BR0307995A - Extrusão por fusão de sais de ingredientes ativos - Google Patents

Extrusão por fusão de sais de ingredientes ativos

Info

Publication number
BR0307995A
BR0307995A BR0307995-3A BR0307995A BR0307995A BR 0307995 A BR0307995 A BR 0307995A BR 0307995 A BR0307995 A BR 0307995A BR 0307995 A BR0307995 A BR 0307995A
Authority
BR
Brazil
Prior art keywords
active ingredient
granule
meth
comprised
melt extrusion
Prior art date
Application number
BR0307995-3A
Other languages
English (en)
Other versions
BRPI0307995B8 (pt
BRPI0307995B1 (pt
Inventor
Hans-Ulrich Petereit
Christian Meier
Andreas Gryczke
Original Assignee
R Hm Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R Hm Gmbh & Co Kg filed Critical R Hm Gmbh & Co Kg
Publication of BR0307995A publication Critical patent/BR0307995A/pt
Publication of BRPI0307995B1 publication Critical patent/BRPI0307995B1/pt
Publication of BRPI0307995B8 publication Critical patent/BRPI0307995B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Seasonings (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)

Abstract

"EXTRUSãO POR FUSãO DE SAIS DE INGREDIENTES ATIVOS". A invenção se refere a um processo para produção de grânulos ou pós contendo ingrediente ativo envolvendo as etapas que se seguem: a) fusão de uma mistura consistindo em um ingrediente farmaceuticamente ativo e um copolímero de (met)acrilato que compreende em 40 a 75% em peso de ésteres C~ 1~-C~ 4~ alquila radicalmente polimerizados de ácido acrílico ou de ácido metacrílico e podem ser compreendidos de 25 a 60% em peso de monómeros de (met)acrilato possuindo um grupo aniónico no radical alquila; b) extrusão da mistura e; c) trituração do extrusado para fornecer grânulos ou pós. O processo da invenção e caracterizado pelo fato de que o ingrediente ativo é o sal de uma substância alcalina e o valor do pH, que pode ser medido no pó ou grânulo obtido, é igual a ou inferior a pH 7,0. A invenção também se refere as formas de dosagem farmacêutica ou precursores das mesmas, que podem ser produzidas usando o processo da invenção.
BRPI0307995A 2002-02-27 2003-01-30 grânulos ou pós contendo ingrediente ativo, seu uso e processo de produção por meio de fusão de sais de ingredientes ativos BRPI0307995B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10208344A DE10208344A1 (de) 2002-02-27 2002-02-27 Schmelzextrusion von Wirkstoffsalzen
DE10208344.4 2002-02-27
PCT/EP2003/000935 WO2003072083A2 (de) 2002-02-27 2003-01-30 Schmelzextrusion von wirkstoffsalzen

Publications (3)

Publication Number Publication Date
BR0307995A true BR0307995A (pt) 2004-12-07
BRPI0307995B1 BRPI0307995B1 (pt) 2019-02-26
BRPI0307995B8 BRPI0307995B8 (pt) 2021-05-25

Family

ID=27675020

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0307995A BRPI0307995B8 (pt) 2002-02-27 2003-01-30 grânulos ou pós contendo ingrediente ativo, seu uso e processo de produção por meio de fusão de sais de ingredientes ativos

Country Status (14)

