のバイオマーカー及びその使用方法 - Google Patents

脂肪肝疾患用のバイオマーカー及びその使用方法 Download PDF

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JP5270684B2
JP5270684B2 JP2010532284A JP2010532284A JP5270684B2 JP 5270684 B2 JP5270684 B2 JP 5270684B2 JP 2010532284 A JP2010532284 A JP 2010532284A JP 2010532284 A JP2010532284 A JP 2010532284A JP 5270684 B2 JP5270684 B2 JP 5270684B2
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biomarkers
steatohepatitis
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sample
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JP2011503547A (ja
JP2011503547A5 (enExample
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クリーディー、ブルース、ジェイ．、ジュニア マク
バーガー、アルヴィン
フー、ユンフ
カルハン、サティシュ、シー．
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Cleveland Clinic Foundation
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/16—Phosphorus containing
    • Y10T436/163333—Organic [e.g., chemical warfare agents, insecticides, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/200833—Carbonyl, ether, aldehyde or ketone containing

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
JP2010532284A 2007-11-02 2008-10-31 脂肪肝疾患用のバイオマーカー及びその使用方法 Active JP5270684B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US98494207P 2007-11-02 2007-11-02
US60/984,942 2007-11-02
US4245908P 2008-04-04 2008-04-04
US61/042,459 2008-04-04
PCT/US2008/082013 WO2009059150A2 (en) 2007-11-02 2008-10-31 Biomarkers for fatty liver disease and methods using the same

Publications (3)

Publication Number Publication Date
JP2011503547A JP2011503547A (ja) 2011-01-27
JP2011503547A5 JP2011503547A5 (enExample) 2011-12-08
JP5270684B2 true JP5270684B2 (ja) 2013-08-21

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US (3) US20100279956A1 (enExample)
EP (3) EP2930512B1 (enExample)
JP (1) JP5270684B2 (enExample)
ES (1) ES2402142T3 (enExample)
WO (1) WO2009059150A2 (enExample)

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BRPI0912175A2 (pt) 2008-05-28 2015-10-06 Basf Se métodos para diagnosticar indução de enzima do fígado, para determinar se um composto é capaz de induzir indução de enzima do fígado em um indivíduo, e para identificar uma substância para tratar indução de enzima do fígado
EP2286236B1 (en) 2008-05-28 2016-04-20 Basf Se Methods for assessing liver toxicity
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CN102741426B (zh) * 2009-09-11 2015-03-25 香港中文大学 用于评估肝病变的方法
JP2011232164A (ja) * 2010-04-27 2011-11-17 Keio Gijuku 肝臓疾患マーカー、その測定方法、装置及び医薬品の検定方法
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CN102971632B (zh) * 2010-06-18 2015-09-02 学校法人庆应义塾 肝病标记物、其测定方法、装置和医药品的检验方法
US8728824B2 (en) 2011-06-22 2014-05-20 Quest Diagnostics Investments Inc. Mass spectrometric determination of fatty acids
WO2013002381A1 (ja) * 2011-06-30 2013-01-03 味の素株式会社 脂肪性肝疾患の評価方法、脂肪性肝疾患評価装置、脂肪性肝疾患評価方法、脂肪性肝疾患評価プログラム、脂肪性肝疾患評価システム、情報通信端末装置、および脂肪性肝疾患の予防・改善物質の探索方法
IN2015DN02868A (enExample) 2012-09-21 2015-09-11 Univ Toronto
CN107076753B (zh) * 2014-09-30 2019-01-18 深圳华大基因科技有限公司 肥胖人群特异性生物标志组合物及其用途
US20170370954A1 (en) * 2014-11-19 2017-12-28 Metabolon, Inc. Biomarkers for Fatty Liver Disease and Methods Using the Same
RU2617236C1 (ru) * 2015-12-02 2017-04-24 государственное бюджетное образовательное учреждение высшего профессионального образования "Северо-Западный государственный медицинский университет им. И.И. Мечникова" Министерства здравоохранения Российской Федерации Способ определения целесообразности проведения иммунологического обследования у пациентов неалкогольной жировой болезнью печени
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CN109060977B (zh) * 2018-07-13 2024-07-02 深圳市绘云生物科技有限公司 用于肝纤维化和肝硬化诊断的生物标志物和试剂盒及使用方法
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WO2020066162A1 (ja) * 2018-09-26 2020-04-02 株式会社島津製作所 非アルコール性脂肪肝疾患の検出方法、非アルコール性脂肪肝疾患検出用キットおよび非アルコール性脂肪肝疾患検出用バイオマーカー
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Also Published As

Publication number Publication date
US20150377910A1 (en) 2015-12-31
US20190120855A1 (en) 2019-04-25
US9977034B2 (en) 2018-05-22
EP2930512A2 (en) 2015-10-14
EP2930512B1 (en) 2018-01-31
WO2009059150A2 (en) 2009-05-07
EP2227689B1 (en) 2012-12-26
EP2546649A3 (en) 2013-03-27
EP2546649A2 (en) 2013-01-16
HK1216189A1 (en) 2016-10-21
ES2402142T3 (es) 2013-04-29
WO2009059150A3 (en) 2009-06-18
JP2011503547A (ja) 2011-01-27
EP2227689A4 (en) 2011-03-30
US20100279956A1 (en) 2010-11-04
EP2546649B1 (en) 2015-02-25
EP2227689A2 (en) 2010-09-15
EP2930512A3 (en) 2015-12-02

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