JP5226304B2 - ハリコンドリンｂ類似体の調製用中間体 - Google Patents

ハリコンドリンｂ類似体の調製用中間体 Download PDF

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JP5226304B2
JP5226304B2 JP2007515643A JP2007515643A JP5226304B2 JP 5226304 B2 JP5226304 B2 JP 5226304B2 JP 2007515643 A JP2007515643 A JP 2007515643A JP 2007515643 A JP2007515643 A JP 2007515643A JP 5226304 B2 JP5226304 B2 JP 5226304B2
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JP2008501715A (ja
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オースタッド，ブライアン
チェイス，チャールズ，イー
ファン，フランシス，ジー
ベナヨウド，ファリド
コーキンズ，トレヴァー・リー
カンパーニャ，シルビオ
クリスト，ウィリアム
フー，ヨンボー
ルイス，ブライアン・エム
プザン，マーク
シュナダーベック，マシュー
ウィルキー，ゴードン
チュー，シャオジエ
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
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  • Chemical & Material Sciences (AREA)
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  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Genetics & Genomics (AREA)
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  • Biotechnology (AREA)
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  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
JP2007515643A 2004-06-03 2005-06-03 ハリコンドリンｂ類似体の調製用中間体 Active JP5226304B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US57664204P 2004-06-03 2004-06-03
US60/576,642 2004-06-03
US62676904P 2004-11-10 2004-11-10
US60/626,769 2004-11-10
US66330005P 2005-03-18 2005-03-18
US60/663,300 2005-03-18
PCT/US2005/019669 WO2005118565A1 (en) 2004-06-03 2005-06-03 Intermediates for the preparation of halichondrin b

Related Child Applications (1)

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JP2012255149A Division JP5705814B2 (ja) 2004-06-03 2012-11-21 ハリコンドリンｂ類似体の調製用中間体

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JP2008501715A JP2008501715A (ja) 2008-01-24
JP5226304B2 true JP5226304B2 (ja) 2013-07-03

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JP2007515643A Active JP5226304B2 (ja) 2004-06-03 2005-06-03 ハリコンドリンｂ類似体の調製用中間体
JP2012255149A Active JP5705814B2 (ja) 2004-06-03 2012-11-21 ハリコンドリンｂ類似体の調製用中間体
JP2014224099A Active JP5964926B2 (ja) 2004-06-03 2014-11-04 ハリコンドリンｂ類似体の調製用中間体
JP2016093633A Active JP6138316B2 (ja) 2004-06-03 2016-05-09 ハリコンドリンｂ類似体の調製用中間体
JP2017042492A Active JP6306235B2 (ja) 2004-06-03 2017-03-07 ハリコンドリンｂ類似体の調製用中間体

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JP2012255149A Active JP5705814B2 (ja) 2004-06-03 2012-11-21 ハリコンドリンｂ類似体の調製用中間体
JP2014224099A Active JP5964926B2 (ja) 2004-06-03 2014-11-04 ハリコンドリンｂ類似体の調製用中間体
JP2016093633A Active JP6138316B2 (ja) 2004-06-03 2016-05-09 ハリコンドリンｂ類似体の調製用中間体
JP2017042492A Active JP6306235B2 (ja) 2004-06-03 2017-03-07 ハリコンドリンｂ類似体の調製用中間体

Country Status (15)

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US (10) USRE46965E1 (es)
EP (4) EP3587408A1 (es)
JP (5) JP5226304B2 (es)
KR (1) KR101434673B1 (es)
CN (2) CN104876896A (es)
AU (1) AU2005250487B2 (es)
CA (3) CA2567984C (es)
ES (1) ES2748200T3 (es)
HR (1) HRP20150543T1 (es)
HU (1) HUE046436T2 (es)
IL (5) IL180252A (es)
PL (1) PL2522663T3 (es)
RS (1) RS54054B1 (es)
SI (1) SI2522663T1 (es)
WO (1) WO2005118565A1 (es)

