JP4942643B2 - 部分的に付加された抗体およびそれらの結合体化方法 - Google Patents

部分的に付加された抗体およびそれらの結合体化方法 Download PDF

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JP4942643B2
JP4942643B2 JP2007502057A JP2007502057A JP4942643B2 JP 4942643 B2 JP4942643 B2 JP 4942643B2 JP 2007502057 A JP2007502057 A JP 2007502057A JP 2007502057 A JP2007502057 A JP 2007502057A JP 4942643 B2 JP4942643 B2 JP 4942643B2
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antibody
drug
cac10
drugs
conjugated
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JP2008500961A5 (https=
JP2008500961A (ja
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ステファン チャールズ アレー，
マイケル トルゴフ，
マイケル サン，
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シアトル ジェネティックス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
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JP2007502057A 2004-03-02 2005-03-02 部分的に付加された抗体およびそれらの結合体化方法 Expired - Lifetime JP4942643B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54947604P 2004-03-02 2004-03-02
US60/549,476 2004-03-02
PCT/US2005/007239 WO2005084390A2 (en) 2004-03-02 2005-03-02 Partially loaded antibodies and methods of their conjugation

Publications (3)

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JP2008500961A JP2008500961A (ja) 2008-01-17
JP2008500961A5 JP2008500961A5 (https=) 2008-04-17
JP4942643B2 true JP4942643B2 (ja) 2012-05-30

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US (2) US7837980B2 (https=)
EP (1) EP1725586B1 (https=)
JP (1) JP4942643B2 (https=)
AU (1) AU2005218642B2 (https=)
CA (1) CA2558399C (https=)
ES (1) ES2533695T3 (https=)
WO (1) WO2005084390A2 (https=)

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US9446160B2 (en) 2014-03-26 2016-09-20 Takimotogiken Kogyo Co., Ltd Chlorine dioxide gas generator
US9839710B1 (en) 2016-12-08 2017-12-12 Takimotogiken Kogyo Co., Ltd. Chlorine dioxide gas generator

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EP1392359B2 (en) 2001-05-11 2013-03-13 Ludwig Institute for Cancer Research Ltd. Specific binding proteins and uses thereof
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
US20050215472A1 (en) 2001-10-23 2005-09-29 Psma Development Company, Llc PSMA formulations and uses thereof
WO2003034903A2 (en) * 2001-10-23 2003-05-01 Psma Development Company, L.L.C. Psma antibodies and protein multimers
SI1545613T1 (sl) 2002-07-31 2011-11-30 Seattle Genetics Inc Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni
US7498298B2 (en) 2003-11-06 2009-03-03 Seattle Genetics, Inc. Monomethylvaline compounds capable of conjugation to ligands
AR059900A1 (es) 2006-03-17 2008-05-07 Genentech Inc Anticuerpos anti-tat226 e inmunoconjugados
WO2008070593A2 (en) 2006-12-01 2008-06-12 Seattle Genetics, Inc. Variant target binding agents and uses thereof
US9090693B2 (en) * 2007-01-25 2015-07-28 Dana-Farber Cancer Institute Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
ES2542152T3 (es) 2007-03-15 2015-07-31 Ludwig Institute For Cancer Research Ltd. Método de tratamiento que emplea anticuerpos de EGFR e inhibidores de Src y formulaciones relacionadas
DK2474557T3 (da) 2007-07-16 2014-11-10 Genentech Inc Anti-CD79b-antistoffer og immunkonjugater og fremgangsmåder til anvendelse
NZ583318A (en) 2007-07-16 2012-07-27 Genentech Inc Humanized anti-cd79b antibodies and immunoconjugates and methods of use
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