JP5156392B2 - Ｈｄａｃ阻害剤を用いる併用療法 - Google Patents

Ｈｄａｃ阻害剤を用いる併用療法 Download PDF

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JP5156392B2
JP5156392B2 JP2007553700A JP2007553700A JP5156392B2 JP 5156392 B2 JP5156392 B2 JP 5156392B2 JP 2007553700 A JP2007553700 A JP 2007553700A JP 2007553700 A JP2007553700 A JP 2007553700A JP 5156392 B2 JP5156392 B2 JP 5156392B2
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cancer
pxd
treatment
lymphoma
inhibitor
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JP2008528671A5 (enExample
JP2008528671A (ja
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リチェンステイン，ヘンリ
ジェファーズ，マイク
チェン，クシャオズハング
シェーステッド，マックスウェル
ペテルセン，カミル，デュモング
リッチー，ジェイムズ
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トポターゲット ユーケー リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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  • Health & Medical Sciences (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2007553700A 2005-02-03 2006-02-03 Ｈｄａｃ阻害剤を用いる併用療法 Expired - Fee Related JP5156392B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US64999105P 2005-02-03 2005-02-03
US60/649,991 2005-02-03
US73566205P 2005-11-10 2005-11-10
US60/735,662 2005-11-10
PCT/GB2006/000391 WO2006082428A2 (en) 2005-02-03 2006-02-03 Combination therapies using hdac inhibitors

Related Child Applications (1)

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JP2012031556A Division JP5640026B2 (ja) 2005-02-03 2012-02-16 Ｈｄａｃ阻害剤を用いる併用療法

Publications (3)

Publication Number Publication Date
JP2008528671A JP2008528671A (ja) 2008-07-31
JP2008528671A5 JP2008528671A5 (enExample) 2012-04-19
JP5156392B2 true JP5156392B2 (ja) 2013-03-06

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Family Applications (4)

Application Number Title Priority Date Filing Date
JP2007553700A Expired - Fee Related JP5156392B2 (ja) 2005-02-03 2006-02-03 Ｈｄａｃ阻害剤を用いる併用療法
JP2012031556A Expired - Fee Related JP5640026B2 (ja) 2005-02-03 2012-02-16 Ｈｄａｃ阻害剤を用いる併用療法
JP2014026011A Pending JP2014111642A (ja) 2005-02-03 2014-02-14 Ｈｄａｃ阻害剤を用いる併用療法
JP2015081543A Pending JP2015147794A (ja) 2005-02-03 2015-04-13 Ｈｄａｃ阻害剤を用いる併用療法

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JP2012031556A Expired - Fee Related JP5640026B2 (ja) 2005-02-03 2012-02-16 Ｈｄａｃ阻害剤を用いる併用療法
JP2014026011A Pending JP2014111642A (ja) 2005-02-03 2014-02-14 Ｈｄａｃ阻害剤を用いる併用療法
JP2015081543A Pending JP2015147794A (ja) 2005-02-03 2015-04-13 Ｈｄａｃ阻害剤を用いる併用療法

Country Status (7)

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US (3) US20080213399A1 (enExample)
EP (7) EP2502649A1 (enExample)
JP (4) JP5156392B2 (enExample)
AU (1) AU2006210746B2 (enExample)
CA (1) CA2596210C (enExample)
NZ (2) NZ589276A (enExample)
WO (1) WO2006082428A2 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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US8017321B2 (en) 2004-01-23 2011-09-13 The Regents Of The University Of Colorado, A Body Corporate Gefitinib sensitivity-related gene expression and products and methods related thereto
JP5422120B2 (ja) 2004-05-27 2014-02-19 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイト 癌患者による上皮成長因子受容体阻害薬に対する臨床転帰の予測方法
NZ589276A (en) 2005-02-03 2012-06-29 Topotarget Uk Ltd Combination therapies using hdac inhibitors and erlotinib (tarceva)
JP2008533053A (ja) * 2005-03-11 2008-08-21 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド ヒストン脱アセチル化酵素阻害剤は、がん細胞を上皮増殖因子受容体阻害剤に対して感受性にする
SI1901729T1 (sl) 2005-05-13 2012-05-31 Topotarget Uk Ltd Farmacevtske formulacije HDAC inhibitorjev
CA2622136A1 (en) * 2005-11-04 2007-05-18 Merck & Co., Inc. Methods of using saha and erlotinib for treating cancer
CA2627923C (en) * 2005-11-10 2016-01-12 Topotarget Uk Limited Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer
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SG174772A1 (en) 2006-09-11 2011-10-28 Curis Inc Multi-functional small molecules as anti-proliferative agents
CA2662617C (en) 2006-09-11 2014-11-18 Changgeng Qian Quinazoline based egfr inhibitors containing a zinc binding moiety
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US8119616B2 (en) 2007-09-10 2012-02-21 Curis, Inc. Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety
ES2526718T3 (es) 2007-09-10 2015-01-14 Curis, Inc. Inhibidores de EGFR basados en sales de tartrato o complejos de quinazolina que contienen un resto que se une al cinc
TW200922564A (en) 2007-09-10 2009-06-01 Curis Inc CDK inhibitors containing a zinc binding moiety
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WO2009067543A2 (en) * 2007-11-19 2009-05-28 The Regents Of The University Of Colorado Treatment of histone deacetylase mediated disorders
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