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EP1087960B1 (en) 1998-06-17 2011-03-23 Eisai R&D Management Co., Ltd. Macrocyclic analogs and methods of their use and preparation
EP3587408A1 (en) 2004-06-03 2020-01-01 Eisai R&D Management Co., Ltd. Intermediates for the preparation of halichondrin b
CN104311571B (zh) * 2007-10-03 2019-07-02 卫材R&D管理有限公司 用于合成软海绵素b类似物的中间体和方法
JP5134686B2 (ja) * 2007-11-16 2013-01-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 ハリコンドリンｂアナログ合成のための新規な中間体及び前記中間体に用いるための新規な脱スルホニル化反応
RU2517167C2 (ru) * 2008-04-04 2014-05-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Аналоги галихондрина в
PL2415470T3 (pl) 2009-03-30 2016-12-30 Kompozycja liposomowa
EP2420504B1 (en) * 2009-04-14 2014-01-15 Nissan Chemical Industries, Ltd. Method for producing tetrahydropyran compound and intermediate thereof
CA2787919C (en) * 2010-01-26 2018-07-31 Eisai R&D Management Co., Ltd. Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs
WO2012147900A1 (en) 2011-04-28 2012-11-01 Eisai R&D Management Co., Ltd. Microreactor process for halichondrin b analog synthesis
WO2013053102A1 (en) * 2011-10-11 2013-04-18 Givaudan Sa Improvements in or relating to organic compounds
CN104053645A (zh) 2011-11-30 2014-09-17 阿方拉研究股份有限公司 用于制备(3r)-2,4-二-离去基团-3-甲基丁-1-烯的工艺
JP2015501818A (ja) 2011-12-16 2015-01-19 アルフォラ リサーチ インコーポレイテッドＡｌｐｈｏｒａ Ｒｅｓｅａｒｃｈ Ｉｎｃ． ３−（（２ｓ，５ｓ）−４−メチレン−５−（３−オキソプロピル）テトラヒドロフラン−２−イル）プロパノール誘導体およびそれらの有用な中間体を調製する方法
CN104080793B (zh) * 2011-12-29 2017-09-19 阿方拉研究股份有限公司 2‑((2s,3s,4r,5r)‑5‑((s)‑3‑氨基‑2‑羟基丙‑1‑基)‑4‑甲氧基‑3‑(苯磺酰甲基)四氢呋喃‑2‑基)乙醛衍生物以及它们的制备方法
AU2013239290B2 (en) 2012-03-30 2017-08-03 Sandoz Ag Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein
MX2015007185A (es) 2012-12-04 2017-09-05 Eisai R&D Man Co Ltd Uso de eribulina en el tratamiento de cancer de pecho.
RU2672585C2 (ru) * 2013-06-26 2018-11-16 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Применение эрибулина и ленватиниба в качестве комбинированной терапии для лечения рака
JP6511613B2 (ja) 2013-07-03 2019-05-15 サンド・アクチエンゲゼルシヤフト ハリコンドリンＢの大環状Ｃ１−ケト類似体の製造のための合成方法及び該方法に有用な中間体、例えば−ＳＯ２−（ｐ−トリル）基を含有する中間体
JP6625533B2 (ja) 2013-11-04 2019-12-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 ハリコンドリンｂの類縁体の合成において有用な大環化反応および中間体
BR112016012237B1 (pt) * 2013-12-06 2023-02-07 Eisai R&D Management Co., Ltd Métodos úteis na síntese de análogos de halicondrina b
TW201617326A (zh) 2014-03-06 2016-05-16 Ａｌｐｈｏｒａ研發股份有限公司 （ｓ）－１－（（２ｒ，３ｒ，４ｓ，５ｓ）－５－烯丙－３－甲氧－４－（對甲苯磺醯甲基）四氫呋喃－２－基）－３－氨基丙－２－醇之結晶衍生物
EP3148526B1 (en) 2014-05-28 2021-01-06 Eisai R&D Management Co., Ltd. Use of eribulin in the treatment of cancer
US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
US10208058B2 (en) 2014-09-09 2019-02-19 Cipla Limited Process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts and intermediates thereof
CA2978226A1 (en) 2015-03-04 2016-09-09 Merck Sharpe & Dohme Corp. Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
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