JP4852211B2 - 原核生物における必須遺伝子の同定 - Google Patents
原核生物における必須遺伝子の同定 Download PDFInfo
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- JP4852211B2 JP4852211B2 JP2001569338A JP2001569338A JP4852211B2 JP 4852211 B2 JP4852211 B2 JP 4852211B2 JP 2001569338 A JP2001569338 A JP 2001569338A JP 2001569338 A JP2001569338 A JP 2001569338A JP 4852211 B2 JP4852211 B2 JP 4852211B2
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- Prior art keywords
- nucleic acid
- seq
- polypeptide
- cell
- gene product
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/255—Salmonella (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/26—Klebsiella (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Computational Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19107800P | 2000-03-21 | 2000-03-21 | |
| US60/191,078 | 2000-03-21 | ||
| US20684800P | 2000-05-23 | 2000-05-23 | |
| US60/206,848 | 2000-05-23 | ||
| US20772700P | 2000-05-26 | 2000-05-26 | |
| US60/207,727 | 2000-05-26 | ||
| US24257800P | 2000-10-23 | 2000-10-23 | |
| US60/242,578 | 2000-10-23 | ||
| US25362500P | 2000-11-27 | 2000-11-27 | |
| US60/253,625 | 2000-11-27 | ||
| US25793100P | 2000-12-22 | 2000-12-22 | |
| US60/257,931 | 2000-12-22 | ||
| US26930801P | 2001-02-16 | 2001-02-16 | |
| US60/269,308 | 2001-02-16 | ||
| PCT/US2001/009180 WO2001070955A2 (en) | 2000-03-21 | 2001-03-21 | Identification of essential genes in prokaryotes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004516805A JP2004516805A (ja) | 2004-06-10 |
| JP2004516805A5 JP2004516805A5 (https=) | 2008-04-24 |
| JP4852211B2 true JP4852211B2 (ja) | 2012-01-11 |
Family
ID=27569239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001569338A Expired - Fee Related JP4852211B2 (ja) | 2000-03-21 | 2001-03-21 | 原核生物における必須遺伝子の同定 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20020061569A1 (https=) |
| EP (1) | EP1268774A2 (https=) |
| JP (1) | JP4852211B2 (https=) |
| KR (1) | KR20020097200A (https=) |
| AU (1) | AU2001249345A1 (https=) |
| CA (1) | CA2404260A1 (https=) |
| WO (1) | WO2001070955A2 (https=) |
Families Citing this family (142)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0785268A1 (en) * | 1996-01-19 | 1997-07-23 | Smithkline Beecham Plc | Staphylococcus aureus methionyl-tRNA synthetase |
| US6800744B1 (en) * | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
| US7101692B2 (en) * | 1999-04-15 | 2006-09-05 | The Regents Of The University Of California | Identification of sortase gene |
| EP1233780A4 (en) * | 1999-04-15 | 2004-09-22 | Univ California | IDENTIFICATION OF THE SORTASE GENE |
| US7125698B2 (en) * | 1999-08-09 | 2006-10-24 | Matthew Glenn | Polynucleotides, materials incorporating them, and methods for using them |
| EP1222197A4 (en) * | 1999-10-04 | 2004-07-21 | Merck & Co Inc | MRAY GEN AND THE ENZYME OF PSEUDOMONAS AERUGINOSA |
| US6861516B1 (en) | 1999-10-04 | 2005-03-01 | Merck & Co., Inc. | MraY gene and enzyme of pseudomonas aeruginosa |
| US20020120408A1 (en) * | 2000-09-06 | 2002-08-29 | Kreiswirth Barry N. | System and method for tracking and controlling infections |
