JP5186384B2 - メタロプロテイナーゼインヒビターとしての（２，５−ジオキソイミダゾリジン−１−イル）−ｎ−ヒドロキシ−アセトアミド - Google Patents
メタロプロテイナーゼインヒビターとしての（２，５−ジオキソイミダゾリジン−１−イル）−ｎ−ヒドロキシ−アセトアミド Download PDFInfo
- Publication number
- JP5186384B2 JP5186384B2 JP2008544873A JP2008544873A JP5186384B2 JP 5186384 B2 JP5186384 B2 JP 5186384B2 JP 2008544873 A JP2008544873 A JP 2008544873A JP 2008544873 A JP2008544873 A JP 2008544873A JP 5186384 B2 JP5186384 B2 JP 5186384B2
- Authority
- JP
- Japan
- Prior art keywords
- mmol
- alkyl
- compound
- mmp
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CN(C)C1C*C1 Chemical compound CN(C)C1C*C1 0.000 description 2
- JORIFJWHACJZTP-FVOAXITGSA-N B/C=C/C[C@@H](C=C)OC[C@H](C(OC)=O)N Chemical compound B/C=C/C[C@@H](C=C)OC[C@H](C(OC)=O)N JORIFJWHACJZTP-FVOAXITGSA-N 0.000 description 1
- CANBJWLXOLNHCM-UHFFFAOYSA-N CC(C)(C)OC(NCCCc1ccccc1C)=O Chemical compound CC(C)(C)OC(NCCCc1ccccc1C)=O CANBJWLXOLNHCM-UHFFFAOYSA-N 0.000 description 1
- PRQCYPIVFMSCHJ-ZDUSSCGKSA-N CC(C)(C)OC(N[C@@H](CCc1ccc(C)cc1)C(O)=O)=O Chemical compound CC(C)(C)OC(N[C@@H](CCc1ccc(C)cc1)C(O)=O)=O PRQCYPIVFMSCHJ-ZDUSSCGKSA-N 0.000 description 1
- IOVSQZHJXLPONT-IBGZPJMESA-N CC(C)(C)OC(N[C@@H](CCc1ccc(CC(c2ccccc2)=O)cc1)C(O)=O)=O Chemical compound CC(C)(C)OC(N[C@@H](CCc1ccc(CC(c2ccccc2)=O)cc1)C(O)=O)=O IOVSQZHJXLPONT-IBGZPJMESA-N 0.000 description 1
- KDYZLBCLDXMJTK-LBPRGKRZSA-N CC(C)(C)OC(N[C@@H](COc(cc1)ccc1Br)C(OC)=O)=O Chemical compound CC(C)(C)OC(N[C@@H](COc(cc1)ccc1Br)C(OC)=O)=O KDYZLBCLDXMJTK-LBPRGKRZSA-N 0.000 description 1
- NLTUZUCMFOOMMW-UHFFFAOYSA-N CC(C)=C(C(NO)=O)N(C(C(CCCCNC(c1ccccc1)=O)N1)=O)C1=O Chemical compound CC(C)=C(C(NO)=O)N(C(C(CCCCNC(c1ccccc1)=O)N1)=O)C1=O NLTUZUCMFOOMMW-UHFFFAOYSA-N 0.000 description 1
- LRMFJQWIIUYCAL-LBPRGKRZSA-N CC(C)=C(C(NO)=O)N(C([C@H](COCc(cc1)ccc1F)N1)=O)C1=O Chemical compound CC(C)=C(C(NO)=O)N(C([C@H](COCc(cc1)ccc1F)N1)=O)C1=O LRMFJQWIIUYCAL-LBPRGKRZSA-N 0.000 description 1
- TUJOTAIRAGUMEH-UHFFFAOYSA-N CC(C)=C(C(OC)=O)N(C(C(COCc(cc1)ccc1-c1cccc(F)c1)N1)=O)C1=O Chemical compound CC(C)=C(C(OC)=O)N(C(C(COCc(cc1)ccc1-c1cccc(F)c1)N1)=O)C1=O TUJOTAIRAGUMEH-UHFFFAOYSA-N 0.000 description 1
- YBOFYDXVJVLCHI-JKSUJKDBSA-N CC(C)[C@H](C(NO)=O)N(C([C@H](CCc1ccc(C(C)(C)C)cc1)N1)=O)C1=O Chemical compound CC(C)[C@H](C(NO)=O)N(C([C@H](CCc1ccc(C(C)(C)C)cc1)N1)=O)C1=O YBOFYDXVJVLCHI-JKSUJKDBSA-N 0.000 description 1
