JP5054278B2 - 作用物質塩の溶融押出 - Google Patents

作用物質塩の溶融押出 Download PDF

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Publication number
JP5054278B2
JP5054278B2 JP2003570829A JP2003570829A JP5054278B2 JP 5054278 B2 JP5054278 B2 JP 5054278B2 JP 2003570829 A JP2003570829 A JP 2003570829A JP 2003570829 A JP2003570829 A JP 2003570829A JP 5054278 B2 JP5054278 B2 JP 5054278B2
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JP
Japan
Prior art keywords
weight
active substance
powder
acrylate
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2003570829A
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English (en)
Japanese (ja)
Other versions
JP2005526731A (ja
Inventor
ペーテライト ハンス−ウルリッヒ
マイアー クリスティアン
グリュツケ アンドレアス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roehm GmbH Darmstadt
Original Assignee
Evonik Roehm GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Roehm GmbH filed Critical Evonik Roehm GmbH
Publication of JP2005526731A publication Critical patent/JP2005526731A/ja
Application granted granted Critical
Publication of JP5054278B2 publication Critical patent/JP5054278B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Seasonings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
JP2003570829A 2002-02-27 2003-01-30 作用物質塩の溶融押出 Expired - Lifetime JP5054278B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10208344A DE10208344A1 (de) 2002-02-27 2002-02-27 Schmelzextrusion von Wirkstoffsalzen
DE10208344.4 2002-02-27
PCT/EP2003/000935 WO2003072083A2 (fr) 2002-02-27 2003-01-30 Extrusion de fusion de sels d'agents actifs

Publications (2)

Publication Number Publication Date
JP2005526731A JP2005526731A (ja) 2005-09-08
JP5054278B2 true JP5054278B2 (ja) 2012-10-24

Family

ID=27675020

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003570829A Expired - Lifetime JP5054278B2 (ja) 2002-02-27 2003-01-30 作用物質塩の溶融押出

Country Status (14)

Country Link
US (1) US8642089B2 (fr)
EP (1) EP1478344B1 (fr)
JP (1) JP5054278B2 (fr)
KR (1) KR100707712B1 (fr)
AT (1) ATE362754T1 (fr)
AU (1) AU2003210196A1 (fr)
BR (1) BRPI0307995B8 (fr)
CA (1) CA2474691C (fr)
DE (2) DE10208344A1 (fr)
ES (1) ES2286447T3 (fr)
IL (2) IL162082A0 (fr)
MX (1) MXPA04008345A (fr)
PL (1) PL204465B1 (fr)
WO (1) WO2003072083A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10239999A1 (de) * 2002-08-27 2004-03-04 Röhm GmbH & Co. KG Granulat oder Pulver zur Herstellung von Überzugs- und Bindemitteln für Arzneiformen
DE10304403A1 (de) 2003-01-28 2004-08-05 Röhm GmbH & Co. KG Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
JP2006028028A (ja) * 2004-07-12 2006-02-02 Teikoku Medix Kk 経口医薬組成物
JP2008525313A (ja) 2004-12-27 2008-07-17 エーザイ・アール・アンド・ディー・マネジメント株式会社 抗痴呆薬の安定化方法
PL1962808T3 (pl) * 2005-12-14 2011-03-31 Hoffmann La Roche Preparat proleku przeciw HCV
US20090317355A1 (en) * 2006-01-21 2009-12-24 Abbott Gmbh & Co. Kg, Abuse resistant melt extruded formulation having reduced alcohol interaction
US20100172989A1 (en) * 2006-01-21 2010-07-08 Abbott Laboratories Abuse resistant melt extruded formulation having reduced alcohol interaction
DE102007009242A1 (de) * 2007-02-22 2008-09-18 Evonik Röhm Gmbh Pellets mit magensaftresistenter Wirkstoff-Matix
DE102007026550A1 (de) 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
MX2010007645A (es) * 2008-01-11 2010-11-05 Cipla Ltd Forma de dosis farmaceutica solida.
TW200950776A (en) * 2008-01-24 2009-12-16 Abbott Gmbh & Co Kg Abuse resistant melt extruded formulation having reduced alcohol interaction
US9226907B2 (en) 2008-02-01 2016-01-05 Abbvie Inc. Extended release hydrocodone acetaminophen and related methods and uses thereof
KR101753222B1 (ko) 2014-12-12 2017-07-04 강원대학교산학협력단 용융압출하여 제조된 당귀-고체분산체 및 그 제조방법
WO2018111459A1 (fr) * 2016-12-14 2018-06-21 Dow Global Technologies Llc Procédé de génération de sels d'ingrédients pharmaceutiques actifs
MX2020012458A (es) 2018-05-24 2021-04-28 Celanese Eva Performance Polymers Llc Dispositivo implantable para liberacion sostenida de un compuesto de farmaco macromolecular.
CN111989068A (zh) 2018-05-24 2020-11-24 塞拉尼斯伊娃高性能聚合物公司 用于持续释放大分子药物化合物的可植入器件

