JP4914005B2 - ストロンチウム−アパタイト−セメント調合物、およびその利用 - Google Patents

ストロンチウム−アパタイト−セメント調合物、およびその利用 Download PDF

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Publication number
JP4914005B2
JP4914005B2 JP2004510853A JP2004510853A JP4914005B2 JP 4914005 B2 JP4914005 B2 JP 4914005B2 JP 2004510853 A JP2004510853 A JP 2004510853A JP 2004510853 A JP2004510853 A JP 2004510853A JP 4914005 B2 JP4914005 B2 JP 4914005B2
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Prior art keywords
salt
strontium
bone
composition
phosphate
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Japanese (ja)
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JP2005531341A (ja
JP2005531341A5 (https=
Inventor
ローベルト ヴェンツ，
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カイフォン・ソシエテ・ア・レスポンサビリテ・リミテ
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0052—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with an inorganic matrix
    • A61L24/0063—Phosphorus containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/121—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L31/123—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B12/00—Cements not provided for in groups C04B7/00 - C04B11/00
    • C04B12/02—Phosphate cements
    • C04B12/025—Phosphates of ammonium or of the alkali or alkaline earth metals
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
    • C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
    • C04B28/344—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition solely as one or more phosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
    • C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
    • C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Ceramic Engineering (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Structural Engineering (AREA)
  • Composite Materials (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
  • Dental Preparations (AREA)
JP2004510853A 2002-06-07 2003-05-14 ストロンチウム−アパタイト−セメント調合物、およびその利用 Expired - Fee Related JP4914005B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10225420A DE10225420A1 (de) 2002-06-07 2002-06-07 Strontium-Apatit-Zement-Zubereitungen, die daraus gebildeten Zemente und die Verwendung davon
DE10225420.6 2002-06-07
PCT/EP2003/005059 WO2003103734A1 (de) 2002-06-07 2003-05-14 Strontium-apatit-zement-zubereitungen und deren verwendungen

Publications (3)

Publication Number Publication Date
JP2005531341A JP2005531341A (ja) 2005-10-20
JP2005531341A5 JP2005531341A5 (https=) 2006-06-15
JP4914005B2 true JP4914005B2 (ja) 2012-04-11

Family

ID=29594328

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004510853A Expired - Fee Related JP4914005B2 (ja) 2002-06-07 2003-05-14 ストロンチウム−アパタイト−セメント調合物、およびその利用

Country Status (9)