- WITXARYDVROXSP-GXTWGEPZSA-N CC(C)[C@H](C(NO)=O)N(C([C@H](CCc1ccccc1OC)N1)=O)C1=O Chemical compound CC(C)[C@H](C(NO)=O)N(C([C@H](CCc1ccccc1OC)N1)=O)C1=O WITXARYDVROXSP-GXTWGEPZSA-N 0.000 description 1
- BOLHEFIVCTXVKX-FOIFJWKZSA-N CC(C)[C@H](C(NOCc1ccccc1)=O)N(C(C(CCCCNC(c1ccccc1)=O)N1)=O)C1=O Chemical compound CC(C)[C@H](C(NOCc1ccccc1)=O)N(C(C(CCCCNC(c1ccccc1)=O)N1)=O)C1=O BOLHEFIVCTXVKX-FOIFJWKZSA-N 0.000 description 1
- BNYGKLUOYJEDCM-VQTJNVASSA-N CC(C)[C@H](C(NOCc1ccccc1)=O)N(C([C@H](COCc(cc1)ccc1Br)N1)=O)C1=O Chemical compound CC(C)[C@H](C(NOCc1ccccc1)=O)N(C([C@H](COCc(cc1)ccc1Br)N1)=O)C1=O BNYGKLUOYJEDCM-VQTJNVASSA-N 0.000 description 1
- BDHUDSGUSAQAEU-QRWMCTBCSA-N CC(C)[C@H](C(O)=O)N(C(C(COc(cc1)ccc1-c1ccccc1)N1)=O)C1=O Chemical compound CC(C)[C@H](C(O)=O)N(C(C(COc(cc1)ccc1-c1ccccc1)N1)=O)C1=O BDHUDSGUSAQAEU-QRWMCTBCSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05112144.0 | 2005-12-14 | ||
| EP05112144 | 2005-12-14 | ||
| PCT/EP2006/012019 WO2007068474A1 (fr) | 2005-12-14 | 2006-12-13 | Inhibiteurs de métalloprotéinase de type (2,5-dioxoimidazolidin-1-yl)-n-hydroxy-acétamides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009519281A JP2009519281A (ja) | 2009-05-14 |
| JP5186384B2 true JP5186384B2 (ja) | 2013-04-17 |
Family
ID=35788378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008544873A Expired - Fee Related JP5186384B2 (ja) | 2005-12-14 | 2006-12-13 | メタロプロテイナーゼインヒビターとしての（２，５−ジオキソイミダゾリジン−１−イル）−ｎ−ヒドロキシ−アセトアミド |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8022092B2 (fr) |
| EP (1) | EP1966153A1 (fr) |
| JP (1) | JP5186384B2 (fr) |
| CN (1) | CN101258132B (fr) |
| AU (1) | AU2006326256B2 (fr) |
| BR (1) | BRPI0619848A2 (fr) |
| CA (1) | CA2628159A1 (fr) |
| HK (1) | HK1115878A1 (fr) |
| TW (1) | TWI361186B (fr) |
| WO (1) | WO2007068474A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2064175B1 (fr) | 2006-09-07 | 2014-08-06 | F. Hoffmann-La Roche AG | Procede de fabrication de snac (salcaprozate sodium) |
| TWI539947B (zh) * | 2007-04-09 | 2016-07-01 | 米希爾金尼公司 | 組蛋白去乙醯基酶之抑制劑 |
| ES2592154T3 (es) | 2010-07-08 | 2016-11-28 | Kaken Pharmaceutical Co., Ltd. | Derivado de N-hidroxiformamida y medicamento que contiene el mismo |
| SG11201506804VA (en) * | 2013-03-21 | 2015-09-29 | Sanofi Aventis Deutschland | Synthesis of hydantoin containing peptide products |
| WO2015107170A1 (fr) * | 2014-01-17 | 2015-07-23 | Alphabeta Ab | Nouveaux ligands pour la prévention de la neurotoxicité du peptide amyloïde-bêta associé à la maladie d'alzheimer |
