JP5128940B2 - 置換イミダゾキノリン、イミダゾピリジン、およびイミダゾナフチリジン - Google Patents
置換イミダゾキノリン、イミダゾピリジン、およびイミダゾナフチリジン Download PDFInfo
- Publication number
- JP5128940B2 JP5128940B2 JP2007516773A JP2007516773A JP5128940B2 JP 5128940 B2 JP5128940 B2 JP 5128940B2 JP 2007516773 A JP2007516773 A JP 2007516773A JP 2007516773 A JP2007516773 A JP 2007516773A JP 5128940 B2 JP5128940 B2 JP 5128940B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- alkylene
- mmol
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C[n]1c(c(*)c(*)nc2)c2nc1* Chemical compound C[n]1c(c(*)c(*)nc2)c2nc1* 0.000 description 7
- ARFLRXBQSACJDT-UHFFFAOYSA-N CCNC1(CC1)O Chemical compound CCNC1(CC1)O ARFLRXBQSACJDT-UHFFFAOYSA-N 0.000 description 1
- ZDXQGELFNKIKJO-UHFFFAOYSA-N CCOCc1nc2c(N)nc(cccc3)c3c2[n]1CC1(CCOCC1)NS(C)(=O)=O Chemical compound CCOCc1nc2c(N)nc(cccc3)c3c2[n]1CC1(CCOCC1)NS(C)(=O)=O ZDXQGELFNKIKJO-UHFFFAOYSA-N 0.000 description 1
- ZXDZVERSDOMZHA-UHFFFAOYSA-N CCOCc1nc2c(N)nc(cccc3)c3c2[n]1CCC1(CCCCC1)O Chemical compound CCOCc1nc2c(N)nc(cccc3)c3c2[n]1CCC1(CCCCC1)O ZXDZVERSDOMZHA-UHFFFAOYSA-N 0.000 description 1
- CSMBBMUEKKEEDW-UHFFFAOYSA-N CCc1nc2c(N)nc(cccc3)c3c2[n]1CC(CC1)(CCN1S(C)(=O)=O)O Chemical compound CCc1nc2c(N)nc(cccc3)c3c2[n]1CC(CC1)(CCN1S(C)(=O)=O)O CSMBBMUEKKEEDW-UHFFFAOYSA-N 0.000 description 1
- XYVOGZHQWDDMIH-UHFFFAOYSA-N CCc1nc2c(N)nc(cccc3)c3c2[n]1CC1(CCCC1)O Chemical compound CCc1nc2c(N)nc(cccc3)c3c2[n]1CC1(CCCC1)O XYVOGZHQWDDMIH-UHFFFAOYSA-N 0.000 description 1
- CVLOKCLWSBSIQZ-UHFFFAOYSA-N COCCc1nc2c(N)nc(cccc3)c3c2[n]1CC1(CCC1)O Chemical compound COCCc1nc2c(N)nc(cccc3)c3c2[n]1CC1(CCC1)O CVLOKCLWSBSIQZ-UHFFFAOYSA-N 0.000 description 1
- GOUOTEXHGINABP-UHFFFAOYSA-N COCCc1nc2c(N)nc(cccc3)c3c2[n]1CC1(CCCCC1)O Chemical compound COCCc1nc2c(N)nc(cccc3)c3c2[n]1CC1(CCCCC1)O GOUOTEXHGINABP-UHFFFAOYSA-N 0.000 description 1
- VKFXAXZJHBUSAD-UHFFFAOYSA-N Cc1nc2c(N)nc(C)c(C)c2[n]1CC1(CCOCC1)O Chemical compound Cc1nc2c(N)nc(C)c(C)c2[n]1CC1(CCOCC1)O VKFXAXZJHBUSAD-UHFFFAOYSA-N 0.000 description 1
- ZQMLODWLYNGVBU-UHFFFAOYSA-N Cc1nc2cnc(C)c(C)c2[n]1CC1(CCOCC1)O Chemical compound Cc1nc2cnc(C)c(C)c2[n]1CC1(CCOCC1)O ZQMLODWLYNGVBU-UHFFFAOYSA-N 0.000 description 1
- YVJDSNJBFUZDKA-UHFFFAOYSA-N Nc1c2nc(CNC(C3CC3)=O)[n](CC3(CCCCC3)O)c2c(cccc2)c2n1 Chemical compound Nc1c2nc(CNC(C3CC3)=O)[n](CC3(CCCCC3)O)c2c(cccc2)c2n1 YVJDSNJBFUZDKA-UHFFFAOYSA-N 0.000 description 1
- YMKWTWVPHJHFNS-UHFFFAOYSA-N Nc1c2nc(CO)[n](CC3(CCCCC3)O)c2c(cccc2)c2n1 Chemical compound Nc1c2nc(CO)[n](CC3(CCCCC3)O)c2c(cccc2)c2n1 YMKWTWVPHJHFNS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58127404P | 2004-06-18 | 2004-06-18 | |
| US60/581,274 | 2004-06-18 | ||
| PCT/US2005/021445 WO2006028545A2 (en) | 2004-06-18 | 2005-06-17 | Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008503484A JP2008503484A (ja) | 2008-02-07 |
| JP2008503484A5 JP2008503484A5 (enExample) | 2008-08-07 |
| JP5128940B2 true JP5128940B2 (ja) | 2013-01-23 |
Family
ID=36036778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007516773A Expired - Fee Related JP5128940B2 (ja) | 2004-06-18 | 2005-06-17 | 置換イミダゾキノリン、イミダゾピリジン、およびイミダゾナフチリジン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7884207B2 (enExample) |
