JP5015787B2 - マイクロニードルアレイの接触コーティング法 - Google Patents

マイクロニードルアレイの接触コーティング法 Download PDF

Info

Publication number
JP5015787B2
JP5015787B2 JP2007543312A JP2007543312A JP5015787B2 JP 5015787 B2 JP5015787 B2 JP 5015787B2 JP 2007543312 A JP2007543312 A JP 2007543312A JP 2007543312 A JP2007543312 A JP 2007543312A JP 5015787 B2 JP5015787 B2 JP 5015787B2
Authority
JP
Japan
Prior art keywords
coating
flexible film
microneedles
microneedle
microneedle array
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2007543312A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008520433A (ja
JP2008520433A5 (https=
Inventor
チョイ,ヒェ−オク
ピー. ナッソン,ゴードン
エム. デイビッド,モーゼス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of JP2008520433A publication Critical patent/JP2008520433A/ja
Publication of JP2008520433A5 publication Critical patent/JP2008520433A5/ja
Application granted granted Critical
Publication of JP5015787B2 publication Critical patent/JP5015787B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05DPROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D1/00Processes for applying liquids or other fluent materials
    • B05D1/28Processes for applying liquids or other fluent materials performed by transfer from the surfaces of elements carrying the liquid or other fluent material, e.g. brushes, pads, rollers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/20Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05DPROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D1/00Processes for applying liquids or other fluent materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicinal Preparation (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
JP2007543312A 2004-11-18 2005-11-18 マイクロニードルアレイの接触コーティング法 Expired - Lifetime JP5015787B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62918704P 2004-11-18 2004-11-18
US60/629,187 2004-11-18
PCT/US2005/041993 WO2006055844A2 (en) 2004-11-18 2005-11-18 Method of contact coating a microneedle array

Publications (3)

Publication Number Publication Date
JP2008520433A JP2008520433A (ja) 2008-06-19
JP2008520433A5 JP2008520433A5 (https=) 2009-01-08
JP5015787B2 true JP5015787B2 (ja) 2012-08-29

Family

ID=36130000

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007543312A Expired - Lifetime JP5015787B2 (ja) 2004-11-18 2005-11-18 マイクロニードルアレイの接触コーティング法

Country Status (9)

