JP5149008B2 - 精製された臭化水素酸を用いたポリペプチド混合物の調製方法 - Google Patents

精製された臭化水素酸を用いたポリペプチド混合物の調製方法 Download PDF

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Publication number
JP5149008B2
JP5149008B2 JP2007531423A JP2007531423A JP5149008B2 JP 5149008 B2 JP5149008 B2 JP 5149008B2 JP 2007531423 A JP2007531423 A JP 2007531423A JP 2007531423 A JP2007531423 A JP 2007531423A JP 5149008 B2 JP5149008 B2 JP 5149008B2
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glatiramer acetate
acetic acid
metal ion
trifluoroacetyl
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Expired - Fee Related
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Japanese (ja)
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JP2008512494A (ja
JP2008512494A5 (enExample
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ドリツキー、ベン−ジオン
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テバ ファーマシューティカル インダストリーズ リミティド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2007531423A 2004-09-09 2005-09-09 精製された臭化水素酸を用いたポリペプチド混合物の調製方法 Expired - Fee Related JP5149008B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60884304P 2004-09-09 2004-09-09
US60/608,843 2004-09-09
PCT/US2005/032395 WO2006029393A2 (en) 2004-09-09 2005-09-09 Process for preparation of mixtures of polypeptides using purified hydrobromic acid

Publications (3)

Publication Number Publication Date
JP2008512494A JP2008512494A (ja) 2008-04-24
JP2008512494A5 JP2008512494A5 (enExample) 2008-10-23
JP5149008B2 true JP5149008B2 (ja) 2013-02-20

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JP2007531423A Expired - Fee Related JP5149008B2 (ja) 2004-09-09 2005-09-09 精製された臭化水素酸を用いたポリペプチド混合物の調製方法

Country Status (27)

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US (2) US7495072B2 (enExample)
EP (3) EP2177528B1 (enExample)
JP (1) JP5149008B2 (enExample)
KR (1) KR101317131B1 (enExample)
CN (1) CN101166754B (enExample)
AT (2) ATE454396T1 (enExample)
AU (1) AU2005282249B2 (enExample)
BR (1) BRPI0515033B1 (enExample)
CA (1) CA2579656C (enExample)
CY (1) CY1110280T1 (enExample)
DE (1) DE602005018800D1 (enExample)
DK (3) DK1799703T3 (enExample)
ES (3) ES2382298T3 (enExample)
HR (3) HRP20100164T1 (enExample)
IL (2) IL181596A (enExample)
IS (1) IS8622A (enExample)
MX (1) MX2007002760A (enExample)
NO (1) NO20071632L (enExample)
NZ (1) NZ554018A (enExample)
PL (3) PL2177528T3 (enExample)
PT (3) PT2177528E (enExample)
RS (3) RS53248B (enExample)
RU (1) RU2388764C2 (enExample)
SI (3) SI2177528T1 (enExample)
UA (1) UA91029C2 (enExample)
WO (1) WO2006029393A2 (enExample)
ZA (1) ZA200702591B (enExample)

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EP2361924B1 (en) 2013-12-11
EP1799703A4 (en) 2008-09-03
EP1799703B1 (en) 2010-01-06
CN101166754A (zh) 2008-04-23
IL181596A (en) 2015-10-29
PL2361924T3 (pl) 2014-08-29
RU2388764C2 (ru) 2010-05-10
IS8622A (is) 2007-03-16
SI1799703T1 (sl) 2010-04-30
US20060052586A1 (en) 2006-03-09
HK1140775A1 (en) 2010-10-22
EP1799703A2 (en) 2007-06-27
UA91029C2 (uk) 2010-06-25
CN101166754B (zh) 2014-04-23
EP2177528A1 (en) 2010-04-21
AU2005282249B2 (en) 2012-08-02
KR20070059137A (ko) 2007-06-11
RS51257B (sr) 2010-12-31
ATE454396T1 (de) 2010-01-15
ZA200702591B (en) 2009-03-25
EP2361924A1 (en) 2011-08-31
DE602005018800D1 (de) 2010-02-25
ES2338138T3 (es) 2010-05-04
CY1110280T1 (el) 2015-01-14
DK2361924T3 (en) 2014-03-10
IL181596A0 (en) 2007-07-04
PT1799703E (pt) 2010-03-04
PL1799703T3 (pl) 2010-06-30
PL2177528T3 (pl) 2012-09-28
JP2008512494A (ja) 2008-04-24
SI2177528T1 (sl) 2012-04-30
US20070021324A1 (en) 2007-01-25
PT2177528E (pt) 2012-03-19
KR101317131B1 (ko) 2013-10-10
IL241702A0 (en) 2015-11-30
AU2005282249A1 (en) 2006-03-16
DK2177528T3 (da) 2012-03-26
ES2451006T3 (es) 2014-03-26
HK1100780A1 (en) 2007-09-28
MX2007002760A (es) 2007-05-18
NZ554018A (en) 2009-06-26
CA2579656C (en) 2014-11-04
NO20071632L (no) 2007-06-05
WO2006029393A3 (en) 2007-12-13
RU2007112956A (ru) 2008-10-20
BRPI0515033A (pt) 2008-07-01
WO2006029393A8 (en) 2007-04-19
HRP20140216T1 (hr) 2014-06-06
ATE536363T1 (de) 2011-12-15
US7495072B2 (en) 2009-02-24
BRPI0515033B1 (pt) 2021-05-25
HK1156637A1 (en) 2012-06-15
ES2382298T3 (es) 2012-06-07
SI2361924T1 (sl) 2014-04-30
EP2177528B1 (en) 2011-12-07
PT2361924E (pt) 2014-03-13
RS53248B (sr) 2014-08-29
CA2579656A1 (en) 2006-03-16
HRP20100164T1 (hr) 2010-07-31
HRP20120209T1 (hr) 2012-06-30
WO2006029393A2 (en) 2006-03-16
DK1799703T3 (da) 2010-04-19
RS52265B (sr) 2012-10-31
BRPI0515033A8 (pt) 2019-01-22

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