| EP (1) | EP1765348B1 (enExample) |
| JP (1) | JP5128940B2 (enExample) |
| AU (1) | AU2005283085B2 (enExample) |
| CA (1) | CA2571360C (enExample) |
| WO (1) | WO2006028545A2 (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6797718B2 (en) | 2002-06-07 | 2004-09-28 | 3M Innovative Properties Company | Ether substituted imidazopyridines |
| US20040265351A1 (en) | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
| US7897597B2 (en) * | 2003-08-27 | 2011-03-01 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted imidazoquinolines |
| JP2007504269A (ja) | 2003-09-05 | 2007-03-01 | スリーエム イノベイティブ プロパティズ カンパニー | Cd5+b細胞リンパ腫の治療方法 |
| US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| AU2004315876B2 (en) | 2003-10-03 | 2011-05-26 | 3M Innovative Properties Company | Pyrazolopyridines and analogs thereof |
| US8871782B2 (en) | 2003-10-03 | 2014-10-28 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
| AU2004293078B2 (en) | 2003-11-25 | 2012-01-19 | 3M Innovative Properties Company | Substituted imidazo ring systems and methods |
| US8541438B2 (en) * | 2004-06-18 | 2013-09-24 | 3M Innovative Properties Company | Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
| WO2006065280A2 (en) | 2004-06-18 | 2006-06-22 | 3M Innovative Properties Company | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods |
| WO2006028962A2 (en) | 2004-09-02 | 2006-03-16 | 3M Innovative Properties Company | 1-alkoxy 1h-imidazo ring systems and methods |
| US8034938B2 (en) | 2004-12-30 | 2011-10-11 | 3M Innovative Properties Company | Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds |
| AU2005322898B2 (en) | 2004-12-30 | 2011-11-24 | 3M Innovative Properties Company | Chiral fused (1,2)imidazo(4,5-c) ring compounds |
| WO2006084251A2 (en) | 2005-02-04 | 2006-08-10 | Coley Pharmaceutical Group, Inc. | Aqueous gel formulations containing immune reponse modifiers |
| CA2597324C (en) | 2005-02-09 | 2015-06-30 | Coley Pharmaceutical Group, Inc. | Alkyloxy substituted thiazoloquinolines and thiazolonaphthyridines |
| EP1877056A2 (en) | 2005-02-09 | 2008-01-16 | Coley Pharmaceutical Group, Inc. | Oxime and hydroxylamine substituted thiazoloý4,5-c¨ring compounds and methods |
| AU2006213746A1 (en) | 2005-02-11 | 2006-08-17 | Coley Pharmaceutical Group, Inc. | Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods |
| EP1845988A2 (en) * | 2005-02-11 | 2007-10-24 | 3M Innovative Properties Company | Substituted imidazoquinolines and imidazonaphthyridines |
| EP1851220A2 (en) | 2005-02-23 | 2007-11-07 | 3M Innovative Properties Company | Hydroxyalkyl substituted imidazonaphthyridines |
| JP2008531567A (ja) * | 2005-02-23 | 2008-08-14 | コーリー ファーマシューティカル グループ,インコーポレイテッド | ヒドロキシアルキル置換イミダゾキノリン化合物および方法 |
| EP1851224A2 (en) * | 2005-02-23 | 2007-11-07 | 3M Innovative Properties Company | Hydroxyalkyl substituted imidazoquinolines |
| WO2006091647A2 (en) * | 2005-02-23 | 2006-08-31 | Coley Pharmaceutical Group, Inc. | Method of preferentially inducing the biosynthesis of interferon |
| CA2602683A1 (en) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridine-1,4-diamines and analogs thereof |
