JP5156392B2 - Ｈｄａｃ阻害剤を用いる併用療法 - Google Patents

Ｈｄａｃ阻害剤を用いる併用療法 Download PDF

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JP5156392B2
JP5156392B2 JP2007553700A JP2007553700A JP5156392B2 JP 5156392 B2 JP5156392 B2 JP 5156392B2 JP 2007553700 A JP2007553700 A JP 2007553700A JP 2007553700 A JP2007553700 A JP 2007553700A JP 5156392 B2 JP5156392 B2 JP 5156392B2
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cancer
pxd
treatment
lymphoma
inhibitor
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JP2008528671A5 (enExample
JP2008528671A (ja
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リチェンステイン，ヘンリ
ジェファーズ，マイク
チェン，クシャオズハング
シェーステッド，マックスウェル
ペテルセン，カミル，デュモング
リッチー，ジェイムズ
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トポターゲット ユーケー リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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  • Health & Medical Sciences (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2007553700A 2005-02-03 2006-02-03 Ｈｄａｃ阻害剤を用いる併用療法 Expired - Fee Related JP5156392B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US64999105P 2005-02-03 2005-02-03
US60/649,991 2005-02-03
US73566205P 2005-11-10 2005-11-10
US60/735,662 2005-11-10
PCT/GB2006/000391 WO2006082428A2 (en) 2005-02-03 2006-02-03 Combination therapies using hdac inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012031556A Division JP5640026B2 (ja) 2005-02-03 2012-02-16 Ｈｄａｃ阻害剤を用いる併用療法

Publications (3)

Publication Number Publication Date
JP2008528671A JP2008528671A (ja) 2008-07-31
JP2008528671A5 JP2008528671A5 (enExample) 2012-04-19
JP5156392B2 true JP5156392B2 (ja) 2013-03-06

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ID=36178242

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2007553700A Expired - Fee Related JP5156392B2 (ja) 2005-02-03 2006-02-03 Ｈｄａｃ阻害剤を用いる併用療法
JP2012031556A Expired - Fee Related JP5640026B2 (ja) 2005-02-03 2012-02-16 Ｈｄａｃ阻害剤を用いる併用療法
JP2014026011A Pending JP2014111642A (ja) 2005-02-03 2014-02-14 Ｈｄａｃ阻害剤を用いる併用療法
JP2015081543A Pending JP2015147794A (ja) 2005-02-03 2015-04-13 Ｈｄａｃ阻害剤を用いる併用療法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2012031556A Expired - Fee Related JP5640026B2 (ja) 2005-02-03 2012-02-16 Ｈｄａｃ阻害剤を用いる併用療法
JP2014026011A Pending JP2014111642A (ja) 2005-02-03 2014-02-14 Ｈｄａｃ阻害剤を用いる併用療法
JP2015081543A Pending JP2015147794A (ja) 2005-02-03 2015-04-13 Ｈｄａｃ阻害剤を用いる併用療法

Country Status (7)

Country Link
US (3) US20080213399A1 (enExample)
EP (7) EP2522395A1 (enExample)
JP (4) JP5156392B2 (enExample)
AU (1) AU2006210746B2 (enExample)
CA (1) CA2596210C (enExample)
NZ (2) NZ589276A (enExample)
WO (1) WO2006082428A2 (enExample)

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WO2005070020A2 (en) 2004-01-23 2005-08-04 The Regents Of The University Of Colorado Gefitinib sensitivity-related gene expression and products and methods related thereto
WO2005117553A2 (en) 2004-05-27 2005-12-15 The Regents Of The University Of Colorado Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients
NZ589276A (en) 2005-02-03 2012-06-29 Topotarget Uk Ltd Combination therapies using hdac inhibitors and erlotinib (tarceva)
US20080234265A1 (en) * 2005-03-11 2008-09-25 The Regents Of The University Of Colorado Histone Deacetylase Inhibitors Sensitize Cancer Cells to Epidermal Growth Factor Inhibitors
CA2606598C (en) 2005-05-13 2014-12-23 Topotarget Uk Limited Pharmaceutical formulations of hdac inhibitors
CN101300015A (zh) * 2005-11-04 2008-11-05 默克公司 使用n-辛二酰苯胺异羟肟酸和厄洛替尼治疗癌症的方法
JP5377968B2 (ja) * 2005-11-10 2013-12-25 トポターゲット ユーケー リミテッド 癌治療のために単独で用いるまたは化学療法薬と併用するヒストンデアセチラーゼ（ｈｄａｃ）阻害剤
JP2010502741A (ja) 2006-09-11 2010-01-28 キュリス，インコーポレイテッド Ｐｔｋインヒビターとしての亜鉛結合部分を含む置換２−インドリノン
KR20090067169A (ko) 2006-09-11 2009-06-24 쿠리스 인코퍼레이션 아연 결합 부분을 함유한 퀴나졸린 계열 ｅｇｆｒ 억제제
CN101534831B (zh) 2006-09-11 2013-07-17 柯瑞斯公司 包含锌结合基团的取代的酪氨酸抑制剂
US7547781B2 (en) 2006-09-11 2009-06-16 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
CN101641338A (zh) * 2006-09-11 2010-02-03 柯瑞斯公司 作为抗增殖制剂的多功能小分子
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JP2010502743A (ja) 2006-09-11 2010-01-28 キュリス，インコーポレイテッド 抗増殖薬剤としての多機能性低分子
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TW200922564A (en) 2007-09-10 2009-06-01 Curis Inc CDK inhibitors containing a zinc binding moiety
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WO2009035718A1 (en) 2007-09-10 2009-03-19 Curis, Inc. Tartrate salts or complexes of quinazoline based egfr inhibitors containing a zinc binding moiety
EP2203421B1 (en) 2007-09-25 2014-05-07 TopoTarget UK Limited Methods of synthesis of certain n-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide compounds
US20110053991A1 (en) * 2007-11-19 2011-03-03 Gore Lia Treatment of Histone Deacetylase Mediated Disorders
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BRPI1004899B8 (pt) 2009-01-08 2021-05-25 Curis Inc composto inibidor de fosfoinositida 3-quinase, composição farmacêutica e uso de um composto
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WO2010148572A1 (en) * 2009-06-26 2010-12-29 Asan Laboratories Co., Ltd. Method for treating or ameliorating mucocutaneous or ocular toxicities
US20140314788A1 (en) * 2010-04-09 2014-10-23 Salk Institute For Biological Studies Modulation of histone deacetylases for the treatment of metabolic disease, methods and compositions related thereto
MX2012014231A (es) * 2010-06-07 2013-01-28 Abraxis Bioscience Llc Metodos de terapia combinada para tratar enfermedades proliferativas.
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