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH668553A5 (de) * 1987-02-02 1989-01-13 Mepha Ag Arzneimittel mit verzoegerter wirkstofffreisetzung.
US5084278A (en) * 1989-06-02 1992-01-28 Nortec Development Associates, Inc. Taste-masked pharmaceutical compositions
WO1993007859A1 (fr) * 1991-10-23 1993-04-29 Warner-Lambert Company Nouveaux granules pharmaceutiques et procede de preparation
US5965161A (en) * 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
US5695781A (en) * 1995-03-01 1997-12-09 Hallmark Pharmaceuticals, Inc. Sustained release formulation containing three different types of polymers
WO1997045091A2 (fr) 1996-05-31 1997-12-04 Euro-Celtique, S.A. Formulations d'oxycodone a liberation prolongee sans effet sur l'etat alimente/a jeun
US6673367B1 (en) * 1998-12-17 2004-01-06 Euro-Celtique, S.A. Controlled/modified release oral methylphenidate formulations
DE19958007A1 (de) 1999-12-02 2001-06-07 Roehm Gmbh Spritzgußverfahren für (Meth)acrylat-Copolymere mit teritiären Ammoniumgruppen
DE50107641D1 (de) 2001-02-27 2005-11-10 Roehm Gmbh Überzugs- und bindemittel für arzneimittelformulierungen mit verbesserter lagerstabilität
DE10239999A1 (de) 2002-08-27 2004-03-04 Röhm GmbH & Co. KG Granulat oder Pulver zur Herstellung von Überzugs- und Bindemitteln für Arzneiformen

Also Published As

Publication number Publication date
MXPA04008345A (es) 2004-11-26
DE10208344A1 (de) 2003-09-04
KR100707712B1 (ko) 2007-04-16
JP2005526731A (ja) 2005-09-08
PL204465B1 (pl) 2010-01-29
WO2003072083A3 (fr) 2004-04-08
US8642089B2 (en) 2014-02-04
EP1478344B1 (fr) 2007-05-23
BRPI0307995B8 (pt) 2021-05-25
KR20040084936A (ko) 2004-10-06
US20040253314A1 (en) 2004-12-16
IL162082A0 (en) 2005-11-20
EP1478344A2 (fr) 2004-11-24
DE50307321D1 (de) 2007-07-05
CA2474691A1 (fr) 2003-09-04
AU2003210196A1 (en) 2003-09-09
BR0307995A (pt) 2004-12-07
ES2286447T3 (es) 2007-12-01
BRPI0307995B1 (pt) 2019-02-26
IL162082A (en) 2009-11-18
ATE362754T1 (de) 2007-06-15
PL370426A1 (en) 2005-05-30
CA2474691C (fr) 2011-04-19
WO2003072083A2 (fr) 2003-09-04

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