PL2307448T3 - Wytwarzanie polilizyny i poliornityny o małym ciężarze cząsteczkowym z wysoką wydajnością - Google Patents

Wytwarzanie polilizyny i poliornityny o małym ciężarze cząsteczkowym z wysoką wydajnością

Info

Publication number
PL2307448T3
PL2307448T3 PL09805374T PL09805374T PL2307448T3 PL 2307448 T3 PL2307448 T3 PL 2307448T3 PL 09805374 T PL09805374 T PL 09805374T PL 09805374 T PL09805374 T PL 09805374T PL 2307448 T3 PL2307448 T3 PL 2307448T3
Authority
PL
Poland
Prior art keywords
polyornithine
preparation
molecular weight
low molecular
high yield
Prior art date
Application number
PL09805374T
Other languages
English (en)
Inventor
Ettigounder Ponnusamy
Original Assignee
Sigma Aldrich Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Aldrich Co Llc filed Critical Sigma Aldrich Co Llc
Publication of PL2307448T3 publication Critical patent/PL2307448T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/04—Preparatory processes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
PL09805374T 2008-08-07 2009-07-29 Wytwarzanie polilizyny i poliornityny o małym ciężarze cząsteczkowym z wysoką wydajnością PL2307448T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8703108P 2008-08-07 2008-08-07
PCT/US2009/052085 WO2010017075A1 (en) 2008-08-07 2009-07-29 Preparation of low molecular weight polylysine and polyornithine in high yield
EP20090805374 EP2307448B1 (en) 2008-08-07 2009-07-29 Preparation of low molecular weight polylysine and polyornithine in high yield

Publications (1)

Publication Number Publication Date
PL2307448T3 true PL2307448T3 (pl) 2015-10-30

Family

ID=41663939

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09805374T PL2307448T3 (pl) 2008-08-07 2009-07-29 Wytwarzanie polilizyny i poliornityny o małym ciężarze cząsteczkowym z wysoką wydajnością

Country Status (6)

Country Link
US (2) US8399600B2 (pl)
EP (1) EP2307448B1 (pl)
ES (1) ES2537022T3 (pl)
HU (1) HUE025042T2 (pl)
PL (1) PL2307448T3 (pl)
WO (1) WO2010017075A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2307448B1 (en) * 2008-08-07 2015-04-22 Sigma-Aldrich Co. LLC Preparation of low molecular weight polylysine and polyornithine in high yield
WO2013016057A1 (en) * 2011-07-22 2013-01-31 Merck Sharp & Dohme Corp. Poly(ornithine) homopolymers for the delivery of oligonucleotides
US10370409B2 (en) 2011-10-25 2019-08-06 The Scripps Research Institute Synthesis of libraries of peptide tertiary amides
WO2013062982A1 (en) * 2011-10-27 2013-05-02 Merck Sharp & Dohme Corp. Poly(lysine) homopolymers for the delivery of oligonucleotides
CN103524728B (zh) * 2013-10-12 2016-01-20 中国科学院长春应用化学研究所 聚(ε-甲基丙烯酰基-L-赖氨酸)均聚物、嵌段共聚物及功能化聚合物
WO2020094823A1 (en) * 2018-11-09 2020-05-14 Basf Se Poly-lysine derivatives to increase effectiveness of agrochemical formulations

