JP5010599B2 - アデノシンａ２ａ受容体のアゴニストであるプリン誘導体 - Google Patents
アデノシンａ２ａ受容体のアゴニストであるプリン誘導体 Download PDFInfo
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- JP5010599B2 JP5010599B2 JP2008521876A JP2008521876A JP5010599B2 JP 5010599 B2 JP5010599 B2 JP 5010599B2 JP 2008521876 A JP2008521876 A JP 2008521876A JP 2008521876 A JP2008521876 A JP 2008521876A JP 5010599 B2 JP5010599 B2 JP 5010599B2
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- Prior art keywords
- amino
- ethyl
- trans
- purin
- methyl
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Classifications
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
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- Endocrinology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0514809.3 | 2005-07-19 | ||
| GBGB0514809.3A GB0514809D0 (en) | 2005-07-19 | 2005-07-19 | Compounds |
| PCT/EP2006/007078 WO2007009757A1 (en) | 2005-07-19 | 2006-07-17 | Purine derivatives as agonists of the adenosine a2a receptor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009501746A JP2009501746A (ja) | 2009-01-22 |
| JP2009501746A5 JP2009501746A5 (https=) | 2009-08-27 |
| JP5010599B2 true JP5010599B2 (ja) | 2012-08-29 |
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| JP2008521876A Expired - Fee Related JP5010599B2 (ja) | 2005-07-19 | 2006-07-17 | アデノシンａ２ａ受容体のアゴニストであるプリン誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7985740B2 (https=) |
| EP (1) | EP1904512B1 (https=) |
| JP (1) | JP5010599B2 (https=) |
| AR (1) | AR054559A1 (https=) |
| ES (1) | ES2387404T3 (https=) |
| GB (1) | GB0514809D0 (https=) |
| PE (1) | PE20070179A1 (https=) |
| TW (1) | TW200740814A (https=) |
| WO (1) | WO2007009757A1 (https=) |
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| NZ556354A (en) * | 2001-10-01 | 2008-10-31 | Univ Virginia | 2-Propynyl adenosine analogs having A2A agonist activity and compositions thereof |
| AU2005267706B2 (en) * | 2004-08-02 | 2011-12-08 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity |
| GT200500281A (es) * | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
| GB0500785D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
| GB0523778D0 (en) * | 2005-11-23 | 2006-01-04 | Glaxo Group Ltd | Novel method |
| US8178509B2 (en) * | 2006-02-10 | 2012-05-15 | University Of Virginia Patent Foundation | Method to treat sickle cell disease |
| GB0607950D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
| PT2322525E (pt) * | 2006-04-21 | 2013-12-26 | Novartis Ag | Derivados de purina para utilização como agonistas do recetor de adenosina a2a |
| US8188063B2 (en) * | 2006-06-19 | 2012-05-29 | University Of Virginia Patent Foundation | Use of adenosine A2A modulators to treat spinal cord injury |
| US7906518B2 (en) * | 2006-06-27 | 2011-03-15 | Cbt Development Limited | Therapeutic compounds |
| EP1889846A1 (en) * | 2006-07-13 | 2008-02-20 | Novartis AG | Purine derivatives as A2a agonists |
| EP1903044A1 (en) * | 2006-09-14 | 2008-03-26 | Novartis AG | Adenosine Derivatives as A2A Receptor Agonists |
| CN101553459A (zh) * | 2006-11-10 | 2009-10-07 | 诺瓦提斯公司 | 环戊烯二醇单乙酸酯衍生物 |
| US8058259B2 (en) | 2007-12-20 | 2011-11-15 | University Of Virginia Patent Foundation | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists |
| AU2009231978C1 (en) | 2008-03-31 | 2014-01-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Purine derivatives as A3 adenosine receptor- selective agonists |
| US8916570B2 (en) | 2008-03-31 | 2014-12-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A3 adenosine receptor agonists and antagonists |
| EP2331542B1 (en) | 2008-08-01 | 2016-07-27 | The United States of America, as Represented by The Secretary, Department of Health and Human Services | A3 adenosine receptor antagonists and partial agonists |
| US9181253B2 (en) | 2008-08-01 | 2015-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adenosine receptor agonists, partial agonists, and antagonists |
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| US3796700A (en) | 1970-06-30 | 1974-03-12 | Takedo Chem Ind Ltd | Adenosine derivatives and the production thereof |
| DE2034785A1 (de) | 1970-07-14 | 1972-01-20 | Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof | Adenosin 5 carbonsäurederivate |
| US4224438A (en) | 1970-07-14 | 1980-09-23 | Boehringer Mannheim Gmbh | Adenosine-5'-carboxylic acid amides |
| CA1019727A (en) | 1971-03-18 | 1977-10-25 | Abbott Laboratories | Adenosine-5'-carboxylic acid amides |
| BE789773A (fr) | 1971-10-08 | 1973-04-06 | Schering Ag | Adenosines n6 -substituees et leur procede de |
