JP5227790B2 - 新規結晶性臭化チオトロピウム - Google Patents

新規結晶性臭化チオトロピウム Download PDF

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JP5227790B2
JP5227790B2 JP2008509408A JP2008509408A JP5227790B2 JP 5227790 B2 JP5227790 B2 JP 5227790B2 JP 2008509408 A JP2008509408 A JP 2008509408A JP 2008509408 A JP2008509408 A JP 2008509408A JP 5227790 B2 JP5227790 B2 JP 5227790B2
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tiotropium bromide
crystalline
solvate
crystalline tiotropium
present
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Japanese (ja)
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JP2008540366A5 (enExample
JP2008540366A (ja
Inventor
ミハエラ マリア ポップ
ウデイエ ステファニー ムルデル
ミマウン ラムカドミ
Original Assignee
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
JP2008509408A 2005-05-02 2006-04-21 新規結晶性臭化チオトロピウム Active JP5227790B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67680705P 2005-05-02 2005-05-02
US60/676,807 2005-05-02
PCT/EP2006/061763 WO2006117299A2 (en) 2005-05-02 2006-04-21 Novel crystalline forms of tiotropium bromide

Publications (3)

Publication Number Publication Date
JP2008540366A JP2008540366A (ja) 2008-11-20
JP2008540366A5 JP2008540366A5 (enExample) 2009-06-18
JP5227790B2 true JP5227790B2 (ja) 2013-07-03

Family

ID=36693210

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008509408A Active JP5227790B2 (ja) 2005-05-02 2006-04-21 新規結晶性臭化チオトロピウム

Country Status (23)

Country Link
US (1) US7879871B2 (enExample)
EP (2) EP1881980B1 (enExample)
JP (1) JP5227790B2 (enExample)
KR (1) KR20080012932A (enExample)
CN (1) CN101166738B (enExample)
AR (1) AR053599A1 (enExample)
AU (1) AU2006243238B2 (enExample)
BR (1) BRPI0609295A2 (enExample)
CA (1) CA2606549A1 (enExample)
DK (1) DK1881980T3 (enExample)
ES (1) ES2393794T3 (enExample)
IL (1) IL187055A (enExample)
MX (1) MX2007013142A (enExample)
NZ (1) NZ563596A (enExample)
PE (1) PE20061438A1 (enExample)
PL (1) PL1881980T3 (enExample)
PT (1) PT1881980E (enExample)
RU (1) RU2417224C2 (enExample)
SI (1) SI1881980T1 (enExample)
TW (1) TWI392674B (enExample)
UY (1) UY29506A1 (enExample)
WO (1) WO2006117299A2 (enExample)
ZA (1) ZA200708048B (enExample)

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CN101360744A (zh) * 2005-12-19 2009-02-04 西科尔公司 纯和稳定的噻托溴铵
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
CN100999521B (zh) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 结晶性抗胆碱药噻托溴铵
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
EP1923393A1 (en) * 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
PT2240477E (pt) * 2008-01-10 2014-11-19 Generics Uk Ltd Um novo processo para a preparação de ésteres de escopina
BRPI0916047A2 (pt) * 2008-11-04 2015-11-10 Cipla Ltd composição farmacêutica em aerossol, uso de uma composição farmacêutica em aerossol, método para tratamento de sintomas crônicos ou agudos severos, moderados ou leves, ou para tratamento profilático de um distúrbio respiratório, dispensador farmacêutico em aerossol, processo para fabricação de um dispensador farmacêutico em aerossol e processo para fabricação de um complexo de um agente ativo e um adjuvante
KR101557633B1 (ko) * 2008-11-04 2015-10-06 시플라 리미티드 낮은 결정화도를 갖는 티오트로피움 브로마이드
WO2010101538A2 (en) 2009-03-06 2010-09-10 Bilgic Mahmut New crystal forms
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
US8697719B2 (en) * 2009-08-07 2014-04-15 Generics [Uk] Limited Anhydrate of tiotropium bromide
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
TR201102068A2 (tr) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
UA115888C2 (uk) * 2012-11-05 2018-01-10 Зентіва, К.С. Стабілізація сольватів тіотропію
KR20150135328A (ko) 2013-04-01 2015-12-02 풀매트릭스 인코퍼레이티드 티오트로피움 건조 분말
EP2913332A1 (en) 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
EP3414243A1 (en) * 2016-02-11 2018-12-19 Sima Patent Ve Lisanslama Hizmetleri Ltd. STI Crystalline form of tiotropium bromide anhydrate
PT115583B (pt) 2019-06-17 2022-05-02 Hovione Farm S A Processo contínuo para a preparação de medicamentos anticolinérgicos

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Also Published As

Publication number Publication date
AU2006243238B2 (en) 2012-05-24
AU2006243238A1 (en) 2006-11-09
RU2007144521A (ru) 2009-06-10
CN101166738A (zh) 2008-04-23
WO2006117299A3 (en) 2007-02-22
CN101166738B (zh) 2011-06-01
US7879871B2 (en) 2011-02-01
KR20080012932A (ko) 2008-02-12
ES2393794T3 (es) 2012-12-28
EP1881980A2 (en) 2008-01-30
NZ563596A (en) 2011-01-28
RU2417224C2 (ru) 2011-04-27
IL187055A (en) 2012-09-24
HK1114856A1 (en) 2008-11-14
MX2007013142A (es) 2008-03-18
EP1881980B1 (en) 2012-08-22
TWI392674B (zh) 2013-04-11
UY29506A1 (es) 2006-11-30
PT1881980E (pt) 2012-12-06
PE20061438A1 (es) 2007-01-12
US20070092453A1 (en) 2007-04-26
BRPI0609295A2 (pt) 2010-03-23
DK1881980T3 (da) 2012-10-01
SI1881980T1 (sl) 2012-12-31
WO2006117299A9 (en) 2006-12-28
IL187055A0 (en) 2008-02-09
AR053599A1 (es) 2007-05-09
JP2008540366A (ja) 2008-11-20
PL1881980T3 (pl) 2013-01-31
WO2006117299A2 (en) 2006-11-09
EP2085396A2 (en) 2009-08-05
EP2085396A3 (en) 2009-11-25
TW200708513A (en) 2007-03-01
CA2606549A1 (en) 2006-11-09
ZA200708048B (en) 2008-10-29

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