JP4850513B2 - 点眼用組成物 - Google Patents
点眼用組成物 Download PDFInfo
- Publication number
- JP4850513B2 JP4850513B2 JP2005511320A JP2005511320A JP4850513B2 JP 4850513 B2 JP4850513 B2 JP 4850513B2 JP 2005511320 A JP2005511320 A JP 2005511320A JP 2005511320 A JP2005511320 A JP 2005511320A JP 4850513 B2 JP4850513 B2 JP 4850513B2
- Authority
- JP
- Japan
- Prior art keywords
- contact lens
- eye
- present
- ophthalmic composition
- contact lenses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- NZHGWWWHIYHZNX-CSKARUKUSA-N tranilast Chemical compound C1=C(OC)C(OC)=CC=C1\C=C\C(=O)NC1=CC=CC=C1C(O)=O NZHGWWWHIYHZNX-CSKARUKUSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Eyeglasses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
酸素透過性ハードコンタクトレンズ装用者10名、ソフトコンタクトレンズ装用者10名、及びコンタクトレンズを装用していないVDT作業従事者10名よりなる、合計30名のボランティアに対して、以下の如き官能試験を行なった。具体的には、ボランティアに対して、1ヶ月の連続した試験期間中に、1回当たり1〜3滴の点眼用組成物を1日に3〜6回の頻度にて点眼し、ボランティア自らが試験期間中の各点眼用組成物による乾燥感の低減効果を評価し、それぞれの点眼用組成物に対する評価を集計した。そして、集計した結果を、下記の基準にて判定し、その判定結果を、下記表1,2に示した。
◎:コンタクトレンズ装用時やVDT作業による乾燥感が顕著に軽減され、且つその軽減効果が持続したと回答した人の割合が75%以上の場合。
△:コンタクトレンズ装用時やVDT作業による乾燥感が顕著に軽減され、且つその軽減効果が持続したと回答した人の割合が50%以上75%未満の場合。
×:コンタクトレンズ装用時やVDT作業による乾燥感が顕著に軽減され、且つその軽減効果が持続したと回答した人の割合が50%未満の場合。
上記乾燥感低減効果試験と同様に、1ヶ月間、合計30名のボランティアに対して、官能試験を行なった。そして、ボランティア自らが試験期間中の各点眼用組成物による使用感を評価し、それぞれの点眼用組成物に対する評価を集計した。そして、集計した結果を、下記の基準にて判定し、その判定結果を、下記表1,2に示した。
◎:点眼後の注し心地及び視力に満足していると答えた人の割合が75%以上の場合。
△:点眼後の注し心地及び視力に満足していると答えた人の割合が50%以上75%未満の場合。
×:点眼後の注し心地及び視力に満足していると答えた人の割合が50%未満の場合。
30名のボランティアに対して、各点眼用組成物を、それぞれ、点眼した。そして、角膜表面を、細隙灯顕微鏡にて観察し、涙液層破壊時間(BUT:tear breakup time)を測定し、下記評価基準により評価を行なって、その結果を、下記表1,2に示した。より具体的には、フルオレセイン染色後、ボランティアに数回瞬目させ、次いで、開瞼を指示して、完全な瞬目の後、角膜上皮の涙液層が最初に破壊されるまでの時間を、コバルトフィルターを用いて測定した。
◎:BUTが15秒以上である。
△:BUTが10秒以上15秒未満である。
×:BUTが10秒未満である。
コンタクトレンズとして、ジョンソン・エンド・ジョンソン株式会社製ワンデーアキュビュー(B.C. 9.0/P -3.00/Dia 14.2) を準備する一方、点眼用組成物として、上記で得られた実施例1,3及び比較例3,6に係る点眼用組成物を、それぞれ、準備した。
Claims (4)
- コンタクトレンズの装用下において点眼が実施されるコンタクトレンズ用点眼剤にして、水系媒体中に、(A)ジェランガム及びペクチンからなる群より選ばれた少なくとも1種以上の化合物と、(B)ポリオキシエチレン−ポリオキシプロピレンブロックコポリマー及びポリオキシエチレンソルビタンモノオレートから選ばれる少なくとも1種以上の非イオン性界面活性剤とを含み、更に張度が、塩化ナトリウム換算で、0.5w/v%以上、0.9w/v%未満に調整されてなることを特徴とするコンタクトレンズ用点眼剤。
- ヒドロキシプロピルメチルセルロースが、更に、0.01w/w%〜5.0w/w%の割合で含有せしめられている請求項1に記載のコンタクトレンズ用点眼剤。
- 前記非イオン性界面活性剤(B)として、その0.1w/w%含有水溶液における表面張力が、25℃にて、55mN/m以下であるものが用いられている請求項1又は請求項2に記載のコンタクトレンズ用点眼剤。
- 前記化合物(A)が、0.05〜0.25w/w%の割合で含有されている請求項1乃至請求項3の何れか一つに記載のコンタクトレンズ用点眼剤。
Priority Applications (1)
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JP2005511320A JP4850513B2 (ja) | 2003-07-03 | 2004-06-22 | 点眼用組成物 |
Applications Claiming Priority (4)
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JP2003270784 | 2003-07-03 | ||
JP2003270784 | 2003-07-03 | ||
PCT/JP2004/008739 WO2005002595A1 (ja) | 2003-07-03 | 2004-06-22 | 点眼用組成物 |
JP2005511320A JP4850513B2 (ja) | 2003-07-03 | 2004-06-22 | 点眼用組成物 |
Publications (2)
Publication Number | Publication Date |
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JPWO2005002595A1 JPWO2005002595A1 (ja) | 2006-08-10 |
JP4850513B2 true JP4850513B2 (ja) | 2012-01-11 |
Family