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1024393A (en) * 1963-03-30 1966-03-30 Asahi Chemical Ind Process for polymerizing n-carboxy-ª‡-amino acid anhydrides
US3594351A (en) * 1967-04-10 1971-07-20 Hitachi Chemical Co Ltd Process for producing a block copolymer of alpha-amino acid-n-carboxy anhydride and an isocyanate and a process for producing synthetic leather by the use thereof
GB1298617A (en) * 1969-06-18 1972-12-06 Kyowa Hakko Kogyo Kk POLYMERISATION OF alpha-AMINO ACID N-CARBOXYANHYDRIDES
US4450150A (en) * 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
US4686295A (en) * 1982-03-10 1987-08-11 Usv Pharmaceutical Corporation N-carboxy anhydride intermediates
US5767227A (en) * 1989-11-03 1998-06-16 Lotus Biochemical Corp. Iodothyronine polymers
JP2966891B2 (ja) * 1990-06-06 1999-10-25 セイコー化成株式会社 スエード調表面仕上用処理剤
WO1992000748A1 (en) 1990-07-06 1992-01-23 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
ES2075402T3 (es) * 1991-07-22 1995-10-01 Bracco Int Bv Conjugados quelados con metales paramagneticos para enfoque deliberado.
IL113812A (en) * 1994-05-24 2000-06-29 Yeda Res & Dev Copolymer-1 pharmaceutical compositions containing it and its use
US5654381A (en) * 1995-06-16 1997-08-05 Massachusetts Institute Of Technology Functionalized polyester graft copolymers
US6441025B2 (en) * 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
US6048565A (en) * 1996-03-25 2000-04-11 Apv Anhydro As Process and apparatus for converting liquid whey into powder
US6410057B1 (en) * 1997-12-12 2002-06-25 Samyang Corporation Biodegradable mixed polymeric micelles for drug delivery
US6680365B1 (en) * 1998-03-19 2004-01-20 The Regents Of The University Of California Methods and compositions for controlled polypeptide synthesis
US6686446B2 (en) * 1998-03-19 2004-02-03 The Regents Of The University Of California Methods and compositions for controlled polypeptide synthesis
FR2776510B1 (fr) * 1998-03-31 2002-11-29 Oreal Derives de polyamino-acides et leur utilisation dans des compositions de traitement des fibres keratiniques
US6800287B2 (en) * 1998-09-25 2004-10-05 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
FR2786098B1 (fr) * 1998-11-20 2003-05-30 Flamel Tech Sa Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s), suspension colloidale les comprenant et leurs procedes de fabrication
FR2814952B1 (fr) * 2000-10-06 2004-01-02 Flamel Tech Sa Suspension colloidale de particules submicromiques de vectorisation de principes actifs et leur mode de preparation
CN1388804A (zh) * 2000-07-04 2003-01-01 三井化学株式会社 在氮原子上具有取代基的氨基酸－n－羧基酸酐
FR2815962B1 (fr) * 2000-10-30 2003-03-07 Isochem Sa Procede de preparation des n-carboxyanhydrides
FR2828195B1 (fr) * 2001-05-31 2003-12-26 Isochem Sa Procede de preparation des n-carboxyanhydrides
ATE410459T1 (de) * 2002-01-14 2008-10-15 Gen Hospital Corp Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung
US20030147958A1 (en) * 2002-01-29 2003-08-07 Cheol-Hee Ahn Biodegradable multi-block copolymers of poly(amino acid)s and poly(ethylene glycol) for the delivery of bioactive agents
CA2411786C (en) * 2002-11-13 2009-01-27 Brantford Chemicals Inc. A process for the preparation of polypeptides from n-carboxyanhydrides of amino acids
US7317070B1 (en) * 2004-03-12 2008-01-08 Sigma-Aldrich Co. Process for the preparation of polyamino acids
US7655221B2 (en) 2004-05-07 2010-02-02 Peptimmune, Inc. Methods of treating disease with random copolymers
WO2006029411A2 (en) 2004-09-09 2006-03-16 Yeda Research And Development Co. Ltd. Mixtures of polypeptides, compositions containing and processes for preparing same, and uses thereof
KR101317131B1 (ko) * 2004-09-09 2013-10-10 테바 파마슈티컬 인더스트리즈 리미티드 정제된 브롬화 수소산을 이용한 폴리펩타이드류의 혼합물의제조방법
WO2006047703A2 (en) * 2004-10-26 2006-05-04 Sigma-Aldrich Co. Synthesis of amino acid, n-carboxyanhydrides
ATE440888T1 (de) * 2004-10-29 2009-09-15 Sandoz Ag Verfahren zur herstellung von glatiramer
KR20080048482A (ko) 2005-08-15 2008-06-02 와이 홍 찬 공중합체-1의 제조 방법
WO2008006026A1 (en) 2006-07-05 2008-01-10 Momenta Pharmaceuticals, Inc. Improved process for the preparation of copolymer-1
US20090035816A1 (en) 2007-08-02 2009-02-05 Scinopharm Taiwan Ltd. Process for the preparation of a polypeptide
ES2449865T5 (es) 2008-04-16 2022-11-18 Momenta Pharmaceuticals Inc Análisis de composiciones de copolímeros de aminoácidos
CN102112485B (zh) * 2008-08-07 2013-11-27 台湾神隆股份有限公司 乙酸格拉默(glatiramer acetate)的合成
EP2307448B1 (en) * 2008-08-07 2015-04-22 Sigma-Aldrich Co. LLC Preparation of low molecular weight polylysine and polyornithine in high yield
KR20100019223A (ko) * 2008-08-08 2010-02-18 삼성전자주식회사 흡광 코팅 부재, 가열 장치, 정착 유닛 및 정착 유닛을 이용한 화상 형성 장치
DE102008037622A1 (de) 2008-08-14 2010-02-25 Bayer Cropscience Ag Herbizid-Kombination mit Dimethoxytriazinyl-substituierten Difluormethansulfonylaniliden
US9617313B2 (en) * 2008-12-24 2017-04-11 Synthon Bv Process for purifying a polymer mixture
US20120071612A1 (en) * 2009-03-10 2012-03-22 Sigma-Aldrich Co., Llc Method for the production of polyamino acid random copolymers
ES2523732T5 (es) * 2009-04-03 2023-10-23 Momenta Pharmaceuticals Inc Control de composiciones de copolímeros
WO2012067974A1 (en) 2010-11-17 2012-05-24 Sigma-Aldrich Co. Llc. A greener method for the production of copolymer 1

Also Published As

Publication number Publication date
US20110054146A1 (en) 2011-03-03
HUE025042T2 (en) 2016-07-28
EP2307448A1 (en) 2011-04-13
WO2010017075A1 (en) 2010-02-11
EP2307448A4 (en) 2012-03-07
US8791226B2 (en) 2014-07-29
ES2537022T3 (es) 2015-06-01
EP2307448B1 (en) 2015-04-22
US8399600B2 (en) 2013-03-19
US20130172517A1 (en) 2013-07-04

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