JP5213297B2 - 単一ラベルオリゴヌクレオチド・プローブ - Google Patents
単一ラベルオリゴヌクレオチド・プローブ Download PDFInfo
- Publication number
- JP5213297B2 JP5213297B2 JP2002519680A JP2002519680A JP5213297B2 JP 5213297 B2 JP5213297 B2 JP 5213297B2 JP 2002519680 A JP2002519680 A JP 2002519680A JP 2002519680 A JP2002519680 A JP 2002519680A JP 5213297 B2 JP5213297 B2 JP 5213297B2
- Authority
- JP
- Japan
- Prior art keywords
- probe
- nucleic acid
- target nucleic
- oligonucleotide
- hybridization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22472600P | 2000-08-11 | 2000-08-11 | |
| US60/224,726 | 2000-08-11 | ||
| US24061000P | 2000-10-16 | 2000-10-16 | |
| US60/240,610 | 2000-10-16 | ||
| PCT/US2001/025231 WO2002014555A2 (en) | 2000-08-11 | 2001-08-10 | Single-labeled oligonucleotide probes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004506431A JP2004506431A (ja) | 2004-03-04 |
| JP2004506431A5 JP2004506431A5 (https=) | 2008-10-09 |
| JP5213297B2 true JP5213297B2 (ja) | 2013-06-19 |
Family
ID=26918967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002519680A Expired - Lifetime JP5213297B2 (ja) | 2000-08-11 | 2001-08-10 | 単一ラベルオリゴヌクレオチド・プローブ |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6635427B2 (https=) |
| EP (1) | EP1307592B1 (https=) |
| JP (1) | JP5213297B2 (https=) |
| AT (1) | ATE332398T1 (https=) |
| CA (1) | CA2417986C (https=) |
| DE (1) | DE60121342T2 (https=) |
| ES (1) | ES2267803T3 (https=) |
| WO (1) | WO2002014555A2 (https=) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10027113A1 (de) * | 1999-12-23 | 2001-09-27 | Andreas Hoeft | Verfahren zur Bestimmung von mikrobieller DNS/RNS, Kit dafür und Verwendung des Verfahrens |
| FI20000333A0 (fi) * | 2000-02-16 | 2000-02-16 | Jussi Nurmi | Homogeeninen menetelmä polynukleotidin havaitsemiseksi |
| EP1278889B1 (en) * | 2000-03-29 | 2006-07-26 | LGC Limited | Hybridisation beacon and method of rapid sequence detection and discrimination |
| US7998673B2 (en) * | 2000-03-29 | 2011-08-16 | Lgc Limited | Hybridisation beacon and method of rapid sequence detection and discrimination |
| CA2484215C (en) | 2002-04-23 | 2015-02-24 | Kirk Max Ririe | Sample withdrawal and dispensing device |
| US7785776B2 (en) * | 2002-05-13 | 2010-08-31 | Idaho Technology, Inc. | Genotyping by amplicon melting curve analysis |
| JP2004024035A (ja) * | 2002-06-21 | 2004-01-29 | Tosoh Corp | 核酸の検出方法 |
| CA2433473A1 (en) * | 2002-07-23 | 2004-01-23 | F. Hoffmann-La Roche Ag | Fluorescent hybridization probes with reduced background |
| US7122384B2 (en) * | 2002-11-06 | 2006-10-17 | E. I. Du Pont De Nemours And Company | Resonant light scattering microparticle methods |
| US7718361B2 (en) | 2002-12-06 | 2010-05-18 | Roche Molecular Systems, Inc. | Quantitative test for bacterial pathogens |
| JP4377375B2 (ja) | 2002-12-06 | 2009-12-02 | エフ.ホフマン−ラ ロシュ アーゲー | 病原性生物の多重分析検出 |
| CA2525482C (en) | 2003-04-04 | 2015-02-17 | F. Hoffmann-La Roche Ag | Improved system for multicolor real-time pcr comprising 3 to 6 pairs of forester resonance energy transfer (fret) probes |
| JP4454249B2 (ja) | 2003-04-18 | 2010-04-21 | アークレイ株式会社 | 膵ラ氏島アミロイドタンパク質変異遺伝子の検出法ならびにそのための核酸プローブおよびキット |
| US20050053950A1 (en) * | 2003-09-08 | 2005-03-10 | Enrique Zudaire Ubani | Protocol and software for multiplex real-time PCR quantification based on the different melting temperatures of amplicons |
| EP1689764B1 (en) * | 2003-11-19 | 2013-01-02 | AlleLogic Biosciences Corporation | Oligonucleotides labeled with a plurality of fluorophores |
| FR2866349B1 (fr) * | 2004-02-12 | 2008-05-16 | Biomerieux Sa | Procede de diagnostic/pronostic d'une thrombose |
| US20080032413A1 (en) * | 2004-04-12 | 2008-02-07 | Byeang-Hyean Kim | Oligonucleotide For Detecting Target Dna Or Rna |
| EP1634965B1 (en) | 2004-09-09 | 2010-01-20 | Roche Diagnostics GmbH | Real time PCR with the addition of pyrophosphatase |
| CA2594223C (en) * | 2005-01-03 | 2016-03-15 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Primer for nucleic acid detection |
| EP1681555B1 (en) | 2005-01-18 | 2007-03-21 | Roche Diagnostics GmbH | Imaging of fluorescence signals using telecentric excitation and imaging optics |
| EP1681556B1 (en) | 2005-01-18 | 2007-04-11 | Roche Diagnostics GmbH | Imaging fluorescence signals using telecentricity |
| US20060172324A1 (en) * | 2005-01-28 | 2006-08-03 | Roche Molecular Systems, Inc. | Methods of genotyping using differences in melting temperature |
| JP4398886B2 (ja) * | 2005-03-07 | 2010-01-13 | ソニー株式会社 | 通信端末装置、通信システム、通信方法、およびプログラム |
| EP1700922B1 (en) | 2005-03-10 | 2016-08-24 | Roche Diagnostics GmbH | 3-Substituted 5-Nitroindole derivatives and labeled oligonucleotide probes containing them |
| US7759469B2 (en) | 2005-03-10 | 2010-07-20 | Roche Diagnostics Operations, Inc. | Labeling reagent |
| US7601498B2 (en) * | 2005-03-17 | 2009-10-13 | Biotium, Inc. | Methods of using dyes in association with nucleic acid staining or detection and associated technology |
| US7776567B2 (en) | 2005-03-17 | 2010-08-17 | Biotium, Inc. | Dimeric and trimeric nucleic acid dyes, and associated systems and methods |
| GB0514889D0 (en) | 2005-07-20 | 2005-08-24 | Lgc Ltd | Oligonucleotides |
| US7781165B2 (en) | 2005-10-19 | 2010-08-24 | Roche Diagnostics Operations, Inc. | Benzimidazolium compounds and salts of benzimidazolium compounds for nucleic acid amplification |
| DE502005008153D1 (de) | 2005-11-23 | 2009-10-29 | Roche Diagnostics Gmbh | Polynukleotid mit Phosphatmimetikum |
| US7759470B2 (en) * | 2006-02-20 | 2010-07-20 | Roche Diagnostics Operations, Inc. | Labeling reagent |
| CN101421417B (zh) | 2006-02-27 | 2013-04-03 | 霍夫曼-拉罗奇有限公司 | 经由镁螯合的pcr热启动 |
| RU2394915C2 (ru) * | 2006-03-24 | 2010-07-20 | Александр Борисович Четверин | Бесконтактные способы обнаружения молекулярных колоний, наборы реагентов и устройство для их осуществления |
| WO2008020090A1 (es) * | 2006-08-18 | 2008-02-21 | Laboratorios Indas, S.A. | Método y kit para diagnosticar el riesgo de desarrollar una enfermedad trombótica venosa |
| CN102851369B (zh) | 2006-12-13 | 2015-01-21 | 卢米耐克斯公司 | 用于实时pcr多重分析的系统和方法 |
| EP2126114B1 (en) * | 2007-02-01 | 2016-09-28 | Abacus Diagnostica OY | Method for detection of presence of target polynucleotide in samples |
| US20100068713A1 (en) * | 2007-07-13 | 2010-03-18 | Arkray, Inc. | Probe for detecting mutation in jak2 gene and use thereof |
| US20090181391A1 (en) * | 2007-11-01 | 2009-07-16 | Zymo Research Corporation | Methods for analysis of dna methylation percentage |
| CA2658520C (en) | 2008-03-19 | 2016-11-08 | F. Hoffmann-La Roche Ag | Nucleic acid amplification in the presence of modified randomers |
| AU2009262870B2 (en) * | 2008-05-30 | 2014-03-20 | Gen-Probe Incorporated | Compositions, kits and related methods for the detection and/or monitoring of Salmonella |
| US9393566B2 (en) | 2008-06-23 | 2016-07-19 | Canon U.S. Life Sciences, Inc. | System and method for temperature referencing for melt curve data collection |
| EP2148187A1 (de) | 2008-07-25 | 2010-01-27 | Roche Diagnostics GmbH | Anregungs- und Abbildungsoptik für die Fluoreszenzdetektion |
| WO2010018245A1 (es) * | 2008-08-12 | 2010-02-18 | Biotools Biotechnological & Medical Laboratories, S.A. | Método para la detección y/o cuantificación de un ácido nucleico substrato |
| US7910720B2 (en) | 2008-09-09 | 2011-03-22 | Roche Diagnostics Operations, Inc. | Polyanion for improved nucleic acid amplification |
| JP5457222B2 (ja) | 2009-02-25 | 2014-04-02 | エフ.ホフマン−ラ ロシュ アーゲー | 小型化ハイスループット核酸分析 |
| US9347092B2 (en) | 2009-02-25 | 2016-05-24 | Roche Molecular System, Inc. | Solid support for high-throughput nucleic acid analysis |
| EP2436777B1 (en) | 2009-05-26 | 2015-08-19 | Xiamen University | Method for detecting variations in nucleic acid sequences |
| WO2010147848A2 (en) | 2009-06-15 | 2010-12-23 | Rd Biosciences, Inc. | Kits and methods for selective amplification and detection of nucleic acid targets |
| US8748095B2 (en) * | 2009-10-30 | 2014-06-10 | Arkray, Inc. | Probe for detecting polymorphism in EGFR gene and use of the probe |
| EP2502994A4 (en) * | 2009-11-19 | 2013-05-22 | Arkray Inc | PRIMER SET FOR MTHFR GENE AMPLIFICATION, MTHFR GENE AMPLIFICATION REAGENT COMPRISING THE SAME, AND USE THEREOF |
| WO2011071046A1 (ja) * | 2009-12-07 | 2011-06-16 | アークレイ株式会社 | 疾患関連遺伝子の多型検出用プローブおよびその用途 |
| US8877437B1 (en) | 2009-12-23 | 2014-11-04 | Biotium, Inc. | Methods of using dyes in association with nucleic acid staining or detection |
| JP5874152B2 (ja) * | 2010-04-21 | 2016-03-02 | 国立研究開発法人理化学研究所 | 消光性ならびに蛍光性の核酸塩基類似体とその応用 |
| JP5940771B2 (ja) | 2010-07-12 | 2016-06-29 | アークレイ株式会社 | abl遺伝子多型の検出用プローブおよびその用途 |
| GB201017978D0 (en) | 2010-10-25 | 2010-12-08 | Oxitec Ltd | Multiplex amplification and detection |
| EP2518165A1 (en) * | 2011-04-28 | 2012-10-31 | ARKRAY, Inc. | Method for simultaneously detecting gene mutations of acetaldehyde dehydrogenase 2 and alcohol dehydrogenase 2 |
| US10557170B2 (en) | 2011-06-16 | 2020-02-11 | Gendiag.Exe, S.L. | Thromboembolic disease markers |
| EP2722388B1 (en) * | 2011-06-16 | 2017-08-09 | Nippon Steel & Sumikin Eco-Tech Corporation | Nucleic acid probe for assaying nucleic acids |
| ES2547075T3 (es) | 2011-06-16 | 2015-10-01 | Gendiag.Exe, S.L. | SNP asociados a enfermedad tromboembólica |
| WO2013034160A1 (en) * | 2011-09-06 | 2013-03-14 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. | Methods for analyzing biological macromolecular complexes and use thereof |
| JP2013074888A (ja) * | 2011-09-15 | 2013-04-25 | Arkray Inc | IL28B(rs8099917)とITPA(rs1127354)の変異を検出する方法 |
| WO2013112458A1 (en) | 2012-01-24 | 2013-08-01 | Beth Israel Deaconess Medical Center, Inc. | Novel chrebp isoforms and methods using the same |
| AU2013202808B2 (en) | 2012-07-31 | 2014-11-13 | Gen-Probe Incorporated | System and method for performing multiplex thermal melt analysis |
| EP4570924A3 (en) * | 2013-01-24 | 2025-09-03 | California Institute of Technology | Chromophore-based characterization and detection methods |
| US10077475B2 (en) | 2013-01-24 | 2018-09-18 | California Institute Of Technology | FRET-based analytes detection and related methods and systems |
| WO2014189843A1 (en) | 2013-05-20 | 2014-11-27 | Board Of Trustees Of The University Of Arkansas | Gep5 model for multiple myeloma |
| GB201319180D0 (en) | 2013-10-30 | 2013-12-11 | Mast Group Ltd | Nucleic acid probe |
| EP3189159A4 (en) | 2014-06-26 | 2018-05-30 | University of Florida Research Foundation, Inc. | Rapid detection of infectious agents |
| JP5813263B1 (ja) * | 2015-03-31 | 2015-11-17 | 日鉄住金環境株式会社 | 遺伝子変異の検出方法及びそれに用いる蛍光標識オリゴヌクレオチド |
| CA2983819A1 (en) | 2015-04-24 | 2016-10-27 | Atila Biosystems Incorporated | Amplification with primers of limited nucleotide composition |
| US11434533B2 (en) | 2016-02-09 | 2022-09-06 | Eiken Kagaku Kabushiki Kaisha | Method for detecting target nucleic acid and nucleic acid probe used therein |
| MA45783A (fr) | 2016-07-29 | 2019-06-05 | Juno Therapeutics Inc | Procédés d'évaluation de la présence ou de l'absence d'un virus compétent pour la réplication |
| JP2020526194A (ja) | 2017-06-29 | 2020-08-31 | ジュノー セラピューティクス インコーポレイテッド | 免疫療法薬と関連する毒性を評価するためのマウスモデル |
| SG11202000606TA (en) | 2017-07-29 | 2020-02-27 | Juno Therapeutics Inc | Reagents for expanding cells expressing recombinant receptors |
| WO2019046832A1 (en) | 2017-09-01 | 2019-03-07 | Juno Therapeutics, Inc. | GENE EXPRESSION AND EVALUATION OF RISK OF DEVELOPMENT OF TOXICITY FOLLOWING CELL THERAPY |
| CN107727618B (zh) * | 2017-09-04 | 2019-12-31 | 江苏大学 | 生物芯片和特异性切割位点dna序列检测汞离子的方法 |
| EP3704229B1 (en) | 2017-11-01 | 2023-12-20 | Juno Therapeutics, Inc. | Process for producing a t cell composition |
| JP2021511802A (ja) | 2018-01-31 | 2021-05-13 | ジュノー セラピューティクス インコーポレイテッド | 複製可能ウイルスの存在または非存在を評価するための方法および試薬 |
| GB201812192D0 (en) | 2018-07-26 | 2018-09-12 | Ttp Plc | Variable temperature reactor, heater and control circuit for the same |
| ES2968737T3 (es) | 2018-11-06 | 2024-05-13 | Juno Therapeutics Inc | Proceso para producir células T manipuladas genéticamente |
| CA3120868A1 (en) | 2018-11-30 | 2020-06-04 | Alpine Immune Sciences, Inc. | Cd86 variant immunomodulatory proteins and uses thereof |
| MX2021012607A (es) | 2019-04-17 | 2022-03-11 | Alpine Immune Sciences Inc | Metodos y usos de proteinas de fusion de ligando icos (icosl) variante. |
| KR20220034782A (ko) | 2019-06-12 | 2022-03-18 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포 매개 세포 독성 요법 및 친생존 bcl2 패밀리 단백질 억제제의 병용 요법 |
| CN114555112A (zh) | 2019-08-22 | 2022-05-27 | 朱诺治疗学股份有限公司 | T细胞疗法和zeste增强子同源物2(ezh2)抑制剂的组合疗法及相关方法 |
| EP4034674B1 (en) * | 2019-09-23 | 2025-03-26 | Universiteit Gent | Probe and method for str-genotyping |
| KR102107589B1 (ko) * | 2019-11-20 | 2020-05-07 | 주식회사 유진셀 | 단일 신호 형광 물질을 이용한 실시간 타겟 핵산 검출 및 정량 방법 |
| WO2021140173A1 (en) | 2020-01-10 | 2021-07-15 | Biouniversa S.R.L. | Methods and uses for treating fibrotic solid tumors with bags inhibitors |
| AU2021209068B2 (en) | 2020-01-13 | 2024-09-19 | Aspen Neuroscience, Inc. | Method of differentiating neural cells and related compositions and methods of use |
| CN115835873A (zh) | 2020-05-13 | 2023-03-21 | 朱诺治疗学股份有限公司 | 用于产生表达重组受体的供体分批细胞的方法 |
| JP2023531531A (ja) | 2020-06-26 | 2023-07-24 | ジュノ セラピューティクス ゲーエムベーハー | 組換え受容体を条件付きで発現する操作されたt細胞、関連ポリヌクレオチド、および方法 |
| US20240329032A1 (en) | 2021-07-21 | 2024-10-03 | Aspen Neuroscience, Inc. | Methods of differentiating neural cells and predicting engraftment thereof and related compositions |
| AU2022402153A1 (en) | 2021-12-03 | 2024-06-13 | Medicinal Genomics Corporation | Psilocybe assay |
| WO2023201361A1 (en) | 2022-04-15 | 2023-10-19 | Aspen Neuroscience, Inc. | Methods of classifying the differentiation state of cells and related compositions of differentiated cells |
| EP4532695A1 (en) | 2022-05-25 | 2025-04-09 | Celgene Corporation | Methods of manufacturing t cell therapies |
| AU2023343062A1 (en) | 2022-09-13 | 2025-04-03 | Medicinal Genomics Corporation | Psilocybe assay |
| WO2025245399A1 (en) | 2024-05-23 | 2025-11-27 | Indapta Therapeutics, Inc. | Method of treating cancer with natural killer cells |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US5597696A (en) * | 1994-07-18 | 1997-01-28 | Becton Dickinson And Company | Covalent cyanine dye oligonucleotide conjugates |
| AU693023B2 (en) | 1995-05-05 | 1998-06-18 | Applied Biosystems, Llc | Methods and reagents for combined PCR amplification and hybridization probing assay |
| GB9602025D0 (en) * | 1996-02-01 | 1996-04-03 | Amersham Int Plc | Nucleoside analogues |
| US5716784A (en) | 1996-02-05 | 1998-02-10 | The Perkin-Elmer Corporation | Fluorescence detection assay for homogeneous PCR hybridization systems |
| AU733647B2 (en) | 1996-05-15 | 2001-05-17 | Biogenex Laboratories | Non-nucleotide linking reagents |
| JP4540754B2 (ja) | 1996-06-04 | 2010-09-08 | ユニバーシティ オブ ユタ リサーチ ファウンデーション | Pcr中のハイブリダイゼーションのモニタリング |
| US5691145A (en) | 1996-08-27 | 1997-11-25 | Becton, Dickinson And Company | Detection of nucleic acids using G-quartets |
| WO1998026093A2 (en) * | 1996-12-13 | 1998-06-18 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Fluorescent nucleotide analog hairpin formation for detection of nucleic acid hybridization |
| SE522077C2 (sv) | 1997-09-05 | 2004-01-13 | Lightup Technologies Ab | Förfarande att välja sekvens hos sond för nukleinsyrahybridisering |
| US6465175B2 (en) * | 1997-09-04 | 2002-10-15 | Bayer Corporation | Oligonucleotide probes bearing quenchable fluorescent labels, and methods of use thereof |
| DE19858588B4 (de) | 1998-08-22 | 2016-04-07 | Qiagen Gmbh | Farbstoffmarkiertes Oligonukleotid zum Markieren eines Nukleinsäuremoleküls |
| EP1046717B1 (en) | 1999-04-20 | 2010-10-06 | National Institute of Advanced Industrial Science and Technology | Method and probes for determining a concentration of target nucleic acid molecules and method for analyzing data obtained by the method |
| SE9902565D0 (sv) | 1999-07-05 | 1999-07-05 | Jonas Karlsson | Probe for analysis of nucleic acids |
| EP1278889B1 (en) * | 2000-03-29 | 2006-07-26 | LGC Limited | Hybridisation beacon and method of rapid sequence detection and discrimination |
-
2001
- 2001-08-10 WO PCT/US2001/025231 patent/WO2002014555A2/en not_active Ceased
- 2001-08-10 JP JP2002519680A patent/JP5213297B2/ja not_active Expired - Lifetime
- 2001-08-10 DE DE60121342T patent/DE60121342T2/de not_active Expired - Lifetime
- 2001-08-10 US US09/927,842 patent/US6635427B2/en not_active Expired - Lifetime
- 2001-08-10 CA CA2417986A patent/CA2417986C/en not_active Expired - Lifetime
- 2001-08-10 ES ES01959722T patent/ES2267803T3/es not_active Expired - Lifetime
- 2001-08-10 AT AT01959722T patent/ATE332398T1/de not_active IP Right Cessation
- 2001-08-10 EP EP01959722A patent/EP1307592B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60121342T2 (de) | 2007-06-28 |
| US6635427B2 (en) | 2003-10-21 |
| EP1307592A2 (en) | 2003-05-07 |
| WO2002014555A3 (en) | 2003-02-27 |
| CA2417986A1 (en) | 2002-02-21 |
| JP2004506431A (ja) | 2004-03-04 |
| EP1307592B1 (en) | 2006-07-05 |
| ATE332398T1 (de) | 2006-07-15 |
| CA2417986C (en) | 2013-11-26 |
| DE60121342D1 (de) | 2006-08-17 |
| ES2267803T3 (es) | 2007-03-16 |
| WO2002014555A2 (en) | 2002-02-21 |
| US20030022177A1 (en) | 2003-01-30 |
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