| US7349808B1 (en) | 2000-09-06 | 2008-03-25 | Egenomics, Inc. | System and method for tracking and controlling infections |
| CA2881568C (en) | 2000-10-27 | 2019-09-24 | Novartis Vaccines And Diagnostics, Inc. | Nucleic acids and proteins from streptococcus groups a & b |
| US20020107368A1 (en) * | 2000-12-07 | 2002-08-08 | Jing-Hui Tian | Helicobacter proteins, gene sequences and uses thereof |
| WO2002053761A2 (en) | 2000-12-28 | 2002-07-11 | Wyeth | Recombinant protective protein from $i(streptococcus pneumoniae) |
| AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| GB0107658D0 (en) * | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| AU2002307448A1 (en) * | 2001-04-20 | 2002-11-05 | President And Fellows Of Harvard College | Methods and compositions for the modulation of biofilm formation |
| WO2003025004A2 (en) * | 2001-09-18 | 2003-03-27 | Affinium Pharmaceuticals, Inc. | Purified bacterial polypeptides involved in nucleic acid processing |
| AU2002328225A1 (en) * | 2001-09-21 | 2003-04-01 | Affinium Pharmaceuticals, Inc. | Bacterial polypeptides involved in protein processing |
| WO2003045985A2 (en) * | 2001-11-26 | 2003-06-05 | Affinium Pharmaceuticals, Inc. | Purified polypeptides involved in carbohydrate and coenzyme metabolism |
| WO2003027274A2 (en) * | 2001-09-25 | 2003-04-03 | Affinium Pharmaceuticals, Inc. | Purified polypeptides from pseudomonas aeruginosa |
| EP1930420A1 (en) * | 2001-09-26 | 2008-06-11 | Merck & Co., Inc. | Isolated nucleic acid molecules encoding a bacterial uracil phosphoribosyl-transferase enzyme, cells transformed therewith and uses thereof |
| JP2005505276A (ja) | 2001-09-26 | 2005-02-24 | メルク エンド カムパニー インコーポレーテッド | 細菌ウラシル輸送体蛋白質及び細菌ウラシルホスホリボシルトランスフェラーゼ酵素をコードする単離核酸分子、前記核酸分子で形質転換した細胞とその使用 |
| US20040029129A1 (en) * | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
| EP1456380B1 (en) * | 2001-11-02 | 2012-04-18 | Giuliani International Limited | Smad7 inhibitors for the treatment of cns diseases |
| RU2229513C2 (ru) | 2001-11-23 | 2004-05-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения l-аминокислот, штамм escherichia coli - продуцент l-аминокислоты (варианты) |
| WO2003045986A2 (en) * | 2001-11-26 | 2003-06-05 | Affinium Pharmaceuticals, Inc. | Purified polypeptides involved in general metabolism as possible drug targets |
| TW200303919A (en) * | 2001-12-05 | 2003-09-16 | Hiroyuki Ohno | Cytotoxic protein and the use |
| US20030170694A1 (en) * | 2001-12-21 | 2003-09-11 | Daniel Wall | Stabilized nucleic acids in gene and drug discovery and methods of use |
| AU2003202378A1 (en) * | 2002-02-04 | 2003-09-02 | Affinium Pharmaceuticals, Inc. | Novel purified polypeptides from staphylococcus aureus |
| US6946267B2 (en) * | 2002-03-13 | 2005-09-20 | Dr. Chip Biotechnology Inc. | Method for detecting Staphylococcus aureus |
| US8691243B2 (en) | 2002-04-02 | 2014-04-08 | Ben-Gurion University Of The Negev Research And Development Authority | Protein-based Streptococcus pneumoniae vaccine |
| US20090252756A1 (en) * | 2002-04-02 | 2009-10-08 | Yaffa Mizrachi-Nebenzahl | Protein-based streptococcus pneumoniae vaccines |
| WO2003087353A2 (en) * | 2002-04-08 | 2003-10-23 | Affinium Pharmaceuticals, Inc. | Purified polypeptides involved in membrane biogenesis |
