BRPI0811649B8 - método para produzir fator de von willebrand maduro a partir de pró-peptídeo de fator de von willebrand - Google Patents

método para produzir fator de von willebrand maduro a partir de pró-peptídeo de fator de von willebrand

Info

Publication number
BRPI0811649B8
BRPI0811649B8 BRPI0811649A BRPI0811649A BRPI0811649B8 BR PI0811649 B8 BRPI0811649 B8 BR PI0811649B8 BR PI0811649 A BRPI0811649 A BR PI0811649A BR PI0811649 A BRPI0811649 A BR PI0811649A BR PI0811649 B8 BRPI0811649 B8 BR PI0811649B8
Authority
BR
Brazil
Prior art keywords
von willebrand
willebrand factor
propeptide
mature
vwf
Prior art date
Application number
BRPI0811649A
Other languages
English (en)
Inventor
Mitterer Artur
Mayer Christa
Hasslacher Meinhard
Mundt Wolfgang
Original Assignee
Baxalta GmbH
Baxalta Inc
Baxter Healthcare Sa
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta GmbH, Baxalta Inc, Baxter Healthcare Sa, Baxter Int filed Critical Baxalta GmbH
Publication of BRPI0811649A2 publication Critical patent/BRPI0811649A2/pt
Publication of BRPI0811649B1 publication Critical patent/BRPI0811649B1/pt
Publication of BRPI0811649B8 publication Critical patent/BRPI0811649B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

método para produzir fator de von willebrand maduro a partir de pró-pertídeo de fator de von willebrand, e, uso de um fator de von willebrand maduro. a presente invenção diz respeito a um método para produzir um fator von willebrand compreendendo as etapas: - imobilizar pró-peptídeo de vwf em uma resina de troca de íon, incubando o pró-peptídeo de vwf imobilizado com furina para obter vwf maduro imobilizado, e -isolar vwf maduro da resina de troca de íon por eluição.
BRPI0811649A 2007-05-18 2008-05-16 método para produzir fator de von willebrand maduro a partir de pró-peptídeo de fator de von willebrand BRPI0811649B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93089107P 2007-05-18 2007-05-18
US60/930,891 2007-05-18
PCT/US2008/006291 WO2008143977A1 (en) 2007-05-18 2008-05-16 Method for producing mature vwf from vwf pro-peptide

Publications (3)

Publication Number Publication Date
BRPI0811649A2 BRPI0811649A2 (pt) 2014-11-11
BRPI0811649B1 BRPI0811649B1 (pt) 2020-11-17
BRPI0811649B8 true BRPI0811649B8 (pt) 2021-05-25

Family

ID=39666205

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0811649A BRPI0811649B8 (pt) 2007-05-18 2008-05-16 método para produzir fator de von willebrand maduro a partir de pró-peptídeo de fator de von willebrand

Country Status (17)

Country Link
US (1) US8058411B2 (pt)
EP (1) EP2152735B1 (pt)
JP (2) JP5053435B2 (pt)
KR (1) KR101156263B1 (pt)
CN (1) CN101679496B (pt)
AU (1) AU2008254522B2 (pt)
BR (1) BRPI0811649B8 (pt)
CA (1) CA2684151A1 (pt)
DK (1) DK2152735T3 (pt)
ES (1) ES2539284T3 (pt)
HK (1) HK1144577A1 (pt)
HU (1) HUE025257T2 (pt)
MX (1) MX2009012387A (pt)
NZ (1) NZ581582A (pt)
PL (1) PL2152735T3 (pt)
PT (1) PT2152735E (pt)
WO (1) WO2008143977A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2652491B1 (en) * 2010-12-15 2017-11-29 Baxalta GmbH Eluate collection using conductivity gradient
US20140276101A1 (en) * 2013-03-14 2014-09-18 Boston Scientific Scimed, Inc. Medical device for detecting a target and related methods of use
TWI666319B (zh) * 2014-08-12 2019-07-21 美商巴克斯歐塔公司 在分泌ｆｕｒｉｎ之哺乳動物表現系統中生產經完全加工且具功能性之因子Ｘ
CN111183151B (zh) 2017-06-23 2024-06-07 武田药品工业株式会社 因子viii亚种的纯化
CA3094644A1 (en) * 2018-03-21 2019-09-26 Baxalta Incorporated Separation of vwf and vwf propeptide by chromatographic methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT404838B (de) * 1995-11-24 1999-03-25 Immuno Ag Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
AT407750B (de) 1999-02-19 2001-05-25 Immuno Ag Verfahren zur herstellung einer vwf-präparation
EP1835938B1 (en) * 2004-12-27 2013-08-07 Baxter International Inc. Polymer-von willebrand factor-conjugates

Also Published As

Publication number Publication date
PT2152735E (pt) 2015-07-21
KR20100028042A (ko) 2010-03-11
JP5053435B2 (ja) 2012-10-17
EP2152735A1 (en) 2010-02-17
AU2008254522A1 (en) 2008-11-27
CN101679496B (zh) 2013-03-13
ES2539284T3 (es) 2015-06-29
PL2152735T3 (pl) 2015-08-31
US20090029918A1 (en) 2009-01-29
WO2008143977A1 (en) 2008-11-27
JP2012210226A (ja) 2012-11-01
KR101156263B1 (ko) 2012-06-13
HK1144577A1 (en) 2011-02-25
NZ581582A (en) 2012-02-24
JP2010527588A (ja) 2010-08-19
BRPI0811649A2 (pt) 2014-11-11
US8058411B2 (en) 2011-11-15
CA2684151A1 (en) 2008-11-27
BRPI0811649B1 (pt) 2020-11-17
AU2008254522B2 (en) 2012-07-12
AU2008254522A2 (en) 2010-02-18
DK2152735T3 (en) 2015-04-20
CN101679496A (zh) 2010-03-24
MX2009012387A (es) 2010-02-10
HUE025257T2 (en) 2016-03-29
EP2152735B1 (en) 2015-03-18

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25A Requested transfer of rights approved

Owner name: BAXALTA GMBH (CH) , BAXALTA INCORPORATED (US)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 17/11/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/05/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B25A Requested transfer of rights approved

Owner name: TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP)

B15V Prolongation of time limit allowed