| EP2907512A1 (fr) | 2014-02-14 | 2015-08-19 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Inhibiteurs de MMP-12 en tant qu'agents antiviraux |
| CN106366168B (zh) * | 2016-08-26 | 2020-09-15 | 上海交通大学 | 羊毛硫肽类抗菌肽及其脱氢衍生物的制备方法 |
| CN112358414B (zh) * | 2019-07-25 | 2022-03-22 | 中国科学院上海药物研究所 | 非天然氨基酸及其在蛋白质定点修饰和蛋白质相互作用中的用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6403632B1 (en) * | 2000-03-01 | 2002-06-11 | Bristol Myers Squibb Pharma Co | Lactam metalloprotease inhibitors |
| US6462063B1 (en) | 2000-02-04 | 2002-10-08 | Fibrogen, Inc. | C-proteinase inhibitors |
| WO2002028829A2 (fr) | 2000-09-25 | 2002-04-11 | Questcor Pharmaceuticals, Inc. | Inhibiteurs de peptide deformylase |
| ES2333412T3 (es) * | 2001-05-25 | 2010-02-22 | Bristol-Myers Squibb Company | Derivados de hidantoina como inhibidores de metaloproteinasas de matriz. |
-
2006
- 2006-12-13 US US12/097,192 patent/US8022092B2/en not_active Expired - Fee Related
- 2006-12-13 WO PCT/EP2006/012019 patent/WO2007068474A1/fr active Application Filing
- 2006-12-13 EP EP06840975A patent/EP1966153A1/fr not_active Withdrawn
- 2006-12-13 CN CN2006800325666A patent/CN101258132B/zh not_active Expired - Fee Related
- 2006-12-13 AU AU2006326256A patent/AU2006326256B2/en not_active Ceased
- 2006-12-13 BR BRPI0619848-1A patent/BRPI0619848A2/pt not_active IP Right Cessation
- 2006-12-13 CA CA002628159A patent/CA2628159A1/fr not_active Abandoned
- 2006-12-13 JP JP2008544873A patent/JP5186384B2/ja not_active Expired - Fee Related
- 2006-12-14 TW TW095146810A patent/TWI361186B/zh not_active IP Right Cessation
-
2008
- 2008-10-23 HK HK08111653.7A patent/HK1115878A1/xx not_active IP Right Cessation
-
2011
- 2011-08-31 US US13/222,883 patent/US8338471B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006326256B2 (en) | 2011-11-03 |
| US8338471B2 (en) | 2012-12-25 |
| BRPI0619848A2 (pt) | 2011-10-18 |
| WO2007068474A1 (fr) | 2007-06-21 |
| AU2006326256A1 (en) | 2007-06-21 |
| CN101258132B (zh) | 2012-04-25 |
| TWI361186B (en) | 2012-04-01 |
| CA2628159A1 (fr) | 2007-06-21 |
| US8022092B2 (en) | 2011-09-20 |
| US20120015994A1 (en) | 2012-01-19 |
| HK1115878A1 (en) | 2008-12-12 |
| JP2009519281A (ja) | 2009-05-14 |
| CN101258132A (zh) | 2008-09-03 |
| EP1966153A1 (fr) | 2008-09-10 |
| US20090215846A1 (en) | 2009-08-27 |
| TW200825056A (en) | 2008-06-16 |
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