| AU2006232375A1 (en) * | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases |
| ZA200803029B (en) | 2005-09-09 | 2009-02-25 | Coley Pharm Group Inc | Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods |
| AU2006287270A1 (en) * | 2005-09-09 | 2007-03-15 | Coley Pharmaceutical Group, Inc. | Amide and carbamate derivatives of N-{2-[4-amino-2- (ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide and methods |
| EP1948173B1 (en) * | 2005-11-04 | 2013-07-17 | 3M Innovative Properties Company | Hydroxy and alkoxy substituted 1h-imidazoquinolines and methods |
| US8951528B2 (en) | 2006-02-22 | 2015-02-10 | 3M Innovative Properties Company | Immune response modifier conjugates |
| WO2007106854A2 (en) * | 2006-03-15 | 2007-09-20 | Coley Pharmaceutical Group, Inc. | Hydroxy and alkoxy substituted 1h-imidazonaphthyridines and methods |
| FR2902100A1 (fr) * | 2006-06-13 | 2007-12-14 | Sanofi Aventis Sa | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique |
| WO2008008432A2 (en) | 2006-07-12 | 2008-01-17 | Coley Pharmaceutical Group, Inc. | Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods |
| US8178539B2 (en) * | 2006-09-06 | 2012-05-15 | 3M Innovative Properties Company | Substituted 3,4,6,7-tetrahydro-5H-1,2a,4a,8-tetraazacyclopenta[cd]phenalenes and methods |
| TW200827340A (en) * | 2006-11-10 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
| US20080149123A1 (en) | 2006-12-22 | 2008-06-26 | Mckay William D | Particulate material dispensing hairbrush with combination bristles |
| WO2009125808A1 (ja) * | 2008-04-11 | 2009-10-15 | 第一三共株式会社 | アミノシクロヘキシル誘導体 |
| WO2009125809A1 (ja) * | 2008-04-11 | 2009-10-15 | 第一三共株式会社 | ピペリジン誘導体 |
| US8232409B2 (en) | 2008-10-15 | 2012-07-31 | Janssen Pharmaceutica N.V. | Heterocyclic benzimidazoles as TRPM8 modulators |
| CN102712640A (zh) * | 2010-01-12 | 2012-10-03 | 弗·哈夫曼-拉罗切有限公司 | 三环杂环化合物、其组合物和应用方法 |
| EP2397482A1 (en) | 2010-06-15 | 2011-12-21 | Almirall, S.A. | Heteroaryl imidazolone derivatives as jak inhibitors |
| RS55819B1 (sr) | 2010-08-17 | 2017-08-31 | 3M Innovative Properties Co | Kompozicije sa lipidiranim modifikatorom imuno-odgovora, formulacije, i postupci |
| MX347240B (es) | 2011-06-03 | 2017-04-20 | 3M Innovative Properties Co | Ligadores heterobifuncionales con segmentos polietilenglicol y conjugados modificadores de la respuesta inmunitaria elaborados a partir de los mismos. |
| MX355623B (es) | 2011-06-03 | 2018-04-25 | 3M Innovative Properties Co | Hidrazino-1h-imidazoquinolin-4-aminas y conjugados elaborados a partir de las mismas. |
| US8729263B2 (en) | 2012-08-13 | 2014-05-20 | Novartis Ag | 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions |
| SI2941233T1 (sl) | 2013-01-07 | 2021-01-29 | The Trustees Of The University Of Pennsylvania | Sestavki in postopki za zdravljenje kutanega T celičnega limfoma |
| WO2014139080A1 (en) * | 2013-03-12 | 2014-09-18 | Boehringer Ingelheim International Trading (Shanghai) Co., Ltd. | Novel process for the manufacture of 3-oxo-tetrahydrofuran |