| WO2003087146A2 (en) * | 2002-04-08 | 2003-10-23 | Affinium Pharmaceuticals, Inc. | Purified polypeptides from s. aureus, h. pylori and e. coli involved in cellular transport and metabolism |
| AU2003218563A1 (en) * | 2002-04-09 | 2003-10-27 | Affinium Pharmaceuticals, Inc. | Enolase polypeptides and structures |
| AU2003218934A1 (en) * | 2002-04-17 | 2003-11-03 | Affinium Pharmaceuticals, Inc. | Purified (3r)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase polypeptide from pseudomonas aeruginosa |
| WO2003102544A2 (en) * | 2002-05-31 | 2003-12-11 | Cognosci, Inc. | Assays for measuring matrix metalloproteinase activities |
| AU2003229205A1 (en) * | 2002-05-31 | 2003-12-19 | Affinium Pharmaceuticals, Inc. | Bacterial polypeptides involved in viability |
| EP1552009A4 (en) * | 2002-07-17 | 2006-09-13 | Merck & Co Inc | METHOD FOR IDENTIFYING CELLULAR GROWTH INHIBITORS |
| WO2004013167A2 (en) * | 2002-08-01 | 2004-02-12 | Affinium Pharmaceuticals, Inc. | Purified polypeptides from enterococcus faecalis |
| AU2003278714A1 (en) * | 2002-08-20 | 2004-03-11 | Chiron Corporation | Random transposon insertion in staphylococcus aureus and use thereof to identify essential genes |
| US20070053924A1 (en) * | 2002-08-26 | 2007-03-08 | Herve Tettelin | Conserved and specific streptococcal genomes |
| FR2846668B1 (fr) * | 2002-11-05 | 2007-12-21 | Univ Aix Marseille Ii | Identification moleculaire des bacteries du genre streptococcus et genres apparentes |
| AU2003280250A1 (en) * | 2002-11-05 | 2004-06-07 | Affinium Pharmaceuticals, Inc. | Crystal structures of bacterial thymidylate kinases |
| WO2004041854A2 (en) * | 2002-11-05 | 2004-05-21 | Affinium Pharmaceuticals, Inc. | Essential novel bacterial polypeptides |
| WO2004081206A2 (en) * | 2003-03-12 | 2004-09-23 | Affinium Pharmaceuticals, Inc. | Novel polypeptides encoded by essential bacterial genes |
| WO2004058812A2 (en) * | 2002-12-26 | 2004-07-15 | Affinium Pharmaceuticals, Inc. | Ribose-phosphate pyrophosphokinase polypeptides and structures |
| AU2003287825A1 (en) * | 2002-12-31 | 2004-07-22 | Affinium Pharmaceuticals, Inc. | Crystal structures of nh3-dependent nad synthetases |
| ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| JP5642916B2 (ja) * | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| US20050026189A1 (en) * | 2003-05-29 | 2005-02-03 | Liangsu Wang | Microbial operons |
| ES2505695T3 (es) | 2003-07-31 | 2014-10-10 | Novartis Vaccines And Diagnostics, Inc. | Composiciones inmunógenas para Streptococcus pyogenes |
| US8945589B2 (en) * | 2003-09-15 | 2015-02-03 | Novartis Vaccines And Diagnostics, Srl | Immunogenic compositions for Streptococcus agalactiae |
| EP1670505B1 (en) * | 2003-09-18 | 2012-11-14 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Dna promoters and anthrax vaccines |
| AU2004274977B2 (en) | 2003-09-19 | 2011-06-23 | Epitopix, Llc | Campylobacter polypeptides and methods of use |
| US20050176033A1 (en) * | 2003-11-10 | 2005-08-11 | Klyachko Elena V. | Mutant phosphoribosylpyrophosphate synthetase and method for producing L-histidine |
