JP5095414B2 - 眼の障害を処置するためのＣＴＧＦのＲＮＡｉ阻害 - Google Patents

眼の障害を処置するためのＣＴＧＦのＲＮＡｉ阻害 Download PDF

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JP5095414B2
JP5095414B2 JP2007548380A JP2007548380A JP5095414B2 JP 5095414 B2 JP5095414 B2 JP 5095414B2 JP 2007548380 A JP2007548380 A JP 2007548380A JP 2007548380 A JP2007548380 A JP 2007548380A JP 5095414 B2 JP5095414 B2 JP 5095414B2
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seq
sequence
interfering rna
antisense
nucleotides
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アラン アール． シェパード，
イオク−ホウ パン，
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アルコン，インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Biochemistry (AREA)
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  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007548380A 2004-12-23 2005-12-19 眼の障害を処置するためのＣＴＧＦのＲＮＡｉ阻害 Expired - Fee Related JP5095414B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63870504P 2004-12-23 2004-12-23
US60/638,705 2004-12-23
PCT/US2005/046064 WO2006069037A1 (en) 2004-12-23 2005-12-19 Rnai inhibition of ctgf for treatment of ocular disorders

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JP2012029499A Division JP2012097119A (ja) 2004-12-23 2012-02-14 眼の障害を処置するためのＣＴＧＦのＲＮＡｉ阻害

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JP2008525460A JP2008525460A (ja) 2008-07-17
JP2008525460A5 JP2008525460A5 (https=) 2009-02-12
JP5095414B2 true JP5095414B2 (ja) 2012-12-12

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JP2012029499A Withdrawn JP2012097119A (ja) 2004-12-23 2012-02-14 眼の障害を処置するためのＣＴＧＦのＲＮＡｉ阻害

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US (4) US7622454B2 (https=)
EP (2) EP1827503A1 (https=)
JP (2) JP5095414B2 (https=)
KR (1) KR20070091337A (https=)
CN (1) CN101160138B (https=)
AR (1) AR052172A1 (https=)
AU (1) AU2005319279B2 (https=)
BR (1) BRPI0516377A (https=)
CA (1) CA2591611A1 (https=)
MX (1) MX2007007654A (https=)
TW (1) TWI386225B (https=)
WO (1) WO2006069037A1 (https=)
ZA (1) ZA200704932B (https=)

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US20060166919A1 (en) 2006-07-27
CN101160138A (zh) 2008-04-09
ZA200704932B (en) 2008-11-26
CA2591611A1 (en) 2006-06-29
AU2005319279B2 (en) 2011-08-18
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AR052172A1 (es) 2007-03-07
AU2005319279A1 (en) 2006-06-29
US20100035969A1 (en) 2010-02-11
US7838507B2 (en) 2010-11-23
KR20070091337A (ko) 2007-09-10
US20140094502A1 (en) 2014-04-03
US20110028534A1 (en) 2011-02-03
JP2008525460A (ja) 2008-07-17
US7622454B2 (en) 2009-11-24
EP2319543A1 (en) 2011-05-11
TW200626721A (en) 2006-08-01
CN101160138B (zh) 2013-05-15
BRPI0516377A (pt) 2008-09-02
TWI386225B (zh) 2013-02-21

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