BRPI0811649B8 - método para produzir fator de von willebrand maduro a partir de pró-peptídeo de fator de von willebrand - Google Patents
método para produzir fator de von willebrand maduro a partir de pró-peptídeo de fator de von willebrandInfo
- Publication number
- BRPI0811649B8 BRPI0811649B8 BRPI0811649A BRPI0811649A BRPI0811649B8 BR PI0811649 B8 BRPI0811649 B8 BR PI0811649B8 BR PI0811649 A BRPI0811649 A BR PI0811649A BR PI0811649 A BRPI0811649 A BR PI0811649A BR PI0811649 B8 BRPI0811649 B8 BR PI0811649B8
- Authority
- BR
- Brazil
- Prior art keywords
- von willebrand
- willebrand factor
- propeptide
- mature
- vwf
- Prior art date
Links
- 108010047303 von Willebrand Factor Proteins 0.000 title abstract 6
- 102100036537 von Willebrand factor Human genes 0.000 title abstract 6
- 229960001134 von willebrand factor Drugs 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000003456 ion exchange resin Substances 0.000 abstract 2
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 2
- 102000004961 Furin Human genes 0.000 abstract 1
- 108090001126 Furin Proteins 0.000 abstract 1
- 238000010828 elution Methods 0.000 abstract 1
- 230000003100 immobilizing effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93089107P | 2007-05-18 | 2007-05-18 | |
| US60/930,891 | 2007-05-18 | ||
| PCT/US2008/006291 WO2008143977A1 (en) | 2007-05-18 | 2008-05-16 | Method for producing mature vwf from vwf pro-peptide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0811649A2 BRPI0811649A2 (pt) | 2014-11-11 |
| BRPI0811649B1 BRPI0811649B1 (pt) | 2020-11-17 |
| BRPI0811649B8 true BRPI0811649B8 (pt) | 2021-05-25 |
Family
ID=39666205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0811649A BRPI0811649B8 (pt) | 2007-05-18 | 2008-05-16 | método para produzir fator de von willebrand maduro a partir de pró-peptídeo de fator de von willebrand |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8058411B2 (enExample) |
| EP (1) | EP2152735B1 (enExample) |
| JP (2) | JP5053435B2 (enExample) |
| KR (1) | KR101156263B1 (enExample) |
| CN (1) | CN101679496B (enExample) |
| AU (1) | AU2008254522B2 (enExample) |
| BR (1) | BRPI0811649B8 (enExample) |
| CA (1) | CA2684151A1 (enExample) |
| DK (1) | DK2152735T3 (enExample) |
| ES (1) | ES2539284T3 (enExample) |
| HU (1) | HUE025257T2 (enExample) |
| MX (1) | MX2009012387A (enExample) |
| NZ (1) | NZ581582A (enExample) |
| PL (1) | PL2152735T3 (enExample) |
| PT (1) | PT2152735E (enExample) |
| WO (1) | WO2008143977A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG191186A1 (en) * | 2010-12-15 | 2013-07-31 | Baxter Int | Eluate collection using conductivity gradient |
| US20140276101A1 (en) * | 2013-03-14 | 2014-09-18 | Boston Scientific Scimed, Inc. | Medical device for detecting a target and related methods of use |
| TWI666319B (zh) * | 2014-08-12 | 2019-07-21 | 美商巴克斯歐塔公司 | 在分泌ｆｕｒｉｎ之哺乳動物表現系統中生產經完全加工且具功能性之因子Ｘ |
| CN111183151B (zh) | 2017-06-23 | 2024-06-07 | 武田药品工业株式会社 | 因子viii亚种的纯化 |
| MX2020009788A (es) * | 2018-03-21 | 2020-12-09 | Takeda Pharmaceuticals Co | Separación de factor de von willebrand (vwf) y propéptido de factor de von willebrand (vwf) por métodos cromatográficos. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT404838B (de) * | 1995-11-24 | 1999-03-25 | Immuno Ag | Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen |
| AT407750B (de) | 1999-02-19 | 2001-05-25 | Immuno Ag | Verfahren zur herstellung einer vwf-präparation |
| KR20070092754A (ko) * | 2004-12-27 | 2007-09-13 | 백스터 인터내셔널 인코포레이티드 | 중합체 - 폰 빌레브란트 인자 - 접합체 |
-
2008
- 2008-05-16 JP JP2010508442A patent/JP5053435B2/ja active Active
- 2008-05-16 PL PL08754504T patent/PL2152735T3/pl unknown
- 2008-05-16 EP EP08754504.2A patent/EP2152735B1/en active Active
- 2008-05-16 CN CN2008800163745A patent/CN101679496B/zh active Active
- 2008-05-16 AU AU2008254522A patent/AU2008254522B2/en active Active
- 2008-05-16 HU HUE08754504A patent/HUE025257T2/en unknown
- 2008-05-16 DK DK08754504T patent/DK2152735T3/en active
- 2008-05-16 ES ES08754504.2T patent/ES2539284T3/es active Active
- 2008-05-16 PT PT87545042T patent/PT2152735E/pt unknown
- 2008-05-16 KR KR1020097026328A patent/KR101156263B1/ko active Active
- 2008-05-16 BR BRPI0811649A patent/BRPI0811649B8/pt active IP Right Grant
- 2008-05-16 NZ NZ581582A patent/NZ581582A/en unknown
- 2008-05-16 MX MX2009012387A patent/MX2009012387A/es active IP Right Grant
- 2008-05-16 US US12/152,762 patent/US8058411B2/en active Active
- 2008-05-16 WO PCT/US2008/006291 patent/WO2008143977A1/en not_active Ceased
- 2008-05-16 CA CA2684151A patent/CA2684151A1/en not_active Abandoned
-
2012
- 2012-07-25 JP JP2012164790A patent/JP2012210226A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| HK1144577A1 (en) | 2011-02-25 |
| AU2008254522A2 (en) | 2010-02-18 |
| EP2152735B1 (en) | 2015-03-18 |
| JP5053435B2 (ja) | 2012-10-17 |
| BRPI0811649A2 (pt) | 2014-11-11 |
| DK2152735T3 (en) | 2015-04-20 |
| CA2684151A1 (en) | 2008-11-27 |
| PL2152735T3 (pl) | 2015-08-31 |
| JP2010527588A (ja) | 2010-08-19 |
| US8058411B2 (en) | 2011-11-15 |
| EP2152735A1 (en) | 2010-02-17 |
| NZ581582A (en) | 2012-02-24 |
| HUE025257T2 (en) | 2016-03-29 |
| US20090029918A1 (en) | 2009-01-29 |
| JP2012210226A (ja) | 2012-11-01 |
| BRPI0811649B1 (pt) | 2020-11-17 |
| KR101156263B1 (ko) | 2012-06-13 |
| KR20100028042A (ko) | 2010-03-11 |
| MX2009012387A (es) | 2010-02-10 |
| AU2008254522A1 (en) | 2008-11-27 |
| WO2008143977A1 (en) | 2008-11-27 |
| ES2539284T3 (es) | 2015-06-29 |
| AU2008254522B2 (en) | 2012-07-12 |
| CN101679496B (zh) | 2013-03-13 |
| CN101679496A (zh) | 2010-03-24 |
| PT2152735E (pt) | 2015-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: BAXALTA GMBH (CH) , BAXALTA INCORPORATED (US) |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 17/11/2020, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/05/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
| B25A | Requested transfer of rights approved |
Owner name: TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) |
|
| B15V | Prolongation of time limit allowed |