Country Link
US (2) US8414959B2 (https=)
EP (2) EP1827715B1 (https=)
JP (1) JP5015787B2 (https=)
KR (1) KR101246015B1 (https=)
CN (1) CN101076409B (https=)
AU (1) AU2005306372B2 (https=)
CA (1) CA2587387C (https=)
IL (1) IL183132A (https=)
WO (1) WO2006055844A2 (https=)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138719A2 (en) 2005-06-17 2006-12-28 Georgia Tech Research Corporation Coated microstructures and method of manufacture thereof
CA2614927A1 (en) * 2005-07-25 2007-02-01 Nanotechnology Victoria Pty Ltd Microarray device
US8554317B2 (en) 2005-11-30 2013-10-08 3M Innovative Properties Company Microneedle arrays and methods of use thereof
NL2001718C2 (nl) 2008-06-24 2009-12-28 Needle Holding B V U Micronaald, micronaaldarray en fabricagewerkwijze daarvoor.
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
RU2570280C2 (ru) * 2010-04-28 2015-12-10 Кимберли-Кларк Ворлдвайд, Инк. Композитная матрица микроигл, содержащая на поверхности наноструктуры
WO2012075339A1 (en) * 2010-12-02 2012-06-07 Lanco Biosciences, Inc. Delivery of heparins by microinjection systems
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
WO2013166162A1 (en) 2012-05-01 2013-11-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
CN103386164B (zh) * 2012-05-08 2015-11-04 中国科学院理化技术研究所 实心微针阵列器件载药的方法及装置
AU2013301312A1 (en) 2012-08-06 2015-03-19 Glaxosmithkline Biologicals S.A. Method for eliciting in infants an immune response against RSV and B. pertussis
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
WO2014073531A1 (ja) * 2012-11-09 2014-05-15 凸版印刷株式会社 針状構造体及びその製造方法
MX2016001695A (es) 2013-08-05 2016-05-02 Glaxosmithkline Biolog Sa Composiciones inmunogenas de combinacion.
AU2015253257B2 (en) * 2014-04-30 2019-09-26 Sorrento Therapeutics, Inc. Draped microneedle array
MX384992B (es) 2014-06-13 2025-03-14 Glaxosmithkline Biologicals Sa Combinaciones inmunógenas.
WO2016018148A1 (en) 2014-07-30 2016-02-04 Biomarque B.V. Biosensor comprising a modified metal surface and method for the modification of a metal surface
WO2016052108A1 (ja) * 2014-09-29 2016-04-07 日本写真印刷株式会社 成形体の製造装置及び成形体の製造方法
AU2016211916B2 (en) * 2015-01-27 2018-10-18 3M Innovative Properties Company Alum-containing coating formulations for microneedle vaccine patches
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
KR101676861B1 (ko) * 2015-04-10 2016-11-17 씨앤텍 주식회사 마이크로 니들 패치 제조장치와 방법, 및 이에 의해 제조되는 마이크로 니들 패치
WO2017062727A1 (en) 2015-10-09 2017-04-13 3M Innovative Properties Company Zinc compositions for coated microneedle arrays
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
WO2017120322A1 (en) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
US10568937B2 (en) 2016-04-18 2020-02-25 Radius Health, Inc. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
US11116955B2 (en) 2017-02-24 2021-09-14 Hisamitsu Pharmaceutical Co., Inc. Method for producing microneedle device
EP3616744A4 (en) * 2017-04-27 2020-05-27 Think-Lands Co., Ltd. PROCESS FOR PRODUCING MICRO NEEDLES
US11460411B2 (en) 2018-06-18 2022-10-04 Kindeva Drug Delivery L.P. Process and apparatus for inspecting microneedle arrays
KR102039582B1 (ko) * 2018-12-12 2019-11-01 주식회사 라파스 인장 공정으로 제조하기에 적합한 마이크로니들 재료의 적합성 시험 방법 및 이를 포함하는 마이크로니들 제조 방법
JP2022531307A (ja) * 2019-05-02 2022-07-06 アイソレーション バイオ インコーポレイテッド 親水性マイクロウェルおよび疎水性間隙空間を有する微細加工装置
AU2020275934B2 (en) 2019-05-16 2025-09-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Microneedle arrays with undercut features for cutaneous and non-cutaneous drug delivery
CN110270007A (zh) * 2019-07-15 2019-09-24 上海交通大学 一种担载生物分子微针及其制备方法
CN113116718B (zh) * 2021-03-26 2023-03-07 上海长征医院 一种用于防治呕吐的穴位埋针复合装置及其包装板
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US12214346B2 (en) 2021-10-13 2025-02-04 Satio, Inc. Dermal patch with a diagnostic test strip
US12023156B2 (en) 2021-10-13 2024-07-02 Satio, Inc. Dermal patch for collecting a physiological sample
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US11452474B1 (en) 2021-04-14 2022-09-27 Satio, Inc. Dual lever dermal patch system
US12053284B2 (en) 2021-11-08 2024-08-06 Satio, Inc. Dermal patch for collecting a physiological sample
US12178979B2 (en) 2021-10-13 2024-12-31 Satio, Inc. Dermal patch for delivering a pharmaceutical
US12048543B2 (en) 2021-11-08 2024-07-30 Satio, Inc. Dermal patch for collecting a physiological sample with removable vial
CN115674522B (zh) * 2021-07-28 2025-11-28 上海悦肤达生物科技有限公司 制备微针的设备和方法
CN116920260A (zh) * 2023-07-19 2023-10-24 北京化工大学 一种可准确控制涂层高度并易于批量化制备涂层微针的方法