| WO2005108626A2 (en) * | 2004-05-07 | 2005-11-17 | Replidyne, Inc. | Mutants of staphylococcal mrs and methods of use |
| JP2008507296A (ja) * | 2004-07-26 | 2008-03-13 | ナノスフェアー インコーポレイテッド | 混合培養物中でメチシリン耐性黄色ブドウ球菌とメチシリン感受性黄色ブドウ球菌とを区別する方法 |
| JP2008508320A (ja) | 2004-07-29 | 2008-03-21 | カイロン コーポレイション | Streptococcusagalactiaeのようなグラム陽性細菌に対する免疫原性組成物 |
| US20060078952A1 (en) * | 2004-09-14 | 2006-04-13 | Carine Robichon | Method for identifying antimicrobial molecules which interfere with apolipoprotein N-acyltransferase activity |
| US20080095792A1 (en) * | 2004-09-17 | 2008-04-24 | Anderson Annaliesa S | Polypeptides For Inducing A Protective Immune Response Against Staphylococcus Aureus |
| US7838010B2 (en) * | 2004-10-08 | 2010-11-23 | Novartis Vaccines And Diagnostics S.R.L. | Immunogenic and therapeutic compositions for Streptococcus pyogenes |
| DE102004055508A1 (de) | 2004-11-17 | 2006-06-01 | Basf Ag | Verfahren zur Herstellung optisch aktiver Alkohole |
| AU2006206577B2 (en) | 2005-01-21 | 2012-03-08 | Merck Sharp & Dohme Corp. | Polypeptides for inducing a protective immune response against Staphylococcus aureus |
| NZ556651A (en) | 2005-01-21 | 2010-05-28 | Epitopix Llc | Yersinia spp. polypeptides and methods of use |
| US8007811B2 (en) | 2005-02-14 | 2011-08-30 | Epitopix, Llc | Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use |
| GB0505949D0 (en) * | 2005-03-23 | 2005-04-27 | Univ Sheffield | Polypeptides |
| EP1871888A4 (en) * | 2005-03-30 | 2013-08-21 | Novartis Vaccines & Diagnostic | HAEMOPHILUS INFLUENZAE OF TYPE B |
| WO2007093848A2 (en) * | 2005-08-03 | 2007-08-23 | Affinium Pharmaceuticals, Inc. | Crystalline enoyl-(acyl-carrier-protein) reductase from heliobacter pylori |
| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| JP5186689B2 (ja) | 2005-11-10 | 2013-04-17 | 国立大学法人広島大学 | 酸化ケイ素含有物質に結合するタンパク質を介したタンパク質の固定化方法および固定化剤 |
| EP2441469A1 (en) | 2006-03-14 | 2012-04-18 | Oregon Health and Science University | Methods for producing an immune response to tuberculosis |
| PT2054431E (pt) * | 2006-06-09 | 2011-11-03 | Novartis Ag | Confórmeros de adesinas bacterianas |
| US20090275058A1 (en) * | 2006-09-14 | 2009-11-05 | Universitat De Girona | Method for specific detection of salmonella spp. |
| FR2906532B1 (fr) * | 2006-09-28 | 2008-12-12 | Biomerieux Sa | Nouvel oligonucleotide marque |
| JPWO2008044599A1 (ja) * | 2006-10-06 | 2010-02-12 | プロテウスサイエンス株式会社 | 炎症腸管標的活性を有するポリペプチド、およびその利用 |
| CA2668018A1 (en) * | 2006-10-30 | 2008-09-12 | Novartis Ag | Immunogenic and therapeutic compositions for streptococcus pyogenes |
| EP2134849B1 (en) * | 2007-04-18 | 2013-07-10 | Butamax (TM) Advanced Biofuels LLC | Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes |
| CA2684570A1 (en) | 2007-04-19 | 2008-10-30 | Molecular Detection Inc. | Methods, compositions and kits for detection and analysis of antibiotic-resistant bacteria |
| JP2010183841A (ja) * | 2007-05-29 | 2010-08-26 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
| US9181329B2 (en) | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
| JP5658564B2 (ja) | 2007-08-31 | 2015-01-28 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | ブドウ球菌肺疾患および状態に対する免疫に関連した方法および組成物 |