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JP2005511320A Expired - Lifetime JP4850513B2 (ja) | 2003-07-03 | 2004-06-22 | 点眼用組成物 |
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JP (1) | JP4850513B2 (ja) |
WO (1) | WO2005002595A1 (ja) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4963359B2 (ja) * | 2005-01-12 | 2012-06-27 | ロート製薬株式会社 | 眼局所適用製剤 |
JP2006248960A (ja) * | 2005-03-10 | 2006-09-21 | Rohto Pharmaceut Co Ltd | 水性外用組成物 |
JP5200365B2 (ja) * | 2005-11-30 | 2013-06-05 | 大正製薬株式会社 | 粘膜適用液剤 |
JPWO2007145344A1 (ja) * | 2006-06-16 | 2009-11-12 | ロート製薬株式会社 | テルペノイドを含有するソフトコンタクトレンズ用眼科組成物 |
WO2008088612A1 (en) * | 2006-12-20 | 2008-07-24 | Bausch & Lomb Incorporated | Method of stimulating the production of mucin in the eye of a patient |
KR100963611B1 (ko) * | 2008-01-23 | 2010-06-15 | 주식회사태준제약 | 알긴산류 화합물을 포함하는 점안용 조성물 및 그의제조방법 |
US20120269862A1 (en) * | 2011-04-22 | 2012-10-25 | Chowhan Masood A | Ophthalmic composition with a viscosity enhancement system having two different viscosity enhancing agents |
EP2714007A2 (en) * | 2011-05-27 | 2014-04-09 | Ratiopharm GmbH | Ophthalmic preparation comprising a pgf2alpha analogue |
JP6223890B2 (ja) * | 2014-03-31 | 2017-11-01 | 株式会社メニコン | 眼科用組成液及びその使用方法 |
JP5654704B1 (ja) * | 2014-05-29 | 2015-01-14 | ロート製薬株式会社 | 眼科組成物 |
CN106163565A (zh) * | 2014-04-09 | 2016-11-23 | 乐敦制药株式会社 | 眼科组合物 |
WO2015156321A1 (ja) * | 2014-04-09 | 2015-10-15 | ロート製薬株式会社 | 眼科組成物 |
JP2016088922A (ja) * | 2014-11-12 | 2016-05-23 | ロート製薬株式会社 | 眼科組成物 |
JP2020075918A (ja) * | 2018-11-02 | 2020-05-21 | 千寿製薬株式会社 | 角膜上皮創傷治癒促進用の眼科用組成物 |
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WO1997028827A1 (fr) * | 1996-02-07 | 1997-08-14 | Rohto Pharmaceutical Co., Ltd. | Composition ophtalmique possedant une viscosite adaptee |
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JPS63159821A (ja) * | 1986-12-23 | 1988-07-02 | Tome Sangyo Kk | コンタクトレンズ用洗浄剤 |
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- 2004-06-22 JP JP2005511320A patent/JP4850513B2/ja not_active Expired - Lifetime
- 2004-06-22 WO PCT/JP2004/008739 patent/WO2005002595A1/ja active Application Filing
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US4287175A (en) * | 1978-06-22 | 1981-09-01 | Merck & Co., Inc. | Contact lens wetting agents |
JPH07157747A (ja) * | 1993-12-10 | 1995-06-20 | Hoya Corp | コンタクトレンズ用剤 |
WO1997028827A1 (fr) * | 1996-02-07 | 1997-08-14 | Rohto Pharmaceutical Co., Ltd. | Composition ophtalmique possedant une viscosite adaptee |
JPH11180858A (ja) * | 1997-12-18 | 1999-07-06 | Rohto Pharmaceut Co Ltd | 清涼化剤を含有するコンタクトレンズ用点眼剤 |
JP2000159659A (ja) * | 1998-11-30 | 2000-06-13 | Kazuo Tsubota | 眼科用人工涙液 |
JP2002332249A (ja) * | 2001-03-08 | 2002-11-22 | Rohto Pharmaceut Co Ltd | アルギン酸含有組成物 |
JP2002332248A (ja) * | 2001-03-08 | 2002-11-22 | Rohto Pharmaceut Co Ltd | Gリッチなアルギン酸含有組成物 |
JP2002322048A (ja) * | 2001-04-24 | 2002-11-08 | Lion Corp | ソフトコンタクトレンズ用組成物 |
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JPWO2005002595A1 (ja) | 2006-08-10 |
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