JP5012505B2 - 抗肥満活性剤及び肥満抑制方法 - Google Patents
抗肥満活性剤及び肥満抑制方法 Download PDFInfo
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- JP5012505B2 JP5012505B2 JP2007517735A JP2007517735A JP5012505B2 JP 5012505 B2 JP5012505 B2 JP 5012505B2 JP 2007517735 A JP2007517735 A JP 2007517735A JP 2007517735 A JP2007517735 A JP 2007517735A JP 5012505 B2 JP5012505 B2 JP 5012505B2
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- Prior art keywords
- fucoxanthinol
- obesity
- fucoxanthin
- visceral fat
- activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Fertilizers (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Epoxy Compounds (AREA)
- Cosmetics (AREA)
Description
脂肪蓄積抑制効果:図3は、3T3−L1脂肪細胞の分化に伴う脂肪蓄積に及ぼすフコキサンチノールの影響を示した説明図である。縦軸は、オイルレッド0による細胞内脂質の定量の際のマイクロプレートリーダーを用いて測定される490nmの吸光値であり、この値が高いほど脂肪細胞が多いことを意味する。図3から明らかなように、前駆脂肪細胞(3T3−L1)は分化することより細胞内には多くの脂肪が蓄積されている。これに対して、フコキサンチノール添加によりその蓄積は顕著に抑制されていることが解かる。フコキサンチノールの添加量に比例して、その抑制効果が如実に現れている。この結果は、細胞レベルでのフコキサンチノールの抗肥満作用を示すものである。従って、フコキサンチノールを添加することは、フコキサンチノールを抗肥満活性剤として添加していることと同じ意味を有する。
動物と飼料:動物実験にはKK−Ayマウス(雌;3週齢)を用いた。試験餌料はAIN−93G組成に従って調製した。飼料中の脂質は動物13.5%にした。フコキサンチノール添加群では飼料油脂の0.2%をフコキサンチノールに置換した。飼料は、調製後直ちに真空パックして給餌まで−20℃以下に保存した。
Claims (5)
- フコキサンチノールを有効成分として成ることを特徴とする内臓脂肪軽減剤。
- フコキサンチノールを医薬品に添加して成ることを特徴とする請求項1記載の内臓脂肪軽減剤。
- 前記フコキサンチノールは生体から抽出したことを特徴とする請求項1又は2に記載の内臓脂肪軽減剤。
- 前記生体はホヤであることを特徴とする請求項3に記載の内臓脂肪軽減剤。
- ワカメから分取したフコキサンチンを添加したことを特徴とする請求項1乃至4の何れか一に記載の内臓脂肪軽減剤。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007517735A JP5012505B2 (ja) | 2005-05-24 | 2006-03-16 | 抗肥満活性剤及び肥満抑制方法 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005150490 | 2005-05-24 | ||
JP2005150490 | 2005-05-24 | ||
JP2007517735A JP5012505B2 (ja) | 2005-05-24 | 2006-03-16 | 抗肥満活性剤及び肥満抑制方法 |
PCT/JP2006/305239 WO2006126325A1 (ja) | 2005-05-24 | 2006-03-16 | 抗肥満活性剤及び肥満抑制方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2006126325A1 JPWO2006126325A1 (ja) | 2008-12-25 |
JP5012505B2 true JP5012505B2 (ja) | 2012-08-29 |
Family
ID=37451757
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007517735A Expired - Fee Related JP5012505B2 (ja) | 2005-05-24 | 2006-03-16 | 抗肥満活性剤及び肥満抑制方法 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20100093847A1 (ja) |
EP (1) | EP1884238B1 (ja) |
JP (1) | JP5012505B2 (ja) |
CA (1) | CA2609454A1 (ja) |
WO (1) | WO2006126325A1 (ja) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5099812B2 (ja) * | 2006-04-07 | 2012-12-19 | 株式会社カネカ | 血糖値上昇抑制剤 |
JP5223083B2 (ja) * | 2006-06-21 | 2013-06-26 | 国立大学法人京都大学 | 血管新生抑制剤 |
JP2008280281A (ja) * | 2007-05-10 | 2008-11-20 | Hokkaido Univ | 抗肥満活性剤 |
CN102040569B (zh) * | 2009-10-20 | 2012-11-07 | 北京绿色金可生物技术股份有限公司 | 类胡萝卜素衍生物及其制备方法和应用 |
WO2011152689A2 (ko) * | 2010-06-03 | 2011-12-08 | 주식회사 리스토어랩스 | 해조류 유래의 푸코산틴의 정제 방법 |
WO2011152692A2 (ko) * | 2010-06-03 | 2011-12-08 | 주식회사 리스토어랩스 | 푸코산틴을 포함하는 항-비만용 크림 조성물 |
JP2012001524A (ja) * | 2010-06-21 | 2012-01-05 | Kyoto Univ | 脂肪前駆細胞分化抑制剤 |
KR101484587B1 (ko) * | 2012-05-22 | 2015-01-26 | 경상대학교산학협력단 | 미역귀와 멍게껍질의 혼합물 추출액을 포함하는 아토피성 피부염 개선용 조성물 |
JP6399920B2 (ja) * | 2014-12-19 | 2018-10-03 | ライオン株式会社 | 体脂肪低減剤、体重減少促進剤、血中中性脂肪低減剤及び血中遊離脂肪酸低減剤 |
CN105087476B (zh) * | 2015-08-31 | 2018-12-07 | 中国医学科学院北京协和医院 | 3t3-l1前脂肪细胞系的诱导分化方法 |
JP2018008893A (ja) * | 2016-07-13 | 2018-01-18 | ライオン株式会社 | 高血糖抑制剤 |
JP7246965B2 (ja) * | 2019-02-20 | 2023-03-28 | オリザ油化株式会社 | サルコペニア肥満予防・改善剤 |
CN111264851A (zh) * | 2020-03-03 | 2020-06-12 | 河南省儿童医院郑州儿童医院 | Pws综合征靶向替代保健食品及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005503103A (ja) * | 2000-09-01 | 2005-02-03 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 単一炭素基質からのカロテノイドの製造 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4109511B2 (ja) | 2002-08-21 | 2008-07-02 | 株式会社小倉屋山本 | フコキサンチンの精製方法 |
US7070952B2 (en) | 2003-05-07 | 2006-07-04 | E. I. Du Pont Nemours And Company | Genes encoding carotenoid compounds |
-
2006
- 2006-03-16 EP EP06729236.7A patent/EP1884238B1/en not_active Not-in-force
- 2006-03-16 WO PCT/JP2006/305239 patent/WO2006126325A1/ja active Application Filing
- 2006-03-16 US US11/915,297 patent/US20100093847A1/en not_active Abandoned
- 2006-03-16 JP JP2007517735A patent/JP5012505B2/ja not_active Expired - Fee Related
- 2006-03-16 CA CA002609454A patent/CA2609454A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005503103A (ja) * | 2000-09-01 | 2005-02-03 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 単一炭素基質からのカロテノイドの製造 |
Also Published As
Publication number | Publication date |
---|---|
JPWO2006126325A1 (ja) | 2008-12-25 |
WO2006126325A1 (ja) | 2006-11-30 |
EP1884238A4 (en) | 2008-07-09 |
US20100093847A1 (en) | 2010-04-15 |
EP1884238B1 (en) | 2013-06-26 |
EP1884238A1 (en) | 2008-02-06 |
CA2609454A1 (en) | 2006-11-30 |
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