| KR101621837B1 (ko) | 2007-09-12 | 2016-05-17 | 노파르티스 아게 | Gas57 돌연변이 항원 및 gas57 항체 |
| AU2008337398B2 (en) * | 2007-12-19 | 2014-04-03 | Basf Plant Science Gmbh | Plants with increased yield and/or increased tolerance to environmental stress (IY-BM) |
| EP2537857B1 (en) | 2007-12-21 | 2017-01-18 | GlaxoSmithKline Biologicals SA | Mutant forms of streptolysin O |
| FI20075976A0 (fi) * | 2007-12-31 | 2007-12-31 | Finnzymes Oy | Menetelmät ja oligonukleotidit utaretulehdusta aiheuttavien bakteerien osoittamiseksi |
| EP2252702B1 (en) | 2008-02-08 | 2014-01-29 | Mayo Foundation for Medical Education and Research | Detection of clostridium difficile |
| CN102015651B (zh) | 2008-03-03 | 2014-12-31 | Irm责任有限公司 | 作为tlr活性调节剂的化合物和组合物 |
| WO2010014304A1 (en) | 2008-07-29 | 2010-02-04 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
| KR100975956B1 (ko) * | 2008-08-08 | 2010-08-13 | 주식회사 콤슨테크놀러지 | 살균기능을 가지는 장애인용 이동장치 |
| US9175353B2 (en) | 2008-11-14 | 2015-11-03 | Gen-Probe Incorporated | Compositions, kits and methods for detection of campylobacter nucleic acid |
| EP2376111A4 (en) * | 2008-11-26 | 2013-01-09 | Merck Sharp & Dohme | POLYPEPTIDES FOR INDUCING A PROTECTIVE IMMUNE RESPONSE AGAINST STAPHYLOCOCCUS AUREUS |
| BRPI1011856A2 (pt) * | 2009-03-23 | 2020-11-03 | Epitopix, Llc | polipeptídeos e composições de imunização contendo polipeptídeos gram-positivos e métodos de uso |
| HUE026855T2 (en) | 2009-04-03 | 2016-07-28 | Univ Chicago | Compositions and methods related to protein a (spa) variants |
| JP5867952B2 (ja) | 2009-06-10 | 2016-02-24 | ノバルティス アーゲー | ベンゾナフチリジン含有ワクチン |
| JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
| WO2011027222A2 (en) | 2009-09-02 | 2011-03-10 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
| BR112012014624A8 (pt) | 2009-12-15 | 2017-12-26 | Novartis Ag | suspensão homogênea de compostos de imunopotenciação e usos dos destes |
| EA031379B1 (ru) | 2010-03-23 | 2018-12-28 | Новартис Аг | Соединения (липопептиды на основе цистеина) и композиции в качестве агонистов tlr2, применяемые для лечения инфекционных, воспалительных, респираторных и других заболеваний |
| EP4015523A1 (en) | 2010-05-05 | 2022-06-22 | New York University | Staphylococcus aureus leukocidins, therapeutic compositions, and uses thereof |
| CA2803298C (en) | 2010-07-02 | 2020-07-14 | The University Of Chicago | Compositions and methods related to protein a (spa) variants |
| US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
| JP6048932B2 (ja) * | 2010-12-28 | 2016-12-21 | 国立大学法人広島大学 | 酸化ケイ素と窒化ケイ素とを識別するポリペプチドおよびその利用 |
| MX347976B (es) | 2011-03-24 | 2017-05-22 | Butamax(Tm) Advanced Biofuels Llc | Celulas huesped y metodos para producir isobutanol. |
| US9085631B2 (en) * | 2011-04-08 | 2015-07-21 | Nov Vac APS | Proteins and nucleic acids useful in vaccines targeting Staphylococcus aureus |
| US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
| GB201116767D0 (en) | 2011-09-28 | 2011-11-09 | St George S Hospital Medical School | Treatment for mitrochondrial neurogastrointestinal encephalomyopathy |