Country Link
EP (1) EP1511521B1 (https=)
JP (1) JP4914005B2 (https=)
KR (1) KR101061308B1 (https=)
CN (1) CN1323726C (https=)
AT (1) ATE391519T1 (https=)
AU (1) AU2003236650A1 (https=)
DE (2) DE10225420A1 (https=)
ES (1) ES2304515T3 (https=)
WO (1) WO2003103734A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10032220A1 (de) 2000-07-03 2002-01-24 Sanatis Gmbh Magnesium-ammonium-phosphat-Zemente, deren Herstellung und Verwendung
US7273523B2 (en) 2002-06-07 2007-09-25 Kyphon Inc. Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof
ES2394782T3 (es) 2003-05-07 2013-02-05 Osteologix A/S Composición con estroncio y vitamina D para la profilaxis y/o tratamiento de afecciones de cartílagos y/o huesos
EP1745791B1 (en) 2003-05-07 2013-06-26 Osteologix A/S Treating cartilage/bone conditions with water-soluble strontium salts
CA2557324C (en) 2004-02-26 2012-10-16 Osteologix A/S Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions
CN1292804C (zh) * 2004-03-08 2007-01-03 西安交通大学 含锶纳米磷酸钙生物活性骨水泥的制备工艺
KR20060134223A (ko) 2004-04-27 2006-12-27 키폰 인크. 뼈 대체 조성물 및 사용 방법
FR2869544B1 (fr) * 2004-05-03 2006-07-21 Centre Nat Rech Scient Cnrse Composition pour ciment injectable, utile comme substitut osseux
US7651701B2 (en) 2005-08-29 2010-01-26 Sanatis Gmbh Bone cement composition and method of making the same
US7754005B2 (en) 2006-05-02 2010-07-13 Kyphon Sarl Bone cement compositions comprising an indicator agent and related methods thereof
US7507286B2 (en) 2006-06-08 2009-03-24 Sanatis Gmbh Self-foaming cement for void filling and/or delivery systems
FR2903684B1 (fr) * 2006-07-12 2008-10-17 Centre Nat Rech Scient Nouveau compose phospho-calco-strontique et ses utilisations dans des ciments endodontiques.
CN101053673B (zh) * 2007-04-20 2010-11-10 西安交通大学 高强韧可降解磷酸锶钙复合骨水泥及其制备方法
ES2573327T3 (es) * 2007-04-23 2016-06-07 Baxter International Inc. Composiciones de fibrina que contienen compuestos de estroncio
US20080317807A1 (en) * 2007-06-22 2008-12-25 The University Of Hong Kong Strontium fortified calcium nano-and microparticle compositions and methods of making and using thereof
US7968616B2 (en) 2008-04-22 2011-06-28 Kyphon Sarl Bone cement composition and method
CN101623514B (zh) * 2009-08-07 2013-04-10 陕西科技大学 一种金属离子掺杂纳米羟基磷灰石的制备方法
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
TWI453174B (zh) * 2010-10-19 2014-09-21 Univ Nat Cheng Kung 骨水泥配方及由其製備的生物可吸收的硬化骨水泥複合材料
CN102430147B (zh) * 2011-09-02 2013-11-06 浙江大学 可生物降解的生物活性掺锶硫酸钙材料、制备方法及应用
WO2013063580A1 (en) * 2011-10-28 2013-05-02 Baxter International Inc. Nonaqueous compositions for bone hemostasis, and methods for their use and manufacture
CZ305232B6 (cs) * 2013-08-28 2015-06-24 Vysoké Učení Technické V Brně Způsob přípravy a použití stroncium samaritého cementu
CN104147639B (zh) * 2014-08-06 2016-01-06 山东明德生物医学工程有限公司 含锶可注射骨水泥及制备方法
KR20170011455A (ko) 2015-07-23 2017-02-02 (주)아이디알 가습기능을 갖는 무드등
PL3777904T3 (pl) * 2019-08-16 2022-08-22 Universität Heidelberg Osteotropowy substytut kości
CN111848150B (zh) * 2020-07-09 2022-05-24 上海交通大学医学院附属第九人民医院 一种SrCuSi4O10－Ca3(PO4)2复合生物陶瓷、骨支架及其用途
CN114229813A (zh) * 2021-12-22 2022-03-25 中国科学院上海硅酸盐研究所 一种羟基磷酸锶超长纳米线及其制备方法和应用
CN116212117B (zh) * 2022-12-29 2025-04-22 西安交通大学 锶镁缓释磷灰石生物活性骨水泥及其制备工艺

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WO2001049327A2 (en) * 2000-01-03 2001-07-12 Hku/Hantak Ortho-Technology Limited Bioactive and osteoprorotic bone cement
JP2001527020A (ja) * 1997-12-23 2001-12-25 コミサリヤ・ア・レネルジ・アトミク 特に生物用途のアパタイトセラミックスの製造方法
WO2002002478A1 (de) * 2000-07-03 2002-01-10 Sanatis Gmbh Magnesium-ammonium-phosphat-zemente, deren herstellung und verwendung

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DE69123312T2 (de) * 1990-08-21 1997-03-20 Asahi Glass Co Ltd Kalziumphosphat Glaskeramik
EP0511868B1 (en) * 1991-05-01 1996-09-25 Chichibu Onoda Cement Corporation Medical or dental hardening compositions
ES2040626B1 (es) * 1991-11-22 1994-05-16 Boltong Maria G Procedimiento para la obtencion de cementos de fosfatos de calcio y su empleo como biomteriales.
DE19853832A1 (de) * 1998-11-21 2000-05-25 Merck Patent Gmbh Polyalkensäuren enthaltende Calcium-Phosphatzemente

Patent Citations (3)

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JP2001527020A (ja) * 1997-12-23 2001-12-25 コミサリヤ・ア・レネルジ・アトミク 特に生物用途のアパタイトセラミックスの製造方法
WO2001049327A2 (en) * 2000-01-03 2001-07-12 Hku/Hantak Ortho-Technology Limited Bioactive and osteoprorotic bone cement
WO2002002478A1 (de) * 2000-07-03 2002-01-10 Sanatis Gmbh Magnesium-ammonium-phosphat-zemente, deren herstellung und verwendung

Also Published As

Publication number Publication date
DE50309585D1 (de) 2008-05-21
ES2304515T3 (es) 2008-10-16
EP1511521B1 (de) 2008-04-09
KR101061308B1 (ko) 2011-08-31
ATE391519T1 (de) 2008-04-15
CN1658913A (zh) 2005-08-24
JP2005531341A (ja) 2005-10-20
KR20050016517A (ko) 2005-02-21
AU2003236650A1 (en) 2003-12-22
WO2003103734A1 (de) 2003-12-18
CN1323726C (zh) 2007-07-04
EP1511521A1 (de) 2005-03-09
DE10225420A1 (de) 2003-12-24

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