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE25637E (en) 1964-09-08 Means for vaccinating
US2619962A (en) 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US3072122A (en) 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3136314A (en) 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3221740A (en) 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3470011A (en) * 1967-02-07 1969-09-30 American Cyanamid Co Process for applying liquid biologicals to applicators for intracutaneous injection
US3466131A (en) 1967-09-07 1969-09-09 Becton Dickinson Co Dispensing applicator package
US3675766A (en) 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
US3688764A (en) 1970-08-20 1972-09-05 Bard Hamilton Co Inc Intracutaneous injection system
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
US4473083A (en) 1981-12-14 1984-09-25 Maganias Nicholas H Device and method for allergy testing
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US5192535A (en) 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5402798A (en) 1991-07-18 1995-04-04 Swierczek; Remi Disposable skin perforator and blood testing device
US5340572A (en) 1993-02-08 1994-08-23 Insite Vision Incorporated Alkaline ophthalmic suspensions
US5440446A (en) 1993-10-04 1995-08-08 Catalina Coatings, Inc. Acrylate coating material
US5611806A (en) 1994-05-23 1997-03-18 Samsung Electro-Mechanics Co., Ltd. Skin perforating device for transdermal medication
AU3758595A (en) 1994-09-30 1996-04-26 Rutgers, The State University Direct introduction of foreign materials into cells
WO1996037155A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
AU5869796A (en) 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
CA2253549C (en) 1996-06-18 2005-10-25 Alza Corporation Device for enhancing transdermal agent delivery or sampling
US5983136A (en) 1996-09-17 1999-11-09 Deka Products Limited Partnership System for delivery of drugs by transport
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US6171276B1 (en) 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
ES2314995T3 (es) 1997-12-11 2009-03-16 Alza Corporation Dispositivo para mejorar el flujo de agentes tansdermicos.
DE69806963T2 (de) 1997-12-11 2002-11-21 Alza Corp., Mountain View Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
CA2229522A1 (en) 1998-04-15 1999-10-15 Thomas Randall Inkpen Needle aid
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
EP1086214B1 (en) 1998-06-10 2009-11-25 Georgia Tech Research Corporation Microneedle devices and methods of their manufacture
US6532386B2 (en) 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
US6713291B2 (en) 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
EP1163024B1 (en) 1999-01-28 2003-12-17 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
TW480759B (en) 1999-03-18 2002-03-21 Seiko Epson Corp Electronic machine, charged electronic machine and control method of electronic machine
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US20020095134A1 (en) 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
CN101238998A (zh) 1999-11-15 2008-08-13 维尔克工业有限公司 皮肤附着件
US6696157B1 (en) * 2000-03-05 2004-02-24 3M Innovative Properties Company Diamond-like glass thin films
US6881538B1 (en) 2000-03-05 2005-04-19 3M Innovative Properties Company Array comprising diamond-like glass film
US6595947B1 (en) 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US7473244B2 (en) 2000-06-02 2009-01-06 The University Of Utah Research Foundation Active needle devices with integrated functionality
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US7141034B2 (en) 2000-06-08 2006-11-28 Altea Therapeutics Corporation Transdermal drug delivery device, method of making same and method of using same
US6589202B1 (en) 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6749575B2 (en) 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
JP5507030B2 (ja) 2000-09-08 2014-05-28 アルザ・コーポレーシヨン 経路閉鎖を阻害することによる経皮的薬物流動の減少の抑制方法
ATE416692T1 (de) 2000-10-13 2008-12-15 Alza Corp Mikronadelelementhalter für schlagapplikator
PL360978A1 (en) 2000-10-13 2004-09-20 Alza Corporation Microblade array impact applicator
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
NZ525551A (en) * 2000-10-26 2005-09-30 Alza Corp Transdermal drug delivery devices having coated microprotrusions
EP2578252B1 (en) 2000-11-30 2019-01-09 Valeritas, Inc. Device with substantially freely movable micro-probe over the housing
EP1345646A2 (en) 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2002074173A1 (en) * 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
ATE444773T1 (de) 2001-04-20 2009-10-15 Alza Corp Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält
US20020193729A1 (en) 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
CN1253220C (zh) 2001-06-29 2006-04-26 贝克顿迪肯森公司 通过微管在真皮内输入疫苗和基因治疗剂
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
JP2003105583A (ja) 2001-09-28 2003-04-09 Seiko Epson Corp 微細構造パターンを備えた構造体製造用母型及びそれを用いた前記構造体の製造方法、並びにこの製造方法によって製造された前記構造体
US6689100B2 (en) 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6908453B2 (en) 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
WO2003092785A1 (en) 2002-04-30 2003-11-13 Morteza Shirkhanzadeh Arrays of microneedles comprising porous calcium phosphate coating and bioactive agents
AU2003279641B2 (en) * 2002-06-28 2009-06-18 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
CN102872526A (zh) 2002-07-19 2013-01-16 3M创新有限公司 微针装置和微针施用设备
JP4691445B2 (ja) 2002-07-22 2011-06-01 ベクトン・ディキンソン・アンド・カンパニー パッチ状注入装置
US7422567B2 (en) 2002-08-29 2008-09-09 Becton, Dickinson And Company Microabrader with controlled abrasion features
EP1590034B1 (en) 2002-10-07 2014-05-14 Biovalve Technologies, Inc. Microneedle array patch
PL1638468T3 (pl) * 2003-06-30 2008-01-31 Alza Corp Sposób powlekania mikrowystępów do przekłuwania skóry
CN1845708A (zh) 2003-07-02 2006-10-11 阿尔扎公司 微突出物阵列免疫贴剂和方法
JP2007501071A (ja) 2003-08-04 2007-01-25 アルザ・コーポレーシヨン 経皮作用剤流率を向上させる方法および装置
MXPA06001373A (es) 2003-08-12 2006-05-15 Becton Dickinson Co Dispositivo de infusion similar a un parche.
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
BRPI0415466A (pt) 2003-10-24 2006-12-19 Alza Corp método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos
AU2004285481A1 (en) 2003-10-24 2005-05-12 Alza Corporation Apparatus and method for enhancing transdermal drug delivery
JP2007535337A (ja) 2003-10-28 2007-12-06 アルザ・コーポレーシヨン 被覆された微小突起による治療用ペプチドおよびタンパクのポリマー接合体の送達
AU2004292953A1 (en) 2003-11-21 2005-06-09 Alza Corporation Ultrasound assisted transdermal vaccine delivery method and system
US20080226699A1 (en) 2003-11-28 2008-09-18 Acrux Dds Pty Ltd Method and System for Rapid Transdermal Administration
RU2006119485A (ru) 2003-12-18 2008-01-27 Ново Нордиск А/С (DK) Струйное устройство для инъекций и способ ввода лекарств через кожу
EP1706171A1 (en) 2003-12-29 2006-10-04 3M Innovative Properties Company Medical devices and kits including same
US20070191761A1 (en) 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
US7627938B2 (en) * 2004-10-15 2009-12-08 Board Of Regents, The Univeristy Of Texas System Tapered hollow metallic microneedle array assembly and method of making and using the same