Country Link
US (1) US8642089B2 (pt)
EP (1) EP1478344B1 (pt)
JP (1) JP5054278B2 (pt)
KR (1) KR100707712B1 (pt)
AT (1) ATE362754T1 (pt)
AU (1) AU2003210196A1 (pt)
BR (1) BRPI0307995B8 (pt)
CA (1) CA2474691C (pt)
DE (2) DE10208344A1 (pt)
ES (1) ES2286447T3 (pt)
IL (2) IL162082A0 (pt)
MX (1) MXPA04008345A (pt)
PL (1) PL204465B1 (pt)
WO (1) WO2003072083A2 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10239999A1 (de) * 2002-08-27 2004-03-04 Röhm GmbH & Co. KG Granulat oder Pulver zur Herstellung von Überzugs- und Bindemitteln für Arzneiformen
DE10304403A1 (de) * 2003-01-28 2004-08-05 Röhm GmbH & Co. KG Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
JP2006028028A (ja) * 2004-07-12 2006-02-02 Teikoku Medix Kk 経口医薬組成物
US8481565B2 (en) 2004-12-27 2013-07-09 Eisai R&D Management Co., Ltd. Method for stabilizing anti-dementia drug
WO2007068615A2 (en) * 2005-12-14 2007-06-21 F. Hoffmann-La Roche Ag Hcv prodrug formulation
US20090317355A1 (en) * 2006-01-21 2009-12-24 Abbott Gmbh & Co. Kg, Abuse resistant melt extruded formulation having reduced alcohol interaction
US20100172989A1 (en) * 2006-01-21 2010-07-08 Abbott Laboratories Abuse resistant melt extruded formulation having reduced alcohol interaction
DE102007009242A1 (de) * 2007-02-22 2008-09-18 Evonik Röhm Gmbh Pellets mit magensaftresistenter Wirkstoff-Matix
DE102007026550A1 (de) 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
JP2011509283A (ja) * 2008-01-11 2011-03-24 シプラ・リミテッド 固体医薬剤形
TW200950776A (en) * 2008-01-24 2009-12-16 Abbott Gmbh & Co Kg Abuse resistant melt extruded formulation having reduced alcohol interaction
JP2011511782A (ja) 2008-02-12 2011-04-14 アボット・ラボラトリーズ 長期放出性ヒドロコドンアセトアミノフェンならびにその関連方法および用途
KR101753222B1 (ko) 2014-12-12 2017-07-04 강원대학교산학협력단 용융압출하여 제조된 당귀-고체분산체 및 그 제조방법
WO2018111459A1 (en) * 2016-12-14 2018-06-21 Dow Global Technologies Llc Method for generating salts of pharmaceutical active ingredients
JP2021524841A (ja) 2018-05-24 2021-09-16 セラニーズ・イーブイエイ・パフォーマンス・ポリマーズ・エルエルシー 高分子薬剤化合物の持続放出用の埋め込み型デバイス
MX2020012459A (es) 2018-05-24 2021-04-28 Celanese Eva Performance Polymers Llc Dispositivo implantable para liberacion sostenida de un compuesto de farmaco macromolecular.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH668553A5 (de) * 1987-02-02 1989-01-13 Mepha Ag Arzneimittel mit verzoegerter wirkstofffreisetzung.
US5084278A (en) * 1989-06-02 1992-01-28 Nortec Development Associates, Inc. Taste-masked pharmaceutical compositions
WO1993007859A1 (en) * 1991-10-23 1993-04-29 Warner-Lambert Company Novel pharmaceutical pellets and process for their production
US5965161A (en) * 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
US5695781A (en) * 1995-03-01 1997-12-09 Hallmark Pharmaceuticals, Inc. Sustained release formulation containing three different types of polymers
WO1997045091A2 (en) * 1996-05-31 1997-12-04 Euro-Celtique, S.A. Sustained release oxycodone formulations with no fed/fast effect
US6673367B1 (en) 1998-12-17 2004-01-06 Euro-Celtique, S.A. Controlled/modified release oral methylphenidate formulations
DE19958007A1 (de) 1999-12-02 2001-06-07 Roehm Gmbh Spritzgußverfahren für (Meth)acrylat-Copolymere mit teritiären Ammoniumgruppen
ES2248291T3 (es) 2001-02-27 2006-03-16 ROHM GMBH & CO. KG Agente de recubrimiento y aglutinante para formulaciones de medicamento con estabilidad al almcenamiento mejorada.
DE10239999A1 (de) 2002-08-27 2004-03-04 Röhm GmbH & Co. KG Granulat oder Pulver zur Herstellung von Überzugs- und Bindemitteln für Arzneiformen

Also Published As

Publication number Publication date
WO2003072083A3 (de) 2004-04-08
AU2003210196A1 (en) 2003-09-09
CA2474691A1 (en) 2003-09-04
ES2286447T3 (es) 2007-12-01
EP1478344B1 (de) 2007-05-23
ATE362754T1 (de) 2007-06-15
DE50307321D1 (de) 2007-07-05
KR20040084936A (ko) 2004-10-06
PL370426A1 (en) 2005-05-30
BRPI0307995B8 (pt) 2021-05-25
PL204465B1 (pl) 2010-01-29
CA2474691C (en) 2011-04-19
BRPI0307995B1 (pt) 2019-02-26
IL162082A (en) 2009-11-18
KR100707712B1 (ko) 2007-04-16
EP1478344A2 (de) 2004-11-24
US8642089B2 (en) 2014-02-04
US20040253314A1 (en) 2004-12-16
JP2005526731A (ja) 2005-09-08
WO2003072083A2 (de) 2003-09-04
JP5054278B2 (ja) 2012-10-24
DE10208344A1 (de) 2003-09-04
IL162082A0 (en) 2005-11-20
MXPA04008345A (es) 2004-11-26

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25D Requested change of name of applicant approved

Owner name: ROEHM GMBH (DE)

Free format text: NOME ALTERADO DE: ROEEHM GMBH AND CO. KG

B25D Requested change of name of applicant approved

Owner name: EVONIK ROEHM GMBH (DE)

Free format text: NOME ALTERADO DE: ROEHM GMBH

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07C Technical examination (opinion): republication [chapter 7.3 patent gazette]

Free format text: REFERENTE A RPI 2457, DE 06/02/2018

B09B Patent application refused [chapter 9.2 patent gazette]
B09T Decision of refusal: decision cancelled [chapter 9.2.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/02/2019, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/01/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B25D Requested change of name of applicant approved

Owner name: ROEHM GMBH (DE)

B25G Requested change of headquarter approved

Owner name: ROEHM GMBH (DE)

B25A Requested transfer of rights approved

Owner name: EVONIK DEGUSSA GMBH (DE)

B25D Requested change of name of applicant approved

Owner name: EVONIK OPERATIONS GMBH (DE)

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 30/01/2023