JP4895608B2 - 二官能性複合体の合成方法 - Google Patents

二官能性複合体の合成方法 Download PDF

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Publication number
JP4895608B2
JP4895608B2 JP2005501801A JP2005501801A JP4895608B2 JP 4895608 B2 JP4895608 B2 JP 4895608B2 JP 2005501801 A JP2005501801 A JP 2005501801A JP 2005501801 A JP2005501801 A JP 2005501801A JP 4895608 B2 JP4895608 B2 JP 4895608B2
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reaction
oligonucleotide
site
reactant
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JP2006515752A5 (https=
JP2006515752A (ja
Inventor
ペール−オラ・フレスクゴード
トーマス・フランク
アレックス・ハーア・ゴーリエフ
ミッケル・ディブロ・ルンドルフ
ヤコブ・フェルディング
エヴァ・カンプマン・オルセン
アネッテ・ホルトマン
セレン・ニベ・ヤコブセン
クリスティアン・サムス
サンネ・シュレーダー・グラズ
キム・ビルケベク・イェンセン
ヘンリク・ペダーセン
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Nuevolution AS
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Nuevolution AS
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/10—Nucleotidyl transfering
    • C12Q2521/101—DNA polymerase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/50—Other enzymatic activities
    • C12Q2521/501—Ligase
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C40B50/10—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support involving encoding steps
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
JP2005501801A 2002-10-30 2003-10-30 二官能性複合体の合成方法 Expired - Lifetime JP4895608B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US42216702P 2002-10-30 2002-10-30
DKPA200201652 2002-10-30
DKPA200201652 2002-10-30
US60/422,167 2002-10-30
US43442502P 2002-12-19 2002-12-19
DKPA200201955 2002-12-19
DKPA200201955 2002-12-19
US60/434,425 2002-12-19
US48619903P 2003-07-11 2003-07-11
DKPA200301064 2003-07-11
US60/486,199 2003-07-11
DKPA200301064 2003-07-11
PCT/DK2003/000739 WO2004039825A2 (en) 2002-10-30 2003-10-30 Method for the synthesis of a bifunctional complex

Related Child Applications (1)

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JP2010226107A Division JP5859723B2 (ja) 2002-10-30 2010-10-05 二官能性複合体の合成方法

Publications (3)

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JP2006515752A JP2006515752A (ja) 2006-06-08
JP2006515752A5 JP2006515752A5 (https=) 2010-12-16
JP4895608B2 true JP4895608B2 (ja) 2012-03-14

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JP2005501801A Expired - Lifetime JP4895608B2 (ja) 2002-10-30 2003-10-30 二官能性複合体の合成方法
JP2010226107A Expired - Lifetime JP5859723B2 (ja) 2002-10-30 2010-10-05 二官能性複合体の合成方法
JP2013155967A Expired - Lifetime JP5643398B2 (ja) 2002-10-30 2013-07-26 二官能性複合体の合成方法

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JP2010226107A Expired - Lifetime JP5859723B2 (ja) 2002-10-30 2010-10-05 二官能性複合体の合成方法
JP2013155967A Expired - Lifetime JP5643398B2 (ja) 2002-10-30 2013-07-26 二官能性複合体の合成方法

Country Status (17)

Country Link
US (8) US8206901B2 (https=)
EP (4) EP2348125B1 (https=)
JP (3) JP4895608B2 (https=)
CN (3) CN102838654B (https=)
AT (1) ATE513055T1 (https=)
AU (1) AU2003273792B2 (https=)
CA (2) CA3066572C (https=)
DK (4) DK2348125T3 (https=)
ES (3) ES2452566T3 (https=)
HU (1) HUE033651T2 (https=)
IL (2) IL207672A (https=)
LT (1) LT2348125T (https=)
NZ (1) NZ538993A (https=)
PT (3) PT2348125T (https=)
SI (3) SI2348125T1 (https=)
WO (1) WO2004039825A2 (https=)
ZA (1) ZA200502624B (https=)

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