CN101160138B - RNAi抑制CTGF用于治疗眼科疾病 - Google Patents

RNAi抑制CTGF用于治疗眼科疾病 Download PDF

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Publication number
CN101160138B
CN101160138B CN2005800479231A CN200580047923A CN101160138B CN 101160138 B CN101160138 B CN 101160138B CN 2005800479231 A CN2005800479231 A CN 2005800479231A CN 200580047923 A CN200580047923 A CN 200580047923A CN 101160138 B CN101160138 B CN 101160138B
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sirna
mrna
rna
ctgf
sequence
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CN101160138A (zh
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A·R·谢帕德
彭玉豪
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Alcon Inc
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Dermatology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2005800479231A 2004-12-23 2005-12-19 RNAi抑制CTGF用于治疗眼科疾病 Expired - Fee Related CN101160138B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63870504P 2004-12-23 2004-12-23
US60/638,705 2004-12-23
PCT/US2005/046064 WO2006069037A1 (en) 2004-12-23 2005-12-19 Rnai inhibition of ctgf for treatment of ocular disorders

Publications (2)

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CN101160138A CN101160138A (zh) 2008-04-09
CN101160138B true CN101160138B (zh) 2013-05-15

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CN2005800479231A Expired - Fee Related CN101160138B (zh) 2004-12-23 2005-12-19 RNAi抑制CTGF用于治疗眼科疾病

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US (4) US7622454B2 (https=)
EP (2) EP1827503A1 (https=)
JP (2) JP5095414B2 (https=)
KR (1) KR20070091337A (https=)
CN (1) CN101160138B (https=)
AR (1) AR052172A1 (https=)
AU (1) AU2005319279B2 (https=)
BR (1) BRPI0516377A (https=)
CA (1) CA2591611A1 (https=)
MX (1) MX2007007654A (https=)
TW (1) TWI386225B (https=)
WO (1) WO2006069037A1 (https=)
ZA (1) ZA200704932B (https=)

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US20060166919A1 (en) 2006-07-27
CN101160138A (zh) 2008-04-09
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AR052172A1 (es) 2007-03-07
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US20100035969A1 (en) 2010-02-11
US7838507B2 (en) 2010-11-23
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US20140094502A1 (en) 2014-04-03
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