| EP2773655A4 (en) * | 2011-10-31 | 2015-04-22 | Merck Sharp & Dohme | PROTECTION BASED ON STAPHYLOCOCCUS AUREUS SA2074 PROTEIN |
| US9556439B2 (en) | 2012-02-09 | 2017-01-31 | Bavarian Nordic A/S | Agonists and antagonists of toll-like receptor (TLR) 13 |
| US9181568B2 (en) * | 2012-04-23 | 2015-11-10 | Exxonmobil Research And Engineering Company | Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases |
| JP6670106B2 (ja) | 2012-04-26 | 2020-03-18 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | ブドウ球菌コアグラーゼ抗原およびその使用方法 |
| NZ701099A (en) | 2012-05-11 | 2017-04-28 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase enzymes and methods of use |
| US9376487B2 (en) | 2012-07-10 | 2016-06-28 | Merck Sharp & Dohme Corp. | Protective vaccine based on Staphylococcus aureus SA2493 protein |
| CA2882620A1 (en) * | 2012-09-19 | 2014-03-27 | Novartis Ag | Clostridium difficile polypeptides as vaccine |
| WO2014052670A1 (en) | 2012-09-26 | 2014-04-03 | Butamax (Tm) Advanced Biofuels Llc | Polypeptides with ketol-acid reductoisomerase activity |
| CA2886748A1 (en) | 2012-10-17 | 2014-04-24 | Enterome | Gene signatures of inflammatory disorders that relate to the liver |
| BR112015018014A2 (pt) | 2013-02-01 | 2017-07-11 | Glaxosmithkline Biologicals Sa | liberação intradérmica de composições imunológicas compreendendo agonistas do receptor do tipo toll |
| US20150031101A1 (en) * | 2013-07-26 | 2015-01-29 | Samsung Electronics Co., Ltd. | Bacterial cell having enhanced succinic acid production and a method for producing the succinic acid using the same |
| AU2014306074B2 (en) * | 2013-08-05 | 2018-08-30 | Greenlight Biosciences, Inc. | Engineered proteins with a protease cleavage site |
| US10100093B2 (en) | 2013-12-31 | 2018-10-16 | Epitopix Llc | Polypeptides and immunizing compositions containing Burkholderia polypeptides and methods of use |
| US20170049848A1 (en) * | 2014-05-06 | 2017-02-23 | Virginia Commonwealth University | Target for Firmicutes and Related Bacteria: The PRP Protease |
| GB201408255D0 (en) * | 2014-05-09 | 2014-06-25 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumours of the blood, such as acute myeloid leukemia (AML) |
| HRP20191671T1 (hr) | 2014-05-09 | 2019-12-13 | Immatics Biotechnologies Gmbh | Nova imunoterapija za liječenje nekoliko tumora krvi, kao što je akutna mijeloidna leukemija (aml) |
| FR3024903A1 (fr) | 2014-08-14 | 2016-02-19 | Biomerieux Sa | Procede de quantification d'au moins un groupe de microorganismes par spectrometrie de masse |
| TWI649331B (zh) * | 2015-06-11 | 2019-02-01 | 國立中興大學 | 鮑氏不動桿菌(Acinetobacter baumannii)多胜肽抗原及其抗體以及編碼該抗原之核酸 |
| EP3356525A4 (en) * | 2015-10-02 | 2019-03-27 | University Of Utah Research Foundation | COMPOSITIONS FOR ADJUSTABLE RIBOSOMTRANSLATION SPEED AND METHOD OF USE |
| US10166280B2 (en) | 2016-06-08 | 2019-01-01 | Epitopix, Llc | Polypeptides and immunizing compositions containing Bacillus polypeptides and methods of use |
| US12247242B2 (en) * | 2017-04-06 | 2025-03-11 | Seoul National University R&Db Foundation | Method for quantitatively controlling plasmid copy number in antibiotic-free plasmid maintenance system |
