JP5230436B2 - グルカゴン受容体アンタゴニスト、製造及び治療的使用 - Google Patents
グルカゴン受容体アンタゴニスト、製造及び治療的使用 Download PDFInfo
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- JP5230436B2 JP5230436B2 JP2008541476A JP2008541476A JP5230436B2 JP 5230436 B2 JP5230436 B2 JP 5230436B2 JP 2008541476 A JP2008541476 A JP 2008541476A JP 2008541476 A JP2008541476 A JP 2008541476A JP 5230436 B2 JP5230436 B2 JP 5230436B2
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- dimethyl
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- biphenyl
- yloxy
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
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- General Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US73872305P | 2005-11-22 | 2005-11-22 | |
| US60/738,723 | 2005-11-22 | ||
| PCT/US2006/060976 WO2007120270A2 (en) | 2005-11-22 | 2006-11-16 | Glucagon receptor antagonists, preparation and therapeutic uses |
Publications (3)
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| JP2009516698A JP2009516698A (ja) | 2009-04-23 |
| JP2009516698A5 JP2009516698A5 (enExample) | 2009-12-17 |
| JP5230436B2 true JP5230436B2 (ja) | 2013-07-10 |
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| CA (1) | CA2629172C (enExample) |
| ES (1) | ES2516691T3 (enExample) |
| WO (1) | WO2007120270A2 (enExample) |
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| SI1758853T1 (sl) * | 2004-06-14 | 2010-05-31 | Lilly Co Eli | Antagonisti glukagonskega receptorja priprava inuporaba v terapiji |
| EP2786985B1 (en) | 2007-02-09 | 2018-11-28 | Metabasis Therapeutics, Inc. | Antagonists of the glucagon receptor |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| CN104803891B (zh) | 2008-08-13 | 2017-10-20 | 症变治疗公司 | 胰高血糖素拮抗剂 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| RU2013127611A (ru) * | 2010-12-23 | 2015-01-27 | Пфайзер Инк. | Модуляторы глюкагонового рецептора |
| MX2013009140A (es) * | 2011-02-08 | 2013-10-01 | Pfizer | Moduladores del receptor de glucagon. |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| RU2013157388A (ru) * | 2011-07-22 | 2015-08-27 | Пфайзер Инк. | Хинолинильные модуляторы глюкагонового рецептора |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9649294B2 (en) | 2013-11-04 | 2017-05-16 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| US10076504B2 (en) | 2014-06-12 | 2018-09-18 | Ligand Pharmaceuticals, Inc. | Glucagon antagonists |
| TW202003453A (zh) | 2018-02-13 | 2020-01-16 | 美商利根德製藥公司 | 升糖素受體拮抗劑 |
| CN108727157B (zh) * | 2018-07-06 | 2020-04-28 | 大连理工大学 | 胰高血糖素受体拮抗剂中间体的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4973731A (en) * | 1987-04-23 | 1990-11-27 | Riker Laboratories, Inc. | Di-t-butylphenyl alkyl and benzyl ether nitriles |
| GB9420557D0 (en) | 1994-10-12 | 1994-11-30 | Zeneca Ltd | Aromatic compounds |
| US6706744B2 (en) * | 2000-11-17 | 2004-03-16 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| EP1463715A1 (en) | 2001-12-03 | 2004-10-06 | Novo Nordisk A/S | Novel glucagon antagonists |
| AU2003233780A1 (en) * | 2002-06-27 | 2004-01-19 | Novo Nordisk A/S | Novel glucagon antagonists/inverse agonists |
| WO2004056763A2 (en) | 2002-12-20 | 2004-07-08 | Novo Nordisk A/S | Novel glucagon antagonists |
| SI1758853T1 (sl) * | 2004-06-14 | 2010-05-31 | Lilly Co Eli | Antagonisti glukagonskega receptorja priprava inuporaba v terapiji |
| US8318760B2 (en) | 2005-03-21 | 2012-11-27 | Merck Sharp & Dohme Corp. | Substituted aryl and heteroaryl derivatives, compositions containing such compounds and methods of use |
-
2006
- 2006-11-16 BR BRPI0618140-6A patent/BRPI0618140A2/pt not_active IP Right Cessation
- 2006-11-16 CN CN2006800436264A patent/CN101312723B/zh not_active Expired - Fee Related
- 2006-11-16 ES ES06850764.9T patent/ES2516691T3/es active Active
- 2006-11-16 CA CA2629172A patent/CA2629172C/en not_active Expired - Fee Related
- 2006-11-16 WO PCT/US2006/060976 patent/WO2007120270A2/en not_active Ceased
- 2006-11-16 JP JP2008541476A patent/JP5230436B2/ja not_active Expired - Fee Related
- 2006-11-16 US US12/093,601 patent/US8691856B2/en not_active Expired - Fee Related
- 2006-11-16 EP EP06850764.9A patent/EP1957068B1/en not_active Not-in-force
- 2006-11-16 AU AU2006342137A patent/AU2006342137B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20090156655A1 (en) | 2009-06-18 |
| CA2629172A1 (en) | 2007-10-25 |
| US8691856B2 (en) | 2014-04-08 |
| EP1957068A2 (en) | 2008-08-20 |
| AU2006342137B2 (en) | 2012-02-16 |
| CN101312723B (zh) | 2012-01-11 |
| CN101312723A (zh) | 2008-11-26 |
| EP1957068B1 (en) | 2014-08-13 |
| JP2009516698A (ja) | 2009-04-23 |
| WO2007120270A2 (en) | 2007-10-25 |
| ES2516691T3 (es) | 2014-10-31 |
| CA2629172C (en) | 2014-05-06 |
| WO2007120270A3 (en) | 2008-02-28 |
| AU2006342137A1 (en) | 2007-10-25 |
| BRPI0618140A2 (pt) | 2011-08-16 |
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