JP5053435B2 - Ｖｗｆプロペプチドから成熟ｖｗｆを産生するための方法。 - Google Patents

Ｖｗｆプロペプチドから成熟ｖｗｆを産生するための方法。 Download PDF

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Publication number
JP5053435B2
JP5053435B2 JP2010508442A JP2010508442A JP5053435B2 JP 5053435 B2 JP5053435 B2 JP 5053435B2 JP 2010508442 A JP2010508442 A JP 2010508442A JP 2010508442 A JP2010508442 A JP 2010508442A JP 5053435 B2 JP5053435 B2 JP 5053435B2
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Japan
Prior art keywords
vwf
furin
propeptide
mature
incubation
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JP2010508442A
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English (en)
Japanese (ja)
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JP2010527588A (ja
JP2010527588A5 (enExample
Inventor
ウォルフガング マント，
アルトゥール ミッテラー，
マインハルト ハスラシェール，
クリスタ マイアー，
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Baxter Healthcare SA
Baxter International Inc
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Baxter Healthcare SA
Baxter International Inc
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Publication of JP2010527588A5 publication Critical patent/JP2010527588A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2010508442A 2007-05-18 2008-05-16 Ｖｗｆプロペプチドから成熟ｖｗｆを産生するための方法。 Active JP5053435B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93089107P 2007-05-18 2007-05-18
US60/930,891 2007-05-18
PCT/US2008/006291 WO2008143977A1 (en) 2007-05-18 2008-05-16 Method for producing mature vwf from vwf pro-peptide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012164790A Division JP2012210226A (ja) 2007-05-18 2012-07-25 Ｖｗｆプロペプチドから成熟ｖｗｆを産生するための方法。

Publications (3)

Publication Number Publication Date
JP2010527588A JP2010527588A (ja) 2010-08-19
JP2010527588A5 JP2010527588A5 (enExample) 2012-03-08
JP5053435B2 true JP5053435B2 (ja) 2012-10-17

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ID=39666205

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010508442A Active JP5053435B2 (ja) 2007-05-18 2008-05-16 Ｖｗｆプロペプチドから成熟ｖｗｆを産生するための方法。
JP2012164790A Withdrawn JP2012210226A (ja) 2007-05-18 2012-07-25 Ｖｗｆプロペプチドから成熟ｖｗｆを産生するための方法。

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012164790A Withdrawn JP2012210226A (ja) 2007-05-18 2012-07-25 Ｖｗｆプロペプチドから成熟ｖｗｆを産生するための方法。

Country Status (16)

Country Link
US (1) US8058411B2 (enExample)
EP (1) EP2152735B1 (enExample)
JP (2) JP5053435B2 (enExample)
KR (1) KR101156263B1 (enExample)
CN (1) CN101679496B (enExample)
AU (1) AU2008254522B2 (enExample)
BR (1) BRPI0811649B8 (enExample)
CA (1) CA2684151A1 (enExample)
DK (1) DK2152735T3 (enExample)
ES (1) ES2539284T3 (enExample)
HU (1) HUE025257T2 (enExample)
MX (1) MX2009012387A (enExample)
NZ (1) NZ581582A (enExample)
PL (1) PL2152735T3 (enExample)
PT (1) PT2152735E (enExample)
WO (1) WO2008143977A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG191186A1 (en) * 2010-12-15 2013-07-31 Baxter Int Eluate collection using conductivity gradient
US20140276101A1 (en) * 2013-03-14 2014-09-18 Boston Scientific Scimed, Inc. Medical device for detecting a target and related methods of use
TWI666319B (zh) * 2014-08-12 2019-07-21 美商巴克斯歐塔公司 在分泌ｆｕｒｉｎ之哺乳動物表現系統中生產經完全加工且具功能性之因子Ｘ
CN111183151B (zh) 2017-06-23 2024-06-07 武田药品工业株式会社 因子viii亚种的纯化
MX2020009788A (es) * 2018-03-21 2020-12-09 Takeda Pharmaceuticals Co Separación de factor de von willebrand (vwf) y propéptido de factor de von willebrand (vwf) por métodos cromatográficos.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT404838B (de) * 1995-11-24 1999-03-25 Immuno Ag Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
AT407750B (de) 1999-02-19 2001-05-25 Immuno Ag Verfahren zur herstellung einer vwf-präparation
KR20070092754A (ko) * 2004-12-27 2007-09-13 백스터 인터내셔널 인코포레이티드 중합체 - 폰 빌레브란트 인자 - 접합체

Also Published As

Publication number Publication date
HK1144577A1 (en) 2011-02-25
AU2008254522A2 (en) 2010-02-18
EP2152735B1 (en) 2015-03-18
BRPI0811649A2 (pt) 2014-11-11
DK2152735T3 (en) 2015-04-20
CA2684151A1 (en) 2008-11-27
PL2152735T3 (pl) 2015-08-31
JP2010527588A (ja) 2010-08-19
US8058411B2 (en) 2011-11-15
EP2152735A1 (en) 2010-02-17
NZ581582A (en) 2012-02-24
HUE025257T2 (en) 2016-03-29
US20090029918A1 (en) 2009-01-29
JP2012210226A (ja) 2012-11-01
BRPI0811649B1 (pt) 2020-11-17
KR101156263B1 (ko) 2012-06-13
BRPI0811649B8 (pt) 2021-05-25
KR20100028042A (ko) 2010-03-11
MX2009012387A (es) 2010-02-10
AU2008254522A1 (en) 2008-11-27
WO2008143977A1 (en) 2008-11-27
ES2539284T3 (es) 2015-06-29
AU2008254522B2 (en) 2012-07-12
CN101679496B (zh) 2013-03-13
CN101679496A (zh) 2010-03-24
PT2152735E (pt) 2015-07-21

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