| US3864483A (en) | 1972-03-22 | 1975-02-04 | Abbott Lab | Adenosine-5{40 -carboxylic acid amides |
| CA1082695A (en) | 1972-04-10 | 1980-07-29 | Francis E. Fischer | Process for preparing adenosine-5'-carboxamides |
| US3966917A (en) | 1974-07-30 | 1976-06-29 | Abbott Laboratories | Platelet aggregation inhibitors |
| DE2621470A1 (de) | 1976-05-14 | 1977-12-01 | Pharma Waldhof Gmbh & Co | Nucleosidcarbonsaeurenitrile und ihre derivate, und verfahren zu ihrer herstellung |
| US4167565A (en) | 1976-11-08 | 1979-09-11 | Abbott Laboratories | Adenosine-5'-carboxamides and method of use |
| AU8379182A (en) | 1981-06-04 | 1982-12-09 | Procter & Gamble Company, The | Composition of salicylates and purine derivatives |
| CA1239397A (en) | 1983-08-01 | 1988-07-19 | James A. Bristol | N.sup.6-substituted adenosines |
| DE3406533A1 (de) | 1984-02-23 | 1985-08-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten |
| EP0300144A3 (en) | 1984-04-18 | 1989-09-27 | Whitby Research Incorporated | N-6 alkyl substituted adenosine derivatives as cardiac vasodilators |
| US5310731A (en) | 1984-06-28 | 1994-05-10 | Whitby Research, Inc. | N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents |
| AU575438B2 (en) | 1984-10-26 | 1988-07-28 | Warner-Lambert Company | N6 - substituted deoxyribose analogues of adenosines |
| CA1254888A (en) | 1984-10-26 | 1989-05-30 | Bharat Trivedi | N.sup.6-bicycloadenosines |
| US4663313A (en) | 1984-10-26 | 1987-05-05 | Warner-Lambert Company | N6 -tricyclic adenosines for treating hypertension |
| US4738954A (en) | 1985-11-06 | 1988-04-19 | Warner-Lambert Company | Novel N6 -substituted-5'-oxidized adenosine analogs |
| US4755594A (en) | 1986-01-31 | 1988-07-05 | Warner-Lambert Company | N6 -substituted adenosines |
| US5106837A (en) | 1988-03-16 | 1992-04-21 | The Scripps Research Institute | Adenosine derivatives with therapeutic activity |
| US4757747A (en) | 1986-04-08 | 1988-07-19 | Vickers, Incorporated | Power transmission |
| JPH0696534B2 (ja) | 1986-04-25 | 1994-11-30 | ヘキストジヤパン株式会社 | 抗痴呆剤 |
| US4767747A (en) | 1986-08-28 | 1988-08-30 | Warner-Lambert Company | Method for treating congestive heart failure with N6 -acenaphthyl adenosine |
| WO1988003148A2 (en) | 1986-10-31 | 1988-05-05 | Warner-Lambert Company | Heteroaromatic derivatives of adenoside |
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| LU87181A1 (fr) | 1987-04-06 | 1988-11-17 | Sandoz Sa | Nouveaux derives de l'acide furannuronique,leur preparation et leur utilisation comme medicaments |
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| IE903747A1 (en) | 1989-10-19 | 1991-04-24 | Searle & Co | Method of treating gastrointestinal motility disorders |
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| KR927003044A (ko) | 1990-01-11 | 1992-12-17 | 크리스토퍼 케이. 미라벨리 | Rna 활성과 유전자 발현을 검출하고 조절하는 조성물 및 그 방법 |
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| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
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| AU654507B2 (en) | 1990-09-25 | 1994-11-10 | Rhone-Poulenc Rorer International (Holdings) Inc. | Compounds having antihypertensive and anti-ischemic properties |
| CA2100863A1 (en) | 1991-01-23 | 1992-07-24 | David A. Bullough | Adenosine kinase inhibitors |
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| PE20060272A1 (es) * | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
-
2005
- 2005-07-19 GB GBGB0514809.3A patent/GB0514809D0/en not_active Ceased
-
2006
- 2006-07-17 EP EP06791541A patent/EP1904512B1/en active Active
- 2006-07-17 PE PE2006000855A patent/PE20070179A1/es not_active Application Discontinuation
- 2006-07-17 AR ARP060103052A patent/AR054559A1/es not_active Application Discontinuation
- 2006-07-17 JP JP2008521876A patent/JP5010599B2/ja not_active Expired - Fee Related
- 2006-07-17 WO PCT/EP2006/007078 patent/WO2007009757A1/en not_active Ceased
- 2006-07-17 US US11/995,921 patent/US7985740B2/en not_active Expired - Fee Related
- 2006-07-17 TW TW095126065A patent/TW200740814A/zh unknown
- 2006-07-17 ES ES06791541T patent/ES2387404T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AR054559A1 (es) | 2007-06-27 |
| EP1904512A1 (en) | 2008-04-02 |
| US7985740B2 (en) | 2011-07-26 |
| TW200740814A (en) | 2007-11-01 |
| EP1904512B1 (en) | 2012-06-20 |
| PE20070179A1 (es) | 2007-03-06 |
| US20080214581A1 (en) | 2008-09-04 |
| WO2007009757A1 (en) | 2007-01-25 |
| JP2009501746A (ja) | 2009-01-22 |
| ES2387404T3 (es) | 2012-09-21 |
| GB0514809D0 (en) | 2005-08-24 |
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