Also Published As

Publication number Publication date
AU2005306372B2 (en) 2011-01-06
CA2587387C (en) 2013-06-25
CA2587387A1 (en) 2006-05-26
JP2008520433A (ja) 2008-06-19
IL183132A (en) 2011-06-30
IL183132A0 (en) 2007-09-20
US8414959B2 (en) 2013-04-09
US8741377B2 (en) 2014-06-03
KR101246015B1 (ko) 2013-03-20
CN101076409B (zh) 2011-11-23
AU2005306372A1 (en) 2006-05-26
EP2388078A1 (en) 2011-11-23
EP1827715B1 (en) 2013-07-17
WO2006055844A2 (en) 2006-05-26
CN101076409A (zh) 2007-11-21
US20120114857A1 (en) 2012-05-10
EP2388078B1 (en) 2013-03-20
US20130216694A1 (en) 2013-08-22
WO2006055844A3 (en) 2006-09-21
EP1827715A2 (en) 2007-09-05
KR20070086222A (ko) 2007-08-27

Similar Documents

Publication Publication Date Title
JP5015787B2 (ja) マイクロニードルアレイの接触コーティング法
US8057842B2 (en) Method of contact coating a microneedle array
JP4927751B2 (ja) マイクロニードルアレイのコーティング方法
US6855372B2 (en) Method and apparatus for coating skin piercing microprojections
JP5419702B2 (ja) マイクロニードルデバイス
WO2007061964A1 (en) Methods for coating microneedles
US20080262416A1 (en) Microneedle Arrays and Methods of Preparing Same
KR102526228B1 (ko) 일본 뇌염 백신 함유 마이크로니들 어레이
WO2007059289A1 (en) Microneedle arrays and methods of preparing same

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081114

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20081114

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110405

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110705

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120508

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120607

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150615

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 5015787

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: R3D02

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term