| MX2020011652A (es) | 2013-07-31 | 2022-09-27 | Novartis Ag | Derivados de piridazina 1,4-disustituida, y su uso para el tratamiento de afecciones relacionadas con la deficiencia de smn. |
| US9920052B2 (en) | 2013-12-09 | 2018-03-20 | Ucb Biopharma Sprl | Imidazopyridine derivatives as modulators of TNF activity |
| WO2017040233A1 (en) | 2015-08-31 | 2017-03-09 | 3M Innovative Properties Company | GUANIDINE SUBSTITUTED IMIDAZO[4,5-c] RING COMPOUNDS |
| CN107922416B (zh) | 2015-08-31 | 2021-07-02 | 3M创新有限公司 | 含有取代的胍基团的咪唑并[4,5-c]环化合物 |
| EP3356371A4 (en) * | 2015-09-29 | 2020-06-24 | The University of Chicago | POLYMER CONJUGATE VACCINES |
| US10526309B2 (en) | 2015-10-02 | 2020-01-07 | The University Of North Carolina At Chapel Hill | Pan-TAM inhibitors and Mer/Axl dual inhibitors |
| AU2017292934B9 (en) | 2016-07-07 | 2024-08-29 | Bolt Biotherapeutics, Inc. | Antibody adjuvant conjugates |
| GB201617758D0 (en) * | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
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| JP7197244B2 (ja) | 2017-12-20 | 2022-12-27 | スリーエム イノベイティブ プロパティズ カンパニー | 免疫応答調節剤として使用するための分岐鎖連結基を有するアミド置換イミダゾ[4,5-c]キノリン化合物 |
| EP3759107B1 (en) * | 2018-02-28 | 2024-12-04 | Solventum Intellectual Properties Company | Substituted imidazo[4,5-c]quinoline compounds with an n-1 branched group |
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| TWI803637B (zh) | 2018-05-23 | 2023-06-01 | 美商輝瑞大藥廠 | 特異性針對gucy2c之抗體及其用途 |
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| US20220370606A1 (en) | 2018-12-21 | 2022-11-24 | Pfizer Inc. | Combination Treatments Of Cancer Comprising A TLR Agonist |
| EP3937984A1 (en) | 2019-03-15 | 2022-01-19 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| EP3946606B1 (en) | 2019-03-27 | 2025-01-01 | Insilico Medicine IP Limited | Bicyclic jak inhibitors and uses thereof |
| US11458163B2 (en) | 2019-04-17 | 2022-10-04 | University Of Kansas | Platinum(IV) conjugates and methods of use |
| KR20220068243A (ko) * | 2019-09-23 | 2022-05-25 | 난징 젱시앙 파마슈티칼스 컴퍼니 리미티드 | 포스포디에스테라제 억제제 및 용도 |
| KR20220114049A (ko) | 2019-12-17 | 2022-08-17 | 화이자 인코포레이티드 | Cd47, pd-l1에 특이적인 항체, 및 그의 용도 |
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-
2005
- 2005-06-17 EP EP05814989.9A patent/EP1765348B1/en not_active Expired - Lifetime
- 2005-06-17 US US11/570,707 patent/US7884207B2/en not_active Expired - Fee Related
- 2005-06-17 CA CA2571360A patent/CA2571360C/en not_active Expired - Fee Related
- 2005-06-17 AU AU2005283085A patent/AU2005283085B2/en not_active Ceased
- 2005-06-17 JP JP2007516773A patent/JP5128940B2/ja not_active Expired - Fee Related
- 2005-06-17 WO PCT/US2005/021445 patent/WO2006028545A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005283085B2 (en) | 2012-06-21 |
| WO2006028545A2 (en) | 2006-03-16 |
| EP1765348A2 (en) | 2007-03-28 |
| CA2571360C (en) | 2014-11-25 |
| EP1765348B1 (en) | 2016-08-03 |
| US20070287724A1 (en) | 2007-12-13 |
| CA2571360A1 (en) | 2006-03-16 |
| JP2008503484A (ja) | 2008-02-07 |
| US7884207B2 (en) | 2011-02-08 |
| WO2006028545A3 (en) | 2007-08-23 |
| EP1765348A4 (en) | 2010-05-26 |
| AU2005283085A1 (en) | 2006-03-16 |
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