| JP7362667B2 (ja) | 2018-02-12 | 2023-10-17 | イニミューン・コーポレーション | Toll様受容体リガンド |
| WO2019169258A1 (en) * | 2018-03-01 | 2019-09-06 | The Regents Of The University Of California | Methods and compositions relating to epoxide hydrolase genes |
| US12514914B2 (en) | 2019-05-14 | 2026-01-06 | The University Of Chicago | Methods and compositions comprising Staphylococcus protein a (SpA) variants |
| CA3148183C (en) * | 2019-08-28 | 2024-10-15 | Inner Mongolia Eppen Biotech Co., Ltd. | RECOMMENDED STRAIN BASED ON ESCHERICHIA COLI AND ITS CONSTRUCTION PROCESS AND APPLICATION |
| CN114929750B (zh) | 2019-09-13 | 2024-11-22 | 芝加哥大学 | 用于治疗葡萄球菌感染的方法和组合物 |
| AU2020368539A1 (en) | 2019-10-16 | 2022-04-28 | Massachusetts Institute Of Technology | Engineered muscle targeting compositions |
| JP7471688B2 (ja) * | 2019-12-03 | 2024-04-22 | 中國醫藥大學 | オリゴペプチド、検出キット及び医薬組成物 |
| CA3185855A1 (en) * | 2020-06-05 | 2021-12-09 | Modernatx, Inc. | Bacterial strains for dna production |
| JP2023547677A (ja) | 2020-11-04 | 2023-11-13 | エリゴ・バイオサイエンス | キューティバクテリウム・アクネス組換えファージ、その産生方法及び使用 |
| WO2023039476A1 (en) * | 2021-09-08 | 2023-03-16 | The Broad Institute, Inc. | Engineered muscle and central nervous system compositions |
| CN114032313B (zh) * | 2021-11-18 | 2024-09-17 | 广东海洋大学 | 一种评估、检测和/预测耗牛的牛肉品质性状的方法 |
| JPWO2023210800A1 (https=) * | 2022-04-28 | 2023-11-02 | ||
| EP4662323A2 (en) * | 2023-02-09 | 2025-12-17 | Kate Therapeutics, Inc. | Muscle targeted capsids |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999013893A1 (en) * | 1997-09-16 | 1999-03-25 | Isis Pharmaceuticals, Inc. | Peptide nucleic acids having antibacterial activity |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5872104A (en) * | 1994-12-27 | 1999-02-16 | Oridigm Corporation | Combinations and methods for reducing antimicrobial resistance |
| AU5442198A (en) * | 1996-11-13 | 1998-06-03 | Q.B.I. Enterprises Ltd. | Gene identification method |
| CA2289116A1 (en) * | 1997-05-06 | 1998-11-12 | Human Genome Sciences, Inc. | Enterococcus faecalis polynucleotides and polypeptides |
| US6610539B1 (en) * | 1997-07-10 | 2003-08-26 | Genesense Technologies, Inc. | Antisense oligonucleotide sequences as inhibitors of microorganisms |
| US6171838B1 (en) * | 1997-08-13 | 2001-01-09 | Smithkline Beecham Corporation | ratB |
| US20020115217A1 (en) * | 1997-10-02 | 2002-08-22 | Smithkline Beecham Corporation | Whole cell assay |
| US6551795B1 (en) * | 1998-02-18 | 2003-04-22 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics |
| KR20010024603A (ko) * | 1998-09-09 | 2001-03-26 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 필수 세균 유전자 및 그의 용도 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO1999013893A1 (en) * | 1997-09-16 | 1999-03-25 | Isis Pharmaceuticals, Inc. | Peptide nucleic acids having antibacterial activity |
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| KR20020097200A (ko) | 2002-12-31 |
| JP2004516805A (ja) | 2004-06-10 |
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| AU2001249345A1 (en) | 2001-10-03 |
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| EP1268774A2 (en) | 2003-01-02 |
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