AU2006243238B2 - Novel crystalline forms of tiotropium bromide - Google Patents

Novel crystalline forms of tiotropium bromide Download PDF

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Publication number
AU2006243238B2
AU2006243238B2 AU2006243238A AU2006243238A AU2006243238B2 AU 2006243238 B2 AU2006243238 B2 AU 2006243238B2 AU 2006243238 A AU2006243238 A AU 2006243238A AU 2006243238 A AU2006243238 A AU 2006243238A AU 2006243238 B2 AU2006243238 B2 AU 2006243238B2
Authority
AU
Australia
Prior art keywords
tiotropium bromide
crystalline
solvate
tiotropium
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006243238A
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English (en)
Other versions
AU2006243238A1 (en
Inventor
Mimoun Lamkadmi
Stephanie Mulder Houdayer
Mihaela Maria Pop
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36693210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2006243238(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of AU2006243238A1 publication Critical patent/AU2006243238A1/en
Application granted granted Critical
Publication of AU2006243238B2 publication Critical patent/AU2006243238B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
AU2006243238A 2005-05-02 2006-04-21 Novel crystalline forms of tiotropium bromide Ceased AU2006243238B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67680705P 2005-05-02 2005-05-02
US60/676,807 2005-05-02
PCT/EP2006/061763 WO2006117299A2 (en) 2005-05-02 2006-04-21 Novel crystalline forms of tiotropium bromide

Publications (2)

Publication Number Publication Date
AU2006243238A1 AU2006243238A1 (en) 2006-11-09
AU2006243238B2 true AU2006243238B2 (en) 2012-05-24

Family

ID=36693210

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006243238A Ceased AU2006243238B2 (en) 2005-05-02 2006-04-21 Novel crystalline forms of tiotropium bromide

Country Status (23)

Country Link
US (1) US7879871B2 (enExample)
EP (2) EP2085396A3 (enExample)
JP (1) JP5227790B2 (enExample)
KR (1) KR20080012932A (enExample)
CN (1) CN101166738B (enExample)
AR (1) AR053599A1 (enExample)
AU (1) AU2006243238B2 (enExample)
BR (1) BRPI0609295A2 (enExample)
CA (1) CA2606549A1 (enExample)
DK (1) DK1881980T3 (enExample)
ES (1) ES2393794T3 (enExample)
IL (1) IL187055A (enExample)
MX (1) MX2007013142A (enExample)
NZ (1) NZ563596A (enExample)
PE (1) PE20061438A1 (enExample)
PL (1) PL1881980T3 (enExample)
PT (1) PT1881980E (enExample)
RU (1) RU2417224C2 (enExample)
SI (1) SI1881980T1 (enExample)
TW (1) TWI392674B (enExample)
UY (1) UY29506A1 (enExample)
WO (1) WO2006117299A2 (enExample)
ZA (1) ZA200708048B (enExample)

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JP2008530251A (ja) * 2005-12-19 2008-08-07 シコール インコーポレイティド 純粋且つ安定な臭化チオトロピウム
PT1869035E (pt) 2005-12-19 2013-01-10 Sicor Inc Novas formas de brometo de tiotrópio e processos para sua preparação
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
CN100999521B (zh) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 结晶性抗胆碱药噻托溴铵
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
EP1923393A1 (en) * 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
WO2009087419A1 (en) * 2008-01-10 2009-07-16 Generics [Uk] Limited Novel process for the preparation of scopine esters
AU2009312582B2 (en) * 2008-11-04 2014-03-27 Cipla Limited Tiotropium bromide having a low degree of crystallinity
BRPI0916047A2 (pt) * 2008-11-04 2015-11-10 Cipla Ltd composição farmacêutica em aerossol, uso de uma composição farmacêutica em aerossol, método para tratamento de sintomas crônicos ou agudos severos, moderados ou leves, ou para tratamento profilático de um distúrbio respiratório, dispensador farmacêutico em aerossol, processo para fabricação de um dispensador farmacêutico em aerossol e processo para fabricação de um complexo de um agente ativo e um adjuvante
EP2403851B1 (en) 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
CA2768553C (en) 2009-08-07 2016-08-02 Generics [Uk] Limited Anhydrate of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
TR201102068A2 (tr) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
ES2620758T3 (es) 2012-11-05 2017-06-29 Zentiva K.S. Estabilización de solvatos de tiotropio
KR20150135328A (ko) 2013-04-01 2015-12-02 풀매트릭스 인코퍼레이티드 티오트로피움 건조 분말
EP2913332A1 (en) 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
WO2017138896A1 (en) * 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
PT115583B (pt) 2019-06-17 2022-05-02 Hovione Farm S A Processo contínuo para a preparação de medicamentos anticolinérgicos

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US20020110529A1 (en) * 2000-10-12 2002-08-15 Karoline Bechtold-Peters Inhalable powder containing tiotropium
US20020169321A1 (en) * 2000-10-12 2002-11-14 Rolf Banholzer Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
US20030087927A1 (en) * 2001-06-22 2003-05-08 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
US20030185766A1 (en) * 2002-03-28 2003-10-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate

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Also Published As

Publication number Publication date
CN101166738A (zh) 2008-04-23
PL1881980T3 (pl) 2013-01-31
IL187055A (en) 2012-09-24
ES2393794T3 (es) 2012-12-28
AU2006243238A1 (en) 2006-11-09
US20070092453A1 (en) 2007-04-26
RU2007144521A (ru) 2009-06-10
UY29506A1 (es) 2006-11-30
PE20061438A1 (es) 2007-01-12
BRPI0609295A2 (pt) 2010-03-23
TW200708513A (en) 2007-03-01
HK1114856A1 (en) 2008-11-14
JP5227790B2 (ja) 2013-07-03
KR20080012932A (ko) 2008-02-12
EP1881980A2 (en) 2008-01-30
EP2085396A3 (en) 2009-11-25
TWI392674B (zh) 2013-04-11
AR053599A1 (es) 2007-05-09
PT1881980E (pt) 2012-12-06
EP2085396A2 (en) 2009-08-05
RU2417224C2 (ru) 2011-04-27
IL187055A0 (en) 2008-02-09
EP1881980B1 (en) 2012-08-22
JP2008540366A (ja) 2008-11-20
CN101166738B (zh) 2011-06-01
WO2006117299A2 (en) 2006-11-09
CA2606549A1 (en) 2006-11-09
WO2006117299A9 (en) 2006-12-28
SI1881980T1 (sl) 2012-12-31
MX2007013142A (es) 2008-03-18
WO2006117299A3 (en) 2007-02-22
US7879871B2 (en) 2011-02-01
NZ563596A (en) 2011-01-28
DK1881980T3 (da) 2012-10-01
ZA200708048B (en) 2008-10-29

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired