JP5190373B2 - 神経防護薬としてのベンゾ縮合複素環スルファミド誘導体の使用 - Google Patents
神経防護薬としてのベンゾ縮合複素環スルファミド誘導体の使用 Download PDFInfo
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- JP5190373B2 JP5190373B2 JP2008547445A JP2008547445A JP5190373B2 JP 5190373 B2 JP5190373 B2 JP 5190373B2 JP 2008547445 A JP2008547445 A JP 2008547445A JP 2008547445 A JP2008547445 A JP 2008547445A JP 5190373 B2 JP5190373 B2 JP 5190373B2
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- benzo
- dihydro
- dioxinyl
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- chloro
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (5)
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| US75149405P | 2005-12-19 | 2005-12-19 | |
| US60/751,494 | 2005-12-19 | ||
| US11/612,146 | 2006-12-18 | ||
| US11/612,146 US20070155823A1 (en) | 2005-12-19 | 2006-12-18 | Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents |
| PCT/US2006/048451 WO2007075698A2 (en) | 2005-12-19 | 2006-12-19 | Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents |
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| JP2009520031A JP2009520031A (ja) | 2009-05-21 |
| JP2009520031A5 JP2009520031A5 (https=) | 2010-10-21 |
| JP5190373B2 true JP5190373B2 (ja) | 2013-04-24 |
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| HR (1) | HRP20120018T1 (https=) |
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| MY (1) | MY149175A (https=) |
| NO (1) | NO20083033L (https=) |
| NZ (1) | NZ569041A (https=) |
| PL (1) | PL1968571T3 (https=) |
| PT (1) | PT1968571E (https=) |
| RS (1) | RS52220B (https=) |
| SI (1) | SI1968571T1 (https=) |
| WO (1) | WO2007075698A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| MY147767A (en) | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| KR20080012360A (ko) * | 2005-05-20 | 2008-02-11 | 얀센 파마슈티카 엔.브이. | 설파미드 유도체의 제조 방법 |
| US8497298B2 (en) | 2005-12-19 | 2013-07-30 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels |
| US8937096B2 (en) | 2005-12-19 | 2015-01-20 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder |
| US8691867B2 (en) | 2005-12-19 | 2014-04-08 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction |
| EA200870556A1 (ru) * | 2006-05-19 | 2009-06-30 | Янссен Фармацевтика Н.В. | Комбинированная терапия в лечении эпилепсии и родственных расстройств |
| US20090247617A1 (en) * | 2008-03-26 | 2009-10-01 | Abdel-Magid Ahmed F | Process for the preparation of benzo-fused heteroaryl sulfamates |
| US20090247616A1 (en) * | 2008-03-26 | 2009-10-01 | Smith-Swintosky Virginia L | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of anxiety |
| JP2011519839A (ja) * | 2008-04-29 | 2011-07-14 | エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ | ドーパミン神経伝達のモジュレーター |
| EP2271638B1 (en) * | 2008-04-29 | 2011-08-31 | NSAB, Filial af NeuroSearch Sweden AB, Sverige | Modulators of dopamine neurotransmission |
| MX2010011724A (es) * | 2008-04-29 | 2010-11-30 | Nsab Af Neurosearch Sweden Ab | Moduladores de neurotransmision de dopamina. |
| EA018567B1 (ru) | 2008-06-23 | 2013-08-30 | Янссен Фармацевтика Нв | Кристаллическая форма (2s)-(-)-n-(6-хлор-2,3-дигидробензо[1,4]диоксин-2-илметил)сульфамида |
| TWI406596B (zh) | 2008-06-30 | 2013-08-21 | Green Solution Tech Co Ltd | 發光二極體驅動電路、發光二極體驅動控制單元及其電晶體開關模組 |
| US8815939B2 (en) * | 2008-07-22 | 2014-08-26 | Janssen Pharmaceutica Nv | Substituted sulfamide derivatives |
| US8609849B1 (en) | 2010-11-30 | 2013-12-17 | Fox Chase Chemical Diversity Center, Inc. | Hydroxylated sulfamides exhibiting neuroprotective action and their method of use |
| JP2014528953A (ja) | 2011-09-29 | 2014-10-30 | ヤンセン ファーマシューティカ エヌ．ベー． | スルファミド誘導体の調製プロセス |
| KR20140082762A (ko) | 2011-09-29 | 2014-07-02 | 얀센 파마슈티카 엔.브이. | 설파미드 유도체의 개선된 제조 방법 |
| MX355261B (es) * | 2012-06-21 | 2018-04-12 | Eisai R&D Man Co Ltd | Derivado de indanosulfamida novedoso. |
| KR20200132858A (ko) | 2018-03-20 | 2020-11-25 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 간질 치료제 |
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| US20060276528A1 (en) * | 2004-08-24 | 2006-12-07 | Abdel-Magid Ahmed F | Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents |
| DE602005008084D1 (de) * | 2004-08-24 | 2008-08-21 | Janssen Pharmaceutica Nv | Als antikonvulsive mittel geeignete neue benzokondensierte heteroarylsulfamidderivate |
| CA2605580A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Benzodioxane and benzodioxolane derivatives and uses thereof |
| KR20080012360A (ko) * | 2005-05-20 | 2008-02-11 | 얀센 파마슈티카 엔.브이. | 설파미드 유도체의 제조 방법 |
| US20070155824A1 (en) * | 2005-12-19 | 2007-07-05 | Smith-Swintosky Virginia L | Use of benzo-fused heterocycle sulfamide derivatives for disease modification / epileptogenesis |
| US20070293476A1 (en) * | 2006-05-19 | 2007-12-20 | Smith-Swintosky Virginia L | Co-therapy for the treatment of epilepsy and related disorders |
| EA200870556A1 (ru) * | 2006-05-19 | 2009-06-30 | Янссен Фармацевтика Н.В. | Комбинированная терапия в лечении эпилепсии и родственных расстройств |
| EP2238122A1 (en) * | 2008-01-07 | 2010-10-13 | Janssen Pharmaceutica, N.V. | Preparation of sulfamide derivatives |
| US20090247618A1 (en) * | 2008-03-26 | 2009-10-01 | Ballentine Scott A | Process for preparation of benzo-fused heteroaryl derivatives |
| US20090247617A1 (en) * | 2008-03-26 | 2009-10-01 | Abdel-Magid Ahmed F | Process for the preparation of benzo-fused heteroaryl sulfamates |
| EA018567B1 (ru) * | 2008-06-23 | 2013-08-30 | Янссен Фармацевтика Нв | Кристаллическая форма (2s)-(-)-n-(6-хлор-2,3-дигидробензо[1,4]диоксин-2-илметил)сульфамида |
| US8815939B2 (en) * | 2008-07-22 | 2014-08-26 | Janssen Pharmaceutica Nv | Substituted sulfamide derivatives |
-
2006
- 2006-12-18 US US11/612,146 patent/US20070155823A1/en not_active Abandoned
- 2006-12-19 HR HR20120018T patent/HRP20120018T1/hr unknown
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- 2006-12-19 AT AT06845823T patent/ATE536182T1/de active
- 2006-12-19 EP EP06845823A patent/EP1968571B1/en active Active
- 2006-12-19 RS RS20120057A patent/RS52220B/sr unknown
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- 2006-12-19 NZ NZ569041A patent/NZ569041A/en not_active IP Right Cessation
- 2006-12-19 KR KR1020087017501A patent/KR20080089405A/ko not_active Ceased
- 2006-12-19 ES ES06845823T patent/ES2375845T3/es active Active
- 2006-12-19 AU AU2006331783A patent/AU2006331783A1/en not_active Abandoned
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- 2006-12-19 DK DK06845823.1T patent/DK1968571T3/da active
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- 2008-06-12 IL IL192106A patent/IL192106A0/en unknown
- 2008-07-04 NO NO20083033A patent/NO20083033L/no not_active Application Discontinuation
- 2008-07-21 CR CR10171A patent/CR10171A/es not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| RS52220B (sr) | 2012-10-31 |
| ATE536182T1 (de) | 2011-12-15 |
| IL192106A0 (en) | 2009-08-03 |
| EA016628B1 (ru) | 2012-06-29 |
| WO2007075698A2 (en) | 2007-07-05 |
| NO20083033L (no) | 2008-09-16 |
| BRPI0620060A2 (pt) | 2011-11-01 |
| CA2634088A1 (en) | 2007-07-05 |
| KR20080089405A (ko) | 2008-10-06 |
| DK1968571T3 (da) | 2012-02-27 |
| AU2006331783A1 (en) | 2007-07-05 |
| HK1124544A1 (en) | 2009-07-17 |
| JP2009520031A (ja) | 2009-05-21 |
| NZ569041A (en) | 2011-04-29 |
| SI1968571T1 (sl) | 2012-03-30 |
| PT1968571E (pt) | 2012-02-01 |
| US20070155823A1 (en) | 2007-07-05 |
| PL1968571T3 (pl) | 2012-04-30 |
| EP1968571A2 (en) | 2008-09-17 |
| CR10171A (es) | 2009-01-16 |
| WO2007075698A3 (en) | 2007-08-16 |
| EP1968571B1 (en) | 2011-12-07 |
| EA200870087A1 (ru) | 2009-12-30 |
| ES2375845T3 (es) | 2012-03-06 |
| HRP20120018T1 (hr) | 2012-01-31 |
| MY149175A (en) | 2013-07-31 |
| CY1112444T1 (el) | 2015-12-09 |
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